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Multiple sclerosis is associated with higher comorbidity and healthcare resource use: a population-based, case-control study in a western Mediterranean region.

Eur J Neurol 2021 Jul 22. Epub 2021 Jul 22.

Servei de Neurología-Neuroimmunología, Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Hospital Universitari, Barcelona, Spain.

Background: Comorbidities are common in multiple sclerosis (MS), and have been associated with worse outcomes and increased healthcare resource usage. We studied the frequency of comorbidities and adverse health behaviors (AHB) in MS patients in the Mediterranean region of Catalonia.

Methods: Population-based, case-control study using primary healthcare information covering 80% of Catalonia's population. Read More

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Analysis of trans-sacral corridors in stabilization of fractures of the pelvic ring.

J Orthop Res 2021 Jul 22. Epub 2021 Jul 22.

Department for Trauma Surgery, Orthopaedics and Plastic Surgery, University Medical Center Göttingen, Robert-Koch Str. 40, 37075, Göttingen, Germany.

Percutaneous screw fixation combined with pelvic reduction is a surgical technique used to stabilize fractures of the posterior pelvic ring. This is the standard surgical treatment of unstable posterior pelvic ring injuries. The primary goal of this treatment is an anatomic reduction and stable fixation. Read More

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Photothermal-Enhanced Fenton-like Catalytic Activity of Oxygen-Deficient Nanotitania for Efficient and Safe Tooth Whitening.

ACS Appl Mater Interfaces 2021 Jul 22. Epub 2021 Jul 22.

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Engineering Research Center of Oral Translational Medicine, Ministry of Education & National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.

The growing demand for charming smiles has led to the popularization of tooth bleaching procedures. Current tooth bleaching products with high-concentration hydrogen peroxide (HP, 30-40%) are effective but detrimental due to the increased risk of enamel destruction, tooth sensitivity, and gingival irritation. Herein, we reported a less-destructive and efficient tooth whitening strategy with a low-concentration HP, which was realized by the remarkably enhanced Fenton-like catalytic activity of oxygen-deficient TiO (TiO). Read More

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Associations between prepregnancy body mass index, gestational weight gain and weight catch-up in small-for-gestational-age children.

Matern Child Nutr 2021 Jul 22:e13235. Epub 2021 Jul 22.

Xinhua Hospital, MOE-Shanghai Key Laboratory of Children's Environmental Health, Department of Child and Adolescent Healthcare, Shanghai Institute for Pediatric Research, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Inadequate gestational weight gain (GWG) was related with a higher incidence of small-for-gestational-age (SGA) births than appropriate GWG; however, the long-term association of maternal GWG with weight catch-up growth in SGA children remains unknown. The objective of this study is to evaluate the associations between prepregnancy body mass index (pBMI), GWG and weight catch-up patterns in SGA children. Data were from the Collaborative Perinatal Project, an American multicentre prospective cohort study. Read More

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Impact of chemotherapy on prognosis of resectable pathological T3N0M0 esophageal cancer patients: a population-based study.

Future Oncol 2021 Jul 22. Epub 2021 Jul 22.

Department of Oncology, Jiangdu People's Hospital Affiliated to Medical College of Yangzhou University, Yangzhou 225200, People's Republic of China.

This study aimed to retrospectively determine the influence factors and survival effects of chemotherapy in pathological T3N0M0 esophageal cancer (EC) patients based on histological type. A total of 1136 pathological T3N0M0 EC patients who had surgery were chosen from the Surveillance, Epidemiology and End Results database. The patients were divided into subgroups based on histological type and chemotherapy status. Read More

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Gene expression changes in male and female rhesus macaque 60 days after irradiation.

PLoS One 2021 21;16(7):e0254344. Epub 2021 Jul 21.

Bundeswehr Institute of Radiobiology, Munich, Germany.

Purpose: Transcriptome changes can be expected in survivors after lethal irradiation. We aimed to characterize these in males and females and after different cytokine treatments 60 days after irradiation.

Material And Methods: Male and female rhesus macaques (n = 142) received a whole-body exposure with 700 cGy, from which 60 animals survived. Read More

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Comparison of Paresthesia Mapping With Anatomic Placement in Burst Spinal Cord Stimulation: Long-Term Results of the Prospective, Multicenter, Randomized, Double-Blind, Crossover CRISP Study.

Neuromodulation 2021 Jul 20. Epub 2021 Jul 20.

Pain & Neuromodulation Academic Research Centre, Guy's & St. Thomas' NHS Foundation Trust, London, UK.

Objectives: Spinal cord stimulation (SCS) is an effective therapy for chronic intractable pain. Conventional SCS involves electrode placement based on intraoperative paresthesia mapping; however, newer paradigms like burst may allow for anatomic placement of leads. Here, for the first time, we report the one-year safety and efficacy of burst SCS delivered using a lead placed with conventional, paresthesia mapping, or anatomic placement approach in subjects with chronic low back pain (CLBP). Read More

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Reporting guideline for interventional trials of primary and incisional ventral hernia repair.

Br J Surg 2021 Jul 21. Epub 2021 Jul 21.

Centre for Medical Imaging, University College London, London, UK.

Background: Primary and incisional ventral hernia trials collect unstandardized inconsistent data, limiting data interpretation and comparison. This study aimed to create two minimum data sets for primary and incisional ventral hernia interventional trials to standardize data collection and improve trial comparison. To support these data sets, standardized patient-reported outcome measures and trial methodology criteria were created. Read More

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Evidence of the medical and economic benefits of implementing hygiene measures by a prevention link physician in trauma surgery: Study protocol for a biphasic multicenter prospective interventional pre-post cohort study using a structured intervention bundle development and tools of behavior change management.

Contemp Clin Trials Commun 2021 Sep 2;23:100815. Epub 2021 Jul 2.

Institute of Hygiene, Cologne Merheim Medical Center, University Hospital Witten/Herdecke Cologne, Germany, Ostmerheimer Str. 200, 51109 Cologne, Germany.

Introduction: The German Commission for Hospital Hygiene and Infection Prevention recommends nominating one authorized medical specialist in every medical department as an infection prevention link physician (PLP). It has been roughly described that a PLP serves as a link between the infection prevention team and the respective clinical departments. No detailed evidence about the contribution made by PLPs to the decrease of infection rates is available in Germany. Read More

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September 2021

"You Are Older, although You Do Not Know That": Time, Consciousness, and Memory in "A Kind of Alaska" by Harold Pinter (1930-2008).

Eur Neurol 2021 Jul 20:1-4. Epub 2021 Jul 20.

UOC Neurology and Stroke Unit, ASST Lecco, Merate, Italy.

"A Kind of Alaska" is a one-act play by the British playwright and Nobel Prize winner Harold Pinter (1930-2008), based on the book Awakenings by the neurologist Oliver Sacks (1933-2015). This play, first performed in 1982, is centered around the character of Deborah, a middle-aged woman, struck by encephalitis lethargica ("sleeping sickness") at the age of 16, who wakes up after 29 years of apparent sleep following the injection of an unnamed drug. This article analyzes how Pinter's drama investigated the mysterious and fascinating relationship between time, memory, and consciousness. Read More

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Quality Care in Survivorship: Lessons Learned From the ASCO Quality Oncology Practice Initiative.

JCO Oncol Pract 2021 Jul 20:OP2100290. Epub 2021 Jul 20.

National Cancer Institute, Division of Cancer Control and Population Sciences, Bethesda, MD.

Purpose: The ASCO Quality Oncology Practice Initiative (QOPI) project was established to evaluate the influence of guideline recommendations on routine clinical practice.

Methods: QOPI provided summary data from 839 unique practices in which data were collected every six months from the Fall of 2015 to the Spring of 2019. From these data, six items were chosen based on their relationship to domains of survivorship. Read More

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Clinical Characteristics and Treatment Response in Microscopic Colitis Based on Age at Diagnosis: A Multicenter Retrospective Study.

Dig Dis Sci 2021 Jul 20. Epub 2021 Jul 20.

Division of Gastroenterology and Hepatology, Massachusetts General Hospital, Boston, MA, USA.

Background: Microscopic colitis (MC) primarily affects older adults; thus, data in younger patients are scarce.

Aims: To compare clinical characteristics and treatment response by age at diagnosis.

Methods: This retrospective cohort study was performed at Mayo Clinic and Massachusetts General Hospital. Read More

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Assessing and conveying risks and benefits of imaging in neonates using ionizing radiation and sedation/anesthesia.

Pediatr Radiol 2021 Jul 20. Epub 2021 Jul 20.

Department of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

Neonates represent a unique subset of the pediatric population that requires special attention and careful thought when implementing advanced cross-sectional imaging with CT or MRI. The ionizing radiation associated with CT and the sedation/anesthesia occasionally required for MRI present risks that must be balanced against the perceived benefit of the imaging examination in the unique and particularly susceptible neonatal population. We review the perceived risks of ionizing radiation and the more concrete risks of sedation/anesthesia in term and preterm neonates in the context of an imaging paradigm. Read More

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Thyroid surgery during the COVID-19 pandemic: results from a systematic review.

J Endocrinol Invest 2021 Jul 19. Epub 2021 Jul 19.

Clinic for Endocrinology and Diabetology, Lugano Regional Hospital, Ente Ospedaliero Cantonale, Lugano, Switzerland.

Purpose: During the COVID-19 pandemic, elective thyroid surgery is experiencing delays. The problem is that the COVID-19 pandemic is ongoing. The research purposes were to systematically collect the literature data on the characteristics of those thyroid operations performed and to assess the safety/risks associated with thyroid surgery during the COVID-19 pandemic. Read More

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Retention of different temporary cements tested on zirconia crowns and titanium abutments in vitro.

Int J Implant Dent 2021 Jul 20;7(1):62. Epub 2021 Jul 20.

Department of Prosthodontics, Geriatric Dentistry and Craniomandibular Disorders, University Charité Berlin, Aßmannshauser Str. 4-6, 14197, Berlin, Germany.

Purpose: The aim of the present study was to examine the retention force of monolithic zirconia copings cemented with various temporary cements on implant abutments in vitro.

Methods: Sixty exercise implants with pre-screwed implant abutments were embedded in resin. Subsequently, 60 CAD/CAM manufactured zirconia copings were divided into three main groups [Harvard Implant Semi-permanent (HAV), implantlink semi Forte (IMP), Temp Bond NE (TBNE)]. Read More

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Primary cam morphology; bump, burden or bog-standard? A concept analysis.

Br J Sports Med 2021 Jul 19. Epub 2021 Jul 19.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.

Background: Cam morphology, a distinct bony morphology of the hip, is prevalent in many athletes, and a risk factor for hip-related pain and osteoarthritis. Secondary cam morphology, due to existing or previous hip disease (eg, Legg-Calve-Perthes disease), is well-described. Cam morphology not clearly associated with a disease is a challenging concept for clinicians, scientists and patients. Read More

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Utilization of Subcutaneous Cardioverter-Defibrillator in Poland and Europe-Comparison of the Results of Multi-Center Registries.

Int J Environ Res Public Health 2021 Jul 5;18(13). Epub 2021 Jul 5.

Cardiology, Cardiac Arrhythmias Management Department, Clinique Pasteur, 31076 Toulouse, France.

The implantation of a subcutaneous cardioverter-defibrillator (S-ICD) may be used instead of a traditional transvenous system to prevent sudden cardiac death. Our aim was to compare the characteristics of S-ICD patients from the multi-center registry of S-ICD implantations in Poland with the published results of the European Snapshot Survey on S-ICD Implantation (ESSS-SICDI). We compared data of 137 Polish S-ICD patients with 68 patients from the ESSS-SICDI registry. Read More

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Diversity, Complexity and Ordinality: Mental Health Services Outside the Institutions-Service Users' and Professionals' Experience-Based Practices and Knowledges, and New Public Management.

Int J Environ Res Public Health 2021 Jul 2;18(13). Epub 2021 Jul 2.

Department of Social Work, Stockholm University, 106 91 Stockholm, Sweden.

In conjunction with the dismantling of psychiatric hospitals, social workers have been commissioned to help service users in their daily living in their homes and in the community. The consequences of these changes for experience-based knowledge and practices in their contexts remain relatively unknown. In this study, eighteen service users and the social workers they described as helpful for them were interviewed. Read More

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Abnormal causal connectivity of left superior temporal gyrus in drug-naïve first- episode adolescent-onset schizophrenia: A resting-state fMRI study.

Psychiatry Res Neuroimaging 2021 Jul 3;315:111330. Epub 2021 Jul 3.

The First Affiliated Hospital, Zhejiang University School of Medicine, The Key Laboratory of Mental Disorder's Management of Zhejiang Province, Hangzhou, Zhejiang, China. Electronic address:

This study aimed to investigate the alterations of causal connectivity between the brain regions in Adolescent-onset schizophrenia (AOS) patients. Thirty-two first-episode drug-naïve AOS patients and 27 healthy controls (HC) were recruited for resting-state functional MRI scanning. The brain region with the between-group difference in regional homogeneity (ReHo) values was chosen as a seed to perform the Granger causality analysis (GCA) and further detect the alterations of causal connectivity in AOS. Read More

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Healthcare professionals' perceptions of dignity-preserving care for older home-dwelling women with incurable cancer in Norway.

J Women Aging 2021 Jul 19:1-15. Epub 2021 Jul 19.

Faculty of Health and Social Sciences, Department of Health and Caring Sciences, Western Norway University of Applied Sciences, Bergen, Norway.

Municipal end-of-life care for older home-dwelling patients with cancer is a complex matter requiring healthcare professionals (HCPs) to recognize gender differences in a social, historical and organizational context. A qualitative approach was chosen to explore and identify HCPs value-based principles and organizational conditions promoting dignity-preserving care practice for these women. HCPs recognized the importance of sheltering the women's identity, their sense of being home and acknowledged their personal preferences as value-based principles, whereas creating a flexible culture of care, establishing a functional professional collaboration and developing individualized plans of care, were crucial organizational conditions influencing the practice of dignity-preserving care. Read More

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"Standalone Ayurvedic treatment of high-risk COVID-19 patients with multiple comorbidities: A case series."

J Ayurveda Integr Med 2021 Jun 17. Epub 2021 Jun 17.

Prema's Medical and Diabetes Research Centre, Chennai, India.

Background: We report a case-series of Ayurvedic treatment in seven COVID-19 positive patients with multiple comorbidities, categorized as high risk for poor outcome from SARS-CoV-2 infection. All of them recovered completely from their illness with resolution of symptoms following Ayurvedic treatment. The data was collected from patients treated during the early months of the COVID-19 pandemic (June 2020 to September 2020) at an out-patient Ayurvedic Clinic, Chennai, India. Read More

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Prenatal and Obstetric Parameters of Late Terminations: A Retrospective Analysis.

Geburtshilfe Frauenheilkd 2021 Jul 13;81(7):807-818. Epub 2021 Jul 13.

Universitätsklinikum Leipzig, Abteilung für Geburtsmedizin, Leipzig, Germany.

In Germany, the highly sensitive issue of late terminations of pregnancy and feticide is regulated in Sec. 218a para. 2 of the German Penal Code (medical indication). Read More

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The potential no man's land for the 4 year dental graduate.

Br J Oral Maxillofac Surg 2021 May 2. Epub 2021 May 2.

Department of Oral and Maxillofacial Surgery, Gloucestershire Royal Hospital, Great Western Rd, Gloucester, GL1 3NN. Electronic address:

The Royal College of Surgeons of England stipulates that to hold a substantive specialty or associate specialist (SAS) grade post a person must be a minimum of 4 years post-graduation and have at least 2 years' experience in their chosen speciality. We have noticed an increasing number of excellent applications for specialty doctor adverts posted by our trust without the necessary 4 years of post-graduate experience. Many of these applicants who do not comply with the RCS stipulations may be forced to take a job outside of their chosen career path. Read More

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Reductase and Light Programmatical Gated DNA Nanodevice for Spatiotemporally Controlled Imaging of Biomolecules in Subcellular Organelles under Hypoxic Conditions.

ACS Appl Mater Interfaces 2021 Jul 19. Epub 2021 Jul 19.

College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, 410006 Hunan, China.

Monitoring hypoxia-related changes in subcellular organelles would provide deeper insights into hypoxia-related metabolic pathways, further helping us to recognize various diseases on subcellular level. However, there is still a lack of real-time, , and controllable means for biosensing in subcellular organelles under hypoxic conditions. Herein, we report a reductase and light programmatical gated nanodevice integrating light-responsive DNA probes into a hypoxia-responsive metal-organic framework for spatiotemporally controlled imaging of biomolecules in subcellular organelles under hypoxic conditions. Read More

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[Comparative study on fracture toughness of digital light processing three-dimensional printing zirconia and milled zirconia].

Zhonghua Kou Qiang Yi Xue Za Zhi 2021 Jul;56(7):639-645

Department of Prosthodontics Ⅱ, West China Hospital of Stomatology, Sichuan University & State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Chengdu 610041, China.

To investigate the influence of digital light processing (DLP) and computer numerical controlmilling (CNC) on the mechanical behavior of zirconia. Prepared DLP samples (experimental group, =52) and CNC samples (control group, =52) with 12 samples in each group were randomly selected using random number table to measure density, grain size and crystal phase composition. According to the different methods fracture toughness test, the samples were divided into indentation method group (IM) and single-edge-V-notch-beam group (SEVNB), with 30 DLP and 30 CNC samples in IM group, 10 DLP and 10 CNC samples in SEVNB group. Read More

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Management of neovascular age-related macular degeneration: Taiwan expert consensus.

J Formos Med Assoc 2021 Jul 14. Epub 2021 Jul 14.

Department of Ophthalmology, Changhua Christian Hospital, Changhua, Taiwan; College of Medicine, Chung-Shan Medical University, Taichung, Taiwan; Department of Optometry, College of Nursing and Health Science, Da-Yeh University, Changhua, Taiwan. Electronic address:

Neovascular age-related macular degeneration (nAMD) is a leading cause of irreversible vision loss. The present consensus provides suggestions on diagnosis, evaluation, treatment, and follow-up strategies for nAMD from a panel of 11 practicing ophthalmologists. The experts suggest that the baseline visit for nAMD management should include a comprehensive ophthalmologic examination via a multimodal approach consisting of visual and anatomical evaluation. Read More

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A prospective study of treatments for adult-onset divergence insufficiency-type esotropia.

J AAPOS 2021 Jul 13. Epub 2021 Jul 13.

University of Arizona, Tucson.

Purpose: To describe 10-week and 12-month outcomes following treatment for divergence insufficiency-type esotropia in adults.

Methods: In this prospective observational study, 110 adults with divergence insufficiency-type esotropia, with a distance esodeviation measuring 2 to 30 and at least 25% larger at distance than near, and binocular diplopia present at least "sometimes" at distance, were enrolled at 28 sites when initiating new treatment. Surgery, prism, or divergence exercises/therapy were chosen at the investigator's discretion. Read More

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Comparison of Outcomes by Reconstructive Strategy in Patients with Prostheses for Proximal Femoral Focal Deficiency.

J Bone Joint Surg Am 2021 Jul 16. Epub 2021 Jul 16.

Children's Hospital Colorado, Denver, Colorado.

Background: The present study compares prosthetic treatment options for proximal femoral focal deficiency in terms of gait analysis, oxygen consumption, and patient-reported outcomes.

Methods: Twenty-three patients who had been managed with a prosthesis for unilateral proximal femoral focal deficiency underwent gait analysis; this group included 7 patients who had received an equinus prosthesis, 6 who had received a rotationplasty prosthesis, and 10 who had undergone Syme amputation and had received an above-the-knee prosthesis. Cadence parameters, kinematic and kinetic data, and oxygen consumption were measured, and the Gait Deviation Index (GDI) was calculated. Read More

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Artificial intelligence in digital cariology: a new tool for the diagnosis of deep caries and pulpitis using convolutional neural networks.

Ann Transl Med 2021 May;9(9):763

Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences, the Affiliated Hospital of Stomatology of Chongqing Medical University, Chongqing, China.

Background: An accurate diagnosis of deep caries and pulpitis on periapical radiographs is a clinical challenge.

Methods: A total of 844 radiographs were included in this study. Of the 844, 717 (85%) were used for training and 127 (15%) were used for testing the three convolutional neural networks (CNNs) (VGG19, Inception V3, and ResNet18). Read More

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