478,425 results match your criteria hospital centre

Stroke and Chronic Kidney Disease.

Contrib Nephrol 2021 Aug 3;199:1-11. Epub 2021 Aug 3.

Ottawa Hospital Research Institute, The Ottawa Hospital, Civic Campus, Ottawa, Ontario, Canada.

Chronic kidney disease (CKD) is strongly associated with the full spectrum of cerebrovascular disease including ischaemic and haemorrhagic stroke, small vessel disease, and vascular cognitive impairment. Shared conventional vascular risk factors such as age, hypertension, and diabetes mellitus may account for many of these associations, but novel renal-specific risk factors such as uraemia-related coagulopathy or endothelial dysfunction have also been proposed. In this chapter, we will explore the impact of CKD on stroke risk, mechanisms, and outcomes. Read More

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Religion, spirituality, and epilepsy.

Ian Bone Simon Dein

Epilepsy Behav 2021 Jul 31;122:108219. Epub 2021 Jul 31.

Psychiatry and Anthropology, Queen Mary College, University of London, Consultant Psychiatrist Princess Alexandra Hospital, Harlow, Essex CM20 1QX UK.

This review provides responses to four questions on epilepsy, religion, and spirituality. Firstly, have early religious beliefs and writings stigmatized and discriminated against epilepsy and if so, what has been done to correct this? We provide textual evidence suggesting an affirmative response. Secondly, which religious luminaries, gods, saints, and religious symbols have connections with epilepsy? We argue that the evidence to suggest that St Paul, Joan of Arc, the Prophet Mohammed, and others had epilepsy is weak and emphasizes the limitations of imposing contemporary neurological frameworks upon them. Read More

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A longitudinal time and motion study quantifying how implementation of an electronic medical record influences hospital nurses' care delivery.

Int J Med Inform 2021 Jul 22;153:104537. Epub 2021 Jul 22.

Department of Pharmacy, Alfred Health, Australia; Monash University, Centre for Medication Use and Safety, Australia.

Aim Background: Many health care services are implementing or planning to undergo digital transformation to keep pace with increasing Electronic Medical Record (EMR) functionality. The aim of this study was to objectively measure nursing care delivery before and following introduction of an EMR.

Design And Methods: An extensive program of work to expand an EMR across our health service using a 'big bang' methodology was undertaken. Read More

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Network analysis of physical and psychiatric symptoms of hospital discharged patients infected with COVID-19.

J Affect Disord 2021 Jul 16;294:707-713. Epub 2021 Jul 16.

Department of Communication, Renmin University of China, China.

In the current study, we aimed to investigate the network structure of COVID-19 symptoms and its related psychiatric symptoms, using a network approach. Specifically, we examined how COVID-19 symptoms relate to psychiatric symptoms and highlighted potential pathways between COVID-19 severity and psychiatric symptoms. With a sample of six hundred seventy-five recovered COVID-19 patients recruited 1 month after hospital discharge, we respectively integrated COVID-19 symptoms with PTSD, depression, and anxiety symptoms and analyzed the three network structures. Read More

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Smoking and vaping patterns during pregnancy and the postpartum: A longitudinal UK cohort survey.

Addict Behav 2021 Jul 15;123:107050. Epub 2021 Jul 15.

Division of Primary Care Research and UK Centre for Tobacco and Alcohol Studies, School of Medicine, University of Nottingham, Nottingham NG7 2RD, UK.

Introduction: There is limited information about longitudinal patterns of vaping during pregnancy and the postpartum. We describe the prevalence, frequency, and reasons for vaping throughout pregnancy and postpartum. We also describe temporal patterns in pregnant women's vaping. Read More

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Frequency of actionable molecular drivers in lung cancer patients with precocious brain metastases.

Clin Neurol Neurosurg 2021 Jul 24;208:106841. Epub 2021 Jul 24.

Department of Neuropathology, Otto-von-Guericke University Magdeburg, Germany. Electronic address:

Brain metastases frequently occur during the course of disease in patients suffering from lung cancer. Occasionally, neurological symptoms caused by brain metastases (BM) might represent the first sign of systemic tumor disease (so called precocious metastases), leading to the detection of the primary lung tumor. The biological basis of precocious BM is largely unknown, and treatment options are not well established for this subgroup of patients. Read More

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Omega-3 fatty acid rescues ischaemia/perfusion-induced testicular and sperm damage via modulation of lactate transport and xanthine oxidase/uric acid signaling.

Biomed Pharmacother 2021 Jul 31;142:111975. Epub 2021 Jul 31.

Bioresources Development Centre, National Biotechnology Development Agency, Ministry of Science and Technology, Ogbomoso, Oyo State, Nigeria. Electronic address:

This study aimed to explore the potential antioxidant, anti-inflammatory, and anti-apoptotic effects of omega 3 fatty acid (Ω-3) in a rat model of testicular torsion/detorsion (T/D). Under ketamine/xylazine anaesthesia, age-matched adult male Wistar rats of comparable weight underwent sham-operation or testicular torsion by fixing the left testis rotated at 720° for two and half hours. After detorsion, animals were treated with either olive oil as vehicle or Ω-3 subcutaneously for three days. Read More

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CT-based radiomics model with machine learning for predicting primary treatment failure in diffuse large B-cell Lymphoma.

Transl Oncol 2021 Jul 30;14(10):101188. Epub 2021 Jul 30.

Jewish General Hospital - McGill University, Canada; Segal Cancer Centre and Lady Davis Institute for Medical Research, Canada.

Biomarkers which can identify Diffuse Large B-Cell Lymphoma (DLBCL) likely to be refractory to first-line therapy are essential for selecting this population prior to therapy initiation to offer alternate therapeutic options that can improve prognosis. We tested the ability of a CT-based radiomics approach with machine learning to predict Primary Treatment Failure (PTF)-DLBCL from initial imaging evaluation. Twenty-six refractory patients were matched to 26 non-refractory patients, yielding 180 lymph nodes for analysis. Read More

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Radiomics diagnosed histopathological growth pattern in prediction of response and 1-year progression free survival for colorectal liver metastases patients treated with bevacizumab containing chemotherapy.

Eur J Radiol 2021 Jul 13;142:109863. Epub 2021 Jul 13.

Department of Radiology, Peking University People's Hospital, 11 Xizhimen South St., Beijing 100044, China. Electronic address:

Objective: To investigate the capability of a radiomics model, which was designed to identify histopathologic growth pattern (HGP) of colorectal liver metastases (CRLMs) based on contrast-enhanced multidetector computed tomography (ceMDCT), to predict early response and 1-year progression free survival (PFS) in patients treated with bevacizumab-containing chemotherapy.

Methods: Patients with unresectable CRLMs who were treated with bevacizumab-containing chemotherapy were included in this multicenter retrospective study. For each target lesion, the radiomics-diagnosed HGP (RAD_HGP) of desmoplastic (D) pattern or replacement (R) pattern was determined. Read More

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Computational Fluid Dynamics in Intracranial Atherosclerosis - Lessons from Cardiology: A Review of CFD in Intracranial Atherosclerosis.

J Stroke Cerebrovasc Dis 2021 Jul 31;30(10):106009. Epub 2021 Jul 31.

Department of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Grattan St, Parkville 3052, Victoria, Australia.

Background: Intracranial atherosclerosis is a common cause of stroke with a high recurrence rate. Haemodynamically significant lesions are associated with a particularly high risk of recurrence. Computational fluid dynamics (CFD) is a tool that has been investigated to identify haemodynamically significant lesions. Read More

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The prediction of morbidity related to vaginal delivery in nulliparous women - A secondary analysis from the genesis multicenter trial.

Eur J Obstet Gynecol Reprod Biol 2021 Jul 19;264:276-280. Epub 2021 Jul 19.

Royal College of Surgeons in Ireland, Rotunda Hospital, Dublin, Ireland.

Objective: In the prospective multicenter Genesis study, we developed a prediction model for Cesarean delivery (CD) in term nulliparous women. The objective of this secondary analysis was to determine whether the Genesis model has the potential to predict maternal and neonatal morbidity associated with vaginal delivery.

Study Design: The national prospective Genesis trial recruited 2,336 nulliparous women with a vertex presentation between 39 + 0- and 40 + 6-weeks' gestation from seven tertiary centers. Read More

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Management and Outcomes of Atrial Fibrillation in 241 Healthy Children and Young Adults: Revisiting "Lone" Atrial Fibrillation. A Multi-Institutional PACES Collaborative Study.

Heart Rhythm 2021 Jul 31. Epub 2021 Jul 31.

Division of Pediatric Cardiology, Cleveland Clinic Children's, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio. Electronic address:

Background: Atrial fibrillation (AF) in healthy children and young adults is rare. Risk of recurrence and treatment efficacy are not well-defined.

Objective: To assess recurrence patterns and treatment efficacy in AF. Read More

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Derivation of a clinical score for prediction of recurrence following evacuation of chronic subdural haematoma: A retrospective cohort study at a national referral centre.

World Neurosurg 2021 Jul 31. Epub 2021 Jul 31.

National Neurosurgical Centre, Beaumont Hospital, Dublin, Ireland; Royal College of Surgeons in Ireland, Dublin, Ireland; Department of Academic Neurology, Trinity College Dublin, Ireland.

Background: Chronic subdural haematoma (cSDH) is a common pathology and recurrence is a common complication, which may be predicted by certain radiological and patient factors. Empiric radiological surveillance has been shown to convey no benefit.

Methods: A retrospective review of a prospectively collated database was performed. Read More

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Symptoms of lumbar spinal stenosis in people with knee or hip osteoarthritis or low back pain: a cross-sectional study of 10,234 participants in primary care.

Osteoarthritis Cartilage 2021 Jul 31. Epub 2021 Jul 31.

Centre for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, 5230 Odense, Denmark; Chiropractic Knowledge Hub, 5230 Odense, Denmark. Electronic address:

Objective: The aims of this study were to evaluate: the proportion of people reporting symptoms associated with lumbar spinal stenosis (LSS) in primary care programs for knee or hip osteoarthritis (OA) or persistent low back pain (LBP) and; the prevalence of self-reported clinical LSS in these three cohorts, according to two sets of adapted criteria.

Method: A cross-sectional analysis of baseline data from the Good Life with osteoArthritis in Denmark primary care programs. Self-report LSS symptom questions were administered to participants with knee OA, hip OA, and persistent LBP. Read More

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What's a SNP between friends: The lineage of Clostridioides difficile R20291 can effect research outcomes.

Anaerobe 2021 Jul 31:102422. Epub 2021 Jul 31.

Clostridia Research Group, BBSRC/EPSRC Synthetic Biology Research Centre (SBRC), School of Life Sciences, Centre for Biomolecular Sciences, The University of Nottingham, Nottingham, NG7 2RD, UK; NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, NG7 2RD, UK. Electronic address:

Clostridioides difficile R20291 is the most studied PCR-Ribotype 027 isolate. The two predominant lineages of this hypervirulent strain, however, exhibit substantive phenotypic differences and possess genomes that differ by a small number of nucleotide changes. It is important that the source of R20291 is taken into account in research outcomes. Read More

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Impact of maternal nutrition in viral infections during pregnancy.

Biochim Biophys Acta Mol Basis Dis 2021 Jul 31:166231. Epub 2021 Jul 31.

Departamento de Fisiología, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, Spain; Epidemiología Clínica y Riesgo Cardiovascular, Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocío/Consejo Superior de Investigaciones Científicas/Universidad de Sevilla, 41013 Sevilla, Spain.

Other than being a physiological process, pregnancy is a condition characterized by major adaptations of maternal endocrine and metabolic homeostasis that are necessary to accommodate the fetoplacental unit. Unfortunately, all these systemic, cellular, and molecular changes in maternal physiology also make the mother and the fetus more prone to adverse outcomes, including numerous alterations arising from viral infections. Common infections during pregnancy that have long been recognized as congenitally and perinatally transmissible to newborns include toxoplasmosis, rubella, cytomegalovirus, and herpes simplex viruses (originally coined as ToRCH infections). Read More

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Inhibition of ribosomal RNA processing 15 Homolog (RRP15), which is overexpressed in hepatocellular carcinoma, suppresses tumour growth via induction of senescence and apoptosis.

Cancer Lett 2021 Jul 31. Epub 2021 Jul 31.

Department of Gastroenterology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China; Department of Gastroenterology, Gaochun People's Hospital, Nanjing, Jiangsu, China; Department of Gastroenterology, Yining People's Hospital, Yining, China. Electronic address:

Recent studies suggest that RRP15 (Ribosomal RNA Processing 15 Homolog) might be a potential target for cancer therapy. However, the role of RRP15 in hepatocarcinogenesis remains poorly delineated. In this study, we aimed to evaluate the expression and biological function of RRP15 in human hepatocellular carcinoma (HCC). Read More

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Brain preparedness: The proactive role of the cortisol awakening response in hippocampal-prefrontal functional interactions.

Prog Neurobiol 2021 Jul 31:102127. Epub 2021 Jul 31.

State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China; Chinese Institute for Brain Research, Beijing, 100069, China. Electronic address:

Upon awakening from a nighttime sleep, the stress hormone cortisol in humans exhibits a robust rise within thirty to forty-five minutes. This cortisol awakening response (CAR), as a crucial point of reference within the healthy cortisol circadian rhythm, has been linked to various psychological, psychiatric and health-related conditions. The CAR is thought to prepare the brain for anticipated challenges of the upcoming day to maintain one's homeostasis and promote adaptive responses. Read More

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The Role of Circadian Rhythm in Choroid Plexus Functions.

Prog Neurobiol 2021 Jul 31:102129. Epub 2021 Jul 31.

CICS-UBI - Health Sciences Research Center, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilhã, Portugal.

For several years, a great effort has been devoted to understand how circadian oscillations in physiological processes are determined by the circadian clock system. This system is composed by the master clock at the suprachiasmatic nucleus which sets the pace and tunes peripheral clocks in several organs. It was recently demonstrated that the choroid plexus epithelial cells that compose the blood-cerebrospinal fluid barrier hold a circadian clock which might control their multiple functions with implications for the maintenance of brain homeostasis. Read More

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FLASH dose-rate helium ion beams: first in vitro investigations.

Int J Radiat Oncol Biol Phys 2021 Jul 31. Epub 2021 Jul 31.

Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany; Clinical Cooperation Unit Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital (UKHD) and German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Molecular and Translational Radiation Oncology, Heidelberg Faculty of Medicine (MFHD) and Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany; German Cancer Consortium (DKTK) Core-Center Heidelberg, German Cancer Research Center (DKFZ), Heidelberg, Germany; Clinical Cooperation Unit Radiation Oncology, Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Oncology (NCRO), Heidelberg University and German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address:

Purpose: To establish and investigate the impact of dose, linear energy transfer (LET) and O concentration on biological response to ultra-high dose-rate (uHDR, FLASH) helium ion beams compared to standard dose-rate (SDR) irradiation.

Methods And Materials: Beam delivery settings for raster-scanned helium ions at both uHDR and SDR were tuned to achieve >100 Gy/s and ∼0.1 Gy/s, respectively. Read More

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<> A potentially challenging diagnosis but an important one for patients.

J Am Acad Dermatol 2021 Jul 31. Epub 2021 Jul 31.

Department of Clinical Chemistry Pathology, St Richard's Hospital, Chichester, UK.

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Diabetes Res Clin Pract 2021 Jul 31:108972. Epub 2021 Jul 31.

Boden Institute, University of Sydney, Australia.

Executive Summary This document updates the 1999 World Health Organization (WHO) classification of diabetes. It prioritizes clinical care and guides health professionals in choosing appropriate treatments at the time of diabetes diagnosis, and provides practical guidance to clinicians in assigning a type of diabetes to individuals at the time of diagnosis. It is a compromise between clinical and aetiological classification because there remain gaps in knowledge of the aetiology and pathophysiology of diabetes. Read More

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Effects of tree canopy on psychological distress: A repeated cross-sectional study before and during the COVID-19 epidemic.

Environ Res 2021 Jul 31:111795. Epub 2021 Jul 31.

Research Institute of Forestry, Chinese Academy of Forestry, Beijing, 100091, China; Key Laboratory of Tree Breeding and Cultivation and Urban Forest Research Centre, National Forestry and Grassland Administration, Beijing, 10091, China. Electronic address:

Background: During the COVID-19 epidemic period, people showed a stronger connection to the environment within their communities. Although tree canopy in residential areas has been shown to positively affect psychological distress, it is not clear whether the COVID-19 epidemic played a role in this process. Elucidation of the relationship between tree canopy and the impact on psychological distress during the COVID-19 epidemic could provide valuable information as to the best methods to help individuals cope with urban mental stress events. Read More

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Concentrations of tetanus and diphtheria antibodies in vaccinated Greenlandic children aged 7-12 years exposed to marine pollutants, a cross sectional study.

Environ Res 2021 Jul 31:111712. Epub 2021 Jul 31.

Department of Environmental Medicine, University of Southern Denmark, Odense, Denmark; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Previous studies have shown immunotoxic effects of environmental chemicals, and the European Food Safety Authority (EFSA) recently identified a need for more studies on PFAS immunotoxicity in different populations. In the Arctic, populations are exposed to several environmental chemicals through marine diet, and the objective of this study was therefore to examine the association between Greenlandic children's exposure to major environmental chemicals and their concentrations of diphtheria and tetanus vaccine antibodies after vaccination. The study includes cross-sectional data from Greenlandic children aged 7-12 years examined during 2012-2015. Read More

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Low dose cone beam CT for paediatric image-guided radiotherapy: image quality and practical recommendations.

Radiother Oncol 2021 Jul 31. Epub 2021 Jul 31.

Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.

Purpose: Cone beam CT (CBCT) is used in paediatric image-guided radiotherapy (IGRT) for patient setup and internal anatomy assessment. Adult CBCT protocols lead to excessive doses in children, increasing the risk of radiation-induced malignancies. Reducing imaging dose increases quantum noise, degrading image quality. Read More

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European principles of care for women and girls with inherited bleeding disorders.

Haemophilia 2021 Aug 3. Epub 2021 Aug 3.

Department of Obstetrics and Gynaecology, Royal Free London NHS Foundation Trust and Institute for Women's Health, University College London, London, UK.

Introduction: Despite increasing awareness of issues faced by women and girls with inherited BDs (WGBD), standards of care are lacking, with disparities in diagnosis and treatment for WGBD across Europe. We aimed to develop practical principles of care (PoC) to promote standardization of care for WGBD within European Haemophilia Treatment and Comprehensive Care Centres (HTC/CCCs).

Methods: The co-creation process, supported by the European Association for Haemophilia and Allied Disorders, consisted of four multidisciplinary meetings with health care providers (HCPs) experienced in WGBD care, and European Haemophilia Consortium representatives, combined with broad patient and HCP consultations in the European haemophilia community. Read More

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Multisystem inflammatory syndrome in children during severe acute respiratory syndrome coronavirus-2 pandemic in Turkey: A single-centre experience.

J Paediatr Child Health 2021 Aug 3. Epub 2021 Aug 3.

Department of Pediatric Infectious Disease, SBU Ankara Dr. Sami Ulus Maternity Child Health and Diseases Training and Research Hospital, Ankara, Turkey.

Aim: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection may result in a life-threatening hyperinflammatory condition named multisystem inflammatory syndrome in children (MIS-C). We aimed to assess demographics, clinical presentations, laboratory characteristics and treatment outcomes of patients with MIS-C.

Methods: We performed a retrospective study of patients with MIS-C managed between August 2020 and March 2021 at Dr. Read More

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Glycated Haemoglobin (HbA1c), Diabetes and Neuropsychological Performance in Community-Dwelling Older Adults.

Diabet Med 2021 Aug 3:e14668. Epub 2021 Aug 3.

Mercer's Institute for Successful Ageing, St James's Hospital, Dublin, Ireland.

Aims: Given that diabetes is associated with cognitive impairment and dementia in later life, we aimed to investigate the relationship between glycated haemoglobin (HbA1c), diabetes and domain-specific neuropsychological performance in older adults.

Methods: Cross-sectional cohort study using data from the Trinity-Ulster-Department of Agriculture (TUDA) study. Participants underwent detailed cognitive and neuropsychological assessment using the Mini-Mental State Examination (MMSE), Frontal Assessment Battery (FAB) and Repeatable Assessment for Neuropsychological Status (RBANS). Read More

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EAACI guideline: Anaphylaxis (2021 update).

Allergy 2021 Aug 3. Epub 2021 Aug 3.

NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton; Clinical and Experimental Sciences and Human Development in Health, Faculty of Medicine, University of Southampton, Southampton; and The David Hide Asthma and Allergy Research Centre, St Mary's Hospital, Isle of Wight, UK.

Anaphylaxis is a clinical emergency which all healthcare professionals need to be able to recognise and manage. The European Academy of Allergy and Clinical Immunology Anaphylaxis multidisciplinary Task Force has updated the 2014 guideline. The guideline was developed using the AGREE II framework and the GRADE approach. Read More

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