1,466,772 results match your criteria hormones

Development and validation of a sensitive LC-MS/MS method for simultaneous quantification of thirteen steroid hormones in human serum and its application to the study of type 2 diabetes mellitus.

J Pharm Biomed Anal 2021 Apr 5;199:114059. Epub 2021 Apr 5.

Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, PR China. Electronic address:

Endogenous steroid hormones with similar structure, poor content and high efficacy are difficult and vital to be quantitatively detected. In this study, a validated method was established for the simultaneous quantification of thirteen steroids in human serum, and applied to the study of type 2 diabetes mellitus (T2DM). An ultra-high performance liquid chromatography coupled with triple quadrupole mass spectrometry (UPLC-MS/MS) was developed for the simultaneous determination of thirteen steroid hormones in human serum, including androstenedione, corticosterone (B), cortisol (F), cortisone, 18-hydroxycortisol (18OHF), 11-deoxycorticosterone, 11-deoxycortisol, pregnenolone, progesterone, 17-hydroxyprogesterone, testosterone, androstanolone and estradiol. Read More

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Endocrine disrupting potential of replacement flame retardants - Review of current knowledge for nuclear receptors associated with reproductive outcomes.

Environ Int 2021 Apr 10;153:106550. Epub 2021 Apr 10.

Masaryk University, Faculty of Science, RECETOX, Kamenice 5, CZ62500 Brno, Czechia. Electronic address:

Background And Aim: Endocrine disrupting chemicals (EDCs) constitute a major public health concern because they can induce a large spectrum of adverse effects by interfering with the hormonal system. Rapid identification of potential EDCs using in vitro screenings is therefore critical, particularly for chemicals of emerging concerns such as replacement flame retardants (FRs). The review aimed at identifying (1) data gaps and research needs regarding endocrine disrupting (ED) properties of replacement FRs and (2) potential EDCs among these emerging chemicals. Read More

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Nicotine and energy balance: A review examining the effect of nicotine on hormonal appetite regulation and energy expenditure.

Appetite 2021 Apr 10:105260. Epub 2021 Apr 10.

School of Nutrition, Ryerson University, Toronto, Ontario, Canada. Electronic address:

Nicotine has been shown to decrease appetite, food intake (FI) and body weight, but the mechanisms are unclear. The purpose of this review was to examine research on the effects of nicotine on energy balance by exploring physiological mechanisms and hormone regulation related to FI, subjective appetite and energy expenditure (EE). We searched PubMed and MEDLINE, and included articles investigating the effects of nicotine on central appetite regulation, FI, leptin, peptide-YY (PYY), ghrelin, glucagon-like peptide-1 (GLP-1), adiponectin, cholecystokinin (CCK), orexin, and EE. Read More

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Chromatin-embedded reporter genes: Quantification of stimulus-induced gene transcription.

Gene 2021 Apr 10:145645. Epub 2021 Apr 10.

Department of Medical Biochemistry and Molecular Biology, Saarland University Medical Faculty, D-66421 Homburg, Germany.

Receptors and ion channels expressed on the cell surface ensure proper communication between the cells and the environment. In multicellular organism, stimulus-regulated gene transcription is the basis for the communication with the environment allowing individual cells to respond to stimuli such as nutrients, chemical stressors and signaling molecules released by other cells of the organism. Hormones, cytokines, and mitogens bind to receptors and ion channels and induce intracellular signaling cascades involving second messengers, kinases, phosphatases, and changes in the concentration of particular ions. Read More

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Genome-wide characterization and expression profiling of the PDR gene family in N. tabacum.

Gene 2021 Apr 10:145637. Epub 2021 Apr 10.

China Tobacco Gene Research Center, Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, 450001, China. Electronic address:

The pleiotropic drug resistance (PDR) proteins of the ATP-binding cassette (ABC) family play essential roles in physiological processes and have been characterized in many plant species. However, no comprehensive investigation of tobacco (Nicotiana tabacum), an important economic crop and a useful model plant for scientific research, has been presented. We identified 32 PDR genes in the tobacco genome and explored their domain organization, chromosomal distribution and evolution, promoter cis-elements, and expression profiles. Read More

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A gut-intrinsic melanocortin signalling complex augments L cell secretion in humans.

Gastroenterology 2021 Apr 10. Epub 2021 Apr 10.

Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Bedford Park, SA 5042, Australia. Electronic address:

Objective: Hypothalamic melanocortin 4 receptors (MC4R) are a key regulator of energy homeostasis. Brain-penetrant MC4R agonists have failed, as concentrations required to suppress food intake also increase blood pressure. However, peripherally located MC4R may also mediate metabolic benefits of MC4R activation. Read More

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Boronic Acid-Functionalized Scholl-Coupling Mesoporous Polymers for Online Solid-Phase Extraction of Brassinosteroids from Plant-Derived Foodstuffs.

J Agric Food Chem 2021 Apr 13. Epub 2021 Apr 13.

School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China.

Brassinosteroids (BRs) are natural, nontoxic, non-hazardous, biosafe, and eco-friendly plant hormones, possessing diverse pharmacological activities. However, little is known about the type and content of BRs in frequently consumed plant-derived foodstuffs because of their low abundance and high abundance of interference. In this study, a selective, accurate, and sensitive method based on the online solid-phase extraction using the boronic acid-functionalized Scholl-coupling microporous polymer was developed for the analysis of BRs in plant-derived foodstuffs. Read More

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Effects of metformin on experimentally induced acne on rabbit ear.

Exp Dermatol 2021 Apr 13. Epub 2021 Apr 13.

Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Evidence for the effectiveness of metformin in the treatment of acne is limited. To assess its efficacy, comedones were experimentally induced in young New Zealand rabbit ear using Isopropyl Myristate (IM) followed by metformin treatment (30 mg/kg bodyweight) for 60 days with continued IM application. In another group, to check whether metformin pre-treatment affects subsequent comedone development by IM, metformin was given for 14 days and then withdrawn (14 days) followed by comedone development with IM and metformin treatment. Read More

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Serum tT4, fT4 and TSH concentrations in German Shepherd dogs depending on age and type of work.

Pol J Vet Sci 2021 Mar;24(1):63-68

Subdepartment of Clinical Diagnostics and Veterinary Dermatology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Głeboka 30, 20-612 Lublin, Poland.

Serum concentration of thyroid hormones in healthy dogs varies according to age, sex, breed or professional activity. The aim of this study was to determine the influence of both age and dogs' work involvement on TSH and thyroid hormones values. Thyroid-stimulating hormone (TSH), total thyroxine (tT4) and free thyroxine (fT4) were tested in the serum of 57 healthy, German Shepherd dogs. Read More

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Molecular mechanisms and signaling pathways of reactive astrocytes responding to traumatic brain injury.

Histol Histopathol 2021 Apr 13:18338. Epub 2021 Apr 13.

Department of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Fudan University, Shanghai, China.

Traumatic brain injury (TBI) is one of the most common causes of death and disability worldwide. Astrocytes are the largest cell types in the central nervous system (CNS) with numerous functions both physiologically and pathologically. In response to TBI, astrocytes go through a series of alterations referred to as reactive astrogliosis. Read More

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Use of community-based reference ranges to estimate the prevalence of polycystic ovary syndrome by the recognised diagnostic criteria, a cross-sectional study.

Hum Reprod 2021 Apr 8. Epub 2021 Apr 8.

Women's Health Research Program, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.

Study Question: Does the application of reference ranges for sex steroids and the modified Ferriman-Gallwey (mFG) scale established in the community from which the study sample was drawn, combined with the most conservative polycystic ovary morphology (PCOM) criteria to the recognised diagnostic criteria for polycystic ovary syndrome (PCOS) improve the certainty of diagnosis of PCOS in non-healthcare-seeking women?

Summary Answer: Despite application of the stringent definitions of the elements used to diagnose PCOS in a non-healthcare seeking community-based sample, the risk of diagnostic uncertainty remains.

What Is Known Already: There is heterogeneity in prevalence estimates for PCOS due, in part, to lack of standardisation of the elements comprising the recognised National Institutes of Health (NIH), Rotterdam and Androgen Excess Society (AE-PCOS) diagnostic criteria. The AE-PCOS Society proposed refinements to the definitions of biochemical androgen excess and PCOM that can now be incorporated into these sets of diagnostic criteria to estimate PCOS prevalence. Read More

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He-Ne laser accelerates seed germination by modulating growth hormones and reprogramming metabolism in brinjal.

Sci Rep 2021 Apr 12;11(1):7948. Epub 2021 Apr 12.

Department of Plant Sciences, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.

A plant's ability to maximize seed germination, growth, and photosynthetic productivity depends on its aptitude to sense, evaluate, and respond to the quality, quantity, and direction of the light. Among diverse colors of light possessing different wavelengths and red light shown to have a high impact on the photosynthetic and growth responses of the plants. The use of artificial light sources where the quality, intensity, and duration of exposure can be controlled would be an efficient method to increase the efficiency of the crop plants. Read More

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Thyroid hormone receptor α1 acts as a new squamous cell lung cancer diagnostic marker and poor prognosis predictor.

Sci Rep 2021 Apr 12;11(1):7944. Epub 2021 Apr 12.

Pathology department, Faculty of Medicine, Minia University, Minia, Egypt.

Lung cancer is considered the major cause of cancer-related deaths worldwide. Unfortunately, all chemotherapy regimens used in lung cancer treatment showed nearly the same efficacy. Finding a new therapeutic target that can be used as an alternative after the failure of or in association with chemotherapy to improve the prognosis is an urgent demand. Read More

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PACAP induces light aversion in mice by an inheritable mechanism independent of CGRP.

J Neurosci 2021 Apr 10. Epub 2021 Apr 10.

Department of Molecular Physiology and Biophysics

The neuropeptides CGRP and PACAP have emerged as mediators of migraine, yet the potential overlap of their mechanisms remains unknown. Infusion of PACAP, like CGRP, can cause migraine in people, and both peptides share similar vasodilatory and nociceptive functions. In this study, we have used light aversion in mice as a surrogate for migraine-like photophobia to compare CGRP and PACAP and ask whether CGRP or PACAP actions were dependent on each other. Read More

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Endocrine Effects of Repeated Hot Thermal Stress and Cold Water Immersion in Young Adult Men.

Am J Mens Health 2021 Mar-Apr;15(2):15579883211008339

Prof, Department of Physical Education in Gorzow Wielkopolski, Poznan University of Physical Education, Poznan, Poland.

The aim of the study was to determine the effect of repeated hot thermal stress and cold water immersion on the endocrine system of young adult men with moderate and high levels of physical activity (PA). The research was conducted on 30 men aged 19-26 years (mean: 22.67 ± 2. Read More

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A study on steroidogenic elaborations of stroma and their regulation in response to ovarian hormones in goats.

Anim Reprod Sci 2021 Mar 27;228:106748. Epub 2021 Mar 27.

Animal Physiology Division, NDRI, Karnal, India.

Stromal tissue is an essential componenlt of the ovary not only for providing structural support but also for contributing to the early follicular growth with their bi-directional paracrine signaling. Estradiol is a major female hormone mainly secreted by the follicular cells in the ovary. To examine the relationship between 17β-estradiol and the factors involved in androgen production in stromal cells, ovarian stromal cells were cultured in the graded concentrations (50 and 100 ng/mL) of 17β-estradiol for varying time periods (24 and 48 h). Read More

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Effect of 4-chloro-2-methylphenoxy acetic acid on tomato gene expression and rhizosphere bacterial communities under inoculation with phosphate-solubilizing bacteria.

J Hazard Mater 2021 Mar 27;416:125767. Epub 2021 Mar 27.

Institute of Horticulture, Anhui Academy of Agricultural Sciences, Hefei 230031, Anhui Province, China; Key Laboratory of Genetic Improvement and Ecophysiology of Horticultural Crops, Hefei 230031, Anhui Province, China.

The herbicide 4-chloro-2-methylphenoxy acetic acid (MCPA) is widely used to control the spread of broad-leaved weeds in agricultural soils, though it remains unclear how tomato plants cope with the phytotoxic effects of MCPA at the molecular level. In this study, RNA-seq and Illumina MiSeq were used to sequence bacterial communities in tomato rhizosphere soils treated with MCPA and the phosphate-solubilizing bacterial strain N3. The results showed that MCPA induced abnormal growth of lateral roots in tomato seedlings and reduced uptake of the nutrients N, P, and K as well as the hormone (ABA and GA3) levels. Read More

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Reproductive characteristics, semen quality, seminal oxidative status, steroid hormones, sperm production efficiency of rabbits fed herbal supplements.

Theriogenology 2021 Mar 31;168:41-49. Epub 2021 Mar 31.

Department of Science Technology, Federal Polytechnic Ado Ekiti, Ekiti State, Nigeria. Electronic address:

Today, orthodox medicine has almost exceeded its limits in resolving subfertility problems in animals, thus making phytomedicine a primary tool in the treatment of infertility. In this work, three herbal supplements obtained from freshly air-dried Moringa oleifera, Phyllanthus amarus and Viscum album leaves were evaluated to ascertain their comparative effect on the reproductive potentials of bucks. Sixty bucks were allotted four diets made up of standard grower rabbit ration without supplement and with 5% Moringa, Mistletoe and Phyllanthus supplementation for 84 days. Read More

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Sex hormones regulate lipid metabolism in adult Sertoli cells: a genome-wide study of estrogen and androgen receptor binding sites.

J Steroid Biochem Mol Biol 2021 Apr 9:105898. Epub 2021 Apr 9.

Department of Neuroendocrinology, ICMR-National Institute for Research in Reproductive Health, Mumbai, India. Electronic address:

Optimal functioning of Sertoli cells is crucial for spermatogenesis which is under tight regulation of sex hormones, estrogen and androgen. Adult rat Sertoli cells expresses estrogen receptor beta (ERβ) and androgen receptor (AR), both of which regulate gene transcription by binding to the DNA. The present study is aimed to acquire a genome-wide map of estrogen- and androgen-regulated genes in adult Sertoli cells. Read More

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Incidence of thyroid diseases: Results from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

Arch Endocrinol Metab 2021 Apr 12. Epub 2021 Apr 12.

Centro de Pesquisa Clínica e Epidemiológica, Universidade de São Paulo, São Paulo, SP, Brasil.

Objective: To evaluate incidence of subclinical and overt hyperthyroidism and hypothyroidism.

Methods: The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) is a prospective cohort study of 15,105 civil servants, examined at baseline and over a 4-year follow-up. This analysis included 9,705 participants with normal thyroid function at baseline, follow-up information about thyroid function and with no report of using drugs that may interfere in the thyroid function. Read More

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Different modes of delivery and hormonal stress response.

Ginekol Pol 2021 Apr 12. Epub 2021 Apr 12.

Chair and Department of Biopharmacy, Faculty of Pharmacy, Medical Univeristy of Lodz, Poland.

Objectives: The aim of the study was to determine how the type of delivery affects the stress response cycle and the level of cortisol, progesterone and corticoliberin.

Material And Methods: The study was conducted among 26 pregnant women admitted to the Gynecology and Obstetrics Ward due to an approaching delivery date or the onset of labor. The participants were aged between 20 and 41 years, with a mean age of approximately 30 years. Read More

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Alzheimer's pathogenic mechanisms and underlying sex difference.

Cell Mol Life Sci 2021 Apr 12. Epub 2021 Apr 12.

Department of Physiology and Neuroscience, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

AD is a neurodegenerative disease, and its frequency is often reported to be higher for women than men: almost two-thirds of patients with AD are women. One prevailing view is that women live longer than men on average of 4.5 years, plus there are more women aged 85 years or older than men in most global subpopulations; and older age is the greatest risk factor for AD. Read More

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Validating Data-driven Methods to Identify Transgender Individuals in the Veterans Affairs.

Am J Epidemiol 2021 Apr 12. Epub 2021 Apr 12.

Center for Healthcare Organization and Implementation Research (CHOIR), VA Bedford Healthcare System, Bedford, Massachusetts, United States.

We sought to operationalize and validate data-driven approaches to identify transgender individuals in the U.S. Department of Veteran Affairs (VA) health care system through a retrospective analysis using VA administrative data from 2006 to 2018. Read More

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The effect of kangaroo care on modulate chronic stress response in preterm infants and mothers.

Stress 2021 Apr 10:1-11. Epub 2021 Apr 10.

Institute of Integral Medicine Professor Fernando Figueira (IMIP), Department of Neonatology, Recife, Brazil.

To assess stress experienced during Neonatal Intensive Care Unit (NICU) stay, we analyzed fingernail Cortisol (CORT) and Dehydroepiandrosterone (DHEA) levels and ratios in mothers and preterm infants (PI); compared hormones levels/ratio (CORT and DHEA) in kangaroo care (KC) versus standard care (SC) groups and examined relationships between PI hormone levels total days spent in the NICU. Mothers and their infants were recruited in the NICU, included levels I-IV and kangaroo care unit, within one week of infant birth in hospitals in Brazil. At 3 months after birth, mothers provided 3-month growth clippings from all ten digits of their own and their infants' fingernails. Read More

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The effect of hydroalcoholic extract of seed on dehydroepiandrosterone-induced polycystic ovarian syndrome in rats: An experimental study.

Int J Reprod Biomed 2021 Mar 21;19(3):271-282. Epub 2021 Mar 21.

Student Research Committee, Qom University of Medical Sciences, Qom, Iran.

Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among women.

Objective: The aim of this study was to investigate the therapeutic effect of hydroalcoholic extract of () seed as a plant, the consumption of which has been recommended in Islam, on dehydroepiandrosterone (DHEA)-induced PCOS rats.

Materials And Methods: This experimental study was carried out on 36 Wistar female rats (3 wk, 60 10 gr). Read More

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Maternal thyroid function test level during the first trimester of pregnancy at a center Yazd, Iran: A cross-sectional study.

Int J Reprod Biomed 2021 Mar 21;19(3):255-260. Epub 2021 Mar 21.

Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Background: Thyroid dysfunction is associated with negative pregnancy outcomes. There is a lack of reliable information on thyroid hormones in Iranian pregnant women, especially in Yazd.

Objective: To determine the safe thyroid hormone levels in women of Yazd and also the first trimester-specific reference ranges for serum thyroid-stimulating hormone (TSH), thyroxine (T4), and triiodothyronine (T3). Read More

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Reproductive toxicity potentials of methanolic extract of in male rats: An experimental study.

Int J Reprod Biomed 2021 Mar 21;19(3):245-254. Epub 2021 Mar 21.

Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Nnewi, Nigeria.

Background: Purslane is an edible widely distributed shrub and one of the herbs used in decoctions for the treatment of different ailments including infertility. However, there is a shortage of evidence to validate its reproductive effects.

Objective: To investigate the effect of methanolic extract of (MEPO) on the reproductive system of male rats. Read More

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Expression and clinical implications of estrogen receptors in thoracic malignancies: a narrative review.

J Thorac Dis 2021 Mar;13(3):1851-1863

Department of Pharmaceutical Sciences, University of Piemonte Orientale, 28100 Novara, Italy.

Thoracic malignancies represent a significant global health burden with incidence and mortality increasing year by year. Thoracic cancer prognosis and treatment options depend on several factors, including the type and size of the tumor, its location, and the overall health status of patients. Gender represents an important prognostic variable in thoracic malignancies. Read More

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Clinical significance of T lymphocyte subsets, immunoglobulin and complement expression in peripheral blood of children with steroid-dependent nephrotic syndrome/frequently relapsing nephrotic syndrome.

Am J Transl Res 2021 15;13(3):1890-1895. Epub 2021 Mar 15.

Department of Pediatrics, Quanzhou First Hospital Affiliated to Fujian Medical University Quanzhou, Fujian Province, China.

Objective: To investigate the clinical significance of T lymphocyte subsets, immunoglobulin and complement expression in the peripheral blood of children with steroid-dependent nephrotic syndrome/frequently relapsing nephrotic syndrome (SDNS/FRNS).

Methods: A prospective study was conducted on 285 children with nephrotic syndrome (NS). Among the 285 patients, 187 children had steroid-sensitive nephrotic syndrome (SSNS) and 98 children had SDNS/FRNS according to their sensitivity to hormones. Read More

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Studies on Selected Jordanian Plants as Dipeptidyl Peptidase-IV Inhibitors for Management of Diabetes Mellitus.

Iran J Pharm Res 2020 ;19(4):95-102

Department of Chemistry, Faculty of Arts and Sciences, University of Petra, Amman, Jordan.

Diabetes mellitus is a chronic disease characterized by hyperglycemia mainly because of the absolute or relative deficiency of insulin hormone. The dipeptidyl peptidase-IV inhibitors represent a class of glucose-lowering agents potentiating the action of the incretin hormones glucagon-likepeptide-1 and glucose dependent insulinotropic polypeptide, which are secreted from the intestinal endocrine cells in response to food ingestion to stimulate insulin secretion from pancreatic beta cells. Natural products have been traditionally used for curing many diseases. Read More

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January 2020