Search Our Scientific Publications & Authors

Pathol Res Pract 2021 Mar 24;221:153415. Epub 2021 Mar 24.

Anatomical Sciences Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran. Electronic address:

Background: Female sex hormones are protective factors against many neurological disorders such as brain ischemia. Heat shock protein like HSP27 is activated after tissue injury. The main purpose of the present study is to determine the effect of a combined estrogen / progesterone cocktail on the morphology of astrocytes, neurons and Hsp27 phosphorylation after cerebral ischemia. Read More

Am J Kidney Dis 2021 Apr 12. Epub 2021 Apr 12.

Department of Medicine, University of Illinois at Chicago, Chicago, IL. Electronic address:

Rationale & Objective: Cardiovascular events are less common in women than men in general populations; however, studies in chronic kidney disease (CKD) are less conclusive. We evaluated sex-related differences in cardiovascular events and death in adults with CKD.

Study Design: Prospective cohort study. Read More

Aliment Pharmacol Ther 2021 Apr 15. Epub 2021 Apr 15.

Stockholm, Sweden.

Background: Menopausal hormone therapy (MHT) has been associated with various malignancies.

Aims: To investigate the association of various MHT regimens with the risk of colorectal cancer (CRC).

Methods: All MHT ever-users (n = 290 186) were included through the Swedish Prescribed Drug Registry, with a 1:3 group-level matching to non-users. Read More

Chemistry 2021 Apr 15. Epub 2021 Apr 15.

Universite Claude-Bernard: Universite Claude Bernard Lyon 1, LAGEPP, FRANCE.

Polysaccharides due to their outstanding properties, have attracted the attention of researchers, working in the biomedical field and especially of those working in drug delivery. Modified/functionalized polysaccharides further increase the importance for various applications with every passing day. Delivery of therapeutics for diverse ailments in different body endocrine glands and hormones in a safe way is focal point of researchers working in the field. Read More

Drug Test Anal 2021 Apr 14. Epub 2021 Apr 14.

Office of Regulatory Science, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD, 20740, USA.

More than 27 million Americans have some kind of thyroid disease. Numerous dietary supplements claiming to support healthy thyroid function, healthy metabolism and balance or promote weight loss are available for purchase in retail stores and on the internet. In the literature, there have been reports of adverse events associated with the consumption of thyroid hormone-containing products. Read More

J Obstet Gynaecol Res 2021 Apr 14. Epub 2021 Apr 14.

Clinical Institute of Laboratory Diagnostics, University Hospital Osijek, Osijek, Croatia.

Aim: The aim of research was to evaluate the maternal serum concentration of selected endogenous steroid hormones during spontaneous parturition at term and to determinate their association with the need for oxytocin augmentation.

Methods: Blood of 108 healthy pregnant women whose parturition started with the regular spontaneous uterine contractions was drawn at the beginning of the labor. Liquid chromatography coupled to the tandem mass spectrometry device was utilized for measurement of sex hormone binding globulin, aldosterone, androstenedione, cortisol, cortisone, corticosterone, dehydroepiandrosterone, dehydroepiandrosteron sulphate, 17-hydroxyprogesterone, progesterone, and testosterone. Read More

Eur J Pediatr 2021 Apr 14. Epub 2021 Apr 14.

Department of Paediatric Endocrinology, Royal Hospital for Children, 1345 Govan Road, Glasgow, G51 4TF, UK.

The clinical needs of young people with gender dysphoria (GD) have outpaced the capacity of health services to provide appropriate care. The study aimed to explore the interface of Paediatric Endocrinology and young people with GD, detailing the clinical characteristics and the clinical care provided, in order to inform future service development. Medical records of all young people with GD (n=91, 59 (65%) birth-assigned females and 32 (35%) birth-assigned males) referred to Paediatric Endocrinology during 2011-2019 for puberty suppression were reviewed. Read More

Heliyon 2021 Mar 25;7(3):e06568. Epub 2021 Mar 25.

Department of Biosciences and Nutrition, Karolinska Institutet, 141 57, Huddinge, Sweden.

[This corrects the article DOI: 10.1016/j.heliyon. Read More

Endocrinol Diabetes Metab 2021 Apr 8;4(2):e00172. Epub 2020 Aug 8.

Department of Academic Family Medicine College of Medicine University of Saskatchewan Saskatchewan Canada.

Objective: To investigate the hormonal interrelationships during the menstrual cycle in women of late reproductive age with suppressed serum AMH and antral follicle count (AFC).

Methods: Serum hormones (AMH, FSH, LH, estradiol, progesterone, inhibin A, inhibin B), AFC (2-10 mm) and AMH/AFC ratio (an estimate of AMH/follicle) were assessed every 2-3 days across the menstrual cycle in 26 healthy ovulatory women aged 18-50 years.

Results: An 11-fold fall in AMH/AFC was observed in women aged ≥45 years compared to those 18-45 years ( < . Read More

Biomedicine (Taipei) 2020 1;10(4):11-17. Epub 2020 Dec 1.

Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Background: manna is used to treat different diseases. Because pregnant women tend to use and Iranian traditional medicine emphasizes the abortifacient potential of this plant, this study aimed to investigate manna abortifacient property and effects on estrogen, progesterone, LH and FSH levels in BALB/c mice.

Method: This experimental study was conducted with 70 female BALB/c mice assigned to seven groups: Nonpregnant, untreated; nonpregnant, extract (400 mg/kg)-treated; pregnant, extract (400, 800 and 1200 mg/kg)-treated; and two pregnant control groups. Read More

Cureus 2021 Mar 11;13(3):e13831. Epub 2021 Mar 11.

Department of Basic Sciences and Surgery, California Northstate University College of Medicine, Elk Grove, USA.

Introduction Obesity, defined as a condition of excessive fat accumulation in adipose tissue, is a global epidemic implicated in a myriad of processes deleterious to human health. It has become one of the leading impediments to public health globally. The study of obesity necessitates adipocyte models, which commonly employ a medium enriched with adipogenic hormones and fetal bovine serum (FBS) to culture terminal adipocytes. Read More

PeerJ 2021 10;9:e10883. Epub 2021 Mar 10.

The Research Center for Ornamental Plants, College of Forestry and Landscape Architecture, South China Agricultural University, Guangdong, China.

The (Snf1-Related protein Kinase) gene family plays crucial roles in various plant signaling pathways and stress-adaptive responses including biotic and abiotic stresses via activating protein phosphorylation pathways. However, there is no information available on the role of the gene family in . is an important crop widely cultivated as an ornamental plant, herb, spice, or condiment. Read More

PeerJ 2021 9;9:e10878. Epub 2021 Mar 9.

College of Horticulture, Sichuan Agricultural University, Chengdu, China.

Sucrose synthase (SUS) plays an important role in sucrose metabolism and plant development. The SUS gene family has been identified in many plants, however, there is no definitive study of SUS gene in . In this study, 14 SUS family genes were identified and comprehensively analyzed using bioinformatics tools. Read More

Front Endocrinol (Lausanne) 2021 29;12:599306. Epub 2021 Mar 29.

Department of Women's and Children's Health, Institute of Life Course and Medical Sciences, University of Liverpool, Member of Liverpool Health Partners, Liverpool, United Kingdom.

Background: Endometriosis and restless leg syndrome (RLS) are both chronic conditions that can negatively affect a woman's quality of life. A higher prevalence of RLS is seen in women and particularly in those who are pregnant, suggesting a possible ovarian hormonal influence. Endometriosis is a common (affecting 1 in 10 women) estrogen driven gynecological condition, and the prevalence of RLS in women with symptoms or a diagnosis of endometriosis is unknown. Read More

Commun Biol 2021 Apr 14;4(1):471. Epub 2021 Apr 14.

Gene Expression and Therapy Group, King's College London, Faculty of Life Sciences & Medicine, Department of Medical and Molecular Genetics, Guy's Hospital, London, UK.

Health effects of pesticides are not always accurately detected using the current battery of regulatory toxicity tests. We compared standard histopathology and serum biochemistry measures and multi-omics analyses in a subchronic toxicity test of a mixture of six pesticides frequently detected in foodstuffs (azoxystrobin, boscalid, chlorpyrifos, glyphosate, imidacloprid and thiabendazole) in Sprague-Dawley rats. Analysis of water and feed consumption, body weight, histopathology and serum biochemistry showed little effect. Read More

Horm Metab Res 2021 Apr 14;53(4):272-279. Epub 2021 Apr 14.

Department of Obstetrics and Gynecology, Peking Union Medical College & Chinese Academy of Medical Science, Beijing, P. R. China.

Thyroid hormone reference intervals are crucial for diagnosing and monitoring thyroid dysfunction during early pregnancy, and the dynamic change trend of thyroid hormones during pregnancy can assist clinicians to assess the thyroid function of pregnant women. This study aims to establish early pregnancy related thyroid hormones models and reference intervals for pregnant women. We established two derived databases: derived database* and derived database#. Read More

Dev Biol 2021 Apr 11. Epub 2021 Apr 11.

Department of Biological Sciences, University of South Carolina, Columbia, SC, 29208. Electronic address:

Neuropharmacology 2021 Apr 11:108561. Epub 2021 Apr 11.

Key Laboratory of Brain, Cognition and Education Sciences (South China Normal University), Ministry of Education, Guangzhou, China; School of Psychology, South China Normal University, Guangzhou, China; Center for Studies of Psychological Application, South China Normal University, Guangzhou, China; Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou, China. Electronic address:

Arginine vasopressin (AVP), a neuropeptide with widespread receptors in brain regions important for socioemotional processing, is critical in regulating various mammalian social behavior and emotion. Although a growing body of task-based brain imaging studies have revealed the effects of AVP on brain activity associated with emotion processing, social cognition and behaviors, the potential modulations of AVP on resting-state brain activity remain largely unknown. Here, the current study addressed this issue by adopting a machine learning approach to distinguish administration of AVP and placebo, employing the amplitude of low-frequency fluctuation (ALFF) as a measure of resting-state brain activity. Read More

Asia Pac J Clin Oncol 2021 Apr 14. Epub 2021 Apr 14.

Department of Endocrine Oncology, University Hospital, Uppsala, Sweden.

Aim: Carcinoid heart disease (CHD) is a well-documented complication of neuroendocrine tumors (NETs) due to secreted hormones causing fibrosis. Somatostatin analogues (SSAs) can decrease hormonal secretion and inhibit tumor growth. The reported incidence of CHD has decreased as SSA use has increased. Read More

Mol Nutr Food Res 2021 Apr 14:e2000923. Epub 2021 Apr 14.

The Rowett Institute, University of Aberdeen, Foresterhill, Aberdeen, Aberdeen, AB25 2ZD, UK.

Scope: Green leafy vegetables (GLV) may improve postprandial glycaemic responses (PGR) and metabolic health. However, inter-individual variations (IIV) preclude conclusive evidence. Sirtuin system is emerging as a key player in blood glucose control. Read More

J Bone Miner Res 2021 Apr 14. Epub 2021 Apr 14.

Department of Biomedical Sciences, University of Copenhagen, 2200, Copenhagen, Denmark.

Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-2 (GLP-2) are gut hormones secreted postprandially. In healthy humans, both hormones decrease bone resorption accompanied by a rapid reduction in parathyroid hormone (PTH). The aim of this study was to investigate whether the changes in bone turnover after meal intake and after GIP- and GLP-2 injections, respectively, are mediated via a reduction in PTH secretion. Read More

Heart Fail Rev 2021 Apr 14. Epub 2021 Apr 14.

Institute of Life Sciences, Scuola Superiore Sant'Anna, Pisa, Italy.

Heart failure (HF) is a significant cause of morbidity and mortality worldwide. Circulating biomarkers reflecting pathophysiological pathways involved in HF development and progression may assist clinicians in early diagnosis and management of HF patients. Natriuretic peptides (NPs) are cardioprotective hormones released by cardiomyocytes in response to pressure or volume overload. Read More

J Proteome Res 2021 Apr 14. Epub 2021 Apr 14.

Département de Biochimie et Génétique, Centre Hospitalier Universitaire, 49933 Angers, France.

The importance of sexual dimorphism of the mouse brain metabolome was recently highlighted, in addition to a high regional specificity found between the frontal cortex, the cerebellum, and the brain stem. To address the origin of this dimorphism, we performed gonadectomy on both sexes, followed by a metabolomic study targeting 188 metabolites in the three brain regions. While sham controls, which underwent the same surgical procedure without gonadectomy, reproduced the regional sexual dimorphism of the metabolome previously identified, no sex difference was identifiable after gonadectomy, through both univariate and multivariate analyses. Read More

AACE Clin Case Rep 2021 Jan-Feb;7(1):57-60. Epub 2020 Dec 28.

Elsie Bertram Diabetes Centre, Norfolk and Norwich University Hospitals NHS Foundation Trust, Colney Lane, Norwich, Norfolk, United Kingdom.

Objective: To describe the case of a woman with long-standing poorly controlled type 1 diabetes mellitus who developed bilateral Charcot foot while pregnant. To the best of our knowledge, this is the first reported case of this condition in pregnancy.

Methods: We performed a retrospective review of physical paper medical records; electronically held laboratory results, including glycated hemoglobin; and imaging reports, including plain radiographs and magnetic resonance imaging. Read More

Ann Transl Med 2021 Mar;9(6):492

NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin, China.

Background: Extracellular matrix proliferation is an issue which leads to lung tissue damage in diabetes mellitus. Glucagon-like peptide-1 (GLP-1) analogues can improve the proliferation of extracellular matrix in diabetic pulmonary disease. In this study, we investigated the effect of GLP-1 on pulmonary fibrosis through the AMPK/microRNA-27a (miR-27a) pathway. Read More

Nan Fang Yi Ke Da Xue Xue Bao 2021 Mar;41(3):471-475

Anhui Provincial Engineering Research Center for Polysaccharide Drugs, Anhui Provincial Key Laboratory of Active Biological Macromolecules, Wuhu 241002, China.

Polysaccharides are a group of compounds composed of multiple monosaccharides of the same or different structures combined by glycosidic bonds, and are widely found in animals and plants and in the cell walls of microorganisms. Polysaccharides possess the advantages of high safety and low toxicity. Recent studies revealed that polysaccharides have a wide range of biological activities including immunoregulation, anti-tumor, antiviral, antioxidant activities, and blood glucose-and lipid- lowering effects. Read More

Nan Fang Yi Ke Da Xue Xue Bao 2021 Mar;41(3):459-463

Nanjing University of Chinese Medicine, Nanjing 210029, China.

Objective: To investigate the relationship between serum C1q tumor necrosis factor-related protein 9 (CTRP9) level and the risk of diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM).

Objective: A total of 291 patients with T2DM underwent fundus examination, and their serum levels of CTRP9, insulin and adiponectin were measured using enzyme- linked immunosorbent assay. According to results of fundus examination, the patients were divided into DR group and non-DR (NDR) group, and logistic regression was used to analyze the relationship between serum CTRP9 levels and DR in T2DM patients. Read More

Nan Fang Yi Ke Da Xue Xue Bao 2021 Mar;41(3):453-458

Intensive Care Union, Guangzhou Chest Hospital, Guangzhou 510095, China.

Objective: To assess the value of serum amyloid A (SAA), procalcitonin (PCT) and high-sensitivity C-reactive protein (hs-CRP) in the diagnosis of pulmonary tuberculosis (PTB) complicated by pneumonia.

Objective: We collected serum samples from patients with pneumonia, patients with PTB, patients with PTB complicated by pneumonia and patients with PTB complicated by sepsis hospitalized in our hospital between April, 2019 and April, 2020. Serum levels of SAA, PCT and hs-CRP were tested, and receiver- operating characteristic (ROC) curves were used to evaluate their efficacy for predicting PTB with concurrent pneumonia and the possibility of differentiating PTB cases with pneumonia from those with sepsis using these 3 parameters. Read More

Nan Fang Yi Ke Da Xue Xue Bao 2021 Mar;41(3):412-417

Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

Objective: To assess the effect and timing of human menopausal gonadotropin (HMG) supplementation in advancedage patients with diminished ovarian reserve (DOR) receiving gonadotropin-releasing hormone antagonist protocol.

Objective: A total of 682 patients with DOR aged over 35 years undergoing IVF-ET treatment were included in this study. All the patients underwent a GnRH antagonist protocol, and controlled ovarian stimulation was initiated on day 2-3 of the menstrual cycle with follicle stimulation hormone (FSH). Read More

Nan Fang Yi Ke Da Xue Xue Bao 2021 Mar;41(3):384-390

General Hospital of the Yangtze River Shipping, Wuhan 430000, China.

Objective: To investigate the mechanism by which angiotensin Ⅱ-induced oxidative stress response inhibits AMPK/ SIRT1 signaling in RAW264.7 macrophages.

Objective: RAW264. Read More