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Skilled swimmers maintain performance stability under changing attentional focus constraints.

Hum Mov Sci 2021 Apr 9;77:102789. Epub 2021 Apr 9.

Performance Services, Australian Institute of Sport, Australia; School of Exercise & Nutrition Sciences, Faculty of Health, Queensland University of Technology, Australia.

Focusing attention externally, rather than internally, has generally proved advantageous as it avoids interfering with self-organzing processes. However, some research has suggested that this may not necessarily be the case with highly skilled individuals who by definition possess a greater capacity to either adapt or maintain stability under varied task constraints. This study aimed to address this gap by comparing the performance of skilled athletes under internal and external attentional focus conditions using the swimming dive start as a task vehicle. Read More

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[Enzymatic resistance in Pseudomonas aeruginosa, clinical and laboratory aspects].

Rev Chilena Infectol 2021 Feb;38(1):69-80

Programa de aseguramiento de la calidad en el laboratorio clínico PROASECAL, Colombia.

Pseudomonas aeruginosa is one of the major pathogens causing healthcare-associated infections (HAI). Its capacity of adaptation, dissemination, intrinsic resistance to antimicrobials and of acquiring new mechanisms through mobile genetic elements, make the treatment of infections by this microorganism a challenge for the clinician. Intrinsically, P. Read More

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February 2021

Melatonin synthesis genes N-acetylserotonin methyltransferases evolved into caffeic acid O-methyltransferases and both assisted in plant terrestrialization.

J Pineal Res 2021 Apr 12:e12737. Epub 2021 Apr 12.

Department of Cell Systems and Anatomy, UT Health, Long School of Medicine, San Antonio, TX, USA.

Terrestrialization is one of the most momentous events in the history of plant life, which led to the subsequent evolution of plant diversity. The transition species, in this process, had to acquire a range of adaptive mechanisms to cope with the harsh features of terrestrial environments compared to that of an aquatic habitat. As an ancient antioxidant, a leading regulator of ROS signaling or homeostasis, and a presumed plant master regulator, melatonin likely assisted plants transition to land and their adaption to terrestrial ecosystems. Read More

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Comparative analysis the performance of electrochemical water softening between high frequency electric fields and direct current electric fields based on orthogonal experimental methods.

Water Sci Technol 2021 Apr;83(7):1677-1690

School of Mechanical & Electrical Engineering, Wuhan Institute of Technology, Wuhan 430000, China E-mail:

Electrochemical water softening has been widely used in industrial circulating cooling water systems; however, their low deposition efficiency is the main drawback that limits usage in medium to large enterprises. In this work, the effect of different parameters on the hardness removal efficiency and energy consumption of the electrochemical water softening system is experimentally studied, and the performance of water softening applied by high frequency electric fields and direct current electric fields are comparative analyzed. The impact factors of the electrochemical water softening system are as follows: initial feed concentration of solute, magnitude of voltage, inter-electrode distance, area of cathode and frequency of power supply. Read More

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Copper-Catalyzed Cycloisomerization of Unactivated Allene-Tethered -Propargyl Oximes: A Domino Reaction Sequence toward the Synthesis of Hexahydropyrrolo[3,4-]azepin-5(4)-ones.

Org Lett 2021 Apr 12. Epub 2021 Apr 12.

Institut fur Organische Chemie, Albert-Ludwigs-Universitat Freiburg Albertstrasse 21, 79104 Freiburg im Breisgau, Germany.

A novel copper-catalyzed cycloisomerization of unactivated allene-tethered propargyl oximes has been developed for the synthesis of hexahydropyrrolo[3,4-]azepin-5(4)-ones. This one-pot domino reaction proceeds via a [2,3]-sigmatropic rearrangement, a [3 + 2] cycloaddition, and another [3,3]-sigmatropic rearrangement. The methodology offers a practical and straightforward route for the rapid assembly of both ring components of the fused bicyclic motifs from acyclic precursors by simultaneously forming four new bonds (a C═O, a C═N, and two C-C bonds) in a single step. Read More

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Genetically predicted bipolar disorder is causally associated with an increased risk of breast cancer: a two-sample Mendelian randomization analysis.

Ann Transl Med 2021 Mar;9(5):401

Department of Thoracic Oncology and Surgery, China State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Background: Epidemiologic findings suggested that bipolar disorder (BD) may be associated with an increased risk of breast cancer. However, there are few studies that comprehensively evaluating their correlation and the causal effect remains unknown. With a two-sample Mendelian randomization (MR) approach, we were able to investigate the causal relationship between genetically predicted BD and breast cancer risk. Read More

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An artificial intelligence platform for the diagnosis and surgical planning of strabismus using corneal light-reflection photos.

Ann Transl Med 2021 Mar;9(5):374

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

Background: Strabismus affects approximately 0.8-6.8% of the world's population and can lead to abnormal visual function. Read More

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Line Hops and Side Hold Rotation Tests Load Both Anterior and Posterior Shoulder: A Biomechanical Study.

Int J Sports Phys Ther 2021 Apr 1;16(2):477-487. Epub 2021 Apr 1.

University of Kentucky.

Background: Clinical tests should replicate the stressful positions encountered during sport participation. Evaluating the kinetic and electromyographical demands of clinical tests enables clinicians to choose appropriate tests for specific sports.

Purpose: To describe the shoulder forces and muscle activation levels during closed chain functional tests of Line Hops (LH) and Side Hold Rotation (SHR). Read More

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Horizontal Transfer of Different (B)-Carrying Mobile Elements Among Strains With Different Serotypes.

Front Microbiol 2021 26;12:628740. Epub 2021 Mar 26.

Ministry of Education (MOE) Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.

Macrolide-resistant is highly prevalent worldwide. The acquisition of the (B) gene mediated by mobile genetic elements (MGEs) in particular integrative and conjugative elements (ICEs) is recognized as the main reason for the rapid spread of macrolide-resistant streptococcal strains. However, knowledge about different (B)-carrying elements responsible for the widespread of macrolide resistance and their transferability in remains poorly understood. Read More

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Dissemination of Gene Among Several Sequence Types in Mexico Associated With Horizontal Transfer Mediated by IncF-Like Plasmids.

Front Microbiol 2021 25;12:611274. Epub 2021 Mar 25.

Laboratorio de Infectología, Microbiología e Inmunología Clínicas, Unidad de Investigación en Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, Mexico.

Nosocomial infections caused by multidrug-resistant (MDR) are a major health problem worldwide. The aim of this study was to describe NDM-1-producing strains causing bacteremia in a tertiary referral hospital in Mexico. MDR isolates were screened by polymerase chain reaction for the presence of resistance genes. Read More

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Radiographic evaluation of a bone substitute material in alveolar ridge preservation for maxillary removable immediate dentures: A randomized controlled trial.

J Prosthet Dent 2021 Apr 8. Epub 2021 Apr 8.

Associate Professor, Prosthodontics Department, Université de Bordeaux - Bordeaux University Hospital, Bordeaux, France.

Statement Of Problem: Maxillary bone resorption after multiple extractions can jeopardize the success of an immediate denture, but whether bone volume preservation techniques are effective is unclear.

Purpose: The purpose of this randomized controlled trial was to evaluate the efficacy of socket grafting with a xenogenic bone substitute in participants receiving maxillary immediate removable complete dentures in terms of bone volume preservation (height and width of the bone ridge).

Material And Methods: The study was a single-blinded, randomized controlled clinical trial with 2 balanced parallel arms. Read More

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Mobilized colistin resistance (mcr) genes from 1 to 10: a comprehensive review.

Mol Biol Rep 2021 Apr 10. Epub 2021 Apr 10.

Ministry of Health, Baghdad, Iraq.

At the present time, the polymyxin antibiotic colistin is considered a last-line treatment option for severe human infections caused by multi-drug and carbapenem-resistant Gram-negative bacteria. Lately, the vast spread of colistin resistance among bacteria has got great attention worldwide due to its significant role as the last refuge in treating diseases caused by the resistant infectious agents. Therefore, the discovery of plasmid-mediated mobile colistin resistance (mcr) genes raised global public health concerns as they can spread by horizontal transfer and have chances of global dissemination. Read More

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Transcranial Doppler Plateau Wave in a Patient with Pseudo-Chiari Malformation.

Acta Neurochir Suppl 2021 ;131:319-322

Intensive Care Unit, Clinicas Hospital School of Medicine, University of the Republic, Montevideo, Uruguay.

Case Report: A 26-year-old woman presented a superior sagittal and transverse sinus thrombosis with venous infarction. Anticoagulation was started. Six months later headache and visual impairment developed, and intracranial hypertension was diagnosed-secondary pseudotumor cerebri. Read More

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January 2021

Electroactive bacterial community augmentation enhances the performance of a pilot scale constructed wetland microbial fuel cell for treatment of textile dye wastewater.

Bioresour Technol 2021 Apr 1;332:125088. Epub 2021 Apr 1.

P. D. Patel Institute of Applied Sciences, Charotar University of Science and Technology, CHARUSAT Campus, Changa 388 421, Anand, Gujarat, India. Electronic address:

This study evaluated the effect of bioaugmentation of a newly enriched electroactive bacterial community DC5 on the performance of a pilot scale sequential two-step Horizontal Sub-surface flow Constructed Wetland-Microbial Fuel Cell (HSCW-MFC) system treating textile dye wastewater. The system consisted of CW-MFC-1 planted with Fimbristylis ferruginea and CW-MFC-2 planted with consortium of Fimbristylis ferruginea and Elymus repens plant species. Before bioaugmentation, HSCW-MFC system showed 62 ± 2% Chemical Oxygen Demand (COD) and 90 ± 1. Read More

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Pangenome analyses of LuxS-coding genes and enzymatic repertoires in cocoa-related lactic acid bacteria.

Genomics 2021 Apr 8. Epub 2021 Apr 8.

University of Verona - Department of Biotechnology, Verona, Italy.

Lactobacillaceae presents potential for interspecific Quorum Sensing (QS) in spontaneous cocoa fermentation, correlated with high abundance of luxS. Three Brazilian isolates from cocoa fermentation were characterized by Whole Genome Sequencing and luxS gene was surveyed in their genomes, in comparison with public databases. They were classified as Lactiplantibacillus plantarum, Limosilactobacillus fermentum and Pediococcus acidilactici. Read More

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Vagus nerve stimulation does not alter brainstem nuclei morphology in patients with refractory epilepsy.

Epilepsy Behav 2021 Apr 7;118:107940. Epub 2021 Apr 7.

Department of Clinical Neurological Sciences, London Health Sciences Centre, Western University, London, Ontario, Canada; Department of Pathology and Lab Medicine, London Health Sciences Centre, Western University, London, Ontario, Canada. Electronic address:

Objective: To describe morphological characteristics of the brainstem nuclei in response to chronic vagus nerve stimulation (VNS) in patients with refractory epilepsy.

Background: VNS is a treatment option for individuals with medically refractory epilepsy. While treatment with VNS may achieve up to 50% seizure reduction and is protective against sudden unexpected death in epilepsy (SUDEP), its mechanism of action is not fully understood. Read More

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Impacts of vegetation on particle concentrations in roadside environments.

Environ Pollut 2021 Apr 1;282:117067. Epub 2021 Apr 1.

International Center for Adaptation Planning and Design, College of Design, Construction and Planning, University of Florida, PO Box 115706, Gainesville, FL, 32611-5706, USA. Electronic address:

In roadside environments, commuters are exposed to a high level of traffic-related pollution. Despite vegetation is often used to mitigate air pollution in road environments, its air quality impacts are complex and could be both positive or negative depending on specific conditions. This study conducted field measurements to assess the air quality impacts of roadside vegetation. Read More

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Effect of Nimodipine and Botulinum Toxin A on Peripheral Nerve Regeneration in Rats: A Pilot Study.

J Surg Res 2021 Apr 7;264:208-221. Epub 2021 Apr 7.

University of Wisconsin School of Medicine and Public Health, Division of Plastic Surgery, Department of Surgery, Madison, Wisconsin. Electronic address:

Background: Peripheral nerve damage is a frequent problem, with an estimated 2.8%-5.0% of trauma admissions involving peripheral nerve injury. Read More

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Anterior-segment optical coherence tomography of filtering blebs in the early postoperative period of ab externo SIBS microshunt implantation with mitomycin C: Morphological analysis and correlation with intraocular pressure reduction.

Acta Ophthalmol 2021 Apr 10. Epub 2021 Apr 10.

Hospital Clínico, Madrid, Spain.

Purpose: To analyse the morphological evolution of filtering blebs with anterior-segment OCT (AS-OCT) and its correlation with intraocular pressure after ab externo SIBS microshunt implantation with mitomycin C (MMC) during a 3-month follow-up period.

Methods: Twenty-eight filtering blebs of 28 patients with open-angle glaucoma were measured horizontally and vertically in the sub-Tenon space with AS-OCT after ab externo SIBS microshunt implantation with MMC. The intraocular pressure (IOP) was monitored simultaneously at each visit. Read More

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Novel Dicistroviruses in an Unexpected Wide Range of Invertebrates.

Food Environ Virol 2021 Apr 10. Epub 2021 Apr 10.

Institute of Plant Virology, Ningbo University, Ningbo, China.

Dicistroviruses are members of a rapidly growing family of small RNA viruses. Related sequences have been discovered in many environmental samples, indicating that our knowledge about dicistrovirus diversity and host range is still limited. In this study, we performed a systematic search against the publicly available transcriptome database, and identified large numbers of dicistrovirus-like sequences in a wide variety of eukaryotic species. Read More

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Feasibility of P wave Centric Ambulatory Electrocardiogram Monitoring in Infants and Young Children.

Pediatr Cardiol 2021 Apr 10. Epub 2021 Apr 10.

Department of Pediatrics, Rush University Medical Center, Chicago, IL, 60612, USA.

P wave centric ambulatory electrocardiographic (ECG) monitoring has emerged as an important tool aiding the diagnosis of arrhythmias. However, their efficacy and user experience in infants and young children are not well established. A retrospective study was performed to detail clinical and user experience of ECG monitoring using the Carnation Ambulatory Monitor (CAM) patch (Bardy Diagnostics Inc. Read More

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Diversity of the type I-U CRISPR-Cas system in Bifidobacterium.

Arch Microbiol 2021 Apr 9. Epub 2021 Apr 9.

Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, People's Republic of China.

The CRISPR-Cas system is widely distributed in prokaryotes and plays an important role in the adaptive immunity of bacteria and archaea. Bifidobacterium is an important component of the intestinal flora of humans and animals, and some species of this bacterium can be employed as food additives. However, the Bifidobacterium CRISPR-Cas system has not been fully elucidated to date. Read More

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Niche and local geography shape the pangenome of wastewater- and livestock-associated Enterobacteriaceae.

Sci Adv 2021 Apr 9;7(15). Epub 2021 Apr 9.

Nuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK.

and other Enterobacteriaceae are diverse species with "open" pangenomes, where genes move intra- and interspecies via horizontal gene transfer. However, most analyses focus on clinical isolates. The pangenome dynamics of natural populations remain understudied, despite their suggested role as reservoirs for antimicrobial resistance (AMR) genes. Read More

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Evolutionary constraints on the acquisition of antimicrobial peptide resistance in bacterial pathogens.

Trends Microbiol 2021 Apr 6. Epub 2021 Apr 6.

Department of Zoology, University of Oxford, Oxford, OX1 3PS, UK.

Antimicrobial peptides (AMPs) offer a potential solution to the antibiotic resistance crisis. Recent studies have revealed important evolutionary constraints on the evolution and horizontal spread of AMP resistance in bacteria. Here, we summarize these advances and highlight their importance for therapeutic development of AMPs. Read More

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A multispecies outbreak of carbapenem-resistant bacteria harboring the bla gene in a non-classical transposon element.

BMC Microbiol 2021 Apr 9;21(1):107. Epub 2021 Apr 9.

Laboratory of Microbiology, Department of Clinical Laboratories, Centro Médico San Joaquín, Escuela de Medicina, Pontificia Universidad Católica de Chile, 3rd floor, Vicuña Mackenna, 4686, Santiago, Chile.

Background: Klebsiella pneumoniae is the most frequent KPC-producing bacteria. The bla gene is frequently embedded in Tn4401 transposon, and less frequently in non-Tn4401 elements (NTE) variants I-III. The first case of KPC in the UC-CHRISTUS Clinical Hospital was detected in Pseudomonas aeruginosa. Read More

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Formalin-induced inflammatory pain increases excitability in locus coeruleus neurons.

Brain Res Bull 2021 Apr 6. Epub 2021 Apr 6.

Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. Electronic address:

Chronic pain is recognized as an important problem in communities. The Locus coeruleus (LC) with extensive ascending and descending projections has a critical role in modulating pain. Some studies indicate how the locus coeruleus-noradrenaline system can remain more active after nociceptive stimulation. Read More

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Large-Scale Phenomic and Genomic Analysis of Brain Asymmetrical Skew.

Cereb Cortex 2021 Apr 9. Epub 2021 Apr 9.

Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen 6525 XD, The Netherlands.

The human cerebral hemispheres show a left-right asymmetrical torque pattern, which has been claimed to be absent in chimpanzees. The functional significance and developmental mechanisms are unknown. Here, we carried out the largest-ever analysis of global brain shape asymmetry in magnetic resonance imaging data. Read More

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In Situ, Protein-Mediated Generation of a Photochemically Active Chlorophyll Analogue in a Mutant Bacterial Photosynthetic Reaction Center.

Biochemistry 2021 Apr 9. Epub 2021 Apr 9.

Department of Chemistry, Washington University in St. Louis, St. Louis, Missouri 63130, United States.

All possible natural amino acids have been substituted for the native LeuL185 positioned near the B-side bacteriopheophytin (H) in the bacterial reaction center (RC) from . Additional mutations that enhance electron transfer to the normally inactive B-side cofactors are present. Approximately half of the isolated RCs with Glu at L185 contain a magnesium chlorin (C) in place of H. Read More

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Distribution of genetic elements associated with antibiotic resistance in treated and untreated animal husbandry waste and wastewater.

Environ Sci Pollut Res Int 2021 Apr 9. Epub 2021 Apr 9.

Department of Biological Sciences, Federal University of Ouro Preto, Campus Morro do Cruzeiro, Ouro Preto, State of Minas Gerais, CEP: 35.400-000, Brazil.

Animal breeding for meat production based on swine, cattle, poultry, and aquaculture is an activity that generates several impacts on the environment, among them the spread of antibiotic resistance. There is a worldwide concern related to the massive use of antibiotics, which causes selective pressure on the microbial community, triggering bacteria that contain "antibiotic resistance genes." According to the survey here presented, antibiotic resistance-related genes such as tetracyclines (tet), erythromycin (erm), and sulfonamides (sul), as well as the genetic mobile element interferon (int), are the most reported genetic elements in qualitative and quantitative studies of swine, cattle, poultry, and aquaculture manure/wastewater. Read More

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The Utility of the Subalar Graft in Nostril Symmetry in Rhinoplasty.

Plast Reconstr Surg 2021 Apr 7. Epub 2021 Apr 7.

From the Department of Surgery, Divisions of Otolaryngology and Surgical Outcomes and Epidemiology, Yale School of Medicine; the Department of Surgery, Division of Plastic and Reconstructive Surgery, University of Massachusetts Medical School-Baystate; and the Department of Otolaryngology Head and Neck Surgery, Icahn School of Medicine at Mount Sinai.

Background: A deviated nose can be attributable to multiple anatomical factors, including asymmetric maxilla. A subalar graft helps to correct maxillary hypoplasia and may be a useful tool for correcting a deviated nose. The authors' objective is to show the effects of the subalar graft in improving nostril symmetry and to propose an algorithm for using this graft in open and endonasal rhinoplasty. Read More

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