143 results match your criteria homologs systemic

Systemic Expression, Purification, and Initial Structural Characterization of Bacteriophage T4 Proteins Without Known Structure Homologs.

Front Microbiol 2021 13;12:674415. Epub 2021 Apr 13.

BioBank, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Bacteriophage T4 of is one of the most studied phages. Research into it has led to numerous contributions to phage biology and biochemistry. Coding about 300 gene products, this double-stranded DNA virus is the best-understood model in phage study and modern genomics and proteomics. Read More

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A unique Malpighian tubule architecture in informs the evolutionary origins of systemic osmoregulation in beetles.

Proc Natl Acad Sci U S A 2021 Apr;118(14)

Department of Biology, Section for Cell and Neurobiology, University of Copenhagen, DK-2100 Copenhagen, Denmark;

Maintaining internal salt and water balance in response to fluctuating external conditions is essential for animal survival. This is particularly true for insects as their high surface-to-volume ratio makes them highly susceptible to osmotic stress. However, the cellular and hormonal mechanisms that mediate the systemic control of osmotic homeostasis in beetles (Coleoptera), the largest group of insects, remain largely unidentified. Read More

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Identification of a novel NPR1 homolog gene, OsNH5N16, which contributes to broad-spectrum resistance in rice.

Biochem Biophys Res Commun 2021 Apr 4;549:200-206. Epub 2021 Mar 4.

National Institute of Agricultural Sciences, Rural Development Administration, Jeonju, 54874, Republic of Korea. Electronic address:

Over half of the earth's population consumes rice as the primary food crop for dietary calories. However, severe loss of rice yield occurs due to bacterial blight caused by Xanthomonas oryzae pv. oryzae (Xoo) and bakanae disease caused by Fusarium fujikuroi (F. Read More

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Epstein Barr Virus and Autoimmune Responses in Systemic Lupus Erythematosus.

Front Immunol 2020 3;11:623944. Epub 2021 Feb 3.

Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States.

Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease. Infections or infectious reactivation are potential triggers for initiation of autoimmunity and for SLE flares. Epstein-Barr virus (EBV) is gamma herpes virus that has been associated with several autoimmune diseases such as SLE, multiple sclerosis, Sjogren's syndrome, and systemic sclerosis. Read More

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February 2021

A conserved role for arrow in posterior axis patterning across Arthropoda.

Dev Biol 2021 Feb 16;475:91-105. Epub 2021 Feb 16.

Department of Integrative Biology, University of Wisconsin-Madison, Madison, WI, USA 53706. Electronic address:

Segmentation is a key characteristic of Arthropoda that is linked to the evolutionary success of this lineage. It has previously been shown in both vertebrates and short germ insects that posterior segmentation requires canonical Wnt (cWnt) signaling, which maintains the expression of Caudal and the posterior growth zone; disruption of cWnt signaling incurs posterior truncations in these lineages due to the loss of the tail bud. However, comparable datasets for Wnt signaling are limited outside of holometabolous insects, due to incomparable phenotypic spectra and inefficacy of gene misexpression methods in certain model species. Read More

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February 2021

Targeting the Protective Arm of the Renin-Angiotensin System: Focused on Angiotensin-(1-7).

J Pharmacol Exp Ther 2021 04 25;377(1):64-74. Epub 2021 Jan 25.

Department of Biomedical and Pharmaceutical Sciences, Idaho State University, Pocatello, ID

The in vivo application and efficacy of many therapeutic peptides is limited because of their instability and proteolytic degradation. Novel strategies for developing therapeutic peptides with higher stability toward proteolytic degradation would be extremely valuable. Such approaches could improve systemic bioavailability and enhance therapeutic effects. Read More

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R-spondin substitutes for neuronal input for taste cell regeneration in adult mice.

Proc Natl Acad Sci U S A 2021 01 21;118(2). Epub 2020 Dec 21.

Monell Chemical Senses Center, Philadelphia, PA 19104

Taste bud cells regenerate throughout life. Taste bud maintenance depends on continuous replacement of senescent taste cells with new ones generated by adult taste stem cells. More than a century ago it was shown that taste buds degenerate after their innervating nerves are transected and that they are not restored until after reinnervation by distant gustatory ganglion neurons. Read More

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January 2021

Bacteria-Derived Hemolysis-Related Genes Widely Exist in Scuticociliates.

Microorganisms 2020 Nov 22;8(11). Epub 2020 Nov 22.

Key Laboratory of Aquatic Biodiversity and Conservation, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.

Scuticociliatosis is an invasive external or systemic infection caused by ciliated protozoa, mainly those within the subclass Scuticociliatia (scuticociliates). Many scuticociliates are fish pathogens, including , , , and . Our previous study showed that hemolysis-related genes derived from bacteria through horizontal gene transfer (HGT) may contribute to virulence in . Read More

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November 2020

Systemic paralogy and function of retinal determination network homologs in arachnids.

BMC Genomics 2020 Nov 23;21(1):811. Epub 2020 Nov 23.

Department of Integrative Biology, University of Wisconsin-Madison, Madison, WI, 53706, USA.

Background: Arachnids are important components of cave ecosystems and display many examples of troglomorphisms, such as blindness, depigmentation, and elongate appendages. Little is known about how the eyes of arachnids are specified genetically, let alone the mechanisms for eye reduction and loss in troglomorphic arachnids. Additionally, duplication of Retinal Determination Gene Network (RDGN) homologs in spiders has convoluted functional inferences extrapolated from single-copy homologs in pancrustacean models. Read More

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November 2020

Respiratory Burst Oxidase Homologs RBOHD and RBOHF as Key Modulating Components of Response in Turnip Mosaic Virus- (L.) Heyhn System.

Int J Mol Sci 2020 Nov 12;21(22). Epub 2020 Nov 12.

Centro de Biotecnología y Genómica de Plantas (CBGP), Universidad Politécnica de Madrid (UPM)-Instituto Nacional de Investigacióny Tecnología Agraria y Alimentaria (INIA), Campus de Montegancedo, 28223 Pozuelo de Alarcón (Madrid), Spain.

Turnip mosaic virus (TuMV) is one of the most important plant viruses worldwide. It has a very wide host range infecting at least 318 species in over 43 families, such as Brassicaceae, Fabaceae, Asteraceae, or Chenopodiaceae from dicotyledons. Plant NADPH oxidases, the respiratory burst oxidase homologues (RBOHs), are a major source of reactive oxygen species (ROS) during plant-microbe interactions. Read More

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November 2020

A genome-wide screening for RNAi pathway proteins in Acari.

BMC Genomics 2020 Nov 12;21(1):791. Epub 2020 Nov 12.

Institute of Plant Protection, Agricultural Research Organization, the Volcani Center, P.O.B 15159, 7505101, Rishon leZion, Israel.

Background: RNA interference (RNAi) is a highly conserved, sequence-specific gene silencing mechanism present in Eukaryotes. Three RNAi pathways are known, namely micro-RNA (miRNA), piwi-interacting RNA (piRNA) and short interfering RNA (siRNA). However, little knowledge exists about the proteins involved in these pathways in Acari. Read More

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November 2020

Characterization of IL-22 Bioactivity and IL-22-Positive Cells in Grass Carp .

Front Immunol 2020 6;11:586889. Epub 2020 Oct 6.

Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean University, Shanghai, China.

Interleukin (IL)-22 plays an important role in regulating inflammation and clearance of infectious pathogens. IL-22 homologs have been discovered in fish, but the functions and sources of IL-22 have not been fully characterized. In this study, an IL-22 homolog was identified in grass carp and its bioactivities were investigated. Read More

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October 2020

Hedgehog pathway activation through nanobody-mediated conformational blockade of the Patched sterol conduit.

Proc Natl Acad Sci U S A 2020 11 2;117(46):28838-28846. Epub 2020 Nov 2.

Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305;

Activation of the Hedgehog pathway may have therapeutic value for improved bone healing, taste receptor cell regeneration, and alleviation of colitis or other conditions. Systemic pathway activation, however, may be detrimental, and agents amenable to tissue targeting for therapeutic application have been lacking. We have developed an agonist, a conformation-specific nanobody against the Hedgehog receptor Patched1 (PTCH1). Read More

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November 2020

Integration of reactive oxygen species and hormone signaling during abiotic stress.

Plant J 2021 01 30;105(2):459-476. Epub 2020 Oct 30.

Division of Plant Sciences, College of Agriculture, Food and Natural Resources, and Interdisciplinary Plant Group, Christopher S. Bond Life Sciences Center University of Missouri, 1201 Rollins St, Columbia, MO, 65201, USA.

Each year, abiotic stress conditions such as drought, heat, salinity, cold and particularly their different combinations, inflict a heavy toll on crop productivity worldwide. The effects of these adverse conditions on plant productivity are becoming ever more alarming in recent years in light of the increased rate and intensity of global climatic changes. Improving crop tolerance to abiotic stress conditions requires a deep understanding of the response of plants to changes in their environment. Read More

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January 2021

Antibody response to homologous epitopes of Epstein-Barr virus, subsp. and IRF5 in patients with different connective tissue diseases and in mouse model of antigen-induced arthritis.

J Transl Autoimmun 2020 17;3:100048. Epub 2020 Mar 17.

Department of Biomedical Sciences, Section of Microbiology and Virology, University of Sassari, Viale San Pietro 43b, 07100, Sassari, Italy.

Background: Improved knowledge of different biomarkers is crucial for early diagnosis of rheumatic diseases and to provide important insights for clinical management. In this study, we evaluated the seroreactivity of patients with different connective tissue diseases (CTDs) (rheumatoid arthritis, RA; systemic lupus erythematosus, SLE; systemic sclerosis, SSc; and Sjogren's syndrome, SSj) to interferon regulatory factor 5 (IRF5) peptide and homologs derived from Epstein-Barr virus (EBV) and subsp. (MAP). Read More

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Orai3: Oncochannel with therapeutic potential.

Cell Calcium 2020 09 26;90:102247. Epub 2020 Jun 26.

Laboratory of Calciomics and Systemic Pathophysiology, Regional Centre for Biotechnology (RCB), Faridabad, Delhi-NCR, India. Electronic address:

Ion channels in particular Calcium (Ca) channels play a critical role in physiology by regulating plethora of cellular processes ranging from cell proliferation, differentiation, transcriptional regulation and programmed cell death. One such physiologically important and highly Ca selective channel family is Orai channels consisting of three homologs Orai1, Orai2 and Orai3. Orai channels are responsible for Ca influx across the plasma membrane in response to decrease in Endoplasmic Reticulum (ER) Ca stores. Read More

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September 2020

Influence of Protein Glycosylation on Physiology.

Front Microbiol 2020 17;11:1191. Epub 2020 Jun 17.

Department of Microbiology, University of Georgia, Athens, GA, United States.

is commonly associated with venereal disease and abortions in cattle and sheep, and can also cause intestinal or systemic infections in humans that are immunocompromised, elderly, or exposed to infected livestock. It is also believed that infection can result from the consumption or handling of contaminated food products, but is rarely detected in food since isolation methods are not suited for its detection and the physiology of the organism makes culturing difficult. In the related species, , the ability to colonize the host has been linked to N-linked protein glycosylation with quantitative proteomics demonstrating that glycosylation is interconnected with cell physiology. Read More

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A Zinc Cluster Transcription Factor Contributes to the Intrinsic Fluconazole Resistance of Candida auris.

mSphere 2020 04 22;5(2). Epub 2020 Apr 22.

Institut für Molekulare Infektionsbiologie, Universität Würzburg, Würzburg, Germany

The recently emerged pathogenic yeast is a major concern for human health, because it is easily transmissible, difficult to eradicate from hospitals, and highly drug resistant. Most isolates are resistant to the widely used antifungal drug fluconazole due to mutations in the target enzyme Erg11 and high activity of efflux pumps, such as Cdr1. In the well-studied, distantly related yeast , overexpression of drug efflux pumps also is a major mechanism of acquired fluconazole resistance and caused by gain-of-function mutations in the zinc cluster transcription factors Mrr1 and Tac1. Read More

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Characterization of tomato protein kinases embedding guanylate cyclase catalytic center motif.

Sci Rep 2020 03 5;10(1):4078. Epub 2020 Mar 5.

Institute of Biotechnology, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, 310058, China.

Guanylate cyclases (GCs) are enzymes that catalyze the reaction to produce cyclic GMP (cGMP), a key signaling molecule in eukaryotes. Nevertheless, systemic identification and functional analysis of GCs in crop plant species have not yet been conducted. In this study, we systematically identified GC genes in the economically important crop tomato (Solanum lycopersicum L. Read More

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Cloning and characterization of a NPR1 gene involved in regulating plant resistance to .

Xia He Yancai Shi

Plant Biotechnol (Tokyo) 2018 Dec;35(4):349-356

Guangxi Institute of Botany, The Chinese Academy of Sciences, Guilin 541006, PR China.

The monkey flower is a new emerging model plant for the study in corolla tube formation, pigmentation patterns and pollinator selection, etc. However, the cultivation and management of this plant are difficult due to its susceptibility to a wide range of pathogens and the lack of rigid varieties with high levels of resistance to pathogens. In this regard, genetic engineering is a promising tool that may possibly allow us to enhance the disease resistance against pathogens. Read More

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December 2018

Prevalence, Distribution, and Phylogeny of Type Two Toxin-Antitoxin Genes Possessed by Species where Homologs Follow Sequence Type Lineages.

Microorganisms 2019 Nov 12;7(11). Epub 2019 Nov 12.

Center of Food Safety and Applied Nutrition, U. S. Food and Drug Administration, 8301 MuirKirk Rd, Laurel, MD 20708, USA.

species are a group of foodborne pathogenic bacteria that cause both intestinal and systemic human disease in individuals of all age groups. Little is known about the mechanisms that employ to survive and persist in foods and other environments. Toxin-antitoxin (TA) genes are thought to play a role in bacterial stress physiology, as well as in the stabilization of horizontally-acquired re-combinatorial elements such as plasmids, phage, and transposons. Read More

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November 2019

Bacillus velezensis 5113 Induced Metabolic and Molecular Reprogramming during Abiotic Stress Tolerance in Wheat.

Sci Rep 2019 11 8;9(1):16282. Epub 2019 Nov 8.

Department of Plant Biology, Uppsala Biocenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, SE75007, Uppsala, Sweden.

Abiotic stresses are main limiting factors for agricultural production around the world. Plant growth promoting rhizobacteria (PGPR) have been shown to improve abiotic stress tolerance in several plants. However, the molecular and physiological changes connected with PGPR priming of stress management are poorly understood. Read More

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November 2019

The Lectin Receptor Kinase LecRK-I.8 Is Involved in Insect Egg Perception.

Front Plant Sci 2019 10;10:623. Epub 2019 May 10.

Department of Plant Molecular Biology, University of Lausanne, Lausanne, Switzerland.

Plants induce defense responses after insect egg deposition, but very little is known about the perception mechanisms. In , eggs of the specialist insect trigger accumulation of reactive oxygen species (ROS) and salicylic acid (SA), followed by induction of defense genes and localized necrosis. Here, the involvement of the clade I L-type lectin receptor kinase LecRK-I. Read More

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Genome-Wide Analysis of Sorghum GT47 Family Reveals Functional Divergences of MUR3-Like Genes.

Front Plant Sci 2018 14;9:1773. Epub 2018 Dec 14.

Key Laboratory of Biofuels, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, China.

Sorghum () is an important bioenergy crop. Its biomass mainly consists of the cellulosic and non-cellulosic polysaccharides, both which can be converted to biofuels. The biosynthesis of non-cellulosic polysaccharides involves several glycosyltransferases (GT) families including GT47. Read More

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December 2018

Regulation of GDSL Lipase Gene Expression by the MPK3/MPK6 Cascade and Its Downstream WRKY Transcription Factors in Immunity.

Mol Plant Microbe Interact 2019 Jun 22;32(6):673-684. Epub 2019 Apr 22.

2 Division of Biochemistry, Interdisciplinary Plant Group, Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, U.S.A.

Mitogen-activated protein kinase (MAPK) cascades serve as unified signaling modules in plant development and defense response. Previous reports demonstrated an essential role of GLIP1, a member of the GDSL-like-motif lipase family, in both local and systemic resistance. expression is highly induced by pathogen attack. Read More

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Transcription Factors Associated With -Mediated Acquired Resistance in Barley Are Potential Resources to Improve Wheat Resistance to .

Front Plant Sci 2018 17;9:1486. Epub 2018 Oct 17.

College of Plant Protection, Biological Control Center for Plant Diseases and Plant Pests of Hebei, Hebei Agricultural University, Baoding, China.

Systemic acquired resistance (SAR) in is established beyond the initial pathogenic infection or is directly induced by treatment with salicylic acid or its functional analogs (SA/INA/BTH). NPR1 protein and WRKY transcription factors are considered the master regulators of SAR. Our previous study showed that homologs in wheat ( L. Read More

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October 2018

A cell surface protein controls endocrine ring gland morphogenesis and steroid production.

Dev Biol 2019 01 24;445(1):16-28. Epub 2018 Oct 24.

Institute for Biology and Saxon Incubator for Clinical Translation (SIKT), University of Leipzig, Philipp-Rosenthal-Str. 55, 04103 Leipzig, Germany; Life&Medical Sciences Institute (LIMES), University of Bonn, 53115 Bonn, Germany. Electronic address:

Identification of signals for systemic adaption of hormonal regulation would help to understand the crosstalk between cells and environmental cues contributing to growth, metabolic homeostasis and development. Physiological states are controlled by precise pulsatile hormonal release, including endocrine steroids in human and ecdysteroids in insects. We show in Drosophila that regulation of genes that control biosynthesis and signaling of the steroid hormone ecdysone, a central regulator of developmental progress, depends on the extracellular matrix protein Obstructor-A (Obst-A). Read More

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January 2019

Epstein Barr Virus Interleukin 10 Suppresses Anti-inflammatory Phenotype in Human Monocytes.

Front Immunol 2018 9;9:2198. Epub 2018 Oct 9.

Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States.

Epstein Barr virus (EBV) is a gamma herpes virus associated with certain malignancies and autoimmune diseases. EBV maintains latency in B cells with occasional reactivation, in part by overcoming the host immune response with viral homologs of several human proteins. EBV interleukin 10 (vIL-10), a lytic phase protein, is a homolog of human IL-10 (hIL-10). Read More

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September 2019

The C-terminal coiled-coil domain of Corynebacterium diphtheriae DIP0733 is crucial for interaction with epithelial cells and pathogenicity in invertebrate animal model systems.

BMC Microbiol 2018 09 4;18(1):106. Epub 2018 Sep 4.

Microbiology Division, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.

Background: Corynebacterium diphtheriae is the etiologic agent of diphtheria and different systemic infections. The bacterium has been classically described as an extracellular pathogen. However, a number of studies revealed its ability to invade epithelial cells, indicating a more complex pathogen-host interaction. Read More

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September 2018

Double-stranded RNA binding protein, Staufen, is required for the initiation of RNAi in coleopteran insects.

Proc Natl Acad Sci U S A 2018 08 30;115(33):8334-8339. Epub 2018 Jul 30.

Department of Entomology, College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY 40546

RNA interference (RNAi) is being used to develop methods to control pests and disease vectors. RNAi is robust and systemic in coleopteran insects but is quite variable in other insects. The determinants of efficient RNAi in coleopterans, as well as its potential mechanisms of resistance, are not known. Read More

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