105 results match your criteria homografts meet

Different sterilization and disinfection methods used for human tendons - a systematic review using mechanical properties to evaluate tendon allografts.

BMC Musculoskelet Disord 2021 Apr 30;22(1):404. Epub 2021 Apr 30.

Cooperation Research Center for Biomechanics, Faculty of Mechanical Engineering, Budapest University of Technology and Economics, Budapest, Hungary.

Background: It is important to know the biomechanical properties of an allograft. This is because when looking to do a transplant of a tendon, the tendon must have very similar biomechanical properties to the original tendon. To use tendon allografts, it is critical to properly sterilize the tendon before implantation. Read More

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Barriers to the Development and Sustainability of Bone Banking Programs in Low- and Middle-Income Countries: A Systematic Review.

Biopreserv Biobank 2021 Apr 29. Epub 2021 Apr 29.

Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

The number of bone allograft transplantations required in low- and middle-income countries (LMICs) is growing very quickly. No previous study has investigated the challenges clinical banks face to sustain operations or meet this demand. The purpose of this study was to conduct a systematic review of the barriers to implementation and sustainability of clinical bone tissue banks in LMICs. Read More

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Recent progress toward clinical translation of tissue engineered heart valves.

Can J Cardiol 2021 Apr 8. Epub 2021 Apr 8.

Translational Biology and Engineering Program, Ted Rogers Centre for Heart Research, Toronto, Ontario, Canada, M5G 1M1; Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada, M5S 3G9; Department of Mechanical & Industrial Engineering, University of Toronto, Toronto, Ontario, Canada, M5S 3G8. Electronic address:

Surgical replacement remains the primary option to treat the rapidly growing number of patients with severe valvular heart disease. While current valve replacements - mechanical, bioprosthetic, and cryopreserved homografts - enhance survival and quality of life for many patients, the ideal prosthetic heart valve that is abundantly available, immunocompatible, and capable of growth, self-repair, and life-long performance has yet to be developed. These features are essential for pediatric patients with congenital defects, children and young adult rheumatic fever patients, and active adult patients with valve disease. Read More

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Early Allograft Dysfunction Increases Hospital Associated Costs After Liver Transplantation-A Propensity Score-Matched Analysis.

Hepatol Commun 2021 Mar 5;5(3):526-537. Epub 2020 Dec 5.

Department of Surgery Charité-Universitätsmedizin Berlin Campus Charité Mitte Campus Virchow-Klinikum Corporate Member of Freie Universität Berlin Humboldt-Universität zu Berlin and Berlin Institute of Health Berlin Germany.

Concepts to ameliorate the continued mismatch between demand for liver allografts and supply include the acceptance of allografts that meet extended donor criteria (ECD). ECD grafts are generally associated with an increased rate of complications such as early allograft dysfunction (EAD). The costs of liver transplantation for the health care system with respect to specific risk factors remain unclear and are subject to change. Read More

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Outcome of T-cell acute lymphoblastic leukemia/lymphoma: Focus on near-ETP phenotype and differential impact of nelarabine.

Am J Hematol 2021 05 18;96(5):589-598. Epub 2021 Mar 18.

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Early T-cell precursor acute lymphoblastic leukemia/lymphoma (ETP-ALL/LBL) is characterized by a distinct immunophenotype (CD1a-negative, CD8-negative, CD5-negative or weak-positive <75%, myeloid/stem-cell markers positive) and poor clinical outcomes. Near-ETP ALL is transcriptionally similar to ETP-ALL but CD5 expression level is not low enough to meet the criteria of ETP immunophenotype. Outcomes of near-ETP ALL are not well characterized. Read More

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Impact of valve fenestrations and structural changes in homografts on the long-term outcome in the recipient.

Cell Tissue Bank 2021 Feb 12. Epub 2021 Feb 12.

Department of Clinical Science Lund, Cardiothoracic Surgery, Lund University and Skane University Hospital, Lund, Sweden.

Homografts have long been used for right ventricular outflow tract (RVOT) reconstruction. Tissue banks struggle to meet the clinical demand of tissue, with insufficient donor availability and strict recommendations on tissue quality with high proportions of discards. This study analyzes the long-term outcome of patients receiving a homograft with small fenestrations of the cusps or other structural changes, to evaluate if minor impairment of the homograft affects the durability. Read More

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February 2021

Principles of bone and tissue banking in Saudi Arabia: 10-year experience report.

Cell Tissue Bank 2021 Mar 4;22(1):93-101. Epub 2020 Oct 4.

Department of Orthopedics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

Background: The role of bone and tissue banking is well known to meet the ever-growing need of bone and soft tissue allografts. Strict guidelines have been established to ensure high standard and minimize complications related to bone transplantation.

Methods: The Bone Bank in King Faisal Specialist Hospital and Research Centre (KFSH&RC), affiliated with the Saudi Council of Organ Transplantation, was inaugurated in 2010, and it has since been an integral part of the KFSH&RC organ retrieval team. Read More

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Molecular assessment of antibody-mediated rejection in human pancreas allograft biopsies.

Clin Transplant 2020 11 30;34(11):e14065. Epub 2020 Aug 30.

Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada.

Pancreas transplant longevity is limited by immune rejection, which is diagnosed by graft biopsy using the Banff Classification. The histological criteria for antibody-mediated rejection (AMR) are poorly reproducible and inconsistently associated with outcome. We hypothesized that a 34-gene set associated with antibody-mediated rejection in other solid organ transplants could improve diagnosis in pancreas grafts. Read More

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November 2020

Warping Characteristics of Rib Allograft Cartilage.

Plast Reconstr Surg 2020 07;146(1):37e-42e

From the Dallas Plastic Surgery Institute.

When septal cartilage is lacking, commercially available costal cartilage allograft can be used. Such allografts have "off-the-shelf" accessibility, are available in multiple sizes, are aseptically processed to meet sterility, and are screened to minimize infectious risks. The purpose of this study was to evaluate the effect of donor age, storage temperature, and orientation of a bilayered construct on the degree of warping of a commercialized fresh frozen costal cartilage allograft in vitro over time. Read More

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Wound Center Without Walls: The New Model of Providing Care During the COVID-19 Pandemic.

Wounds 2020 07 24;32(7):178-185. Epub 2020 Apr 24.

Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA.

The COVID-19 pandemic poses a major challenge in delivering care to wound patients. Due to multiple comorbidities, wound patients are at an increased risk for the most extreme complications of COVID-19 and providers must focus on reducing their exposure risk. The Federal, State, and local governments, as well as payers, have urged hospitals and providers to reduce utilization of nonessential health services, but they also have given more flexibility to shift the site of necessary care to lower risk environments. Read More

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Clinical translation of liver regeneration therapies: A conceptual road map.

Biochem Pharmacol 2020 05 5;175:113847. Epub 2020 Feb 5.

Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland. Electronic address:

The increasing incidence of severe liver diseases worldwide has resulted in a high demand for curative liver transplantation. Unfortunately, the need for transplants by far eclipses the availability of suitable grafts leaving many waitlisted patients to face liver failure and often death. Routine use of smaller grafts (for example left lobes, split livers) from living or deceased donors could increase the number of life-saving transplants but is often limited by the graft versus recipient weight ratio defining the safety margins that minimize the risk of small for size syndrome (SFSS). Read More

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Targeting glutamine metabolism slows soft tissue sarcoma growth.

Nat Commun 2020 01 24;11(1):498. Epub 2020 Jan 24.

Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.

Tumour cells frequently utilize glutamine to meet bioenergetic and biosynthetic demands of rapid cell growth. However, glutamine dependence can be highly variable between in vitro and in vivo settings, based on surrounding microenvironments and complex adaptive responses to glutamine deprivation. Soft tissue sarcomas (STSs) are mesenchymal tumours where cytotoxic chemotherapy remains the primary approach for metastatic or unresectable disease. Read More

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January 2020

Athletes With Bone-Patellar Tendon-Bone Autograft for Anterior Cruciate Ligament Reconstruction Were Slower to Meet Rehabilitation Milestones and Return-to-Sport Criteria Than Athletes With Hamstring Tendon Autograft or Soft Tissue Allograft : Secondary Analysis From the ACL-SPORTS Trial.

J Orthop Sports Phys Ther 2020 May 27;50(5):259-266. Epub 2019 Nov 27.

Objective: Graft choices for athletes undergoing anterior cruciate ligament reconstruction (ACLR) include bone-patellar tendon-bone (BPTB) and hamstring tendon (HT) autografts and soft tissue allografts. The objective was to assess time to meet clinical milestones by graft type in athletes who completed a return-to-sport (RTS) program after ACLR.

Design: Retrospective cohort study. Read More

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Ectopic mineralization in heart valves: new insights from and procalcific models and promising perspectives on noncalcifiable bioengineered valves.

J Thorac Dis 2019 May;11(5):2126-2143

Department of Medicine, University of Udine, Udine, Italy.

Ectopic calcification of native and bioprosthetic heart valves represents a major public health problem causing severe morbidity and mortality worldwide. Valve procalcific degeneration is known to be caused mainly by calcium salt precipitation onto membranes of suffering non-scavenged cells and dead-cell-derived products acting as major hydroxyapatite nucleators. Although etiopathogenesis of calcification in native valves is still far from being exhaustively elucidated, it is well known that bioprosthesis mineralization may be primed by glutaraldehyde-mediated toxicity for xenografts, cryopreservation-related damage for allografts and graft immune rejection for both. Read More

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Noninvasive biomarkers in monitoring kidney allograft health.

Curr Opin Organ Transplant 2019 08;24(4):411-415

Nuffield Department of Surgical Sciences, Centre for Evidence in Transplantation, University of Oxford, Oxford, UK.

Purpose Of Review: A key aspect of posttransplant management is to identify and treat graft injury before it becomes irreversible. The gold-standard for detection is histology, but biopsy is uncomfortable for the patient and carries a risk of complications. Detection of changes at a molecular level may preempt histological injury, and thereby identify injury earlier. Read More

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Presumed Consent: A Potential Tool for Countries Experiencing an Organ Donation Crisis.

Dig Dis Sci 2019 05 5;64(5):1346-1355. Epub 2018 Dec 5.

Department of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.

Background: There is currently an inadequate supply of allografts to meet the number of transplant candidates worldwide. A number of controversial policies, including implementation of a presumed consent organ donation system, have been considered to rectify the organ donation crisis.

Aims: A secondary retrospective data analysis aimed to assess the impact of switching to a presumed consent organ donation model on organ donation rates. Read More

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Can haploidentical transplantation meet all patients' needs?

Daniel Weisdorf

Best Pract Res Clin Haematol 2018 12 21;31(4):410-413. Epub 2018 Sep 21.

Division of Hematology, Oncology and Transplantation, University of Minnesota, 420 Delaware Street SE, MMC 480, Minneapolis, MN 55455, USA. Electronic address:

Allotransplantation in the absence of an HLA-matched sibling donor can offer numerous donor options including unrelated donor and umbilical cord blood grafting. Recently, haploidentical transplantation has exploded in popularity and worldwide use following the application of post-transplant cyclophosphamide (PTCy) for GVHD prophylaxis. Various approaches, disease states, conditioning intensities and supportive care advances have improved all these choices without demonstrable superiority of one approach versus the others. Read More

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December 2018

Regulatory T Cells and Ocular Graft Versus Host Disease: A Novel Treatment Approach.

Med Hypothesis Discov Innov Ophthalmol 2018 ;7(3):119-121

Department of Allergy and Immunology, Mashhad University of Medical Sciences, Mashhad, Iran.

Graft Versus Host Disease (GVHD) is an inflammatory immune disease, mediated by the donor's immune cells and can arise after allogeneic Hematopoietic Stem Cell Transplantation (HSCT) for the treatment of hematologic malignancies. It can lead to destructive manifestations in various tissues, particularly dermatological, gastrointestinal, and ocular tissues. The most common ocular morbidity is dry eyes, which is often the first manifestation of GVHD. Read More

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January 2018

Development of Clinical Criteria for Functional Assessment to Predict Primary Nonfunction of High-Risk Livers Using Normothermic Machine Perfusion.

Liver Transpl 2018 10;24(10):1453-1469

National Institute for Health Research Birmingham, Liver Biomedical Research Centre, College of Medical and Dental Sciences, University of Birmingham.

Increased use of high-risk allografts is critical to meet the demand for liver transplantation. We aimed to identify criteria predicting viability of organs, currently declined for clinical transplantation, using functional assessment during normothermic machine perfusion (NMP). Twelve discarded human livers were subjected to NMP following static cold storage. Read More

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October 2018

Update on the supply and use of allografts in locomotor system pathologies in France.

Orthop Traumatol Surg Res 2018 11 20;104(7):1125-1130. Epub 2018 Sep 20.

CNRS, SIGMA Clermont, ICCF, université Clermont Auvergne, CHU Clermont-Ferrand, 63000 Clermont-Ferrand, France.

Allografts are increasingly used in orthopedics. The main aim of the present study was to map the use of locomotor system allografts in France between 2012 and 2016. The study hypothesis was that there are great differences in the distribution and activity of tissue banks and graft preservation procedure quality, failing to meet national requirements. Read More

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November 2018

Domino Hepatocyte Transplantation: A Therapeutic Alternative for the Treatment of Acute Liver Failure.

Can J Gastroenterol Hepatol 2018 2;2018:2593745. Epub 2018 Jul 2.

Laboratório de Comunicação Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.

Background And Aims: Acute liver failure (ALF) is a severe syndrome with an elevated mortality rate, ranging from 40 to 80 %. Currently, liver transplantation is the only definitive treatment for these patients and new therapies aiming to treat ALF include artificial organs implant and stem cells therapy, for example. However, a major limitation of liver donors exists. Read More

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February 2019

Allogeneic mesenchymal stem cells as induction therapy are safe and feasible in renal allografts: pilot results of a multicenter randomized controlled trial.

J Transl Med 2018 03 7;16(1):52. Epub 2018 Mar 7.

Department of Renal Transplantation, The Third Affiliated Hospital, Sun Yat-sen University, Kaichuang Road 2693, Huangpu District, Guangzhou, 510530, People's Republic of China.

Background: Kidneys from deceased donors are being used to meet the growing need for grafts. However, delayed graft function (DGF) and acute rejection incidences are high, leading to adverse effects on graft outcomes. Optimal induction intervention should include both renal structure injury repair and immune response suppression. Read More

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Unrelated donor choices for allogeneic hematopoietic cell transplantation in Canada: an evaluation of factors influencing donor selection.

Transfusion 2018 03 25;58(3):718-725. Epub 2017 Dec 25.

OneMatch Stem Cell & Marrow Network, Canadian Blood Services.

Background: Utilization of unrelated donors and cord blood units (CBUs) for allogeneic hematopoietic cell transplantation continues to increase. Understanding the practices of donor selection by transplant centers is critical for unrelated donor registries and cord blood banks to optimize registry composition and inventory to meet patient need.

Study Design And Methods: Unrelated donor and CBU selection practices of Canadian transplant centers served by Canadian Blood Services' OneMatch Stem Cell & Marrow Network (OM) were reviewed, including HLA match level, locus of disparity, age, sex, and product choice (donor vs. Read More

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Short-term adverse effects of early subclinical allograft inflammation in kidney transplant recipients with a rapid steroid withdrawal protocol.

Am J Transplant 2018 07 17;18(7):1710-1717. Epub 2018 Jan 17.

Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

The impact of subclinical inflammation (SCI) noted on early kidney allograft biopsies remains unclear. This study evaluated the outcome of SCI noted on 3-month biopsy. A total of 273/363 (75%) kidney transplant recipients with a functioning kidney underwent allograft biopsies 3-months posttransplant. Read More

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Characteristics and Performance of Unilateral Kidney Transplants from Deceased Donors.

Clin J Am Soc Nephrol 2018 01 7;13(1):118-127. Epub 2017 Dec 7.

Division of Nephrology, Department of Medicine and

Background And Objectives: The fraction of kidneys procured for transplant that are discarded is rising in the United States. Identifying donors from whom only one kidney was discarded allows us to control for donor traits and better assess reasons for organ discard.

Design, Setting, Participants, & Measurements: We conducted a retrospective cohort study using United Network for Organ Sharing Standard Transplant Analysis and Research file data to identify deceased donors from whom two kidneys were procured and at least one was transplanted. Read More

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January 2018

Imminent Death Liver Donation for Children: Potential to Meet an Unmet Need.

JAMA Surg 2018 02;153(2):103-104

Division of Abdominal Transplantation, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas.

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February 2018

91-Year-Old Allograft: Oldest Surviving Donor Heart Still Going: A Case Report.

Transplant Proc 2017 Sep;49(7):1663-1666

Department of Cardiology, Loma Linda University Medical Center, Loma Linda, California.

For patients with end-stage heart failure, heart transplantation remains one of the most successful therapies with excellent long-term survival rates. However, over the past few decades, there has been a worsening supply/demand mismatch given the rising epidemic of heart failure and the relatively fixed availability of donor hearts. In this case report, we describe the case of a 30-year-old woman who underwent transplantation with a 68-year-old donor heart and who has survived for 23 years without any major cardiac problems. Read More

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September 2017

Acellular Hypothermic Extracorporeal Perfusion Extends Allowable Ischemia Time in a Porcine Whole Limb Replantation Model.

Plast Reconstr Surg 2017 Apr;139(4):922e-932e

Boston, Mass.; and Bochum and Heidelberg, Germany.

Background: One of the major challenges in traumatic amputation is the need to keep ischemia time brief (4 to 6 hours) to avoid ischemic damage and enable successful replantation. The current inability to meet this challenge often leads to traumatic limb loss, which has a considerable detrimental impact on the quality of life of patients.

Methods: The authors' team built a portable extracorporeal membrane oxygenator device for the perfusion of amputated extremities with oxygenated acellular solution under controlled parameters. Read More

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Electrospun Nanofiber Scaffolds and Their Hydrogel Composites for the Engineering and Regeneration of Soft Tissues.

Methods Mol Biol 2017 ;1570:261-278

Department of Orthopaedic Surgery, University of Connecticut Health, Farmington, CT, USA.

Electrospinning has emerged as a simple, elegant, and scalable technique that can be used to fabricate polymeric nanofibers. Pure polymers as well as blends and composites of both natural and synthetic ones have been successfully electrospun into nanofiber matrices for many biomedical applications. Tissue-engineered medical implants, such as polymeric nanofiber scaffolds, are potential alternatives to autografts and allografts, which are short in supply and carry risks of disease transmission. Read More

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February 2018