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Dosimetric Comparison of Whole Breast Radiotherapy Using Field-in-Field and Volumetric Modulated Arc Therapy Techniques in Left-Sided Breast Cancer Patients.

Cureus 2021 Jun 18;13(6):e15732. Epub 2021 Jun 18.

Department of Clinical and Radiation Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, PAK.

Introduction The radiotherapy of left-sided breast cancers is challenging because of neighboring critical organs, posing an increased risk of complications. Various radiation delivery techniques have been used to deliver the desired dose of radiation to the target area while keeping the doses to nearby structures within constraints. The main aim of this study is to quantify doses delivered to the organs at risk (OARs) including heart, left lung, spinal cord, and contralateral breast, and to the planning target volume (PTV) using Field-in-Field (FIF) and Volumetric Modulated Arc Therapy (VMAT). Read More

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Concordance of intrinsic brain connectivity measures is disrupted in Alzheimer's disease.

Brain Connect 2021 Jul 16. Epub 2021 Jul 16.

Research Centre Jülich, 28334, Julich, Nordrhein-Westfalen, Germany.

Background: Recently, a new resting-state functional magnetic resonance imaging (rs-fMRI) measure to evaluate the concordance between different rs-fMRI metrics has been proposed and has not been investigated in Alzheimer's disease (AD).

Methods: 3T rs-fMRI data were obtained from healthy young controls (YC, n=26), senior controls (SC, n=29), and AD patients (n=35). The fractional amplitude of low-frequency fluctuations (fALFF), regional homogeneity (ReHo), and degree centrality (DC) were analyzed, followed by the calculation of their concordance using Kendall's W for each brain voxel across time. Read More

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Mutually exclusive substrate selection strategy by human m3C RNA transferases METTL2A and METTL6.

Nucleic Acids Res 2021 Jul 15. Epub 2021 Jul 15.

State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China.

tRNAs harbor the most diverse posttranscriptional modifications. The 3-methylcytidine (m3C) is widely distributed at position C32 (m3C32) of eukaryotic tRNAThr and tRNASer species. m3C32 is decorated by the single methyltransferase Trm140 in budding yeasts; however, two (Trm140 and Trm141 in fission yeasts) or three enzymes (METTL2A, METTL2B and METTL6 in mammals) are involved in its biogenesis. Read More

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CT radiomic features of photodynamic priming in clinical pancreatic adenocarcinoma treatment.

Phys Med Biol 2021 Jul 14. Epub 2021 Jul 14.

Thayer School of Engineering at Dartmouth, Hanover, New Hampshire, UNITED STATES.

Photodynamic therapy (PDT) offers localized focal ablation in unresectable pancreatic tumors while tissues surrounding the treatment volume experience a lower light dose, termed photodynamic priming (PDP). While PDP does not cause tissue damage, it has been demonstrated to promote vascular permeability, improve drug delivery, alleviate tumor cell density, and reduce desmoplasia and the resultant internal pressure in pre-clinical evaluation. Preclinical data supports PDP as a neoadjuvant therapy beneficial to subsequent chemotherapy or immunotherapy, yet it is challenging to quantify PDP effects in clinical treatment without additional imaging and testing. Read More

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Altered spontaneous brain activity patterns in dysthyroid optic neuropathy: a resting-state fMRI study.

J Integr Neurosci 2021 Jun;20(2):375-383

Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi Province, China.

This research investigates the characteristics of spontaneous brain activity in dysthyroid optic neuropathy patients using the regional homogeneity technique. Sixteen patients with dysthyroid optic neuropathy and 16 thyroid-associated ophthalmopathy patients without dysthyroid optic neuropathy were recruited, matched for weight, height, age, sex, and educational level. All participants underwent resting-state functional nuclear resonance imaging, and the characteristics of spontaneous brain activity were evaluated using the regional homogeneity technique. Read More

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Analysis of the impact of various vertical release patterns on the atmospheric dispersion and total deposition of Cs from Chernobyl Nuclear Power Plant accident.

Environ Sci Pollut Res Int 2021 Jul 8. Epub 2021 Jul 8.

Department of Environmental Engineering, Dokuz Eylul University, 35390, Izmir, Turkey.

The Chernobyl Nuclear Power Plant (NPP) catastrophe of 1986 has been a milestone in the use of nuclear power for energy generation. After the accident, various topics have been discussed to evaluate the details of occurrence of the event and to understand its impacts on human, animal and plant life. One of the most controversial topics is the release height and homogeneity of radionuclides at release point in the atmosphere. Read More

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Safety, Efficacy, and Cost of 0.4-mg Versus 2-mg Intranasal Naloxone for Treatment of Prehospital Opioid Overdose.

Ann Pharmacother 2021 Jul 6:10600280211030918. Epub 2021 Jul 6.

University of Michigan, Ann Arbor, MI, USA.

Background: Intranasal naloxone is commonly used to treat prehospital opioid overdose. However, the optimal dose is unclear, and currently, no study exists comparing the clinical effect of intranasal naloxone at different doses.

Objective: The goal of this investigation was to compare the safety, efficacy, and cost of 0. Read More

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[Energy metabolism characteristic with risk of secondary bacterial infection in patients with hepatitis B virus-related chronic liver disease].

Zhonghua Gan Zang Bing Za Zhi 2021 Jun;29(6):558-564

Department of Hepatology, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, China.

To investigate and analyze the energy metabolism characteristics and the correlation between energy metabolism and the risk of secondary bacterial infection in patients with hepatitis B virus-related chronic liver disease (HBV-CLD). Data of 183 cases admitted to the Mengchao Hepatobiliary Hospital of Fujian Medical University from November 2017 to November 2020 were retrospectively analyzed. 79 cases of chronic hepatitis B, 51 cases of hepatitis B-related liver cirrhosis, and 53 cases of hepatitis B-related liver failure were collected. Read More

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The Application of Convolutional Neural Network Model in Diagnosis and Nursing of MR Imaging in Alzheimer's Disease.

Interdiscip Sci 2021 Jul 5. Epub 2021 Jul 5.

Department of CSE, Ramco Institute of Technology, Rajapalayam, Tamilnadu, India.

The disease Alzheimer is an irrepressible neurologicalbrain disorder. Earlier detection and proper treatment of Alzheimer's disease can help for brain tissue damage prevention. The study was intended to explore the segmentation effects of convolutional neural network (CNN) model on Magnetic Resonance (MR) imaging for Alzheimer's diagnosis and nursing. Read More

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Changes of Regional Neural Activity Homogeneity in Preclinical Alzheimer's Disease: Compensation and Dysfunction.

Front Neurosci 2021 17;15:646414. Epub 2021 Jun 17.

Department of Gerontology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Introduction: Subjective cognitive decline (SCD) is the preclinical stage of Alzheimer's disease and may develop into amnestic mild cognitive impairment (aMCI). Finding suitable biomarkers is the key to accurately identifying SCD. Previous resting-state functional magnetic resonance imaging (rs-fMRI) studies on SCD patients showed functional connectivity disorders. Read More

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Detecting and predicting changes in milk homogeneity using data from automatic milking systems.

J Dairy Sci 2021 Jul 1. Epub 2021 Jul 1.

DeLaval International AB, PO Box 39, SE-147 21 Tumba, Sweden.

To ensure milk quality and detect cows with signs of mastitis, visual inspection of milk by prestripping quarters before milking is recommended in many countries. An objective method to find milk changed in homogeneity (i.e. Read More

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Influence of Matrix and Surfactant on Piezoelectric and Dielectric Properties of Screen-Printed BaTiO/PVDF Composites.

Polymers (Basel) 2021 Jun 30;13(13). Epub 2021 Jun 30.

Univ. Lyon, INSA-Lyon, LGEF, EA682, 69621 Villeurbanne, France.

The aim of this paper was to provide insight into the impact of matrix and surfactants on the rheology, morphology, and dielectric and piezoelectric properties of screen-printed BaTiO/PVDF composites. Two matrices were compared (PVDF-HFP and PVDF-TrFE), and lead-free BaTiO microparticles were added in volume fractions of 30% and 60%. Here, we demonstrated that the presence of surfactants, helping to prevent phase separation, was crucial for achieving a decent screen-printing process. Read More

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Influence of Amorphous Boron Grain Size, High Isostatic Pressure, Annealing Temperature, and Filling Density of Unreacted Material on Structure, Critical Parameters, -Value, and Engineering Critical Current Density in Mgb Wires.

Materials (Basel) 2021 Jun 28;14(13). Epub 2021 Jun 28.

Institute of Materials Science and Engineering, Military University of Technology, Kaliskiego 2, 00-908 Warsaw, Poland.

Our results show that a lower density of unreacted Mg + B material during an Mg solid-state synthesis reaction leads to a significant reduction in the quantity of the superconducting phase and lowers the homogeneity of the superconducting material. It also significantly reduces the irreversible magnetic field (B), critical temperature (T), upper magnetic field (B), engineered critical current density (J), and -value, despite high isostatic pressure (HIP) treatment and the use of nanoboron in the sample. Our measurements show that samples with large boron grains with an 8% higher density of unreacted Mg + B material allow better critical parameters to be achieved. Read More

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Texture indices of 4'-[methyl-C]-thiothymidine uptake predict p16 status in patients with newly diagnosed oropharyngeal squamous cell carcinoma: comparison with F-FDG uptake.

Eur J Hybrid Imaging 2020 Nov 2;4(1):20. Epub 2020 Nov 2.

Department of Radiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.

Background: In oropharyngeal squamous cell carcinoma (OPSCC), human papillomavirus (HPV)/p16 status is important as a prognostic biomarker.

Purpose: We evaluated the relationship between 4'-[methyl-C]-thiothymidine (C-4DST) and F-FDG PET texture indices and p16 status in patients with newly diagnosed OPSCC.

Methods: We retrospectively reviewed the collected data of 256 consecutive, previously untreated patients with primary head and neck tumors enrolled between November 2011 and October 2019. Read More

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November 2020

A hybrid approach for composing groups in collaborative learning contexts.

Heliyon 2021 Jun 10;7(6):e07249. Epub 2021 Jun 10.

Universidad Nacional de Colombia-Sede Medellín, Medellín, Colombia.

Considering that there are many alternatives in the literature for composing groups in collaborative learning contexts, we present a proposal that exhibits several features. First, and from the operational point of view, our proposal is highly flexible because i) it allows for several group sizes and an arbitrary array of grouping attributes, and ii) it may be easily adapted to consider several homogeneity/heterogeneity criteria. Second, and from the algorithmic point of view, it combines the best of two apparently opposite worlds: it uses a local brute-force search within an iterative process guided by a randomized heuristic criterion. Read More

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Analysis of Geometric and Dosimetric Effects of Bra Application to Support Large or Pendulous Breasts During Radiotherapy Planning: A Retrospective Single-Center Study.

Technol Cancer Res Treat 2021 Jan-Dec;20:15330338211027909

Department of Radiation Oncology, Jeju National University Hospital, Jeju University College of Medicine, Jeju, South Korea.

Purpose: To evaluate geometric and dosimetric effects of bra application during radiotherapy planning for breast cancer patients with large and pendulous breasts.

Materials And Methods: Twenty patients with chest sizes >38 inches between April 2019 and July 2019 underwent radiotherapy planning with and without a radiation bra (Chabner XRT). Geometric and dosimetric parameters included the breast volume, superior-inferior (SI) distance, separation (S) as the distance of the longest diameter of the clinical target volume (CTV), conformity number (CN), and homogeneity index (HI) of CTV. Read More

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Value of Quantitative CTTA in Differentiating Malignant From Benign Bosniak III Renal Lesions on CT Images.

J Comput Assist Tomogr 2021 Jun 26. Epub 2021 Jun 26.

From the Departments of Urology Radiology, China-Japan Union Hospital of Jilin University Department of Anesthesiology, the Second Hospital of Jilin University, Changchun, China.

Objective: The aim of this study was to investigate whether computed tomography texture analysis can differentiate malignant from benign Bosniak III renal lesions on computed tomography (CT) images.

Methods: This retrospective case-control study included 45 patients/lesions (22 benign and 23 malignant lesions) with Bosniak III renal lesions who underwent CT examination. Axial image slices in the unenhanced phase, corticomedullary phase, and nephrographic phase were selected and delineated manually. Read More

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Prenatal exposure to organophosphate and pyrethroid insecticides and the herbicide 2,4-dichlorophenoxyacetic acid and size at birth in urban pregnant women.

Environ Res 2021 Jun 24;201:111539. Epub 2021 Jun 24.

Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA. Electronic address:

Background: Organophosphate insecticides and the herbicide, 2,4-dichlorophenoxyacetic acid (2,4-D) are used to protect crops or control weeds. Pyrethroids are used to manage pests both in agriculture and in residences, and to reduce the transmission of insect-borne diseases. Several studies have reported inverse associations between exposure to organophosphates (as a larger class) and birth outcomes but these associations have not been conclusive for pyrethroids or 2,4-D, specifically. Read More

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Psychometric Evaluation of the Korean Version of Control Attitudes Scale-Revised.

J Cardiovasc Nurs 2021 Jun 22. Epub 2021 Jun 22.

Kyoung Suk Lee, PhD, RN, MPH Associate Professor, College of Nursing, The Research Institute of Nursing Science, Seoul, Republic of Korea; ORCID: https://orcid.org/0000-0002-5083-3743 Da-In Park, PhD, RN Assistant Professor, Department of Nursing, College of Life Science and Nano Technology, Hannam University, Daejeon, Republic of Korea; ORCID: https://orcid.org/0000-0002-4738-5046.

Background: Heart failure (HF) is a chronic heart condition that requires patients to adapt to the disease and maintain a high degree of self-management. Patients with HF commonly feel loss of control, which has a negative effect on their compliance to self-care, health-related quality of life, and health outcomes. To promote self-care behavior and to develop healthy coping mechanisms, it is important to understand individual HF patients' perceived control, a self-generated belief that one has the ability to bring forth desired outcomes. Read More

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Role of social deprivation on asthma care quality among a cohort of children in US community health centres.

BMJ Open 2021 06 23;11(6):e045131. Epub 2021 Jun 23.

Family Medicine, Oregon Health & Science University, Portland, Oregon, USA.

Objective: Social deprivation is associated with worse asthma outcomes. The Social Deprivation Index is a composite measure of social determinants of health used to identify neighbourhood-level disadvantage in healthcare. Our objective was to determine if higher neighbourhood-level social deprivation is associated with documented asthma care quality measures among children treated at community health centres (CHCs). Read More

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Biological variation of cardiac myosin-binding protein C in healthy individuals.

Clin Chem Lab Med 2021 Jun 23. Epub 2021 Jun 23.

Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway.

Objectives: Cardiac myosin-binding protein C (cMyC) is a novel biomarker of myocardial injury, with a promising role in the triage and risk stratification of patients presenting with acute cardiac disease. In this study, we assess the weekly biological variation of cMyC, to examine its potential in monitoring chronic myocardial injury, and to suggest analytical quality specification for routine use of the test in clinical practice.

Methods: Thirty healthy volunteers were included. Read More

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Inter-reader reliability of contrast-enhanced ultrasound Liver Imaging Reporting and Data System: a meta-analysis.

Abdom Radiol (NY) 2021 Jun 22. Epub 2021 Jun 22.

Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Republic of Korea.

Purpose: To systematically determine the inter-reader reliability of the contrast-enhanced ultrasound (CEUS) Liver Imaging Reporting and Data System (LI-RADS), with emphasis on its major features for hepatocellular carcinoma (HCC) and LR-M (LI-RADS category M) features for non-HCC malignancy.

Methods: MEDLINE, EMBASE, and Cochrane databases were searched from January 2016 to March 2021 to identify original articles reporting the inter-reader reliability of CEUS LI-RADS. Meta-analytic pooled kappa values (κ) were calculated for major features [nonrim arterial-phase hyperenhancement (APHE), mild and late washout], LR-M features (rim APHE, early washout), and LI-RADS categorization using the DerSimonian-Laird random-effects model. Read More

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Altered spontaneous activity in the frontal gyrus in dry eye: a resting-state functional MRI study.

Sci Rep 2021 Jun 21;11(1):12943. Epub 2021 Jun 21.

Department of Ophthalmology and Radiology, Jiangxi Center of Natural Ocular Disease Clinical Research Center, The First Affiliated Hospital of Nanchang University, No 17, YongWaiZheng Street, DongHu District, Nanchang, 330006, Jiangxi, People's Republic of China.

This study investigated neurologic changes in patients with dry eye (DE) by functional magnetic resonance imaging (fMRI) and to used regional homogeneity (ReHo) analysis to clarify the relationship between these changes and clinical features of DE. A total of 28 patients with DE and 28 matched healthy control (HC) subjects (10 males and 18 females in each group) were enrolled. fMRI scans were performed in both groups. Read More

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Population structure and insecticide resistance status of Tuta absoluta populations from Turkey.

Pest Manag Sci 2021 Jun 20. Epub 2021 Jun 20.

Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion, Greece.

Background: Tuta absoluta is a devastating pest in tomato production areas worldwide. After its first introduction to Turkey in 2009, it quickly became the major pest of tomato-growing areas. Although some biocontrol agents have been used, especially in greenhouses, the main control of T. Read More

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Homogeneous grey matter patterns in patients with obsessive-compulsive disorder.

Neuroimage Clin 2021 Jun 13;31:102727. Epub 2021 Jun 13.

Department of Neuroradiology & TUM-Neuroimaging Center (TUM-NIC), Klinikum rechts der Isar, Technische Universität München, Ismaninger Straße 22, 81675 Munich, Germany.

Background: Changes in grey matter volume have frequently been reported in patients with obsessive-compulsive disorder (OCD). Most studies performed whole brain or region-of-interest based analyses whereas grey matter volume based on structural covariance networks has barely been investigated up to now. Therefore, the present study investigated grey matter volume within structural covariance networks in a sample of 228 participants (n = 117 OCD patients, n = 111 healthy controls). Read More

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Self-categorization and autism: Exploring the relationship between autistic traits and group homogeneity.

J Exp Psychol Appl 2021 Jun 17. Epub 2021 Jun 17.

School of Psychology, The University of Queensland.

The Integrated Self-Categorization model of Autism (ISCA; Bertschy et al., 2019; Skorich & Haslam, 2021) argues that the theory of mind differences seen in autism arises from Enhanced Perceptual Functioning/Weak Central Coherence, via a dysfunctional self-categorization mechanism. The ISCA model also makes the novel prediction that phenomena that arise from self-categorization should also be affected in autistic people. Read More

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Black-white racial disparities in household food insecurity from 2005 to 2014, Canada.

Can J Public Health 2021 Jun 15. Epub 2021 Jun 15.

Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

Objectives: To understand the differential vulnerability to household food insecurity of the Black population as compared with white counterparts in Canada.

Methods: Using data for households with Black and white respondents in pooled Canadian Community Health Survey cycles from 2005 to 2014, the 18-question Household Food Security Survey Module was analyzed (N = 491,400). Bivariate and multivariate logistic and multinomial regression models were run using respondent's race, immigration status, and six well-established predictors of household food insecurity in the general population. Read More

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Comparison of conventional magnetic resonance imaging and diffusion-weighted imaging in the differentiation of bone plasmacytoma from bone metastasis in the extremities.

Diagn Interv Imaging 2021 Jun 11. Epub 2021 Jun 11.

Department of Radiology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, 06591 Seoul, Republic of Korea.

Purpose: To compare conventional magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) in the differentiation of bone plasmacytoma from bone metastasis in the extremities.

Materials And Methods: A total of 65 patients with 27 bone plasmacytomas (11 men; mean age, 63.6±8. Read More

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Effectiveness of Perioperative Opioid Educational Initiatives: A Systematic Review and Meta-Analysis.

Anesth Analg 2021 Jun 11. Epub 2021 Jun 11.

Department of Anesthesiology, Hospital for Special Surgery, New York, New York.

Background: Opioids are the most commonly prescribed analgesics in the United States. Current guidelines have proposed education initiatives to reduce the risk of chronic opioid consumption, yet there is lack of efficacy data on such interventions. Our study evaluates the impact of perioperative opioid education on postoperative opioid consumption patterns including opioid cessation, number of pills consumed, and opioid prescription refills. Read More

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Brain functional changes in patients with Crohn's disease: A resting-state fMRI study.

Brain Behav 2021 Jun 14. Epub 2021 Jun 14.

Department of Radiology, Jing'an District Centre Hospital of Shanghai, Fudan University, Shanghai, China.

Background: Crohn's disease (CD) is a chronic recurrent intestinal inflammatory disease, often accompanied by poor adaptation and excessive stress response. However, the potential neurological mechanisms of these symptoms have not yet been studied in-depth.

Objective: To investigate alterations in brain activity in patients with Crohn's disease and study the relationship between altered regions and clinical indices. Read More

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