1,164 results match your criteria hodge test

Persistent spectral hypergraph based machine learning (PSH-ML) for protein-ligand binding affinity prediction.

Brief Bioinform 2021 Apr 9. Epub 2021 Apr 9.

Division of Mathematical Sciences, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371.

Molecular descriptors are essential to not only quantitative structure activity/property relationship (QSAR/QSPR) models, but also machine learning based chemical and biological data analysis. In this paper, we propose persistent spectral hypergraph (PSH) based molecular descriptors or fingerprints for the first time. Our PSH-based molecular descriptors are used in the characterization of molecular structures and interactions, and further combined with machine learning models, in particular gradient boosting tree (GBT), for protein-ligand binding affinity prediction. Read More

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A feasibility cluster randomised controlled trial of a paramedic-administered breathlessness management intervention for acute-on-chronic breathlessness (BREATHE).

ERJ Open Res 2021 Jan 29;7(1). Epub 2021 Mar 29.

Wolfson Palliative Care Research Group, Hull York Medical School, Hull, UK.

Chronic breathlessness, persistent and disabling despite optimal treatment of underlying causes, is a prevalent and frightening symptom and is associated with many emergency presentations and admission to hospital. Breathlessness management techniques used by paramedics may reduce the need for conveyance to hospital. The Breathlessness RElief AT HomE study (BREATHE) aims to explore the feasibility of conducting a definitive cluster randomised controlled trial (cRCT) for people with acute-on-chronic breathlessness who have called an ambulance, to evaluate the effectiveness and cost-effectiveness of a paramedic-administered non-pharmacological breathlessness intervention. Read More

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January 2021

Genomic Breeding for Diameter Growth and Tolerance to Gall Wasp and / Fungal Disease Complex in .

Front Plant Sci 2021 26;12:638969. Epub 2021 Feb 26.

Department of Biochemistry, Genetics and Microbiology, Forestry and Agricultural Biotechnology Institute, University of Pretoria, Pretoria, South Africa.

is one of the most important species for hardwood plantation forestry around the world. At present, its commercial deployment is in decline because of pests and pathogens such as gall wasp (), and often co-occurring fungal stem diseases such as and (). This study analyzed , , and stem diameter growth in an multi-environmental, genetic trial. Read More

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February 2021

Changes in Physical Activity Pre-, During and Post-lockdown COVID-19 Restrictions in New Zealand and the Explanatory Role of Daily Hassles.

Front Psychol 2021 25;12:642954. Epub 2021 Feb 25.

Department of Tourism, University of Otago, Dunedin, New Zealand.

Covid-19 lockdown restrictions constitute a population-wide "life-change event" disrupting normal daily routines. It was proposed that as a result of these lockdown restrictions, physical activity levels would likely decline. However, it could also be argued that lifestyle disruption may result in the formation of increased physical activity habits. Read More

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February 2021

n-3 Fatty Acid Biomarkers and Incident Type 2 Diabetes: An Individual Participant-Level Pooling Project of 20 Prospective Cohort Studies.

Diabetes Care 2021 Mar 3. Epub 2021 Mar 3.

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA

Objective: Prospective associations between n-3 fatty acid biomarkers and type 2 diabetes (T2D) risk are not consistent in individual studies. We aimed to summarize the prospective associations of biomarkers of α-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) with T2D risk through an individual participant-level pooled analysis.

Research Design And Methods: For our analysis we incorporated data from a global consortium of 20 prospective studies from 14 countries. Read More

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Dynamics and risk of transmission of bovine tuberculosis in the emerging dairy regions of Ethiopia.

Epidemiol Infect 2021 02 24;149:e69. Epub 2021 Feb 24.

Aklilu Lemma Institute of Pathobiology, Addis Ababa University, P. O. Box 1176, Addis Ababa, Ethiopia.

The Ethiopian government has several initiatives to expand and intensify the dairy industry; however, the risk of bovine tuberculosis (bTB) spread is a challenge. To assess the rate of expansion and risk factors for transmission of bTB within-herds, we carried out a repeated cross-sectional survey at two time points, 2016/17 and 2018, in three regional cities, namely, Gondar, Hawassa and Mekelle, representing the emerging dairy belts of Ethiopia. The total number of herds involved was 128, comprising an average of 2303 cattle in each round. Read More

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February 2021

Participatory COVID-19 Surveillance Tool in Rural Appalachia : Real-Time Disease Monitoring and Regional Response.

Public Health Rep 2021 Feb 18:33354921990372. Epub 2021 Feb 18.

Buncombe County Health and Human Services, Asheville, NC, USA.

Introduction: Few US studies have examined the usefulness of participatory surveillance during the coronavirus disease 2019 (COVID-19) pandemic for enhancing local health response efforts, particularly in rural settings. We report on the development and implementation of an internet-based COVID-19 participatory surveillance tool in rural Appalachia.

Methods: A regional collaboration among public health partners culminated in the design and implementation of the COVID-19 Self-Checker, a local online symptom tracker. Read More

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February 2021

Discordance Rate Among Bilateral Simultaneous and Sequential Temporal Artery Biopsies in Giant Cell Arteritis: Role of Frozen Sectioning Based on the Mayo Clinic Experience.

JAMA Ophthalmol 2021 Feb 18. Epub 2021 Feb 18.

Department of Neurology, Mayo Clinic College of Medicine & Science, Rochester, Minnesota.

Importance: Frozen section temporal artery biopsy (TAB) may prevent a contralateral biopsy from being performed.

Objective: To evaluate the sensitivity and specificity of TAB frozen vs permanent section pathology results for giant cell arteritis (GCA) and determine the discordance rate of bilateral TABs.

Design, Setting, And Participants: In this retrospective cohort study, medical records were reviewed from 795 patients 40 years or older who underwent TAB from January 1, 2010, to December 1, 2018, treated at a single tertiary care center with the ability to perform both frozen and permanent histologic sections. Read More

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February 2021

Anticonvulsant use and bone health in a population-based study of men and women: cross-sectional data from the Geelong Osteoporosis Study.

BMC Musculoskelet Disord 2021 Feb 11;22(1):172. Epub 2021 Feb 11.

IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, PO Box 281, Barwon Health, Geelong, Vic, 3220, Australia.

Background: Anticonvulsant use has been linked to bone deficits in specific patient populations. We studied the association between anticonvulsant use and bone health in a population-based sample of men and women.

Methods: Data from 926 men (24-73 yr) and 1070 women (21-94 yr) participating in the Geelong Osteoporosis Study were included. Read More

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February 2021

Detection of carbapenemase-producing bacteria in a public healthcare center from Venezuela.

J Infect Dev Ctries 2020 Dec 27;15(1):163-167. Epub 2020 Dec 27.

School of Medicine, Medical Faculty, University of Zulia, Maracaibo, Venezuela.

Introduction: The dramatic increase in the prevalence and clinical impact of infections caused by Carbapenemase-Producing Bacteria in the nosocomial setting in Latin America represents an emerging challenge to public health. The present study detected carbapenemase-producing Gram-negative bacteria in patients from a Hospital from Venezuela, by phenotypic and genotypic methods.

Methodology: The bacterial identification was carried out using conventional methods. Read More

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December 2020

Sputum TNF markers are increased in neutrophilic and severe asthma and are reduced by azithromycin treatment.

Allergy 2021 Feb 11. Epub 2021 Feb 11.

Faculty of Health and Medicine and Priority Research Centre for Healthy Lungs, School of Medicine and Public Health, The University of Newcastle, Newcastle, NSW, Australia.

Background: The AMAZES randomized controlled trial demonstrated that long-term low-dose azithromycin treatment reduces exacerbations of poorly controlled asthma, but the therapeutic mechanisms remain unclear. Dysregulation of the inflammatory tumour necrosis factor (TNF) pathway is implicated in asthma and could be suppressed by azithromycin. We aimed to determine the inflammatory and clinical associations of soluble TNF signalling proteins (TNF receptors [TNFR] 1 and 2, TNF) in sputum and serum, and to test the effect of 48 weeks of azithromycin vs placebo on TNF markers. Read More

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February 2021

Diet and risk of gastro-oesophageal reflux disease in the Melbourne Collaborative Cohort Study.

Public Health Nutr 2021 Jan 21:1-13. Epub 2021 Jan 21.

Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC, Australia.

Objective: To examine associations between diet and risk of developing gastro-oesophageal reflux disease (GERD).

Design: Prospective cohort with a median follow-up of 15·8 years. Baseline diet was measured using a FFQ. Read More

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January 2021

Impaired Pre-Motor Circuit Activity and Movement in a Drosophila Model of KCNMA1-Linked Dyskinesia.

Mov Disord 2021 Jan 15. Epub 2021 Jan 15.

Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, United Kingdom.

Background: Paroxysmal dyskinesias (PxDs) are characterized by involuntary movements and altered pre-motor circuit activity. Causative mutations provide a means to understand the molecular basis of PxDs. Yet in many cases, animal models harboring corresponding mutations are lacking. Read More

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January 2021

The Impact of Different Induction Immunosuppressive Therapy on Long-Term Kidney Transplant Function When Measured by Iothalamate Clearance.

J Clin Med Res 2020 Dec 18;12(12):787-793. Epub 2020 Dec 18.

Department of Transplant, Mayo Clinic Florida, Jacksonville, FL 32224, USA.

Background: Improvement in short-term outcomes after kidney transplant has been achieved by using different induction and maintenance therapeutic approaches. Long-term outcomes have not matched the expectations of the transplant stakeholders. Our study aimed to address the early impact of induction agents on long-term outcome of kidney transplant when measured by iothalamate clearance. Read More

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December 2020

Comparison of four low-cost carbapenemase detection tests and a proposal of an algorithm for early detection of carbapenemase-producing Enterobacteriaceae in resource-limited settings.

PLoS One 2021 12;16(1):e0245290. Epub 2021 Jan 12.

Department of Biochemistry and Clinical Chemistry, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.

Rapidly progressing antibiotic resistance is a great challenge in therapy. In particular, the infections caused by carbapenem-resistant Enterobacteriaceae (CRE) are exceedingly difficult to treat. Carbapenemase production is the predominant mechanism of resistance in CRE. Read More

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January 2021

Association of Race, Socioeconomic Factors, and Treatment Characteristics With Overall Survival in Patients With Limited-Stage Small Cell Lung Cancer.

JAMA Netw Open 2021 01 4;4(1):e2032276. Epub 2021 Jan 4.

Division of Hematology and Medical Oncology, Mayo Clinic, Jacksonville, Florida.

Importance: It has been established that disparities in race and socioeconomic status are associated with outcomes of non-small cell lung cancer. However, it remains unknown whether this extends to stage I, II, or III small cell lung cancer (SCLC), or limited-stage SCLC (L-SCLC).

Objective: To investigate the associations of race, socioeconomic factors, and treatment characteristics with survival among patients with L-SCLC. Read More

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January 2021

Toxoplasma gondii infection and the risk of adult glioma in two prospective studies.

Int J Cancer 2021 Jan 11. Epub 2021 Jan 11.

Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.

Toxoplasma gondii (T gondii) is a common parasite that shows affinity to neural tissue and may lead to the formation of cysts in the brain. Previous epidemiologic studies have suggested an association between glioma and increased prevalence of T gondii infection, but prospective studies are lacking. Therefore, we examined the association between prediagnostic T gondii antibodies and risk of glioma in two prospective cohorts using a nested case-control study design. Read More

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January 2021

Goals of children with unilateral cerebral palsy in a brain stimulation arm rehabilitation trial.

Dev Med Child Neurol 2021 May 24;63(5):584-591. Epub 2020 Dec 24.

Alberta Children's Hospital Research Institute, Calgary, AB, Canada.

Aim: To explore relationships between category classifications for children's rehabilitation goals, outcomes, and participant characteristics.

Method: Children with hemiparetic cerebral palsy due to perinatal stroke rated self-selected goals with the Canadian Occupational Performance Measure (COPM) and completed the Assisting Hand Assessment (AHA) and Box and Block Test (BBT), at baseline and 6 months, in a randomized, controlled 10-day neuromodulation rehabilitation trial using repetitive transcranial magnetic stimulation. Goals were classified with the Canadian Model of Occupational Performance and Engagement and the International Classification of Functioning, Disability and Health. Read More

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Comparison of Genotypic and Phenotypic Methods of Metallo-β- lactamase Detection in spp.

J Glob Infect Dis 2020 Jul-Sep;12(3):141-143. Epub 2020 Aug 29.

Department of Orthopaedics, JPNA Trauma Centre, All India Institute of Medical Sciences, New Delhi, India.

Introduction: MBL containing genes have been reported in all GNBs including spp since 1990s which are worrisome as they are transmitted by mobile genetic elements. Thus, early detection of MBL encoding organisms is necessary. The current study was designed to identify the most sensitive cost-effective test which could be used as a screening test for detection of cabapenamase producing isolates. Read More

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A qualitative exploration of how people with bipolar disorder consider risk-taking in everyday decisions.

Behav Cogn Psychother 2021 May 18;49(3):314-327. Epub 2020 Dec 18.

Division of Health Research, Faculty of Health and Medicine, Lancaster University, Lancaster, UK.

Background: Difficulties with decision making and risk taking in individuals with bipolar disorder (BD) have been associated with mood episodes. However, there is limited information about these experiences during euthymia, the mood state where people with BD spent the majority of their time.

Aims: To examine how individuals with BD consider risk in everyday decisions during their euthymic phase. Read More

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Study protocol for the systematic review and meta-analyses of the association between schizophrenia and bone fragility.

BMJ Open 2020 12 12;10(12):e041859. Epub 2020 Dec 12.

Deakin University, IMPACT - Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Geelong, Victoria, Australia.

Introduction: Individuals with schizophrenia are known to be at higher risk of comorbid conditions, both physical and psychological. Osteoporosis is possibly one of these, leading to public health concerns due to higher rates of associated mortality and morbidity. We aim to systematically search all available evidence across electronic databases regarding the relationship between schizophrenia and bone fragility. Read More

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December 2020

Germline transmission of donor, maternal and paternal mtDNA in primates.

Hum Reprod 2021 Jan;36(2):493-505

Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR, USA.

Study Question: What are the long-term developmental, reproductive and genetic consequences of mitochondrial replacement therapy (MRT) in primates?

Summary Answer: Longitudinal investigation of MRT rhesus macaques (Macaca mulatta) generated with donor mtDNA that is exceedingly distant from the original maternal counterpart suggest that their growth, general health and fertility is unremarkable and similar to controls.

What Is Known Already: Mitochondrial gene mutations contribute to a diverse range of incurable human disorders. MRT via spindle transfer in oocytes was developed and proposed to prevent transmission of pathogenic mtDNA mutations from mothers to children. Read More

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January 2021

Calibration of the Active Australia questionnaire and application to a logistic regression model.

J Sci Med Sport 2021 May 23;24(5):474-480. Epub 2020 Nov 23.

Cancer Epidemiology Division, Cancer Council Victoria, Australia; Melbourne School of Population and Global Health, The University of Melbourne, Australia; Physical Activity Laboratory, Baker Heart and Diabetes Institute, Australia.

Objectives: To estimate the extent of measurement error in the Active Australia questionnaire, and to examine the impact of measurement error on the association of moderate-vigorous physical activity (MVPA) with obesity.

Design: Accelerometer Validation Study, cross-sectional; data from the third wave of a prospective cohort (Australian Diabetes, Obesity, and Lifestyle (AusDiab) Study)).

Methods: Self-reported physical activity data were obtained from 4005 participants of the third wave of the AusDiab study via the Active Australia questionnaire. Read More

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Application Value of Triton X-100 to Modified Hodge Test and Carbapenem Inactivation Method in the Detection of Carbapenemase.

Infect Drug Resist 2020 24;13:4283-4288. Epub 2020 Nov 24.

Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei City 230022, People's Republic of China.

Aim: To compare the sensitivity and specificity before and after the addition of Triton X-100 in the modified Hodge test (MHT) and carbapenem inactivation method (CIM) for the detection of carbapenemase in

Materials And Methods: A total of 135 isolates of (83 carbapenem-resistant and 52 carbapenem-sensitive) were selected and the carbapenemase genotypes were detected using PCR. Carbapenemase phenotypes were tested using the MHT, Triton-MHT (THT), CIM, modified CIM (mCIM), and Triton-CIM (TCIM). Different concentrations (0. Read More

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November 2020

Phenotypic and Genotypic Features of Harboring Carbapenemases in Egypt: OXA-48-Like Carbapenemases as an Investigated Model.

Antibiotics (Basel) 2020 Nov 28;9(12). Epub 2020 Nov 28.

Department of Microbiology and Immunology, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo 11884, Egypt.

This study aimed at the characterization of carbapenem-resistant isolates focusing on typing of the genes. Additionally, the correlation between the resistance pattern and biofilm formation capacity of the carbapenem-resistant isolates was studied. The collected isolates were assessed for their antimicrobial resistance and carbapenemases production by a modified Hodge test and inhibitor-based tests. Read More

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November 2020

FR-Match: robust matching of cell type clusters from single cell RNA sequencing data using the Friedman-Rafsky non-parametric test.

Brief Bioinform 2020 Nov 30. Epub 2020 Nov 30.

J. Craig Venter Institute La Jolla Campus, an Adjunct Professor of Pathology at the University of California San Diego, and an Adjunct Professor at the La Jolla Institute for Immunology.

Single cell/nucleus RNA sequencing (scRNAseq) is emerging as an essential tool to unravel the phenotypic heterogeneity of cells in complex biological systems. While computational methods for scRNAseq cell type clustering have advanced, the ability to integrate datasets to identify common and novel cell types across experiments remains a challenge. Here, we introduce a cluster-to-cluster cell type matching method-FR-Match-that utilizes supervised feature selection for dimensionality reduction and incorporates shared information among cells to determine whether two cell type clusters share the same underlying multivariate gene expression distribution. Read More

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November 2020

Accuracy and efficacy of pre-dengue vaccination screening for previous dengue infection with five commercially available immunoassays: a retrospective analysis of phase 3 efficacy trials.

Lancet Infect Dis 2021 04 16;21(4):529-536. Epub 2020 Nov 16.

Translational Sciences and Biomarkers, Sanofi Pasteur, Swiftwater, PA, USA.

Background: The tetravalent dengue vaccine (CYD-TDV) has been shown to provide protection against dengue disease over 5-year follow-up in participants with previous dengue infection, but increased the risk of dengue hospitalisation and severe dengue during long-term follow-up in those without previous dengue infection. WHO recommended pre-vaccination screening to identify those with previous dengue infection (ie, dengue seropositive) who would benefit from vaccination. We re-evaluated CYD-TDV efficacy in those identified as dengue seropositive using five commercially available immunoassays, and assessed immunoassay performance. Read More

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Carbapenemase OXA-423: A Novel OXA-23 Variant in .

Infect Drug Resist 2020 10;13:4069-4075. Epub 2020 Nov 10.

Department of Clinical Laboratory, Yijishan Hospital of Wannan Medical College, Wuhu, People's Republic of China.

Purpose: A novel variant of OXA-23, named OXA-423, was identified in an clinical isolate. The aim of this study was to analyse the resistance phenotype of OXA-423.

Methods: The strain WY-0713 was isolated from an intensive care unit patient. Read More

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November 2020

Carbapenem Resistant Carrying Isolated From Two Solid Organ Transplant Patients.

Front Cell Infect Microbiol 2020 26;10:563482. Epub 2020 Oct 26.

Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, United States.

resides in a variety of aquatic environments. Infections with mainly occur after contact with fresh or brackish water. Nosocomial infections with can also occur. Read More

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October 2020

Antibiogram and Genetic Characterization of Carbapenem-Resistant Gram-Negative Pathogens Incriminated in Healthcare-Associated Infections.

Infect Drug Resist 2020 4;13:3991-4002. Epub 2020 Nov 4.

Department of Bacteriology, Immunology and Mycology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt.

Purpose: Carbapenems are considered the most efficient antibiotic used in the treatment of nosocomial infections. Carbapenem-resistant Gram-negative rods are becoming a serious hazard in hospitals threatening public health. The aim of the current study was to investigate the prevalence of carbapenem-resistant Gram-negative pathogens incriminated in healthcare-associated infections, along with antimicrobial resistance profiles, carbapenemase and metallo-β-lactamase production, and their molecular characterization. Read More

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November 2020