Behav Brain Res 2021 Sep 6:113562. Epub 2021 Sep 6.
Institute of Neurology, the First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, P. R. China; Institute of Neuroscience, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, P. R. China. Electronic address:
Background: Our previous works demonstrated that β2-microglobulin (β2m), a systemic pro-aging factor, induce depressive-like behaviors. Hydrogen sulfide (HS) is identified as a potential target for treatment of depression. The aim of the present work is to explore whether HS antagonizes β2m-induced depressive-like behaviors and the underlying mechanisms. Read More