39,074 results match your criteria hiv-positive patients

A Comprehensive Clinicopathologic and Molecular Study of 19 Primary Effusion Lymphomas in HIV-infected Patients.

Am J Surg Pathol 2021 Sep 23. Epub 2021 Sep 23.

Departments of Pathology Clinical Immunology Hematological Cytogenetics Laboratory Hematology Laboratory, Saint-Louis Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP) University of Paris, Paris Department of Pathology, Henri Mondor Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP) INSERM U955, University Paris-Est Créteil, Créteil, France.

Primary effusion lymphoma (PEL) is associated with human herpesvirus 8 and frequently with Epstein-Barr virus (EBV). We report here a single-center series of 19 human immunodeficiency virus-associated PELs, including 14 EBV+ and 5 EBV- PELs. The objectives were to describe the clinicopathologic features of PELs, with a focus on programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) expression, to search for genetic alterations by targeted deep sequencing analysis, and to compare the features between EBV+ and EBV- cases. Read More

View Article and Full-Text PDF
September 2021

Laryngeal disorders in people living with HIV.

Am J Otolaryngol 2021 Sep 20;43(1):103234. Epub 2021 Sep 20.

Department of Otolaryngology - Head and Neck Surgery, Johns Hopkins University, Baltimore, MD, United States of America.

Objectives: Several studies have shown that HIV infected individuals are at higher risk compared to the general population of developing non-AIDS defining conditions such as some types of cancer, kidney disease, liver disease and others. In this case-control study, we compared the incidence of laryngeal disorders between a treatment-seeking HIV-positive population and uninfected controls. We aimed to investigate whether there are any laryngeal disorders that are overrepresented in HIV-positive individuals. Read More

View Article and Full-Text PDF
September 2021

The Impact of IgG administration on the cellular immunity status in the patients with multidrug-resistant tuberculosis/HIV with CD4 + lymphocyte cells below 50 cells/ μl.

Int J Mycobacteriol 2021 Apr-Jun;10(2):122-128

Department of Pharmacology and Pharmacognosy, Odesa National Medical University, Odessa, Ukraine.

Background: Treatment of the patients with multidrug-resistant tuberculosis (MDR-TB)/HIV coinfection in a state of severely suppressed immune system remains unsatisfactory.

Methods: The study involved 52 HIV-positive patients with MDR-TB and CD4+ lymphocyte cells below 50 cells/μCL. Patients in control group (Group 1) and in basic group (Group 2) received standard treatment with second-line antituberculosis agents and antiretroviral agents. Read More

View Article and Full-Text PDF
September 2021

Role of Epstein-Barr Virus and Human Papillomavirus Coinfection in Cervical Intraepithelial Neoplasia in Chinese Women Living With HIV.

Front Cell Infect Microbiol 2021 7;11:703259. Epub 2021 Sep 7.

Department of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Given that only a small percentage of human papillomavirus (HPV)-positive women develop cancer, HPV is necessary but insufficient for carcinogenesis. Mucosally transmitted viral cofactors appear to contribute to HPV-related cervical cancer, such as Epstein-Barr virus (EBV), but previous studies have shown inconsistent outcomes. The exact role of EBV in cervical cancer remains unclear, and more studies are needed to determine its involvement. Read More

View Article and Full-Text PDF
September 2021

Transudative pleural effusion as an initial presentation of a disseminated cryptococcosis infection in a HIV-negative patient with cirrhosis.

Med Mycol Case Rep 2021 Dec 6;34:18-21. Epub 2021 Sep 6.

SUNY Upstate Medical University, 750 E. Adams St, Syracuse, NY, 13210, USA.

To our knowledge, this is the first case report of a transudative pleural effusion with positive antigen and culture. We describe a 32-year-old male with end-stage liver disease (ESLD) who presented to an outside hospital with dyspnea and a large pleural effusion. An initial pleural fluid analysis was positive for Ag. Read More

View Article and Full-Text PDF
December 2021

High prevalence of gastrointestinal manifestations among Cytomegalovirus end-organ disease in the combination antiretroviral era.

J Virus Erad 2021 Sep 9;7(3):100052. Epub 2021 Sep 9.

Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.

Background: Cytomegalovirus (CMV) end-organ disease (EOD) continues to pose a significant risk to patients with advanced HIV disease despite decreased incidence with combination anti-retroviral therapy (ART) and lower mortality with effective -CMV therapy. Subclinical CMV shedding may also contribute to ongoing inflammation and non-infectious comorbidities.

Methods: We examined the occurrence of CMV EOD and CMV shedding in a cohort of patients participating in a prospective observational study of severely immunosuppressed (CD4 ≤100 cells/μl), ART-naïve, HIV-1 infected adult participants. Read More

View Article and Full-Text PDF
September 2021

The mycological and molecular study of pneumonia among HIV and non-HIV immunocompromised patients hospitalized in pulmonary units in Guilan, Northern Iran.

Iran J Microbiol 2021 Aug;13(4):518-524

Department of Pharmacognosy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Background And Objectives: pneumonia (PJP) is a serious infection that usually affects those with a weak immune system. Since the prevalence of this infection in Iran and in the world is not clearly defined, the present study aimed to evaluate the incidence, clinical spectrum, and demographic characteristics of PJP among HIV and non-HIV immunocompromised patients.

Materials And Methods: Bronchoalveolar Lavage (BAL) specimens were obtained from 3 groups of immunocompromised patients, including acquired immunodeficiency syndrome (AIDS) patients, diabetic patients, and patients receiving immunosuppressive therapies. Read More

View Article and Full-Text PDF

Determinants of Common Mental Disorders Among People Living with HIV/AIDS Attending ART Service in Southern Ethiopia.

HIV AIDS (Auckl) 2021 16;13:917-925. Epub 2021 Sep 16.

Department of Psychiatry, Dilla University, Dilla, Ethiopia.

Background: Worldwide, the rates of psychological problems have been shown to have a dramatic increase, particularly among people living with chronic diseases. Besides the known clinical factors, it is important to address an individual's level of resilience as an included factor for mental health outcome for people living with HIV/AIDS.

Aim: The aim of the study was to assess determinants of common mental disorders among people living with human immune virus/acquired immune deficiency virus (HIV/AIDS). Read More

View Article and Full-Text PDF
September 2021

Prevalence and risk factors of chronic kidney disease in an HIV positive Mexican cohort.

BMC Nephrol 2021 Sep 23;22(1):317. Epub 2021 Sep 23.

Universidad de Guadalajara, Instituto de Investigación en Inmunodeficiencias y VIH (InIVIH), Centro Universitario de Ciencias de La Salud, Jalisco, México.

Background: HIV subjects have several kidney pathologies, like HIV-associated nephropathy or antiretroviral therapy injury, among others. The global prevalence of Chronic Kidney Disease (CKD) is 8-16%; however, in HIV subjects, the prevalence varies between geographic regions (2-38%). The aim was to determine the prevalence of CKD and identify the associated risk factors. Read More

View Article and Full-Text PDF
September 2021

Mutations in the John Cunningham virus VP1 gene could predispose to the development of progressive multifocal leukoencephalopathy in multiple sclerosis patients undergoing treatment with natalizumab.

Mult Scler Relat Disord 2021 Sep 15;56:103266. Epub 2021 Sep 15.

Neuroimmunology Unit, National Institute of Neurology and Neurosurgery, Mexico City, Mexico. Electronic address:

Background: Patients with Multiple Sclerosis (MS) undergoing treatment with natalizumab (NTZ) are at risk of developing progressive multifocal leukoencephalopathy (PML) due to the reactivation of John Cunningham (JC) virus. A relevant characteristic among PML cases is the development of single nucleotide mutations in the VP1 gene of the causal JC virus. The identification of such mutations in timely manner can provide valuable information for MS management. Read More

View Article and Full-Text PDF
September 2021

Clinical outcomes of patients with and without HIV hospitalized with COVID-19 in England during the early stages of the pandemic: a matched retrospective multi-centre analysis (RECEDE-C19 study).

HIV Med 2021 Sep 23. Epub 2021 Sep 23.

Institute for Global Health, UCL, London, UK.

Background: The contribution of HIV to COVID-19 outcomes in hospitalized inpatients remains unclear. We conducted a multi-centre, retrospective matched cohort study of SARS-CoV-2 PCR-positive hospital inpatients analysed by HIV status.

Methods: HIV-negative patients were matched to people living with HIV (PLWH) admitted from 1 February 2020 to 31 May 2020 up to a 3:1 ratio by the following: hospital site, SARS-CoV-2 test date ± 7 days, age ± 5 years, gender, and index of multiple deprivation decile ± 1. Read More

View Article and Full-Text PDF
September 2021

Acceptance of chronic pain in depressed patients with HIV: correlations with activity, functioning, and emotional distress.

AIDS Care 2021 Sep 23:1-9. Epub 2021 Sep 23.

Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, USA.

Chronic pain is highly prevalent among persons with HIV (PWH), as is depression. Both comorbidities might contribute to, as well as be maintained by, avoidance-based coping. A promising alternative to avoidance-based coping is acceptance. Read More

View Article and Full-Text PDF
September 2021

Tuberculosis screening coverage and isoniazid preventive therapy among people living with HIV at Gambella Hospital, southwest Ethiopia: a retrospective study design.

J Int Med Res 2021 Sep;49(9):3000605211046133

Department of Public Health, Medicine and Health Sciences College, Ambo University, Ambo, Ethiopia.

Objective: We aimed to assess the coverage of tuberculosis screening and isoniazid preventive therapy (IPT) among people living with human immunodeficiency virus (PLHIV) at Gambella Hospital, southwest Ethiopia.

Methods: We conducted a 5-year retrospective study of PLHIV receiving care in an antiretroviral therapy clinic from 1 January 2011 to 30 December 2015. We reviewed a total of 900 medical records of patients with complete information. Read More

View Article and Full-Text PDF
September 2021

Clinical, epidemiological and therapeutic characteristics of Mycoplasma genitalium infection in a French STI center.

Infect Dis Now 2021 Sep 18. Epub 2021 Sep 18.

Sorbonne Université, AP-HP, Hôpitaux Universitaires Pitié Salpêtrière-Charles Foix, Services des maladies infectieuses et tropicales, Paris, France; Sorbonne Université, AP-HP, Hôpitaux Universitaires Pitié Salpêtrière-Charles Foix, Centre de santé sexuelle CeGIDD (Centre Gratuit d'information, de Dépistage et de Diagnostic), Paris, France.

Objectives: We report the characteristics of Mycoplasma genitalium (MG) infection in patients from a STI center in Paris. We evaluated outcomes after treatment.

Methods: We included all patients tested for MG, Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) infection in our center from January 2017 to December 2018, using multiplex PCR on urine specimen, vaginal or rectal swabs. Read More

View Article and Full-Text PDF
September 2021

Decline of tuberculosis notification rate in different populations and regions in Portugal, 2010-2017.

Pulmonology 2021 Sep 17. Epub 2021 Sep 17.

Multidisciplinary Unit for Biomedical Research (UMIB), Institute of Biomedical Sciences Abel Salazar, University of Porto, Porto, Portugal. Electronic address:

Background: Tuberculosis (TB) incidence declined in Portugal in recent decades, but trends differ between regions and population subgroups. We investigated these differences to inform prevention and control programmes.

Methods: We extracted TB notifications from the Portuguese National TB Surveillance System (SVIG-TB) in 2010-2017, disaggregated by region, age group, country of birth and HIV status. Read More

View Article and Full-Text PDF
September 2021

Plasmablastic lymphoma: case report.

Rev Med Inst Mex Seguro Soc 2020 ;58(4):511-516

Instituto Mexicano del Seguro Social, Centro Médico Nacional La Raza, Hospital de Especialidades "Dr. Antonio Fraga Mouret", Departamento de Medicina Interna. Ciudad de México, México.

IntroducciÓn: El linfoma plasmablástico es un linfoma no Hodgkin de alto grado. Se describe en pacientes con infección por el virus de la inmunodeficiencia humana (VIH), en receptores de trasplantes y en pacientes de edad avanzada. Se presenta en la cuarta década de la vida, siendo la cavidad oral el sitio más común de afección. Read More

View Article and Full-Text PDF
January 2020

Health-related quality of life and its association with sociodemographic, economic, health status and lifestyles among HIV-positive patients in northern Malaysia.

AIDS Care 2021 Sep 20:1-6. Epub 2021 Sep 20.

Discipline of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia.

Sociodemographic status and medical problems were widely reported as the major factors in people living with HIV (PLHIV) with lower health-related quality of life (HRQoL). However, lifestyles and cultural changes are rarely studied. A multicentred cross-sectional study was conducted among 137 virally suppressed PLHIV on antiretroviral therapy (ART) in northern Malaysia by face-to-face interviews and World Health Organization Quality of Life (WHOQOL)-BREF questionnaire. Read More

View Article and Full-Text PDF
September 2021

Linezolid population pharmacokinetics in South African adults with drug-resistant tuberculosis.

Antimicrob Agents Chemother 2021 Sep 20:AAC0138121. Epub 2021 Sep 20.

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.

Linezolid is widely used for drug-resistant tuberculosis (DR-TB) but has a narrow therapeutic index. To inform dose optimisation, we aimed to characterise the population pharmacokinetics of linezolid in South African participants with DR-TB and explore the effect of covariates, including HIV-co-infection, on drug exposure. Data were obtained from pharmacokinetic sub-studies in a randomised controlled trial and an observational cohort study, both of which enrolled adults with drug-resistant pulmonary tuberculosis. Read More

View Article and Full-Text PDF
September 2021

Assessing gender differences among presumed and diagnosed patients with pulmonary TB: observations from Guinea-Bissau.

Trans R Soc Trop Med Hyg 2021 Sep 20. Epub 2021 Sep 20.

Ban dim Health Project, INDEPTH Network, Apartado 861, 1004 Bissau Codex, Guinea-Bissau.

Background: Globally, more males than females are diagnosed with pulmonary TB (PTB); however, the cause of this gender disparity remains unknown. We aimed to assess gender differences in an observational cohort of patients with presumed PTB (prePTB) at the Bandim Health Project, Guinea-Bissau.

Methods: Adult patients with signs and symptoms suggestive of PTB seeking medical care were invited to participate and were referred to comprehensive diagnostic work-up. Read More

View Article and Full-Text PDF
September 2021

The aetiology, clinical presentation and treatment of patients with pulmonary hypertension in Cape Town: A preliminary report from the Groote Schuur Hospital Pulmonary Hypertension Registry.

Afr J Thorac Crit Care Med 2018 20;24(4). Epub 2018 Dec 20.

Division of Pulmonology, Department of Medicine, Groote Schuur Hospital, Cape Town, South Africa.

Background: There is a paucity of knowledge about pulmonary hypertension (PH) in sub-Saharan Africa and an urgent need for its investigation in this context. The impact of HIV infection in PH is also unknown.

Objectives: To determine the aetiology, clinical presentation, severity and current management of PH at a tertiary-level hospital in Cape Town, South Africa (SA). Read More

View Article and Full-Text PDF
December 2018

The clinical features and management of pulmonary embolism at Chris Hani Baragwanath Academic Hospital.

Afr J Thorac Crit Care Med 2018 10;24(3). Epub 2018 Sep 10.

Department of Internal Medicine, Chris Hani Baragwanath Academic Hospital and University of the Witwatersrand, Johannesburg, South Africa.

Background: Pulmonary embolism (PE) is the most common cause of preventable deaths in hospitalised patients.

Objectives: To determine the prevalence and associated features of PE at Chris Hani Baragwanath Academic Hospital (CHBAH) over a period of one year.

Methods: A retrospective study was performed of patients with acute PE, as confirmed by computed tomography of the pulmonary arteries (CTPA). Read More

View Article and Full-Text PDF
September 2018

Analysing "tear-drop" prints of acute promyelocytic leukemia (APML): immunophenotypic prognostication of APML by FCM.

Am J Blood Res 2021 15;11(4):446-457. Epub 2021 Aug 15.

ICMR-National Institute of Pathology, Safdarjung Hospital Campus Ansari Nagar, New Delhi, India.

Introduction: Acute promyelocytic leukemia (APML), although genetically and morphologically distinct from other AML (acute myeloid leukemia) subtypes, is one of the most best responsive acute myeloid leukemia. -Conventional diagnostic methods and morphological hints often fail in the majority of the cases in the peripheral laboratories owing to resource constraints, unavailability of cytogenetic work-up, hypogranular variants, morphological mimicry by AML-monocytic and myelo-monocytic, etc. Flowcytometry (FCM), however, can be utilized as a feasible and reliable immunophenotypic diagnostic and prognostic tool for prompt identification of APML. Read More

View Article and Full-Text PDF

Pharmacist Intervention Lowers HgbA1c in Diabetic Patients Regardless of HIV Status.

J Pharm Pract Res 2021 Aug 26;51(4):307-313. Epub 2021 Jul 26.

University of California, Davis Health, 2315 Stockton Blvd, Sacramento, CA 95817.

Aim: Compare glycemic control in human immunodeficiency (HIV)-positive patients on antiretroviral therapy to HIV-negative patients following pharmacist interventions.

Methods/results: This retrospective observational cohort study conducted at a Federally Qualified Health Center included adults with type II diabetes mellitus who attended at least two clinical pharmacy appointments between January 1, 2018 and July 31, 2019. Exclusion criteria included missing pre- or post-hemoglobin A1c (HgbA1c) values, type 1 diabetes, pregnancy, breastfeeding, deceased, or untreated HIV. Read More

View Article and Full-Text PDF

Potential of recombinant LiHyQ, a novel Leishmania infantum protein, for the diagnosis of canine visceral leishmaniasis and as a diagnostic and prognostic marker for human leishmaniasis and human immunodeficiency virus co-infection: a preliminary study.

Acta Trop 2021 Sep 16:106126. Epub 2021 Sep 16.

Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30.130-100, Minas Gerais, Brazil; Departamento de Patologia Clínica, COLTEC, Universidade Federal de Minas Gerais, Belo Horizonte, 31270-901, Minas Gerais, Brazil. Electronic address:

Laboratory diagnosis of leishmaniasis shows variable efficacy in detecting infected mammalian hosts and there is a need to identify suitable antigens to improve the accuracy of diagnostic tests. In the present study, a L. infantum hypothetical protein called LiHyQ was evaluated for the diagnosis of tegumentary (TL) and visceral (VL) leishmaniasis using canine and human samples. Read More

View Article and Full-Text PDF
September 2021

Human Immunodeficiency Virus Infection Promotes Human Papillomavirus-Mediated Anal Squamous Carcinogenesis: An Immunologic and Pathobiologic Review.

Pathobiology 2021 Sep 14:1-12. Epub 2021 Sep 14.

Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

Background: Anal squamous cell carcinoma (SCC) is a rare gastrointestinal malignancy with rising incidence, both in the United States and internationally. The primary risk factor for anal SCC is human papillomavirus (HPV) infection. However, there is a growing burden of disease in patients with human immunodeficiency virus (HIV) and HPV coinfection, with the incidence of anal SCC significantly increasing in this population. Read More

View Article and Full-Text PDF
September 2021

Evaluation of endothelial function and subclinical atherosclerosis in patients with HIV infection.

Sci Rep 2021 Sep 16;11(1):18431. Epub 2021 Sep 16.

Infectious Diseases Service, Hospital Universitario Marqués de Valdecilla-IDIVAL, University of Cantabria, Av. Valdecilla s/n, 39008, Santander, Spain.

The aim of this study was to analyse the association between human immunodeficiency virus (HIV) related clinical and analytical parameters and the presence of subclinical atherosclerosis as well as endothelial dysfunction. This was a prospective cohort study of HIV-positive patients who underwent intima media thickness (IMT) determination and coronary artery calcium scoring to determine subclinical atherosclerosis. To detect endothelial dysfunction, the breath holding index, flow-mediated dilation and the concentration of endothelial progenitor cells (EPCs) were measured. Read More

View Article and Full-Text PDF
September 2021

Epidemiological risk factors associated with primary infection by Epstein-Barr virus in HIV-1-positive subjects in the Brazilian Amazon region.

Sci Rep 2021 Sep 16;11(1):18476. Epub 2021 Sep 16.

Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém, Pará, Brazil.

To identify the prevalence and risk factors for primary Epstein-Barr virus (EBV) infection in human immunodeficiency virus (HIV)-1-positive adult treatment-naïve patients between January 2018 and December 2019 in a state of the Brazilian Amazon region. A total of 268 HIV-1 positive patients and 65 blood donors participated in the study. Epidemiological data were obtained from medical records and through a designed questionnaire. Read More

View Article and Full-Text PDF
September 2021

Genotypic HIV-1 tropism determination might help to identify people with exhausted treatment options and advanced disease.

J Antimicrob Chemother 2021 Sep 16. Epub 2021 Sep 16.

Department of Experimental Medicine, University of Rome 'Tor Vergata', Rome, Italy.

Objectives: To evaluate HIV-1 tropism in 1382 combined antiretroviral therapy (cART)-experienced patients failing therapy to characterize those with exhausted therapeutic options.

Methods: HIV-1 genotypic tropism was inferred through Geno2Pheno by estimating the false-positive-rate (FPR) values. Cumulative resistance and drug activity were evaluated by Stanford algorithm. Read More

View Article and Full-Text PDF
September 2021

The use of secukinumab in an HIV-positive patient with axial spondyloarthritis: a case-based review.

Clin Rheumatol 2021 Sep 16. Epub 2021 Sep 16.

Department of Rheumatology, Consorci Parc de Salut MAR/Hospital del Mar, Passeig Marítim 25-29, 08003, Barcelona, Spain.

Axial spondyloarthritis in HIV-positive patients raises specific treatment challenges as immunosuppressant and immunomodulating agents may adversely affect the course of the HIV infection and could increase the risk of opportunistic infections. The efficacy and safety of secukinumab in patients with HIV is unknown due to HIV patients were largely excluded from clinical trials and nowadays, the clinical evidence for the treatment with biological disease-modifying antirheumatic drugs (DMARDs) is provided from scarce case reports and case series. We hereby discuss a case of a male patient with concomitant axial spondyloarthritis and HIV infection successfully treated with secukinumab, achieving disease remission and without any associated complications. Read More

View Article and Full-Text PDF
September 2021

Evaluation of hepatitis B virus, hepatitis C virus, and human immunodeficiency virus seroprevalence in patients with diffuse large B cell lymphoma and Hodgkin's lymphoma.

J Cancer Res Ther 2021 Jul-Sep;17(4):951-955

University of Health Sciences, Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, Hematology Clinic and Bone Marrow Transplantation Unit, Ankara, Turkey.

Backgrounds: Non-Hodgkin's lymphoma and Hodgkin's lymphomas (HL) are lymphoid neoplasms. Hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) are viruses that could proliferate in lymphoid tissues. These viruses may cause lymphoproliferative diseases. Read More

View Article and Full-Text PDF
September 2021