454 results match your criteria hiv pwh


Aging-Related Concerns of People Living with HIV Referred for Geriatric Consultation.

HIV AIDS (Auckl) 2021 30;13:467-474. Epub 2021 Apr 30.

Division of Infectious Diseases, Weill Cornell Medicine, New York, NY, 10065, USA.

Purpose: People with HIV (PWH) are living longer lives and likely experiencing accentuated aging. Comprehensive geriatric assessment (CGA) has been proposed as a way to identify and help meet each individual patient's needs.

Patients And Methods: We performed a retrospective review of the results of CGA in an HIV clinic in New York City. Read More

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Viral hepatitis in haemophilia: historical perspective and current management.

Br J Haematol 2021 May 6. Epub 2021 May 6.

Sheffield Haemophilia and Thrombosis Centre, Royal Hallamshire Hospital, Sheffield, UK.

The introduction of clotting factor concentrates has substantially improved the lives of people with clotting factor deficiencies. Unfortunately, the transmission of blood-borne viral infections through these plasma-derived products led to a huge epidemic of human immunodeficiency virus and viral hepatitis in people with haemophilia (PWH). In a significant proportion of PWH exposed to these viruses, the ensuing decades-long chronic infection resulted in excess morbidity and mortality. Read More

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Implementation of a comprehensive intervention focused on hospitalized patients with HIV by an existing stewardship program: successes and lessons learned.

Ther Adv Infect Dis 2021 Jan-Dec;8:20499361211010590. Epub 2021 Apr 19.

Department of Internal Medicine, Atrium Health, Charlotte, NC, USA.

Background: Several national organizations have advocated for inpatient antiretroviral stewardship to prevent the consequences of medication-related errors. This study aimed to evaluate the impact of a stewardship initiative on outcomes in people with HIV (PWH).

Methods: A pharmacist-led audit and review of adult patients admitted with an ICD-10 code for HIV was implemented to an existing antimicrobial stewardship program. Read More

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Generally rare but occasionally severe weight gain after switching to an integrase inhibitor in virally suppressed AGEhIV cohort participants.

PLoS One 2021 5;16(5):e0251205. Epub 2021 May 5.

Department of Internal Medicine, Amsterdam Infection and Immunity Institute and Amsterdam Public Health Research Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Objectives: Recent studies have reported disproportionate weight gain associated with integrase strand transfer inhibitor (INSTI) initiation in antiretroviral therapy(ART)-naive people with HIV (PWH), particularly among black women. We investigated if HIV-positive AGEhIV participants with suppressed viremia switching to INSTI-containing ART experienced more weight gain compared to HIV-positive virally-suppressed non-switching and HIV-negative controls.

Methods: In the AGEhIV cohort, standardized weight measurements were performed biennially. Read More

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Knowledge and Impact of COVID-19 on Middle-Aged and Older People living with HIV in Lima, Peru.

medRxiv 2021 Apr 26. Epub 2021 Apr 26.

COVID-19 has had an unprecedented worldwide impact, and Peru has had one of the highest COVID-19 case rates despite implementation of an early strict nationwide quarantine. Repercussions on Peru's healthcare system may impact vulnerable populations, particularly people with HIV (PWH). We explored the knowledge of COVID-19 and the socioeconomic and health impact of the pandemic among middle-aged and older PWH. Read More

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Large Mitochondrial DNA Deletions in HIV Sensory Neuropathy.

Neurology 2021 May 4. Epub 2021 May 4.

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Objective: The primary objective of this study was to evaluate the correlation of large mitochondrial DNA deletions in skin samples of people with human immunodeficiency virus (PWH) with measures of neuropathy and prior exposure to therapy. We hypothesized that deletions would be associated with neuropathy. As secondary objectives we determined the correlation of deletion burden with demographic data and neuropathy measures. Read More

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Scale-up of antiretroviral treatment access among people living with HIV in Rivers State, Nigeria, 2019--2020.

AIDS 2021 Jun;35(7):1127-1134

Division of Global HIV and TB, Centers for Disease Control and Prevention.

Objective: The aim of this study was to describe and evaluate the impact of the programme intervention of the Rivers State Antiretroviral Treatment (ART) Surge, a collaboration between the US President's Emergency Plan for AIDS Relief (PEPFAR) and the State Ministry of Health, to increase HIV case-finding and ART access in Rivers State, the state with the largest ART gap among people living with HIV (PWH) in Nigeria.

Design: During April 2019-September 2020, the intervention included six specific strategies: using local government area-level ART gap analysis to guide case-finding; expanding targeted community testing; tailoring comprehensive key population HIV services; engaging HIV treatment programme stakeholders; synchronizing team efforts; and using near real-time data for programme action.

Methods: Weekly reported facility and community data on tests conducted, PWH diagnosed, and PWH initiated on ART were aggregated. Read More

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Psychological Connection to the Gay Community and Negative Self-Appraisals in Middle-Aged and Older Men Who Have Sex with Men: The Mediating Effects of Fitness Engagement.

J Gerontol B Psychol Sci Soc Sci 2021 May 4. Epub 2021 May 4.

Department of Medicine, Division of General Internal Medicine, Georgetown University.

Objectives: Connections to the gay community may elicit negative self-appraisals among men who have sex with men (MSM), which may be exacerbated for people with HIV (PWH). Fitness engagement may mediate self-appraisals by maintaining or improving appearance and health. We hypothesized that gay community connections would be positively related to negative self-appraisal and explored whether this association would be mediated by fitness engagement and moderated by HIV status. Read More

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Higher circulating intermediate monocytes are associated with cognitive function in women with HIV.

JCI Insight 2021 Apr 29. Epub 2021 Apr 29.

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, United States of America.

Background: Identifying a quantitative biomarker of neuropsychiatric dysfunction in people with HIV (PWH) remains a significant challenge in the neuroHIV field. The strongest evidence to date implicates the role of monocytes in central nervous system (CNS) dysfunction in HIV, yet no study has examined monocyte subsets in blood as a correlate and/or predictor of neuropsychiatric function in virally suppressed PWH.

Methods: In two independent cohorts of virologically suppressed women with HIV (vsWWH; n=25 and n=18), whole blood samples were obtained either in conjunction with neuropsychiatric assessments (neuropsychological [NP] test battery, self-report depression and stress-related symptom questionnaires) or one year prior to assessments. Read More

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Progression risk in people with HIV and COVID-19: Predictive performance of current risk scores.

AIDS Res Hum Retroviruses 2021 Apr 29. Epub 2021 Apr 29.

Ramon y Cajal University Hospital, 16507, Infectious Diseases, Madrid, Madrid, Spain;

People with HIV (PWH) might have a higher risk of adverse coronavirus disease 2019 (COVID-19) outcomes. Several scores were developed to predict COVID-19 progression to critical disease and are often used among PWH. We assessed the performance of two commonly used risk equations among PWH and COVID-19. Read More

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Self-Reported Cannabis Use and Markers of Inflammation in Men Who Have Sex With Men With and Without HIV.

Cannabis Cannabinoid Res 2021 Apr 15;6(2):165-173. Epub 2021 Apr 15.

Division of Infectious Diseases, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

Chronic inflammation contributes to aging and organ dysfunction in the general population, and is a particularly important determinant of morbidity and mortality among people with HIV (PWH). The effect of cannabis use on chronic inflammation is not well understood among PWH, who use cannabis more frequently than the general population. We evaluated participants in the Multicenter AIDS Cohort Study (MACS) beginning in 2004 with available data on cannabis use and inflammatory biomarkers. Read More

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Cannabis and the Gut-Brain Axis Communication in HIV Infection.

Cannabis Cannabinoid Res 2021 Apr 15;6(2):92-104. Epub 2021 Apr 15.

Departments of Neurosciences and Psychiatry, University of California, San Diego, San Diego, California, USA.

People living with HIV infection (PWH) disclose that cannabis is an effective strategy for alleviating symptoms associated with HIV disease. However, some medical providers feel ill-informed to engage in evidence-based conversations. HIV leads to alterations in the gut microbiome, gut-brain axis signaling, and chronic inflammation. Read More

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Moving on from HAND: why we need new criteria for cognitive impairment in people with HIV and a proposed way forward.

Clin Infect Dis 2021 Apr 27. Epub 2021 Apr 27.

HIV Mental Health Research Unit, Department of Psychiatry and Mental Health, Neuroscience Institute, South Africa.

HIV-associated neurocognitive disorders (HAND) criteria are frequently used to describe cognitive impairment in people with HIV (PWH) across diverse populations globally. These criteria typically find 20-60% of PWH meet criteria for HAND, which does not tally with clinical observations in the modern era that cognitive disorders present relatively infrequently. Most with HAND have asymptomatic neurocognitive impairment (ANI), however the significance of low cognitive test performance without symptoms is uncertain. Read More

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Low-Level HIV RNA in Cerebrospinal Fluid and Neurocognitive Performance: A Longitudinal Cohort Study.

J Acquir Immune Defic Syndr 2021 Apr 20. Epub 2021 Apr 20.

Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine Departments of Psychiatry bioMONTR Labs, Research Triangle Park, North Carolina Neurosciences Medicine, University of California, San Diego.

Background: Cognitive complications persist in persons with HIV (PWH) during suppressive antiretroviral therapy (ART). Low levels of HIV during ART could contribute to these complications. In this study, we measured cerebrospinal fluid (CSF) HIV using a single copy assay (SCA) to investigate a possible relationship between low level HIV and cognition. Read More

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Statin effect on coronary calcium distribution, mass and volume scores and associations with immune activation among HIV+ persons on antiretroviral therapy.

Antivir Ther 2021 Apr 26. Epub 2021 Apr 26.

School of Medicine, Case Western Reserve University, Cleveland, OH, USA.

Background: Inflammation has been associated with whole heart coronary artery calcification (CAC) among people with HIV (PWH) on antiretroviral therapy (ART); however, prior studies have not evaluated the distribution of calcium or separated mass vs. volume scores, which are differentially associated with clinical events in the general population. Statins may also have a greater effect on CAC mass compared to volume. Read More

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Hepatitis C Virus Testing Among Men With Human Immunodeficiency Virus Who Have Sex With Men: Temporal Trends and Racial/Ethnic Disparities.

Open Forum Infect Dis 2021 Apr 17;8(4):ofaa645. Epub 2021 Apr 17.

Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Background: National guidelines recommend that sexually active people with human immunodeficiency virus (PWH) who are men who have sex with men (MSM) be tested for hepatitis C virus (HCV) infection at least annually. Hepatitis C virus testing rates vary by race/ethnicity in the general population, but limited data are available for PWH.

Methods: We analyzed medical records data from MSM in the HIV Outpatient Study at 9 human immunodeficiency virus (HIV) clinics from January 1, 2011 through December 31, 2019. Read More

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Emergency Department Utilization Among People Living With HIV on Chronic Opioid Therapy.

J Int Assoc Provid AIDS Care 2021 Jan-Dec;20:23259582211010952

Boston Medical Center / Boston University School of Medicine, Boston, MA, USA.

Chronic pain among people with HIV (PWH) is a driving factor of emergency department (ED) utilization, and it is often treated with chronic opioid therapy (COT). We conducted a cross-sectional analysis of a prospective observational cohort of PWH on COT at 2 hospital-based clinics to determine whether COT-specific factors are associated with ED utilization among PWH. The primary outcome was an ED visit within 12 months after study enrollment. Read More

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T cell Homeostatic Imbalance in Placentae from Women with HIV in the absence of Vertical Transmission.

J Infect Dis 2021 Apr 21. Epub 2021 Apr 21.

Division of Immunology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa.

Background: Implementation of universal antiretroviral therapy (ART) has significantly lowered vertical transmission rates but has also increased numbers of HIV-exposed uninfected children (HEU), who remain vulnerable to morbidities. Here, we investigated whether T cell alterations in the placenta contribute to altered immune status in HEU.

Methods: We analyzed T cells from term placentae decidua and villous tissue and paired cord blood from pregnant women with HIV (PWH) who initiated ART late in pregnancy (n=21) with pregnant women not living with HIV (PWNH) (n=9). Read More

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Association between Pain, Pulmonary Function, and Respiratory Symptoms in People with HIV.

J Acquir Immune Defic Syndr 2021 Apr 5. Epub 2021 Apr 5.

Department of Medicine, University of Pittsburgh, Pittsburgh, PA Department of Medicine, Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle, WA Division of HIV, Infectious Diseases, and Global Medicine and Division of Pulmonary and Critical Care Medicine, Zuckerberg San Francisco General, University of California San Francisco, San Francisco, CA Department of Medicine, Veterans Affairs Pittsburgh Health Care System Department of Immunology, University of Pittsburgh, Pittsburgh, PA.

Background: People with HIV (PWH) experience chronic pain and respiratory symptoms, which are closely related in the general population. Pain may impact the impaired pulmonary function seen in PWH beyond its association with HIV alone. Our objective was to investigate the relationship of pain severity to pulmonary function, respiratory symptoms, and sleep disturbance in PWH. Read More

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Transcriptional and Immunologic Correlates of Response to Pandemic Influenza Vaccine in Aviremic, HIV-Infected Children.

Front Immunol 2021 25;12:639358. Epub 2021 Mar 25.

Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, United States.

People living with HIV (PWH) often exhibit poor responses to influenza vaccination despite effective combination anti-retroviral (ART) mediated viral suppression. There exists a paucity of data in identifying immune correlates of influenza vaccine response in context of HIV infection that would be useful in improving its efficacy in PWH, especially in younger individuals. Transcriptomic data were obtained by microarray from whole blood isolated from aviremic pediatric and adolescent HIV-infected individuals (4-25 yrs) given two doses of Novartis/H1N1 09 vaccine during the pandemic H1N1 influenza outbreak. Read More

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Risk for incident diabetes is greater in pre-diabetic men with HIV than without HIV.

AIDS 2021 Apr 15. Epub 2021 Apr 15.

Infectious Diseases Unit Hôtel-Dieu Hospital, APHP centre, Université de Paris, F-75004, France Johns Hopkins University, Baltimore, MD. USA Feinberg School of Medicine, Northwestern University, Chicago, IL, USA School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA University of Texas Health Science Center, Houston, TX. USA.

Background: Diabetes mellitus (DM) is a major comorbidity in people living with HIV (PWH). Hyperglycemia below diabetic range defines pre-diabetes (pre-DM). We compared the progression from pre-DM to DM in PWH and people without HIV (PWOH). Read More

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Growth Hormone Releasing Hormone Reduces Circulating Markers of Immune Activation in Parallel with Effects on Hepatic Immune Pathways in Individuals with HIV-Infection and Nonalcoholic Fatty Liver Disease.

Clin Infect Dis 2021 Apr 14. Epub 2021 Apr 14.

Metabolism Unit, Massachusetts General Hospital (MGH) and Harvard Medical School (HMS), Boston, MA, USA.

Background: The growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis modulates critical metabolic pathways; however, little is known regarding effects of augmenting pulsatile GH secretion on immune function in humans. This study used proteomics and gene set enrichment analysis to assess effects of a GH releasing hormone (GHRH) analog, tesamorelin, on circulating immune markers and liver tissue in people with HIV (PWH) and NAFLD.

Methods: 92 biomarkers associated with immunity, chemotaxis, and metabolism were measured in plasma samples from 61 PWH with NAFLD who participated in a double-blind, randomized trial of tesamorelin versus placebo for 12 months. Read More

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IgG intrathecal synthesis in HIV-associated neurocognitive disorder (HAND) according to the HIV-1 subtypes and pattern of HIV RNA in CNS and plasma compartments.

J Neuroimmunol 2021 Jun 8;355:577542. Epub 2021 Mar 8.

HIV Neurobehavioral Research Center, University of California, San Diego, San Diego, CA, USA.

We hypothesized that humoral immunity stimulation in the CNS in HIV-1C patients would be lower than that in HIV-1B due to a defective Tat chemokine dimotif (C30C31) that might influence cellular trafficking and CNS inflammation. Sixty-eight paired CSF and blood samples from people with HIV (PWH), free of CNS opportunistic infections, were included, HIV-1B (n = 27), HIV-1C (n = 26), and HIV negative (n = 25). IgG intrathecal synthesis was assayed using quantitative and qualitative methods. Read More

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What's new in bone disease and fractures in HIV?

Curr Opin HIV AIDS 2021 May;16(3):186-191

Centre for Experimental Pathogen Host Research, School of Medicine, University College Dublin.

Purpose Of Review: People living with HIV (PWH) are at greater risk of low bone mineral density (BMD) and fractures compared to the general population. This narrative review summarises recent literature in the field, including the relative contribution of antiretroviral therapy and frailty to low BMD and fractures in PWH.

Recent Findings: The body of evidence indicating less impact on BMD from the use of tenofovir alafenamide compared to tenofovir disoproxil fumarate continues to grow, although this has not yet translated into data supporting a reduction in fracture incidence. Read More

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COVID-19 Infection among People with HIV/AIDS in Africa: Knowledge Gaps, Public Health Preparedness and Research Priorities.

Int J MCH AIDS 2021 24;10(1):113-118. Epub 2021 Mar 24.

Institute of Community Health, University of Houston College of Pharmacy, Houston, Texas, USA.

The emergence of novel virus SARS-CoV-2 that causes COVID-19 has complicated Africa's public health challenges, especially with the pre-existing epidemics such as HIV/AIDS. We highlight the known evidence related to COVID-19 infections among people with HIV (PWH) with specific reference to Africa. The knowledge gaps, level of public health preparedness and the potential research priorities are also outlined. Read More

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Clinical consequences of asymptomatic cytomegalovirus in treated human immunodeficency virus infection.

Curr Opin HIV AIDS 2021 May;16(3):168-176

Department of Medicine, University of California, San Francisco, California, USA.

Purpose Of Review: Despite antiretroviral therapy (ART)-mediated viral suppression, people with human immunodeficiency virus (HIV) (PWH) have increased morbidity and mortality. Immune activation and inflammation persist on ART and predict these complications. Over 90% of PWH have cytomegalovirus (CMV) co-infection, and CMV is considered a plausible contributor to this persistent immune activation. Read More

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Frailty: the current challenge for aging people with HIV.

Curr Opin HIV AIDS 2021 May;16(3):133-140

Divisions of Infectious Diseases and Geriatric Medicine, University of Colorado Denver-Anschutz Medical Campus, Aurora, Colorado, USA.

Purpose Of Review: Older adults account for the majority of people with HIV (PWH) in high-income countries and have increasingly complex clinical profiles related to premature aging. Frailty is an important geriatric syndrome affecting a minority of PHW. Frailty negatively affects PHW's clinical status and quality of life. Read More

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Metabolic syndrome in Zambian adults with human immunodeficiency virus on antiretroviral therapy: Prevalence and associated factors.

Medicine (Baltimore) 2021 Apr;100(14):e25236

University of Zambia School of Public Health.

Abstract: Metabolic syndrome (MetS) is a constellation of factors including hypertension, abdominal obesity, dyslipidemia, and insulin resistance that separately and together significantly increase risk for cardiovascular disease (CVD) and diabetes. In sub-Saharan Africa, with a substantial burden of human immunodeficiency virus (HIV) and increasing prevalence of CVD and diabetes, there is a paucity of epidemiological data on demographic, laboratory, and clinical characteristics associated with MetS among people with HIV (people with human [PWH]). Therefore, this study aimed to determine the burden and factors influencing MetS in antiretroviral therapy (ART)-experienced individuals in Zambia. Read More

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Incident obstructive lung disease and mortality among HIV-positive and negative persons with a history of injecting drugs.

AIDS 2021 Apr 6. Epub 2021 Apr 6.

Department of Family Medicine, University of California, Los Angeles Department of Epidemiology, University of North Carolina, Chapel Hill Department of Pulmonary Diseases and Critical Care Medicine, University of North Carolina, Chapel Hill Department of Epidemiology, Johns Hopkins University.

Objective: People with HIV (PWH) experience increased prevalence of obstructive lung disease (OLD), regardless of greater observed smoking behaviors. We investigated whether the effect of incident OLD on mortality differed by HIV and HIV viral suppression among persons who inject drugs (PWID) and report smoking history.

Design: ALIVE is a longitudinal, observational cohort study of HIV-positive and seronegative PWID. Read More

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Common pathogen-associated molecular patterns induce the hyper-activation of NLRP3 inflammasome in circulating B lymphocytes of HIV-infected individuals.

AIDS 2021 05;35(6):899-910

Laboratório de Imunogenética, Departamento de Imunologia, Instituto de Ciências Biomédicas da Universidade de São Paulo (ICB/USP).

Objective: Despite the antiretroviral treatment, people with HIV (PWH) still experience systemic chronic inflammation and immune-senescence, which represent risk factors for severe comorbidities and inefficient response to pathogens and vaccines. Given the dysregulation of NLRP3 inflammasome in PWH and the recently demonstrated role played by NLRP3 in B lymphocytes, we hypothesized that NLRP3 dysregulation in B cells can contribute to chronic inflammation and humoral dysfunction in PWH.

Design: NLRP3 inflammasome activation was evaluated in B lymphocytes and correlated with antibodies production and immunization response in PWH. Read More

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