32,524 results match your criteria hiv negative


Maternal depressed mood and child development over the first five years of life in South Africa.

J Affect Disord 2021 Jul 16;294:346-356. Epub 2021 Jul 16.

Institute for Life Course Health Research, Department of Global Health, Stellenbosch University, Cape Town, South Africa; Arizona State University, Tempe, AZ, United States; School of Nursing and Midwifery, Queens University, Belfast, United Kingdom. Electronic address:

Background: While the negative impact of peri-natal depression is well-documented in high-income countries, the long-term effects across the life course in low and middle-income countries is less clear. Children's adjustment over the first five years is examined as a function of patterns of maternal depressed mood.

Methods: Pregnant women in 24 peri-urban townships (N = 1,238) were randomized to a home-visiting intervention or standard care and reassessed five times, with high retention. Read More

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Examining the association of alcohol use and psychotropic medication adherence among women with severe mental illness in South Africa.

Psychiatry Res 2021 Jul 19;304:114127. Epub 2021 Jul 19.

HIV Mental Health Research Unit, Department of Psychiatry and Mental Health, University of Cape Town, Groote Schuur Hospital, Anzio Road Observatory, Cape Town 7925, South Africa.

Women with severe mental illness (SMI) in South Africa face numerous psychosocial challenges and alcohol use is widely used in this population as a coping strategy. Although hazardous alcohol use has a documented negative effect on medication adherence or chronic illness, research has mostly ignored the role of alcohol on psychotropic medication adherence in women with SMI. The primary aim of this study was to explore the association of hazardous alcohol use on psychotropic medication adherence in adult women living with SMI (N = 119), attending a psychiatric clinic for treatment in Cape Town. Read More

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Use of fourth-generation rapid combined antigen and antibody diagnostic tests for the detection of acute HIV infection in a community centre for men who have sex with men, between 2016 and 2019.

PLoS One 2021 27;16(7):e0255065. Epub 2021 Jul 27.

Tuberculosis Research Unit of Barcelona (UITB) Foundation, Barcelona, Spain.

Objective: To assess the use of fourth-generation rapid diagnostic tests in identifying acute infection of Human Immunodeficiency Virus (HIV).

Methods: BCN Checkpoint promotes sexual health among men who have sex with men (MSM), with a focus on diagnosing HIV early, initiating combined antiretroviral treatment (cART) promptly, and recommending regular repeat testing for those who have tested negative. This cross-sectional study included all test results obtained at the centre between 25 March 2016 and 24 March 2019. Read More

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Comparing non-invasive predictors of neurosyphilis among syphilis patients with and without HIV co-infection based on the real-world diagnostic criteria: a single-centre, retrospective cohort study in China.

AIDS Res Hum Retroviruses 2021 Jul 27. Epub 2021 Jul 27.

Second Department of Infectious Disease, Xixi Hospital of Hangzhou, Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China, Second Department of Infectious disease, Xixi Hospital of Hangzhou, Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310023, P.R. China, Hangzhou , China, 310023;

Background: Diagnosis of neurosyphilis is currently based on the cerebrospinal fluid (CSF) assessments and CSF-Venereal Disease Research Laboratory (CSF-VDRL) is the traditional "gold standard". In the real world, CSF assessments or CSF-VDRL are not always available. This study aimed to identify non-invasive predictors of neurosyphilis based on real-world clinical parameters and diagnostic criteria in populations with different HIV status. Read More

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Conceptualizing Consent: Cross-national and Temporal Representations of Sexual Consent in Young Africans' Creative Narratives on HIV.

J Sex Res 2021 Jul 27:1-12. Epub 2021 Jul 27.

Hubert Department of Global Health, Rollins School of Public Health at Emory University.

Sexual violence, comprising all non-consensual sexual acts, is an important driver of HIV infection in sub-Saharan Africa. Definitions of sexual violence rely on understandings of sexual consent, understood as a feeling of willingness that is communicated via shared indicators of consent. In this paper, through analysis of young authors' narrative-based social representations, we sought to provide insight into young Africans' sense-making around sexual consent in order to develop a conceptual framework that can guide future methodological and conceptual work. Read More

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Isolated B-cell lymphopenia and autoimmune hemolytic anemia as a curious combination of findings at the time of advanced Hodgkin lymphoma diagnosis: a pediatric case report.

AME Case Rep 2021 25;5:26. Epub 2021 Jul 25.

Division of Allergy and Immunology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA.

Lymphopenia is associated with poor outcome in Hodgkin lymphoma (HL), but the impact of specific cytopenias is unexplored. We report a case of isolated B-cell lymphopenia with HL, EBV infection, and autoimmune hemolytic anemia (AIHA). Our patient is a 19-year-old male without any significant past medical history who presented with two weeks of epigastric abdominal pain, subjective fevers, night sweats, fatigue and a five-pound weight loss. Read More

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Municipal police support for harm reduction services in officer-led referrals of people who inject drugs in Tijuana, Mexico.

Harm Reduct J 2021 Jul 26;18(1):76. Epub 2021 Jul 26.

Department of Medicine, University of California San Diego School of Medicine, La Jolla, CA, USA.

Background: Police constitute a structural determinant of health and HIV risk of people who inject drugs (PWID), and negative encounters with law enforcement present significant barriers to PWID access to harm reduction services. Conversely, police may facilitate access via officer-led referrals, potentiating prevention of HIV, overdose, and drug-related harms. We aimed to identify police characteristics associated with support for officer-led referrals to addiction treatment services and syringe service programs (SSP). Read More

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The Community PrEP Study: a randomized control trial leveraging community-based platforms to improve access and adherence to pre-exposure prophylaxis to prevent HIV among adolescent girls and young women in South Africa-study protocol.

Trials 2021 Jul 26;22(1):489. Epub 2021 Jul 26.

The Desmond Tutu HIV Centre, University of Cape Town, Anzio Road, Observatory, Cape Town, South Africa.

Background: HIV incidence among South African adolescent girls and young women (AGYW) remains high, but could be reduced by highly effective pre-exposure prophylaxis (PrEP). Unfortunately, AGYW report significant barriers to clinic-based sexual and reproductive health services. Even when AGYW access PrEP as an HIV prevention method, poor prevention-effective use was a serious barrier to achieving its optimal HIV prevention benefits. Read More

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Pilot Randomized Controlled Trial of Motivational Interviewing with Sexual Minority Male Couples to Reduce Drug Use and Sexual Risk: The Couples Health Project.

AIDS Behav 2021 Jul 23. Epub 2021 Jul 23.

Department of Psychiatry and Neurobehavioral Sciences, Center for Behavioral Health and Technology, University of Virginia School of Medicine, Charlottesville, VA, USA.

A randomized controlled trial evaluated the preliminary efficacy of a dyadically-delivered motivational interviewing (MI) intervention to reduce drug use and sexual risk in a sample of 50 sexual minority (cis)male (SMM) couples. In each couple, at least one partner was aged 18-29; reported drug use and sexual HIV transmission risk; and was HIV-negative. Couples were randomized to either the three-session MI intervention or an attention-matched control, with follow-up surveys completed at 3- and 6-months post-baseline. Read More

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An unusual case of paediatric plasmablastic lymphoma presenting with malignant effusion and the challenges in its diagnosis.

Diagn Cytopathol 2021 Jul 23. Epub 2021 Jul 23.

Department of Pathology, Tata Memorial Hospital, Mumbai, India.

Plasmablastic lymphoma (PBL) is an aggressive non-Hodgkin lymphoma occurring commonly in the oral mucosa and jaw of human immunodeficiency virus (HIV) positive adult males. PBL is not a common occurrence in children and a presentation with malignant effusion is rarely reported. Herein, we share our experience in the challenges confronted in the diagnosis of PBL in a 6-year-old, HIV positive boy presenting with malignant pleural and peritoneal effusions along with gum hypertrophy, lymphadenopathy and paranasal sinus mass. Read More

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Distinguishing repeated polymerase chain reaction positivity from re-infections in COVID-19.

Influenza Other Respir Viruses 2021 Jul 23. Epub 2021 Jul 23.

Liver Transplantation Research Center, Department of Infectious Diseases, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.

Background: Possibility of reinfection with SARS-CoV-2 changes our view on herd immunity and vaccination and can impact worldwide quarantine policies. We performed real-time polymerase chain reaction (RT-PCR) follow-up studies on recovered patients to assess possible development of reinfections and re-positivity.

Methods: During a 6-month period, 202 PCR-confirmed recovering COVID-19 patients entered this study. Read More

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Primary membranous glomerulonephritis with negative serum PLA2R in haemophilia A successfully managed with rituximab - case report and review of the literature.

BMC Nephrol 2021 Jul 22;22(1):268. Epub 2021 Jul 22.

Department of Renal Medicine, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.

Background: Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) cause a wide range of glomerular pathologies. In people with haemophilia, transfusion-associated infections with these viruses are common and definitive pathological diagnosis in this population is complicated by the difficulty of safely obtaining a renal biopsy. Membranous nephropathy (MN) is a common cause of adult onset nephrotic syndrome occurring in both primary and secondary forms. Read More

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Field evaluation of a prototype tuberculosis lipoarabinomannan lateral flow assay on HIV-positive and HIV-negative patients.

PLoS One 2021 26;16(7):e0254156. Epub 2021 Jul 26.

Global Good Fund, Intellectual Ventures, Bellevue, Washington, United States of America.

Detection of tuberculosis at the point-of-care (POC) is limited by the low sensitivity of current commercially available tests. We describe a diagnostic accuracy field evaluation of a prototype urine Tuberculosis Lipoarabinomannan Lateral Flow Assay (TB-LAM LFA) in both HIV-positive and HIV-negative patients using fresh samples with sensitivity and specificity as the measures of accuracy. This prototype combines a proprietary concentration system with a sensitive LFA. Read More

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Exploring and comparing the structure of sexual networks affected by Neisseria gonorrhoeae using sexual partner services investigation and genomic data.

Sex Transm Dis 2021 Jul 23. Epub 2021 Jul 23.

Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA Oak Ridge Institute for Science and Education Research Participation and Fellowship Program, Oak Ridge, Tennessee, USA Division of HIV/STD/Viral Hepatitis, Indiana Department of Health, Indianapolis, Indiana, USA Bureau of Sexually Transmitted Infections, New York City Department of Health and Mental Hygiene, Queens, New York, USA City of Milwaukee Health Department Laboratory, Milwaukee, Wisconsin, USA Division of Allergy and Infectious Disease, University of Washington, Seattle, Washington, USA HIV/STD Program, Public Health - Seattle and King County, Seattle, Washington, USA Colorado Department of Public Health and Environment, Denver, Colorado, USA Department of Health, Honolulu, Hawaii, USA San Francisco Department of Public Health, San Francisco, California, USA Wake Forest University School of Medicine/Guilford County Department of Health, North Carolina, USA.

Background: Sexual networks are difficult to construct due to incomplete sexual partner data. The proximity of people within a network may be inferred from genetically similar infections. We explored genomic data combined with partner services investigation (PSI) data to extend our understanding of sexual networks affected by Neisseria gonorrhoeae (NG). Read More

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Effectiveness of syphilis partner notification after adjusting for treatment dates, 7 jurisdictions.

Sex Transm Dis 2021 Jul 24. Epub 2021 Jul 24.

Centers for Disease Control and Prevention, Atlanta, GA North Carolina Department of Health and Human Services, Raleigh, NC Florida Department of Health, Tallahassee, FL Louisiana Department of Health, New Orleans, LA Michigan Department of Health and Human Services, Detroit, MI Virginia Department of Health, Richmond, VA New York City Department of Health and Mental Hygiene, New York City, NY San Francisco Department of Public Health, San Francisco, CA.

Introduction: Disease intervention specialists (DIS) prevent syphilis by assuring treatment for patients' sex partners through partner notification (PN). Different interpretations of how to measure partners treated due to DIS efforts complicates PN evaluation. We measured PN impact by counting partners treated for syphilis after DIS interviewed the patient. Read More

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Utility of the Loop-Mediated Isothermal Amplification Assay for the Diagnosis of Visceral Leishmaniasis from Blood Samples in Ethiopia.

Am J Trop Med Hyg 2021 Jul 26. Epub 2021 Jul 26.

Mekelle University College of Health Sciences, Mekelle, Ethiopia.

Rapid and accurate diagnosis of visceral leishmaniasis (VL) is needed to initiate prompt treatment to reduce morbidity and mortality. Here, we evaluated the performance of loop-mediated isothermal amplification (LAMP) assay for the diagnosis of VL from blood in an endemic area in Ethiopia. LAMP was positive in 117/122 confirmed VL cases and negative in 149/152 controls, resulting in a sensitivity of 95. Read More

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Binge Drinking Relates to Worse Neurocognitive Functioning Among Adults Aging with HIV.

J Int Neuropsychol Soc 2021 Jul 26:1-11. Epub 2021 Jul 26.

UC San Diego, Department of Psychiatry, San Diego, CA, USA.

Objective: Given the aging population of people with HIV (PWH), along with increasing rates of binge drinking among both PWH and the general older adult population, this study examined the independent and interactive effects of HIV, binge drinking, and age on neurocognition.

Method: Participants were 146 drinkers stratified by HIV and binge drinking status (i.e. Read More

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The substantial burden of non-communicable diseases and HIV-comorbidity amongst adults: Screening results from an integrated HIV testing services clinic for adults in Soweto, South Africa.

EClinicalMedicine 2021 Aug 14;38:101015. Epub 2021 Jul 14.

Perinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Chris Hani Baragwanath Academic Hospital, Johannesburg 1864, South Africa.

Background: South Africa is disproportionately impacted by non-communicable diseases (NCDs) and HIV/AIDS. We investigated the prevalence of known/unknown NCD risk factors, HIV, and NCD risk factor-HIV comorbidity; and treatment status on known diseases to determine the prevalence of controlled/uncontrolled disease.

Methods: This cross-sectional study (June 2018-March 2019) within an integrated testing centre in Soweto, South Africa, screened adults (aged ≥18 years) for body mass index (BMI), hypertension (HT), rapid glucose and cholesterol, and HIV. Read More

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What motivates or demotivates injecting drug users to participate in hypothetical HIV vaccine efficacy trials? A qualitative study from urban Tanzania.

East Afr Health Res J 2020 26;4(2):128-139. Epub 2020 Nov 26.

Equity and Health Policy Research Group, Department of Global Public Health, KarolinskaInstitutet, Tomtebodavägen 18A, 171 77 Stockholm, Sweden.

Background: HIV vaccine efficacy trials require the active participation of volunteers who are committed and adherent to the study protocol. However, information about the influence of Injecting Drug Users (IDUs) to participate in HIV vaccine efficacy trials in low-income countries is inadequate. The present study explored the factors that motivate or hinder IDUs from participating in HIV vaccine efficacy trials in Dar es Salaam, Tanzania. Read More

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November 2020

A Qualitative Description of Community Participation in Water and Sanitation Activities in the Control of Schistosomiasis in Nyalenda B, an Informal Settlement in Kisumu City, Western Kenya.

East Afr Health Res J 2019 30;3(1):48-56. Epub 2019 Jul 30.

Neglected Tropical Diseases Branch, Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.

Background: Community participation is central to the success of primary health care. However, over 30 years since the Alma Ata declaration, the absence of universal community participation remains a major obstacle to combating all types of diseases. This study investigated community participation in water and sanitation activities towards schistosomiasis control in Nyalenda B, an informal settlement in Kisumu City. Read More

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Going Bareback: Time and Aging in a Gay-for-Pay Porn Career.

Authors:
Joseph Brennan

Sex Cult 2021 Jul 17:1-24. Epub 2021 Jul 17.

Wonga Beach, Queensland Australia.

This article explores a critical moment of in the career of arguably the biggest gay porn performer of the 2010s, Johnny Rapid. The analysis reveals a decidedly negative reception of Rapid, the promotion of bareback as event, and the quality of the bareback performance itself, all of which I read in accordance with what these narratives have to tell us about bareback at the time. Yet I also take the opportunity-writing several years after this critical moment in Rapid's career-to reflect on the success of the campaign. Read More

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Performance Comparison of Xpert HIV-1 Viral Load Assay and Roche Taqman and Abbott M2000 RT in Bamako, Mali.

J AIDS Clin Res 2020 30;11(7). Epub 2020 Jul 30.

Center for Innovation in Global Health Technologies (CIGHT), Northwestern University, Evanston, Illinois, USA.

Background: Routine monitoring of HIV-1 Viral Load (VL) is important in patients on Antiretroviral Therapy (ART) management. Access to HIV VL remains a challenge in resource-limited settings, especially in rural areas. Universal access to VL requires more simplified and less restrictive alternatives to current conventional VL methods. Read More

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Invasive aspergillosis and endocarditis.

Rev Med Interne 2021 Jul 21. Epub 2021 Jul 21.

Department of Intensive Care Unit, Groupe Hospitalier Nord Essonne, Site Longjumeau, 159, rue du Président François Mitterrand, 91160 Longjumeau, France.

Introduction: Aspergillusfumigatus can cause a systemic infection called invasive aspergillosis causing pulmonary and extra-pulmonary damage. Aspergillus endocarditis (AE) is a relatively rare disease but can be life-threatening.

Case Reports: We report here on five cases of endocarditis due to invasive aspergillosis: a 58-year-old man receiving immunosuppressive medication following a kidney graft, a 58-year-old man undergoing chemotherapy for chronic lymphocytic leukaemia, a 55-year-old man receiving corticosteroids for IgA vasculitis, a 52-year-old HIV-infected woman under no specific treatment and a 17-year-old boy under immunosuppressive therapy for auto-immune chronic neutropenia. Read More

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Should the management of high grade cervical squamous intraepithelial lesion (HSIL) be different in HIV-positive women?

AIDS Res Ther 2021 Jul 23;18(1):44. Epub 2021 Jul 23.

Department of Obstetrics and Gynecology, Saint Pierre University Hospital Brussels, Université Libre de Bruxelles (ULB), Free University of Brussels (ULB-VUB), 322 Rue Haute, 1000, Brussels, Belgium.

Background: This study compares the management and outcome of high grade squamous intraepithelial lesions (HSIL) in HIV-positive and -negative women and identifies risk factors for treatment failure.

Methods: This retrospective, controlled study includes 146 HIV-positive women, matched for HSIL, age and year of diagnosis, with 146 HIV-negative women. Differences were analysed using parametric and non-parametric tests and Kaplan-Meier survival curves. Read More

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Simultaneous determination of first-line anti-tuberculosis drugs and one metabolite of isoniazid by liquid chromatography/tandem mass spectrometry in patients with human immunodeficiency virus-tuberculosis coinfection.

Heliyon 2021 Jul 9;7(7):e07532. Epub 2021 Jul 9.

Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.

The incidence rate of tuberculosis (TB) in patients with human immunodeficiency virus (HIV) infection is 26 times higher than that in other patients. Patients with both infections require long-term combination therapy, which increases therapy complexity and might lead to serious adverse reactions and drug-drug interactions. To optimize therapy for patients with HIV and TB coinfection, we developed an ultra-high-performance liquid chromatography/tandem mass spectrometry (UHPLC-MS/MS) method to simultaneously quantify four anti-tuberculosis drugs and one isoniazid (INH) metabolite. Read More

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HIV-1-Specific CAR-T Cells With Cell-Intrinsic PD-1 Checkpoint Blockade Enhance Anti-HIV Efficacy .

Front Microbiol 2021 6;12:684016. Epub 2021 Jul 6.

State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology, Ministry of Education, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China.

Adoptive cellular immunotherapy therapy using broadly neutralizing antibody-based chimeric antigen receptor-T cells (bNAb-based CAR-T) has shown great potency and safety for the functional cure of HIV. The efficacy of bNAb-based CAR-T cells could be compromised by adaptive resistance during HIV chronic infection according to the phenomenon that cellular exhaustion was observed in endogenous cytotoxic T-lymphocytes (CTLs) along with upregulated expression of PD-1. Here, we created HIV-specific CAR-T cells using human peripheral blood mononuclear cells (PBMCs) and a 3BNC117-DNR CAR (3BD CAR) construct that enables the expression of PD-1 dominant negative receptor (DNR) and the single-chain variable fragment of the HIV-1-specific broadly neutralizing antibody 3BNC117 to target native HIV envelope glycoprotein (Env). Read More

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HPV 16 and 18 contribute to development of anal dysplasia in HIV infection irrespective of gender and sexual orientation.

HIV Med 2021 Jul 22. Epub 2021 Jul 22.

Infectious Diseases Unit, Azienda Socio Sanitaria Territoriale (ASST) Monza, San Gerardo Hospital, Monza, Italy.

Objectives: The aim of the present study was too investigate prevalence and persistence of human papilloma virus (HPV) and cytological abnormalities (CAs) in the anal swabs of people living with HIV (PLWH): men who have sex with men (MSM), men who have sex with women (MSW) and women (W).

Methods: Between March 2010 and January 2019, an anal swab for cytological and HPV genotyping tests was offered to all PLWH attending our clinic. Logistic regression analysis was conducted to identify predictors of infection. Read More

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Ending the HIV epidemic using National HIV Behavioral Surveillance (NHBS): Recommendations based on DC model.

PLoS One 2021 22;16(7):e0253594. Epub 2021 Jul 22.

Strategic Information Division, HIV/AIDS, Hepatitis, STD, and TB Administration (HAHSTA), District of Columbia Department of Health, Government of the District of Columbia, Washington, DC, United States of America.

Introduction: Social network strategies have been used by health departments to identify undiagnosed cases of HIV. Heterosexual cycle (HET4) of National HIV Behavioral Surveillance (NHBS) is a social network strategy implemented in jurisdictions. The main objectives of this research are to 1) evaluate the utility of the NHBS HET cycle data for network analysis; 2) to apply statistical analysis in support of previous HIV research, as well as to develop new research results focused on demographic variables and prevention/intervention with respect to heterosexual HIV risk; and 3) to employ NHBS data to inform policy with respect to the EHE plan. Read More

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Clinic screening for adverse childhood experiences in people living with HIV to Improve Care Delivery.

AIDS Care 2021 Jul 22:1-9. Epub 2021 Jul 22.

University of Pennsylvania School of Nursing, Philadelphia, PA, USA.

Adverse childhood experiences (ACEs) are associated with negative health outcomes; however, screening for ACEs is not routinely performed among people living with HIV (PLWH). We conducted a single-center, cross-sectional pilot study to define the (1) prevalence of ACEs in PLWH and (2) acceptability of ACEs screening in routine out-patient clinical care. One hundred participants completed screening: median age of participants was 49 years (interquartile range: 38. Read More

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Patterns of Immune Activation in HIV and Non HIV Subjects and Its Relation to Cardiovascular Disease Risk.

Front Immunol 2021 5;12:647805. Epub 2021 Jul 5.

Ezintsha, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Introduction: Insight into inflammation patterns is needed to understand the pathophysiology of HIV and related cardiovascular disease (CVD). We assessed patterns of inflammation related to HIV infection and CVD risk assessed with carotid intima media thickness (CIMT).

Methods: A cross-sectional study was performed in Johannesburg, South Africa, including participants with HIV who were virally suppressed on anti-retroviral therapy (ART) as well as HIV-negative participants who were family members or friends to the HIV-positive participants. Read More

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