9,801 results match your criteria history seizures


Is this Withdrawal or Intoxication? Case Report Regarding Complications of Unregulated Use of Tianeptine, Etizolam, and Phenibut in the USA.

CNS Spectr 2021 Apr;26(2):169

University of Arizona, Department of Psychiatry, Tucson, AZ, USA.

Background: The internet allows easy access for the sales of psychoactive agents that are not regulated by the FDA. Some of those agents are used to help manage anxiety, depression and sleep, such as tianeptine, etizolam, and phenibut. These medications have the potential for abuse and potentially leading to altered mental status when intoxicated or withdrawing. Read More

View Article and Full-Text PDF

The Challenge of Managing Patients Suffering from TBI: The Utility of Multiparametric MRI.

CNS Spectr 2021 Apr;26(2):178-179

Western University of Health Sciences, Pomona, CA, USA.

Traumatic brain injury (TBI) is a complex phenomenon affecting multiple areas of the brain in multiple ways. Both right and left hemispheres are affected as well as supratentorial and infratentorial compartments. These multifocal injuries are caused by many factors including acute mechanical injury, focal intracranial hemorrhage, blunt and rotational forces, epidural and subdural hematoma, hypoxemia, hypotension, edema, axonal damage, neuronal death, gliosis and blood brain barrier disruption. Read More

View Article and Full-Text PDF

Koolen-de Vries Syndrome: Preliminary Observations of Topiramate Efficacy.

Child Neurol Open 2021 Jan-Dec;8:2329048X211019183. Epub 2021 Jun 1.

Child Neuropsychiatry Unit, ASST Sette Laghi, Varese, Italy.

We describe the case of a baby-girl affected by the Koolen-de Vries syndrome (KdVS), with epilepsy. Our patient has microdeletions in the 17q21.31 region (array CGH). Read More

View Article and Full-Text PDF

Potential Adverse Consequences of Combination Therapy with Gabapentin and Pregabalin.

Case Rep Med 2021 2;2021:5559981. Epub 2021 Jun 2.

Kentucky College of Osteopathic Medicine, University of Pikeville, Pikeville, KY 41501, USA.

Gabapentinoids comprise the medications gabapentin and pregabalin. These were designed to not only look chemically like the central inhibitory neurotransmitter gamma-aminobutyric acid (GABA) but also act like it. The prototype gabapentin was primarily introduced to be used as antiepileptic medication. Read More

View Article and Full-Text PDF

Is sexual trauma a risk factor for functional (psychogenic) seizures?

Neurosci Biobehav Rev 2021 Jun 10. Epub 2021 Jun 10.

Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

The relationship between functional seizures (FS) and sexual trauma has received attention in many previous studies. However, the mechanisms underlying this relationship have not been elucidated yet. The purpose of this narrative review is to explore and speculate on the underpinning neurobiological mechanisms for the association and link between sexual trauma and functional seizures. Read More

View Article and Full-Text PDF

Postmortem whole-genome sequencing on a dried blood spot identifies a novel homozygous SUOX variant causing isolated sulfite oxidase deficiency.

Cold Spring Harb Mol Case Stud 2021 Jun 11;7(3). Epub 2021 Jun 11.

Rady Children's Institute for Genomic Medicine, San Diego, California 92123, USA.

Rapid whole-genome sequencing (rWGS) has shown that genetic diseases are a common cause of infant mortality in neonatal intensive care units. Dried blood spots collected for newborn screening allow investigation of causes of infant mortality that were not diagnosed during life. Here, we present a neonate who developed seizures and encephalopathy on the third day of life that was refractory to antiepileptic medications. Read More

View Article and Full-Text PDF

Genetic and Metabolic Neonatal Epilepsies.

Pediatr Ann 2021 Jun 1;50(6):e245-e253. Epub 2021 Jun 1.

Seizures are a common neonatal neurological disorder with an incidence of 1 to 5 in 1,000 live births. Genetic and metabolic epilepsies account for 10% to 12% of all neonatal seizures. Correct identification and diagnosis are important factors, as they carry treatment and management implications. Read More

View Article and Full-Text PDF

Changes in trends and outcomes of eclampsia: a success story from Qatar.

Qatar Med J 2019 20;2019(1):10. Epub 2019 Sep 20.

Women's Wellness and Research Center, Hamad Medical Corporation, Doha, Qatar.

Preeclampsia and eclampsia are two hypertensive disorders of pregnancy that significantly contribute to higher morbidity and mortality rates. Eclampsia is the occurrence of seizures in patients with preeclampsia without any previous history of seizure disorders. The incidence and prevalence of eclampsia varies, and there is scarce literature about the prevalence and trends of eclampsia in the Arabian Gulf countries. Read More

View Article and Full-Text PDF
September 2019

Case Report: Severe Adolescent Major Depressive Syndrome Turns Out to Be an Unusual Case of Anti-NMDA Receptor Encephalitis.

Front Psychiatry 2021 25;12:679996. Epub 2021 May 25.

Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a neuroinflammatory condition mediated by autoantibodies against the GluN1 subunit of the receptor. Clinically, it is characterized by a complex neuropsychiatric presentation with rapidly progressive psychiatric symptoms, cognitive deficits, seizures, and abnormal movements. Isolated psychiatric manifestations of anti-NMDAR encephalitis are rare and usually dominated by psychotic symptoms. Read More

View Article and Full-Text PDF

A novel PTRH2 missense mutation causing IMNEPD: a case report.

Hum Genome Var 2021 Jun 10;8(1):23. Epub 2021 Jun 10.

Department of Medical Genetics, Shiraz University of Medical Sciences, Shiraz, Iran.

PTRH2 deficiency is associated with an extremely rare disease, infantile-onset multisystem neurologic, endocrine, and pancreatic disease (IMNEPD). We report the first Iranian patient with IMNEPD. We detected a pathogenic variant in the PTRH2 gene (NM_016077. Read More

View Article and Full-Text PDF

Epilepsy and the smell of fear.

Epilepsy Behav 2021 Jun 7;121(Pt A):108078. Epub 2021 Jun 7.

Department of Neurology, University of Colorado, 1635 Aurora Court, Aurora, CO 80045, United States.

Objective: In our canine scent detection research involving a specific volatile organic compound (VOC) associated with human epileptic seizure, we began to suspect involvement of the primitive neural networks associated with production of a previously undescribed human alarm pheromone as the origin of our seizure scent. We hypothesized that if we presented fear-scented sweat to our canine seizure scent detection team, and they identified the fear scent as their seizure scent, then that would suggest that they are identical compounds.

Methods: Following consent and approval, sweat samples taken from volunteers associated with the Brooke Gordon Comprehensive Epilepsy Center at Denver Health were processed by the Canine Assistants (CA) service dog team that had been imprinted to recognize the unique seizure scent from our previous study. Read More

View Article and Full-Text PDF

New-onset seizures in adults: Low diagnostic yield of gadolinium contrast in initial brain MRI evaluation.

J Neuroimaging 2021 Jun 10. Epub 2021 Jun 10.

Department of Radiology, University of Colorado Hospital, Aurora, Colorado, USA.

Background And Purpose: The diagnostic utility of contrast MR-imaging in adult new-onset seizures without clinically suspected neoplasia or infection is not well defined in the literature. Imaging guidelines consider both contrast and noncontrast MR-imaging examinations appropriate in this clinical scenario. The purpose of this study was to evaluate the utility of contrast MR-sequences in evaluation of seizure in patients without suspicion for neoplasia or infection. Read More

View Article and Full-Text PDF

[Emergency department management of epileptic seizures in patients with epilepsy].

Rev Neurol 2021 Jun;72(12):419-425

Hospital Clínico Universitario Lozano Blesa, 50009 Zaragoza, España.

Aim: To analyse the care of patients with epilepsy (PwE) who visit the hospital emergency department (ED) due to an epileptic seizure.

Materials And Methods: Single-centre retrospective observational study, based on the clinical history of the PwE seen in the ED for epileptic seizures between January 2016 and December 2018. Demographic, clinical and ED management variables were collected. Read More

View Article and Full-Text PDF

Focal epilepsy due to de novo SCN1A mutation.

Epileptic Disord 2021 Jun 8. Epub 2021 Jun 8.

Service de Neurologie Pédiatrique, Hôpital Robert Debré, Paris, France, Université de Paris, INSERM U1141, F-75019, Paris, France.

Objective: Our aim was to identify patients with SCN1A-related epilepsy with a phenotype of pure focal epilepsy.

Methods: We conducted a retrospective study and a systematic review in Pubmed to identify patients with focal epilepsy associated with SCN1A pathogenic variants.

Results: We found three patients among 1,191 in our rare epilepsy database in 2017. Read More

View Article and Full-Text PDF

Electroclinical markers to differentiate between focal and generalized epilepsies.

Epileptic Disord 2021 Jun 9. Epub 2021 Jun 9.

Paediatric Neurology Division, Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, Cape Town, South Africa, Neurosciences Institute, University of Cape Town, South Africa.

Generalized-onset seizures originate at a point within the brain and rapidly engage bilaterally distributed networks, whilst focal-onset seizures originate within networks limited to one hemisphere which may be discretely localized or more widely distributed. Challenges in data capturing have resulted in a lack of consistency across incidence and prevalence studies for estimates of generalized versus focal epilepsies in population groups, with a preponderance of unclassified cases. Infants and young children can further challenge delineation due to variable expression at different stages of brain maturation and impaired ability to express sensory seizure semiology. Read More

View Article and Full-Text PDF

Association of vitamin D receptor gene polymorphisms in North Indian children with asthma: a case-control study.

Int J Mol Epidemiol Genet 2021 15;12(2):24-34. Epub 2021 Apr 15.

Department of Pediatrics, King George's Medical University Lucknow, India.

Asthma is a complex genetic disease. Vitamin D and vitamin D receptor () gene polymorphisms are involved in asthma pathogenesis. However, accurate inflammatory mechanisms and their role in gene polymorphisms are unclear. Read More

View Article and Full-Text PDF

Case Report: Identification of a Microdeletion 1q44 in a Patient With Seizures and Developmental Delay.

Front Genet 2021 20;12:648351. Epub 2021 May 20.

Department of Neurology, Children's Hospital of Nanjing Medical University, Nanjing, China.

1q44 microdeletion syndrome is difficult to diagnose due to the wide phenotypic spectrum and strong genetic heterogeneity. We explore the correlation between the chromosome microdeletions and phenotype in a child with 1q44 microdeletion syndrome, we collected the clinical features of the patient and combined them with adjacent copy number variation (CNV) regions previously reported. We collected the full medical history of the patient and summarized her clinical symptoms. Read More

View Article and Full-Text PDF

Third ventricular diverticulum of the suprapineal recess can be a rare and confounding complication of chronic hydrocephalus: A case report with 2-year follow-up.

Childs Nerv Syst 2021 Jun 6. Epub 2021 Jun 6.

Department of Neurosurgery, Aga Khan University Hospital, Karachi, Pakistan.

Purpose: Chronic hydrocephalus is rarely seen in developed countries due to the widespread availability of CT scans for diagnosis and early treatment. In developing countries, it is more frequently encountered along with its rare complication of diverticulum formation.

Methods: We report a case of a previously healthy 6 year old girl who presented with a 10 day history of headache, 3 day history of drowsiness and a single episode of generalized tonic clonic seizures. Read More

View Article and Full-Text PDF

Corpus callosotomy for drug-resistant epilepsy in a pediatric patient with Waardenburg syndrome Type I.

Surg Neurol Int 2021 10;12:217. Epub 2021 May 10.

Department of Neurosurgery, Kyushu University.

Background: Waardenburg syndrome (WS) is caused by autosomal dominant mutations. Since the coexistence of epilepsy and WS type I is rare, the detailed clinical features and treatment of epilepsy, including surgery, have not been fully reported for these patients. We report the first case of an individual with WS type I, who underwent corpus callosotomy (CC) for drug-resistant epilepsy and obtained good seizure outcomes. Read More

View Article and Full-Text PDF

Psychosocial profiles and their predictors in epilepsy using patient-reported outcomes and machine learning.

Epilepsia 2020 Jun 20;61(6):1201-1210. Epub 2020 May 20.

Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Objective: To apply unsupervised machine learning to patient-reported outcomes to identify clusters of epilepsy patients exhibiting unique psychosocial characteristics.

Methods: Consecutive outpatients seen at the Calgary Comprehensive Epilepsy Program outpatient clinics with complete patient-reported outcome measures on quality of life, health state valuation, depression, and epilepsy severity and disability were studied. Data were acquired at each patient's first clinic visit. Read More

View Article and Full-Text PDF

Assessing seizure burden in pediatric epilepsy using an electronic medical record-based tool through a common data element approach.

Epilepsia 2021 Jun 2. Epub 2021 Jun 2.

Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Objective: Improvement in epilepsy care requires standardized methods to assess disease severity. We report the results of implementing common data elements (CDEs) to document epilepsy history data in the electronic medical record (EMR) after 12 months of clinical use in outpatient encounters.

Methods: Data regarding seizure frequency were collected during routine clinical encounters using a CDE-based form within our EMR. Read More

View Article and Full-Text PDF

Brain dysfunction and thyroid antibodies: autoimmune diagnosis and misdiagnosis.

Brain Commun 2021 5;3(2):fcaa233. Epub 2021 Jan 5.

Department of Neurology, Mayo Clinic, Rochester, MN, USA.

Hashimoto encephalopathy, also known as steroid-responsive encephalopathy associated with autoimmune thyroiditis, has been defined by sub-acute onset encephalopathy, with elevated thyroid antibodies, and immunotherapy responsiveness, in the absence of specific neural autoantibodies. We aimed to retrospectively review 144 cases referred with suspected Hashimoto encephalopathy over a 13-year period, and to determine the clinical utility of thyroid antibodies in the course of evaluation of those patients. One hundred and forty-four patients (all thyroid antibody positive) were included; 72% were women. Read More

View Article and Full-Text PDF
January 2021

Toxic epidermal necrolysis and Stevens-Johnson syndrome/toxic epidermal necrolysis overlap in pediatric patients with a focus on newer antiepileptic drugs: A 25-year retrospective study at a single tertiary care center.

Pediatr Dermatol 2021 May 31. Epub 2021 May 31.

Department of Dermatology, The University of Texas Medical Branch, Galveston, TX, USA.

Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis Syndrome (TEN) are rare immune-mediated diseases. Extensive research on adult triggers of SJS and TEN is available; however, research in children is more limited.

Objective: We sought to investigate and report the experience with pediatric SJS and TEN in our center, identifying associated medications. Read More

View Article and Full-Text PDF

Cerebral Venous Thrombosis Presenting as a Subacute Headache in a Young Man With Undiagnosed Factor V Leiden Mutation.

Cureus 2021 Apr 24;13(4):e14665. Epub 2021 Apr 24.

Internal Medicine, Baptist Health-University of Arkansas for Medical Sciences, North Little Rock, USA.

Cerebral venous sinus thrombosis (CVT) is a rare but potentially life-threatening condition that presents with non-specific symptoms. This condition is more common in women and can be associated with local infection and hypercoagulable conditions, including protein C and S deficiency, factor V Leiden mutation, anti-thrombin III deficiency, thrombophilia, vasculitis, and malignancy. We report the case of a 24-year-old man who presented with a left temporal headache and right upper and lower extremity paresthesia. Read More

View Article and Full-Text PDF

Acute manic state with psychotic features in a teenager with autoimmune encephalitis: a case report.

J Med Case Rep 2021 May 31;15(1):295. Epub 2021 May 31.

Region Skåne, Child and Adolescent Psychiatry, Regional Inpatient Care, Emergency Unit, Malmö, Sweden.

Introduction: Autoimmune disorders have become increasingly acknowledged as having a more causative role in encephalitis than previously assumed. Anti-N-methyl-D-aspartate receptor encephalitis seems to be the most prevalent disorder. Symptoms of the neuropsychiatric phase in children and adolescents include abnormal behavior, seizures, and neurologic symptoms. Read More

View Article and Full-Text PDF

A study on the relationship between non-epileptic fast (40 - 200 Hz) oscillations in scalp EEG and development in children.

Brain Dev 2021 May 26. Epub 2021 May 26.

Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences and Okayama University Hospital, Okayama, Japan.

Objective: Physiological gamma and ripple activities may be linked to neurocognitive functions. This study investigated the relationship between development and non-epileptic, probably physiological, fast (40-200 Hz) oscillations (FOs) including gamma (40 - 80 Hz) and ripple (80 - 200 Hz) oscillations in scalp EEG in children with neurodevelopmental disorders.

Methods: Participants were 124 children with autism spectrum disorder (ASD) and/or attention deficit/hyperactivity disorder (ADHD). Read More

View Article and Full-Text PDF

Risk factors affecting seizure recurrence in childhood epilepsy during short-term follow-up.

Childs Nerv Syst 2021 May 28. Epub 2021 May 28.

Department of Pediatrics, Faculty of Medicine, Training and Research Hospital, Bolu Abant Izzet Baysal University, Bolu, Turkey.

Purpose: The aim of this study is to examine the factors affecting seizure recurrence in pediatric patients diagnosed with epilepsy.

Methods: Three hundred patients presenting to the pediatric neurology clinic between 2015 and 2018 and diagnosed with epilepsy and treated with single antiseizure drug were included in the study. Medical histories and clinical and laboratory findings were retrieved retrospectively from the hospital data system. Read More

View Article and Full-Text PDF

Deep-Phenotyping the Less Severe Spectrum of Deficiency and Linking the Gene to Myoclonic Atonic Seizures.

Front Genet 2021 11;12:663643. Epub 2021 May 11.

Department of Epilepsy Genetics and Personalized Medicine, Danish Epilepsy Centre, Dianalund, Denmark.

The two aims of this study were (i) to describe and expand the phenotypic spectrum of deficiency in affected individuals harboring the c.1582G>A; p.Val528Met or the c. Read More

View Article and Full-Text PDF

Tension Pneumocephalus.

R I Med J (2013) 2021 Jun 1;104(5):47-48. Epub 2021 Jun 1.

PGY3, Emergency Medicine Residency, the Alpert Medical School of Brown University, Providence, RI.

Tension pneumocephalus (TPC) is a rare but devastating intracranial condition where increased intracranial pressure due to entrapped air causes compression of the brain leading to headache, seizures, altered mental status (AMS), and death. The author presents the case of patient with a past medical history of eye-enucleation who subsequently developed TPC in the setting of occult trauma. The diagnosis was made via commuted tomography (CT) scan and the patient underwent needle and burr-hole decompression in the emergency department (ED). Read More

View Article and Full-Text PDF

Cerebrospinal fluid findings in patients with seizure in the setting of COVID-19: A review of the literature.

Seizure 2021 May 17;89:99-106. Epub 2021 May 17.

Department of Neurology, NYU Langone Medical Center, New York, NY, USA; Department of Neurosurgery, NYU Langone Medical Center, New York, NY, USA.

We reviewed the literature on cerebrospinal fluid (CSF) studies in patients who had a seizure in the setting of COVID-19 infection to evaluate for evidence of viral neuroinvasion. We performed a systematic review of Medline and Embase to identify publications that reported one or more patients with COVID-19 who had a seizure and had CSF testing preformed. The search ranged from December 1st 2019 to November 18th 2020. Read More

View Article and Full-Text PDF