Circ Genom Precis Med 2021 Apr 12. Epub 2021 Apr 12.
Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO.
- Polygenic risk scores (PRS) for coronary heart disease (CHD) may contribute to assess the overall risk of CHD. We evaluated how PRS may influence CHD risk when the distribution of age-at-onset, sex, and family health history differ significantly. - Our study included three family-based ascertainments: Long Life Family Study (LLFS, N=4,572), which represents a low CHD risk, and Family Heart Study, which consists of randomly selected families (FamHS-Random, N=1,806), and high CHD risk families (FamHS-High Risk, N=2,301). Read More