1,123,060 results match your criteria histories


Effectiveness of antibiotic prophylaxis in patients with centipede stings: a randomized controlled trial.

Clin Exp Emerg Med 2021 Mar 31;8(1):43-47. Epub 2021 Mar 31.

Department of Emergency Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Objective: Centipede stings are a common problem in tropical countries. Current treatment guidelines do not include recommendations for antibiotic prophylaxis to prevent the associated bacterial infection since no previous study has assessed the effectiveness of antibiotic treatment in patients bitten by centipedes. Thus, this study aimed to compare the effectiveness of antibiotic prophylaxis over placebo for the skin infections that occur after a centipede sting. Read More

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Hidden mover-stayer model for disease progression accounting for misclassified and partially observed diagnostic tests: Application to the natural history of human papillomavirus and cervical precancer.

Stat Med 2021 Apr 12. Epub 2021 Apr 12.

Biostatistics Branch, Division of Cancer and Epidemiology, National Cancer Institute, Rockville, Maryland, USA.

Hidden Markov models (HMMs) have been proposed to model the natural history of diseases while accounting for misclassification in state identification. We introduce a discrete time HMM for human papillomavirus (HPV) and cervical precancer/cancer where the hidden and observed state spaces are defined by all possible combinations of HPV, cytology, and colposcopy results. Because the population of women undergoing cervical cancer screening is heterogeneous with respect to sexual behavior, and therefore risk of HPV acquisition and subsequent precancers, we use a mover-stayer mixture model that assumes a proportion of the population will stay in the healthy state and are not subject to disease progression. Read More

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The number of biopsy specimens can influence the non-lifting sign in colorectal laterally spreading tumors.

Z Gastroenterol 2021 Apr 12;59(4):321-325. Epub 2021 Apr 12.

Medical School of Southeast University, Nanjing, China.

Background:  Although the problem of whether to perform a biopsy before endoscopic treatment for colorectal laterally spreading tumor (LST) troubles clinicians, about 50 % of lesions still undergo a preceding biopsy. We aimed to explore factors affecting the non-lifting sign in LST and examine the influence of "biopsy-related factors", such as the number of biopsy specimens and the interval after biopsy on non-lifting sign in cases with a history of biopsy.

Methods:  Clinical data of 159 LSTs regarding age, gender, history of biopsy, tumor location, tumor size, the depth of submucosal invasion, tumor configuration, histologic type, location with respect to the fold, and result of non-lifting sign testing were investigated retrospectively. Read More

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Short- and Mid-Term Impact of Tobacco Smoking on Donor Renal Function Following Living Kidney Donation at a Tertiary Referral Hospital.

Rev Invest Clin 2021 Apr 12. Epub 2021 Apr 12.

Department of Urology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

Background: The negative impact of tobacco smoking on renal function has been widely studied. However, there is limited knowledge about the effect of smoking on pre-operative and post-operative renal function in living kidney donors.

Objective: The objective of the study was to evaluate the short- and mid-term impact of smoking on donor renal function. Read More

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Management of BRCA Mutation Carriers With Pancreatic Adenocarcinoma.

J Natl Compr Canc Netw 2021 Apr 1;19(4):469-473. Epub 2021 Apr 1.

2Oncology Department, Hôpital Paul Brousse (AP-HP), Villejuif; and.

Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis, with a 5-year survival rate of ≤7% across all stages. Most patients are diagnosed with advanced disease and median overall survival is limited. The limited success of conventional therapies for PDAC is at least partially attributable to its genetic heterogeneity. Read More

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Painless foot drop: an unusual acute presentation of new onset type 1 diabetes mellitus.

Endocrinol Diabetes Metab Case Rep 2021 Mar 16;2021. Epub 2021 Mar 16.

Department of Diabetes and Endocrinology, Guy's and St Thomas' NHS Foundation trust, London, UK and School of Cardiovascular Medicine and Sciences, King's College London UK.

Summary: A 26-year-old Caucasian female with no past medical history or family history of auto-immune disease presented to the emergency department with new onset painless left foot drop. A panel of blood tests revealed blood glucose of 49.9 mmol/L and raised blood ketone levels. Read More

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Hypoglycemia after bariatric surgery: importance of exhaustive hormonal study.

Endocrinol Diabetes Metab Case Rep 2021 Mar 20;2021. Epub 2021 Mar 20.

Endocrinology and Nutrition, Hospital Universitari Germans Trias I Pujol, Badalona, Spain.

Summary: Hypoglycemia is an uncommon clinical problem in non-diabetic patients or patients not being treated for diabetes mellitus. It is a rare, but well-established complication of bariatric surgery and, in some cases, it can be the only symptom of another medical problem. A 50-year-old woman with a history of partially recovered hypopituitarism after transsphenoidal surgery for a non-functioning pituitary macroadenoma complained about symptomatic hypoglycemia after sleeve gastrectomy surgery. Read More

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New dammarane-type glycosides from Gynostemma pentaphyllum and their lipid-lowering activity.

Bioorg Chem 2021 Apr 1;111:104843. Epub 2021 Apr 1.

Department of Natural Medicinal Chemistry, School of TCM & State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, PR China. Electronic address:

Gynostemma pentaphyllum (Thunb.) Makino has a long history as food and diary supplement in China. At present, there are some products for hyperlipidemia in the market, including G. Read More

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An essential clinical dataset intervention for nursing documentation of a pediatric admission history database.

J Pediatr Nurs 2021 Apr 9;59:110-114. Epub 2021 Apr 9.

Old Dominion University, Norfolk, VA, United States of America.

Purpose: The purpose of this study was to improve nursing documentation efficiencies and satisfaction of a pediatric admission history workflow. Secondary aims determined if defining essential data elements was associated with decreased pediatric admission history documentation time, increased dataset completion rate, and increased satisfaction.

Design And Methods: A quasi-experimental between-group difference comparison was conducted for a nurse-led quality improvement study that included implementation of a pediatric essential clinical dataset (ECD) tool for pre/post-intervention analysis of nursing admission history documentation time, dataset completion rate, and satisfaction. Read More

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Intramedullary Schwannoma of Cervicomedullary Junction: A Case report.

Neurochirurgie 2021 Apr 9. Epub 2021 Apr 9.

Istanbul Medipol University, School of Medicine, Department of Neurosurgery, Istanbul, Turkey.

Background: Intramedullary schwannomas of brain stem and spinal cord are extremely rare. In almost all cases, homogeneous, asymmetrical or circular intensive gadolinium enhancement has been demonstrated. However, no cases reported previously with minimal contrast enhancement in cervicomedullary junction. Read More

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Hemifacial spasm caused by a tortuous recurrent perforating artery: A case report.

Neurochirurgie 2021 Apr 9. Epub 2021 Apr 9.

Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, China. Electronic address:

Introduction: When the culprit vessel in hemifacial spasm (HFS) is hard to determine, this is a challenge in microvascular decompression (MVD) surgery. In such a situation, small arteries such as perforators to the brainstem might be suspected. But small arteries are omnipresent near the facial nerve root exit/entry zone (fREZ). Read More

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Drug abuse amongst anesthetists in Brazil: a national survey.

Braz J Anesthesiol 2021 Apr 9. Epub 2021 Apr 9.

Hospital Sirio-Libanes, Serviços Médicos de Anestesia Ltda, São Paulo, SP, Brazil; Universidade de São Paulo (USP), Faculdade de Medicina (FM), Instituto do Câncer do Estado de São Paulo, Disciplina de Anestesiologia, São Paulo, SP, Brazil.

Background: The prevalence of Substance Use Disorders (SUD) and acceptance of drug testing among anesthetists in Brazil has not been determined.

Methods: An internet-based survey was performed to investigate the prevalence of SUD among anesthetists in Brazil, to explore the attitudes of anesthetists regarding whether SUD jeopardizes the health of an impaired provider or their patient, and to determine the provider's perspective regarding acceptance and effectiveness of drug testing to reduce SUD. The questionnaire was distributed via social media. Read More

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Paternal and maternal effects in a mosquito: A bridge for life history transition.

J Insect Physiol 2021 Apr 9:104243. Epub 2021 Apr 9.

Florida Medical Entomology Laboratory, Entomology and Nematology Department, Institute of Food and Agricultural Sciences, University of Florida, Vero Beach, FL 32962, USA. Electronic address:

Parental (transgenerational) effects occur when the conditions experienced by a mother or father contribute to offspring phenotype. Here we show that parental larval diet in mosquitoes, Aedes aegypti, results in differential allocation of resources in offspring of parents depending on the nutritional condition (quality) of their mate. Maternal effects influenced the number of eggs produced by females as well as their lipid investment. Read More

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TNM 8 staging is a better prognosticator than TNM 7 for patients with locally advanced oral cavity squamous cell carcinoma treated with surgery and post-operative radiotherapy.

Radiother Oncol 2021 Apr 9. Epub 2021 Apr 9.

Department of Clinical Oncology, Guy's and St Thomas, NHS Trust London, UK; King's College London, UK.

Purpose: To assess TNM 8 staging in discriminating overall survival (OS) amongst patients with locally advanced oral cavity squamous cell carcinoma (OCSCC) treated with surgery and post-operative radiotherapy (PORT), compared to TNM 7.

Material And Methods: Data from OCSCC patients treated with surgery and PORT between January 2010 and December 2018 were reviewed. Demographics, tumour characteristics and treatment response data were collected, and patients staged according to both TNM 7 and TNM 8. Read More

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Classification criteria for Vogt-Koyanagi-Harada Disease.

Am J Ophthalmol 2021 Apr 9. Epub 2021 Apr 9.

the Department of Medicine, Texas A&M University, College Station, TX, USA.

Purpose: To determine classification criteria for Vogt-Koyanagi-Harada (VKH) disease DESIGN: Machine learning of cases with VKH disease and 5 other panuveitides.

Methods: Cases of panuveitides were collected in an informatics-designed preliminary database, and a final database was constructed of cases achieving supermajority agreement on the diagnosis, using formal consensus techniques. Cases were split into a training set and a validation set. Read More

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Classification criteria for Sympathetic Ophthalmia.

Am J Ophthalmol 2021 Apr 9. Epub 2021 Apr 9.

Department of Medicine, Texas A&M University, College Station, TX, USA.

Purpose: To determine classification criteria for sympathetic ophthalmia DESIGN: Machine learning of cases with sympathetic ophthalmia and 5 other panuveitides.

Methods: Cases of panuveitides were collected in an informatics-designed preliminary database, and a final database was constructed of cases achieving supermajority agreement on the diagnosis, using formal consensus techniques. Cases were split into a training set and a validation set. Read More

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Classification criteria for spondyloarthritis/HLA-B27-associated anterior uveitis.

Am J Ophthalmol 2021 Apr 9. Epub 2021 Apr 9.

the Department of Medicine, Texas A&M University, College Station, TX, USA.

Purpose: To determine classification criteria for spondyloarthritis/HLA-B27-associated anterior uveitis DESIGN: Machine learning of cases with spondyloarthritis/HLA-B27-associated anterior uveitis and 8 other anterior uveitides.

Methods: Cases of anterior uveitides were collected in an informatics-designed preliminary database, and a final database was constructed of cases achieving supermajority agreement on the diagnosis, using formal consensus techniques. Cases were split into a training set and a validation set. Read More

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SARS-CoV-2 infection rates of antibody-positive compared with antibody-negative health-care workers in England: a large, multicentre, prospective cohort study (SIREN).

Lancet 2021 Apr 9. Epub 2021 Apr 9.

Public Health England Colindale, Colindale, London, UK; The National Institute for Health Research Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance at the University of Oxford, University of Oxford, Oxford, UK.

Background: Increased understanding of whether individuals who have recovered from COVID-19 are protected from future SARS-CoV-2 infection is an urgent requirement. We aimed to investigate whether antibodies against SARS-CoV-2 were associated with a decreased risk of symptomatic and asymptomatic reinfection.

Methods: A large, multicentre, prospective cohort study was done, with participants recruited from publicly funded hospitals in all regions of England. Read More

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Myelofibrosis: challenges for preclinical models and emerging therapeutic targets.

Expert Opin Ther Targets 2021 Apr 12. Epub 2021 Apr 12.

Division of Hematology, Mayo Clinic, Rochester, MN, USA.

: Myelofibrosis (MF) is characterized by anemia, splenomegaly, constitutional symptoms and bone marrow fibrosis. MF has no curative treatment to date, except for a small subset of patients that are eligible for allogeneic hematopoietic stem cell transplant. The discovery in recent years of the MF mutational landscape and the role of bone marrow microenvironment in disease pathogenesis has led to further insights into disease biology and consequentially rationally derived therapies. Read More

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Development and Validation of a Clinical Diagnostic Scoring System for the Diagnosis of IPF.

Ann Am Thorac Soc 2021 Apr 12. Epub 2021 Apr 12.

Inova Fairfax Hospital, 23146, Advanced Lung Disease Program, Falls Church, Virginia, United States.

Rationale: Interpreting the radiological data in conjunction with an objective clinical score could help to harmonize IPF diagnostic and improve accuracy.

Objectives: We sought to establish and validate a multivariable objective scoring model based on clinical parameters, by stratifying the risk for patients to be diagnosed as IPF versus other forms of interstitial lung disease (ILD).

Methods: A clinical score was derived from review of patients evaluated at the Inova Fairfax ILD program and validated in three distinct cohorts. Read More

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Heterogeneity of the Predictive Polygenic Risk Scores for Coronary Heart Disease Age-at-onset in Three Different CHD Family-based Ascertainments.

Circ Genom Precis Med 2021 Apr 12. Epub 2021 Apr 12.

Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO.

- Polygenic risk scores (PRS) for coronary heart disease (CHD) may contribute to assess the overall risk of CHD. We evaluated how PRS may influence CHD risk when the distribution of age-at-onset, sex, and family health history differ significantly. - Our study included three family-based ascertainments: Long Life Family Study (LLFS, N=4,572), which represents a low CHD risk, and Family Heart Study, which consists of randomly selected families (FamHS-Random, N=1,806), and high CHD risk families (FamHS-High Risk, N=2,301). Read More

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Associations between Gilbert's syndrome and personality characteristics.

Trends Psychiatry Psychother 2021 Apr 2. Epub 2021 Apr 2.

Department of Gastroenterology, Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey.

Objective: Gilbert's syndrome (GS) is a benign genetic disorder that is characterized by intermittent mild jaundice in which the liver doesn't process bilirubin properly. The aim of this study was to determine whether GS patients have a different personality structure and if there are associations between properties of temperament and character and total bilirubin levels.

Methods: A total of 1665 young male individuals aged from 19 to 30 who were admitted for occupational examinations were included in this study. Read More

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Active search of adult patients with persistently low serum alkaline phosphatase levels for the diagnosis of hypophosphatasia.

Arch Endocrinol Metab 2021 Apr 12. Epub 2021 Apr 12.

Divisão de Endocrinologia, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.

Objective: Alkaline phosphatase (ALP) is the main laboratory marker of hypophosphatasia (HPP), a rare disease unknown to most physicians. The prevalence of HPP has been widely discussed in the literature due to the diverse phenotypes of HPP. The purpose of this study was to search for patients with hypophosphatasemia based on previous biochemistry tests and reevaluate them to confirm the diagnosis of HPP. Read More

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Cost-effectiveness of risk-based breast cancer screening: A systematic review.

Int J Cancer 2021 Apr 12. Epub 2021 Apr 12.

Division of Health Economics, German Cancer Research Center (DKFZ), Heidelberg, Germany.

To analyse published evidence on the economic evaluation of risk-based screening (RBS), a full systematic literature review was conducted. After a quality appraisal, we compared the cost-effectiveness of risk-based strategies (low-risk, medium-risk, and high-risk) with no screening and age-based screening. Studies were also analysed for modelling, risk stratification methods, input parameters, data sources, and harms and benefits. Read More

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MOLECULAR INVESTIGATION AND PHYLOGENETIC ANALYSIS OF ANAPLASMOSIS IN DOGS.

J Parasitol 2021 Mar;107(2):295-303

Department of Clinical Medicine and Surgery University of Veterinary and Animal Sciences, Lahore, Pakistan.

Anaplasmosis is a widespread vector-borne disease affecting dogs, and Anaplasma platys is the major etiological agent of the disease. The study examines anaplasmosis molecular prevalence, related risk factors, and alteration of hematological variables in Anaplasma-affected dogs. A total of 150 blood samples were collected from dogs in the district of Lahore, Pakistan. Read More

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[Commitment of the central nervous system by Eikenella corrodens. Literature review about a clinical case].

Rev Chilena Infectol 2021 Feb;38(1):119-125

Pontificia Universidad Católica de Chile, Chile.

We present the case of a 22-year-old patient with no morbid history who developed a brain abscess secondary to endocarditis due to Eikenella corrodens. The diagnosis was established by detecting the microorganism by universal polymerase chain reaction in fluid from the brain collection. Trans-esophageal echocardiogram study confirmed vegetations in the mitral valve. Read More

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February 2021

[Taurolidine for the prevention of catheter-related infections in children with intestinal insufficiency: preliminary experience in a Chilean tertiary hospital].

Rev Chilena Infectol 2021 Feb;38(1):15-21

Hospital Gustavo Fricke, Universidad de Valparaíso, Viña del Mar, Chile.

Background: Taurolidine is a molecule with anti-endotoxic, anti-microbial and anti-inflammatory properties that inhibits bacterial adhesion, allowing for its use as lock therapy for the prevention of catheter-related bloodstream infections (CRBSI) in long-term central venous catheters (CVC).

Aim: To report a preliminary experience, the first one in Chile, using lock therapy with taurolidine for the prevention of CRBSI and to report its efficacy.

Method: A taurolidine-based solution was instilled in the CVC of three children with intestinal insufficiency dependent on parenteral nutrition, attended in a Chilean tertiary hospital, and the rate of CRBSI before and after its use was compared in retrospect. Read More

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February 2021

[Cushing syndrome caused by a giant adrenal carcinoma. Report of one case].

Rev Med Chil 2020 Nov;148(11):1679-1683

Facultad de Medicina, Universidad de Antofagasta, Antofagasta, Chile.

We report a previously healthy 34-year-old woman, presenting with a seven-month history of arterial hypertension, amenorrhea, weight gain, facial edema, acne, hirsutism and low back pain. A CT scan showed a right adrenal mass of 18 × 13 × 12.5 cm, and multiple vertebral and rib fractures. Read More

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November 2020