18,262 results match your criteria histological parameters


Leaf powder supplementation of Senna alexandrina ameliorates oxidative stress, inflammation, and hepatic steatosis in high-fat diet-fed obese rats.

PLoS One 2021 20;16(4):e0250261. Epub 2021 Apr 20.

Department of Pharmaceutical Sciences, North South University, Dhaka, Bangladesh.

Obesity is an enduring medical issue that has raised concerns around the world. Natural plant extracts have shown therapeutic potential in preventing oxidative stress and inflammation related to obesity complications. In this study, Senna alexandrina Mill. Read More

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Mechanisms in cochlear hair cell mechano-electrical transduction for acquisition of sound frequency and intensity.

Cell Mol Life Sci 2021 Apr 19. Epub 2021 Apr 19.

School of Life Sciences, Tsinghua University, 1 Qinghuayuan, Beijing, 100084, China.

Sound signals are acquired and digitized in the cochlea by the hair cells that further transmit the coded information to the central auditory pathways. Any defect in hair cell function may induce problems in the auditory system and hearing-based brain function. In the past 2 decades, our understanding of auditory transduction has been substantially deepened because of advances in molecular, structural, and functional studies. Read More

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Impact of COVID-19 On Breast Cancer Management: A Radiological Prespective from A Tertiary Centre.

Eur J Breast Health 2021 Apr 31;17(2):180-187. Epub 2021 Mar 31.

Department of Radiodiagnosis, All India Institute of Medical Science Rishikesh, Rishikesh, India.

Objective: The coronavirus-2019 (COVID-19) pandemic caused delaying breast cancer management, increasing time interval in chemotherapy cycles and surgery. This has implications on radiological manifestation of cancer. Further, we evaluated changes observed in mammography. Read More

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Phytochemical and toxicological evaluations of (GUILL. and PERR.) extract on albino wistar rats.

Toxicol Res 2021 Apr 6;37(2):183-195. Epub 2020 Jul 6.

Institute of Agro-Products Processing, Jiangsu Academy of Agricultural Sciences, Nanjing, Jiangsu China.

In this study, we investigated the phytochemical and toxicological impacts of the ethanol leaf extract of in albino rats. Preliminary phytochemical analysis was done using established methods. Acute and 28-day sub-chronic toxicity evaluations of the extract were carried out in wistar rats. Read More

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Cigarette smoke exposure causes systemic and autonomic cardiocirculatory changes in rats depending on the daily exposure dose.

Life Sci 2021 Apr 14:119498. Epub 2021 Apr 14.

Medical School, University of Ribeirão Preto, Ribeirão Preto, SP, Brazil. Electronic address:

Aims: To evaluate the systemic changes and autonomic cardiocirculatory control of awaken rats chronically exposed to the cigarette smoke (CS) of 1 or 2 cigarettes/day.

Main Methods: Rats were exposed to clean air (control) or cigarette smoke of 1 (CS1) or 2 (CS2) cigarettes/animal/day for 30 days. Then, arterial pressure (AP) and heart rate (HR) were recorded in conscious rats to assess spontaneous baroreflex sensitivity and HR and AP variabilities. Read More

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Temporal evolution of the biological response to laser-induced refractive index change (LIRIC) in rabbit corneas.

Exp Eye Res 2021 Apr 14:108579. Epub 2021 Apr 14.

The Institute of Optics, University of Rochester, Rochester, NY, 14627, USA; The Center for Visual Science, University of Rochester, Rochester, NY, 14627, USA; The Flaum Eye Institute, University of Rochester, Rochester, NY, 14642, USA. Electronic address:

Laser induced refractive index change (LIRIC) is a new, non-incisional, non-ablative, femtosecond photo-modification technique being developed for vision correction in humans. Prior, ex-vivo studies showed intra-tissue refractive index change to induce minimal cell death, restricted to the laser focal zone in the corneal stroma, and with no observable damage to the epithelium or endothelium. Here, we used live rabbits to ascertain longer-term consequences of LIRIC in vivo. Read More

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Three-Dimensional Bioprinting Scaffolding for Nasal Cartilage Defects: A Systematic Review.

Tissue Eng Regen Med 2021 Apr 17. Epub 2021 Apr 17.

Multidisciplinary 3D Printing Platform (3DPP), Biodonostia Health Research Institute, 20014, San Sebastian, Spain.

Background: In recent years, three-dimensional (3D)-printing of tissue-engineered cartilaginous scaffolds is intended to close the surgical gap and provide bio-printed tissue designed to fit the specific geometric and functional requirements of each cartilage defect, avoiding donor site morbidity and offering a personalizing therapy.

Methods: To investigate the role of 3D-bioprinting scaffolding for nasal cartilage defects repair a systematic review of the electronic databases for 3D-Bioprinting articles pertaining to nasal cartilage bio-modelling was performed. The primary focus was to investigate cellular source, type of scaffold utilization, biochemical evaluation, histological analysis, in-vitro study, in-vivo study, animal model used, length of research, and placement of experimental construct and translational investigation. Read More

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Embryonic thermal manipulation of Japanese quail: effects on embryonic development, hatchability, and post-hatch performance.

Trop Anim Health Prod 2021 Apr 16;53(2):263. Epub 2021 Apr 16.

Anatomy and Embryology Department, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt.

Embryonic thermal manipulation led to several modifications in molecular, physiological, and biochemical parameters which affect pre- and post-hatch growth performance. The current study aims to elucidate the onset and long-term effects of intermittent thermal manipulations (TM) during two-time windows, early/late, of embryogenesis in Japanese quail (Coturnix japonica) on embryonic development, hatchability, muscle histogenesis, and post-hatch growth performance. Four groups were created; quail eggs in the control group were incubated at 37. Read More

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Pilot study on the effects of low intensity focused ultrasound in a swine model of neuropathic pain.

J Neurosurg 2021 Apr 16:1-8. Epub 2021 Apr 16.

Departments of1Neurosurgery.

Objective: The authors' laboratory has previously demonstrated beneficial effects of noninvasive low intensity focused ultrasound (liFUS), targeted at the dorsal root ganglion (DRG), for reducing allodynia in rodent neuropathic pain models. However, in rats the DRG is 5 mm below the skin when approached laterally, while in humans the DRG is typically 5-8 cm deep. Here, using a modified liFUS probe, the authors demonstrated the feasibility of using external liFUS for modulation of antinociceptive responses in neuropathic swine. Read More

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Histopathological, hematological, and biochemical changes in high-latitude fish Phoxinus lagowskii exposed to hypoxia.

Fish Physiol Biochem 2021 Apr 16. Epub 2021 Apr 16.

Key Laboratory of Biodiversity of Aquatic Organisms, College of Life Science and Technology, Harbin Normal University, Harbin, 150025, China.

Hypoxia is one of the most significant threats to biodiversity in aquatic systems. The ability of high-latitude fish to tolerate hypoxia with histological and physiological responses is mostly unknown. We address this knowledge gap by investigating the effects of exposures to different oxygen levels using Phoxinus lagowskii (a high-latitude, cold-water fish) as a model. Read More

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Effect of capacitive radiofrequency on the dermis of the abdominal region.

Lasers Med Sci 2021 Apr 16. Epub 2021 Apr 16.

Department of Applied Physiotherapy, Institute of Health Sciences, Federal University of Triângulo Mineiro, Rua Vigário Carlos, 100, 4° andar, sala 407, Uberaba, CEP-38025-350, Brazil.

The purpose of this study is to evaluate the effects of radiofrequency (RF) on sagging skin. This is a case series study with five volunteers who received a single application of capacitive RF (BTL-6000 TR-Therapy Pro®) in the right infraumbilical abdominal region, with epidermal temperature above 40°C, for 10 min (2 min per applicator area), and the skin of the contralateral region was used as control. After 30 days, on average, the skin of the abdominal region was collected for histological analysis and stained with hematoxylin and eosin, Picro-sirus, and Verhoff. Read More

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PSMA Expression in Glioblastoma as a Basis for Theranostic Approaches: A Retrospective, Correlational Panel Study Including Immunohistochemistry, Clinical Parameters and PET Imaging.

Front Oncol 2021 30;11:646387. Epub 2021 Mar 30.

Department of Neurosurgery, University Hospital, LMU Munich, Munich, Germany.

Aim: The aim of the current study was to enlighten the evolution of prostate-specific membrane antigen (PSMA) expression in glioblastoma between initial diagnosis and recurrence in order to provide preliminary insight for further clinical investigations into innovative PSMA-directed treatment concepts in neuro-oncology.

Methods: Patients who underwent resection for de-novo glioblastoma (GBM) and had a re-resection in case of a recurrent tumor following radiochemotherapy and subsequent chemotherapy were included (n = 16). Histological and immunohistochemical stainings were performed at initial diagnosis and at recurrence (n = 96 tissue specimens). Read More

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Cevimeline-induced anti-inflammatory effect through upregulations of mucins in the ocular surface of a dry eye mouse model.

Biomed Pharmacother 2021 Apr 13;139:111571. Epub 2021 Apr 13.

T2B infrastructure Center for Ocular Disease, Inje University Busan Paik Hospital, Busan 47392, Republic of Korea; Department of Ophthalmology, Inje University College of Medicine, Inje University Busan Paik Hospital, Busan 47392, Republic of Korea. Electronic address:

This study aimed to investigate the effects of various concentrations of cevimelines (CVMs) and compare them with commercial drugs in a murine model of dry eye. The experimental mouse model used male and female NOD.B10. Read More

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A conceptual framework linking immunology, pathology, and clinical features in primary membranous nephropathy.

Kidney Int 2021 Apr 12. Epub 2021 Apr 12.

Department of Medicine, Section of Nephrology, Boston University School of Medicine, Boston Medical Center, 650 Albany St Evans Biomed Research Ctr, Boston, MA 02118. Electronic address:

Primary membranous nephropathy (PMN) is a leading cause of adult nephrotic syndrome. The field took a major step forward with the identification of phospholipase A2 receptor (PLA2R) as target antigen in the majority of cases and with the ability to measure circulating autoantibodies to this protein (aPLA2R). Since then, the existence of additional target antigens such as thrombospondin type-1 domain containing 7A, exostosin 1 and 2, NELL-1, Semaphorin-3B has been demonstrated. Read More

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Response of eosinophilic oesophagitis to proton pump inhibitors is associated with impedance-pH parameters implying anti-reflux mechanism of action.

Aliment Pharmacol Ther 2021 Apr 15. Epub 2021 Apr 15.

Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, University of Padova, Padua, Italy.

Background: Proton pump inhibitors (PPIs) are effective therapies for eosinophilic oesophagitis (EoE), but the mechanism of action is uncertain. At on-PPI impedance-pH monitoring, improvement in oesophageal chemical clearance assessed with post-reflux swallow-induced peristaltic wave (PSPW) index characterises PPI-responsive EoE and reflux disease. Off-PPI, higher efficacy of the oesophago-salivary reflex as measured with PSPW-associated pH increments characterises PPI-responsive reflux disease and could typify PPI-responsive EoE as well. Read More

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Food restriction reduces hepatic alterations associated with experimental periodontitis.

J Periodontol 2021 Apr 15. Epub 2021 Apr 15.

Laboratory of Histological Analysis and Preparation (LAPHis), Federal University of the Parnaiba Delta (UFDPar), Parnaíba, PI, Brazil.

Background: Periodontitis is a chronic inflammatory and multifactorial disease that affects the periodontal structures and can cause alterations in the hepatic tissue. The aim of the present study was to evaluate whether a diet with food restriction can decrease oral and liver alterations associated with ligature-induced periodontitis.

Methods: Twenty-four female Wistar rats were used in this study, randomized into three groups (n = 8 for each group): control (regular food); periodontitis (regular food + periodontitis induced with ligatures) and food restriction (diet with food restriction and periodontitis induction). Read More

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and Effects of Light Therapy on Cartilage Regeneration for Knee Osteoarthritis: A Systematic Review.

Cartilage 2021 Apr 15:19476035211007902. Epub 2021 Apr 15.

Center for Micro-ElectroMechanical Systems (CMEMS-UMINHO), University of Minho, Guimarães, Portugal.

Objective: To analyze the effects of light therapy (LT) on cartilage repair for knee osteoarthritis (OA) treatment.

Design: The PubMed, Embase, Scopus, and Web of Science databases were searched up to August 31, 2020 to identify and studies that analyzed the effects of LT on knee cartilage for OA treatment. The study and sample characteristics, LT intervention parameters and posttreatment outcomes were analyzed. Read More

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Metabolic fate and cardiometabolic effects of phenolic compounds from red-fleshed apple in hypercholesterolemic rats: A comparative study with common white-fleshed apple. The AppleCOR Study.

Mol Nutr Food Res 2021 Apr 14:e2001225. Epub 2021 Apr 14.

Food Technology Department, XaRTA-TPV, Agrotecnio Center, Escola Tècnica Superior d'Enginyeria Agrària, University of Lleida. Avda/ Alcalde Rovira Roure 191, Catalonia, 25198-Lleida, Spain.

The present study aimed to investigate the metabolic fate and the cardiometabolic effects of phenolic compounds (PC) provided by a red-fleshed apple variety biofortified in anthocyanins (ACN). Wistar rats were feed with high-fat diet (HFD) to induce hypercholesterolemia and supplemented with red-fleshed apple (HFD+R), white-fleshed apple (HFD+W) or an ACN-rich infusion from aronia fruit (HFD+A) providing matched content and profile of ACN. Plasma biochemical parameters, histological analysis and phenol biological metabolites were determined. Read More

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High-resolution three-dimensional visualization of hepatic sinusoids in cirrhotic rats via serial histological sections.

Histol Histopathol 2021 Apr 14:18339. Epub 2021 Apr 14.

School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin, China.

Aim: As a specialized intraparenchymal vascular conduit, hepatic sinusoids play a key role in liver microcirculation. This study aimed to explore the three-dimensional (3D) morphological changes of cirrhotic sinusoids by serial histological sections.

Methods: Cirrhosis was induced by tail vein injection of albumin in Wistar rats with a positive antibody. Read More

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[Role of prostacyclin and thromboxane A2 in pulmonary hyper-permeability induced by mechanical ventilation in rabbits].

Nan Fang Yi Ke Da Xue Xue Bao 2021 Mar;41(3):418-423

Department of Anesthesiology, First People's Hospital of Yunnan Province, Kunming 650032, China.

Objective: To explore the role of prostacyclin (PGI2) and thromboxane A2 (TXA2) in lung hyper-permeability induced by mechanical ventilation (MV) in rabbits.

Objective: Forty-eight healthy Japanese white rabbits were randomly allocated to vehicle treatment group (group V), tranylcypromine (a PGI2 synthase inhibitor) treatment group (group T), dazoxiben (a TXA2 synthase inhibitor) treatment group (group D), vehicle-treated MV group (group VM), tranylcyprominetreated MV group (group TM) and dazoxiben-treated MV group (group DM). The contents of PGI2 and TXA2 in the lung tissues and TNF-α level in BALF and lung tissues were measured by ELISA. Read More

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Lugol's solution but not formaldehyde affects bone microstructure and bone mineral density parameters at the insertion site of the rotator cuff in rats.

J Orthop Surg Res 2021 Apr 13;16(1):254. Epub 2021 Apr 13.

Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria.

Background: This study aimed to investigate whether rodent shoulder specimens fixed in formaldehyde for histological and histomorphometric investigations and specimens stained using Lugol's solution for soft tissue visualization by micro-computed tomography (microCT) are still eligible to be used for bone architecture analysis by microCT.

Methods: In this controlled laboratory study, 11 male Sprague-Dawley rats were used. After sacrifice and exarticulation both shoulders of healthy rats were assigned into three groups: (A) control group (n = 2); (B) formaldehyde group (n = 4); (C) Lugol group (n = 5). Read More

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Chronic scrotal hyperthermia induces azoospermia and severe damage to testicular tissue in mice.

Acta Histochem 2021 Apr 10;123(4):151712. Epub 2021 Apr 10.

Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Scrotal hyperthermia leads to altered spermatogenesis due to heat-related oxidative stress. One of the main causes of infertility in men is oxidative stress, which refers to an imbalance in the levels of reactive oxygen species (ROS) and antioxidants. Therefore, this study aimed to evaluate the effects of chronic scrotal hyperthermia on testicular tissue structure, sperm parameters, and oxidative stress in adult mice. Read More

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Diagnostic Performance of FibroTouch Ultrasound Attenuation Parameter and Liver Stiffness Measurement in Assessing Hepatic Steatosis and Fibrosis in Patients With Nonalcoholic Fatty Liver Disease.

Clin Transl Gastroenterol 2021 Apr 13;12(4):e00323. Epub 2021 Apr 13.

Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Introduction: To evaluate the diagnostic performance of ultrasound attenuation parameter (UAP) and liver stiffness measurement (LSM) by FibroTouch for diagnosis of hepatic steatosis and fibrosis in patients with nonalcoholic fatty liver disease (NAFLD).

Methods: We recruited 237 patients undergoing FibroTouch and liver biopsy within 2 weeks. The pathological findings of liver biopsy were scored by Nonalcoholic Steatohepatitis Clinical Research Network, and the diagnostic accuracy of UAP for steatosis and LSM for fibrosis was evaluated by area under the receiver operating characteristic curve (AUROC). Read More

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Feeding pattern, biochemical, anthropometric and histological effects of prolonged access to sucrose, honey and glucose-fructose solutions in Wistar rats.

Nutr Res Pract 2021 Apr 3;15(2):187-202. Epub 2020 Dec 3.

Instituto de Investigaciones en Comportamiento Alimentario y Nutrición, Centro Universitario del Sur, Universidad de Guadalajara, Z.C. 49000, City Guzmán, Municipio de Zapotlán el Grande, Jalisco, México.

Background/objectives: The exposure to sucrose in rats has mimic abnormalities attributed to metabolic syndrome (MetS). The effects of honey bee and "free" glucose and fructose, have not been explored in this context. The aim was to expose Wistar rodents to sucrose solution (SS), honey solution (HS) and fructose/glucose solution (GFS) at 30% to assess their effects. Read More

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Contribution of Clinically Indicated Repeat Renal Biopsy in Indian Patients with Lupus Nephritis.

Indian J Nephrol 2020 Nov-Dec;30(6):377-381. Epub 2020 Feb 11.

Department of Histopathology, PGIMER, Chandigarh, India.

Background: Repeat renal biopsy is usually done for lupus nephritis (LN) flare or resistant disease. We analyzed the changes between first and repeat biopsy and the contribution of repeat biopsy on renal outcome in LN patients.

Methods: This was a retrospective study carried out at a tertiary care center in India. Read More

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February 2020

The effect of astaxanthin on testicular torsion-detorsion injury in rats - Detailed morphometric evaluation of histological sections.

J Pediatr Urol 2021 Mar 27. Epub 2021 Mar 27.

Department of Histology and Embriology, University of Zagreb, School of Medicine, Šalata 3, Zagreb, 10000, Croatia.

Introduction: Testicular torsion is one of the conditions of the acute scrotum that requires immediate surgical intervention. If not recognized at time, it can result of ischemic injuries and testicular loss. Restoration of blood flow is essential to save ischemic tissue, but reperfusion itself paradoxically causes further damage. Read More

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Loss of function of lysosomal acid lipase (LAL) profoundly impacts osteoblastogenesis and increases fracture risk in humans.

Bone 2021 Apr 7;148:115946. Epub 2021 Apr 7.

Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074, USA; Center for Bone Biology, Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address:

Lysosomal acid lipase (LAL) is essential for cholesteryl ester (CE) and triacylglycerol (TAG) hydrolysis in the lysosome. Clinically, an autosomal recessive LIPA mutation causes LAL deficiency (LALD), previously described as Wolman Disease or Cholesteryl Ester Storage Disease (CESD). LAL-D is associated with ectopic lipid accumulation in the liver, small intestine, spleen, adrenal glands, and blood. Read More

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Copper chloride inhibits brush border membrane enzymes, alters antioxidant and metabolic status and damages DNA in rat intestine: a dose-dependent study.

Environ Sci Pollut Res Int 2021 Apr 10. Epub 2021 Apr 10.

Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, UP, 202002, India.

Copper (Cu) is an extensively used heavy metal and an indispensible micronutrient for living beings. However, Cu is also toxic and exerts multiple adverse health effects when humans are exposed to high levels of this metal. We have examined the effect of single acute oral dose of copper chloride (CuCl) on parameters of oxidative stress, cellular metabolism, membrane and DNA damage in rat intestine. Read More

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The feasibility of a radial turbo-spin-echo T2 mapping for preoperative prediction of the histological grade and lymphovascular space invasion of cervical squamous cell carcinoma.

Eur J Radiol 2021 Apr 1;139:109684. Epub 2021 Apr 1.

MR Collaboration, Siemens Healthcare Ltd., Beijing, China.

Purpose: The study aimed to analyze the feasibility of a radial turbo-spin-echo (TSE) T2 mapping to differentiate the histological grades and lymphovascular space invasion (LVSI) of cervical squamous cell carcinoma (CSCC) in comparison with diffusion-weighted imaging (DWI).

Methods: A total of 58 patients with CSCC and 40 healthy volunteers underwent T2 mapping and DWI before therapy. The T2 and apparent diffusion coefficient (ADC) values were calculated using different tumor characteristics. Read More

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The ameliorative role of Physalis pubescens L. against neurological impairment associated with streptozotocin induced diabetes in rats.

Metab Brain Dis 2021 Apr 9. Epub 2021 Apr 9.

Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt.

Neuropathy is considered a critical complication of diabetes mellitus (DM). Scientific studies are needed to relieve these painful complications. The current study aims to estimate the ameliorative role of Physalis juice (PJ) against neurological impairment in streptozotocin (STZ)-induced diabetic rats. Read More

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