21,873 results match your criteria histological examinations


Determination of neuron-specific enolase in patients with midgut-type tumour treated with somatostatin analogues.

Endokrynol Pol 2021 Jul 22. Epub 2021 Jul 22.

Department of Endocrinology, Metabolism, and Internal Diseases, Poznan University of Medical Sciences, Poznan, Poland.

Introduction: The biochemical diagnosis of neuroendocrine tumours (NETs) uses assays of specific and nonspecific markers. Nonspecific markers include, among others, neuron-specific enolase (NSE). The aim of this study was to evaluate NSE in patients with midgut type tumours treated with somatostatin analogues. Read More

View Article and Full-Text PDF

B -Corrected T1 Mapping in Lung Cancer: Repeatability, Reproducibility, and Identification of Histological Types.

J Magn Reson Imaging 2021 Jul 22. Epub 2021 Jul 22.

Siemens Healthineers Digital Technology Co., Ltd, Shanghai, China.

Background: T1 mapping can potentially quantitatively assess the intrinsic properties of tumors. B correction can reduce the magnetic field inhomogeneity.

Purpose: To assess the repeatability and reproducibility of B -corrected T1 mapping for lung cancer and the ability to identify pathological types. Read More

View Article and Full-Text PDF

Vaginal collagen I and III changes after carbon dioxide laser application in postmenopausal women with the genitourinary syndrome: a pilot study.

Climacteric 2021 Jul 22:1-9. Epub 2021 Jul 22.

Department of Obstetrics and Gynecology, University of Zaragoza Faculty of Medicine, Zaragoza, Spain.

Objective: The aim of the study was to evaluate the clinical response and collagen remodeling in the vaginal wall after three sessions of carbon dioxide (CO) laser application.

Methods: Fourteen postmenopausal women with vulvovaginal atrophy, aged 45-65 years and sexually active, were evaluated with clinical questionnaires, gynecological examinations and histological techniques before and after 20 weeks of treatment (ClinicalTrials.gov NCT03939078). Read More

View Article and Full-Text PDF

Communication Strategies in Mohs Micrographic Surgery: A Survey of Methods, Time Savings, and Perceived Patient Satisfaction.

Cutis 2021 May;107(5):249-252

Dr. Yousefi is from the University of Michigan Medical School, College of Medicine, Ann Arbor. Drs. McLawhorn, Quinn, Chen, Stasko, and Collins as well as Mr. Stubblefield are from the University of Oklahoma Health Sciences Center, Oklahoma City. Drs. McLawhorn, Quinn, Stasko, and Collins are from the College of Medicine, Department of Dermatology, and Dr. Chen is from the Department of Biostatistics and Epidemiology.

Mohs micrographic surgery (MMS) entails multiple time-consuming surgical and histological examinations for each patient. Efficient communication is key in improving clinic flow, and we surveyed members of the American College of Mohs Surgery to evaluate the efficacy of different techniques utilized by Mohs surgeons across the nation. Read More

View Article and Full-Text PDF

Cytological Appearances of Ovarian Seromucinous Borderline Tumor in Ascites: Presentation of 2 Cases.

Acta Cytol 2021 Jul 20:1-8. Epub 2021 Jul 20.

Department of Pathology, Saga University Hospital, Saga, Japan.

Background: Seromucinous borderline tumor (SMBT) is a rare neoplasm which was newly defined in the 2014 WHO classification. Although the clinical and histopathological characteristics of SMBT have been well described, its cytological characteristics have not. We recently experienced 2 cases of SMBT which were defined by cytological findings of ascites. Read More

View Article and Full-Text PDF

Hepatoprotective Impact of Ghrelin against Cyclophosphamide-Induced Toxicity in the Male Mice.

Drug Res (Stuttg) 2021 Jul 19. Epub 2021 Jul 19.

Department of Anatomical Sciences and Pathology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.

Background: Despite its vast spectrum of clinical usage, cyclophosphamide (CP) exerts many adverse impacts, including hepatotoxicity. Antioxidant properties of ghrelin might protect the liver from CP-induced toxicity. The current study aimed to assess the protective impacts of ghrelin on CP-induced liver toxicity. Read More

View Article and Full-Text PDF

Gastroenteropancreatic neuroendocrine neoplasm - a complex presentation in imaging methods.

Neuro Endocrinol Lett 2021 Jul 19;42(3):141-149. Epub 2021 Jul 19.

II. Department of Radiology, Faculty of Medicine of Comenius University in Bratislava and St. Elisabeth's Cancer Institute, Bratislava, Slovakia.

Neuroendocrine neoplasms comprise an ever greater ratio of primary gastrointestinal tract tumors, thanks to the improving diagnostics. The clinical presentation can be quite diverse depending on the type of the tumor. Imaging methods - both the spectrum of radiological methods and methods of nuclear medicine - are an integral part of the diagnostics. Read More

View Article and Full-Text PDF

Longitudinal Multiparametric MRI Assessment of Irradiated Salivary Gland in a Rat Model: Correlated With Histological Findings.

J Magn Reson Imaging 2021 Jul 18. Epub 2021 Jul 18.

Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Background: Several magnetic resonance imaging (MRI) sequences have been applied to assess injured glands but without histological validation.

Purpose: To evaluate longitudinal changes in multiparametric MRI (mp-MRI) of irradiated salivary glands in a rat model and investigate correlations between mp-MRI and histological findings.

Study Type: Prospective. Read More

View Article and Full-Text PDF

Primary synovial sarcoma of the mediastinum: a poor prognosis in a 14-year-old girl.

Respirol Case Rep 2021 Aug 8;9(8):e00811. Epub 2021 Jul 8.

Thoracic and Cardiovascular Surgery Department Abderrahmen Mami Hospital Ariana Tunisia 2080 Tunisia.

Synovial sarcoma is a soft tissue sarcoma. Its occurrence as a primary mediastinal neoplasm is very rare. We report a case of mediastinal synovial sarcoma in a 14-year-old girl with exertive dyspnoea at presentation. Read More

View Article and Full-Text PDF

A Case of Colonic Tuberculosis Revealed by Polymerase Chain Reaction.

Clin Lab 2021 Jul;67(7)

Background: The authors report a case of tumor-like colonic tuberculosis revealed by PCR in a 32-year-old patient with a low-level peritoneal effusion on CT scan with negative histological study on colonic biopsy.

Methods: The colonic biopsy received at the laboratory after grinding in a porcelain mortar, was the object of a molecular study by GeneXpert MT/RIF (Cepheid, Sunnyvale, CA, USA) using the automated real-time PCR technique and a conventional study based on Ziehl-Nielsen staining and culture on Lowenstein-Jensen® solid medium (LJ) and Mycobacteria Growth Indicator Tube (MGIT®) liquid medium.

Results: The patient was a 32-year-old male without any personal or family history of tuberculosis and without signs of tuberculosis impregnation. Read More

View Article and Full-Text PDF

Moroccan Bee Bread Improves Biochemical and Histological Changes of the Brain, Liver, and Kidneys Induced by Titanium Dioxide Nanoparticles.

Biomed Res Int 2021 23;2021:6632128. Epub 2021 Jun 23.

Laboratory of Natural Substances, Pharmacology, Environment, Modeling, Health and Quality of Life (SNAMOPEQ), Faculty of Sciences Dhar El Mahraz, University Sidi Mohamed Ben Abdellah, Fez, Morocco.

Titanium dioxide nanoparticles (TiO) were used in various fields such as food industry, cosmetics, medicine, and agriculture. Despite the many advantages of nanotechnology, the adverse effects of nanoparticles are inevitable. The present study was conducted to evaluate the protective effect of bee bread on titanium dioxide (TiO) nanoparticle toxicity. Read More

View Article and Full-Text PDF

Surgical Resection of Primary Tumors Provides Survival Benefits for Lung Cancer Patients With Unexpected Pleural Dissemination.

Front Surg 2021 23;8:679565. Epub 2021 Jun 23.

Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.

Surgery is not generally recommended for non-small cell lung cancer (NSCLC) patients with malignant pleural dissemination (PD). However, in some cases, PD is found unexpectedly during surgery. There is no consensus on whether surgical intervention can provide survival benefit for them. Read More

View Article and Full-Text PDF

Streptococcus, Centrocestus formosanus and Myxobolus tilapiae concurrent infections in farmed Nile tilapia (Oreochromis niloticus).

Microb Pathog 2021 Jul 8;158:105084. Epub 2021 Jul 8.

Department of Fish Diseases and Management, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt.

Stress triggered concurrent microbial/parasitic infections are prevalent in earthen pond based farmed Nile tilapia Oreochromis niloticus. In the current study, a total of thirty five O. niloticus were collected from a commercial fish farm with a history of severe mortalities at Port Said, Egypt. Read More

View Article and Full-Text PDF

Atypical histological abnormalities in an adult patient with nephronophthisis harboring NPHP1 deletion: a case report.

BMC Nephrol 2021 Jul 10;22(1):261. Epub 2021 Jul 10.

Department of Nephrology, Juntendo University Faculty of Medicine, Tokyo, Japan.

Background: Nephronophthisis (NPHP) is a chronic tubular interstitial disorder that exhibits an autosomal recessive genetic form and causes progressive renal failure in children. Patients with NPHP rarely show urinary abnormalities, edema, or hypertension. Thus, NPHP is often detected only when renal failure becomes advanced. Read More

View Article and Full-Text PDF

LncRNA PAXIP1-AS1 fosters the pathogenesis of pulmonary arterial hypertension via ETS1/WIPF1/RhoA axis.

J Cell Mol Med 2021 Jul 10. Epub 2021 Jul 10.

Department of Respiratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.

Pulmonary arterial hypertension (PAH) is a life-threatening disease featured with elevated pulmonary vascular resistance and progressive pulmonary vascular remodelling. It has been demonstrated that lncRNA PAXIP1-AS1 could influence the transcriptome in PAH. However, the exact molecular mechanism of PAXIP1-AS1 in PAH pathogenesis remains largely unknown. Read More

View Article and Full-Text PDF

Therapeutic advancement of simvastatin-loaded solid lipid nanoparticles (SV-SLNs) in treatment of hyperlipidemia and attenuating hepatotoxicity, myopathy and apoptosis: Comprehensive study.

Biomed Pharmacother 2021 Jul 8;139:111494. Epub 2021 May 8.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Fayoum University, Fayoum, Egypt. Electronic address:

This study set out to optimize simvastatin (SV) in lipid nanoparticles (SLNs) to improve bioavailability, efficacy and alleviate adverse effects. Simvastatin-loaded solid lipid nanoparticles (SV-SLNs) were prepared by hot-melt ultrasonication method and optimized by box-Behnken experimental design. Sixty Wister albino rats were randomly assigned into six groups and treated daily for 16 weeks: control group, the group fed with 20 g of high-fat diet (HFD), group treated with vehicle (20 mg/kg, P. Read More

View Article and Full-Text PDF

Distant metastasis of hepatocellular carcinoma to Meckel's cave and cranial nerves: A case report and review of literature.

World J Hepatol 2021 Jun;13(6):709-716

Department of Gastroenterology, Kobe Asahi Hospital, Kobe 653-0801, Hyogo, Japan.

Background: Metastasis occurs as a late event in the natural history of hepatocellular carcinoma (HCC), and most patients die of liver failure attributed to the tumor supplanting the liver. Conversely, the brain is a less common metastatic site.

Case Summary: We describe a rare case of hepatitis C virus-related multiple HCC metastasizing to the cavernous sinus, Meckel's cave, and the petrous bone involving multiple cranial nerves in an 82-year-old woman. Read More

View Article and Full-Text PDF

Uncovering the Protective Mechanism of the Volatile Oil of against Acute Myocardial Ischemia Injury Using Network Pharmacology and Experimental Validation.

Evid Based Complement Alternat Med 2021 22;2021:6630795. Epub 2021 Jun 22.

Key Laboratory of Modern Preparation of Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China.

is a traditional aromatic resuscitation drug that can be clinically used to prevent cardiovascular diseases. The volatile oil of (VOA) possesses important medicinal properties, including protection against acute myocardial ischemia (MI) injury. However, the pharmacodynamic material basis and molecular mechanisms underlying this protective effect remain unclear. Read More

View Article and Full-Text PDF

Muscular pathological features in patients with myasthenia gravis.

Clin Neuropathol 2021 Jul 8. Epub 2021 Jul 8.

Objective: To analyze muscle histopathology of myasthenia gravis (MG) patients and further explore the underlying mechanism comparing with previous literature.

Materials And Methods: We analyzed the clinicopathological features of 8 MG patients who had muscle biopsy examinations.

Results: Eight patients with a diagnosis of MG were retrospectively recruited from the Chinese PLA General Hospital. Read More

View Article and Full-Text PDF

Trichoblastoma Arising From the Nevus Sebaceus of Jadassohn.

Cureus 2021 May 29;13(5):e15325. Epub 2021 May 29.

Dermatology Unit, Cheikh Khalifa International University Hospital, Mohammed VI University of Health Sciences, Casablanca, MAR.

Trichoblastoma is a rare benign skin adnexal tumour, belonging to the category of trichogenic tumours. The clinical and histological findings may often be confused with basal cell carcinoma, a malignant epidermal skin tumour. We report here a case of a 70-year-old man presented with a dome-shaped, dark-pigmented nodule within a yellowish hairless plaque on the scalp. Read More

View Article and Full-Text PDF

Adipose Tissue-Derived Mesenchymal Stem Cells (ADMSCs) and ADMSC-Derived Secretome Expedited Wound Healing in a Rodent Model - A Preliminary Study.

Clin Cosmet Investig Dermatol 2021 30;14:753-764. Epub 2021 Jun 30.

Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, Special Administrative Region of China.

Introduction: The biological role of mesenchymal stem cells (MSCs) in wound healing has been demonstrated. However, there were limited studies on the healing effect of secretome which consists of many biological factors secreted by MSCs. In this study, we aimed to compare the therapeutic effects of secretome with MSCs on facilitating wound healing. Read More

View Article and Full-Text PDF

The tissue origin of human mesenchymal stem cells dictates their therapeutic efficacy on glucose and lipid metabolic disorders in type II diabetic mice.

Stem Cell Res Ther 2021 07 7;12(1):385. Epub 2021 Jul 7.

SIAT-GHMSCB Biomedical Laboratory for Major Diseases, Dongguan Enlife Stem Cell Biotechnology Institute, Dongguan Avenue 430, Dongguan, Guangdong, China.

Background: The therapeutic efficacy of mesenchymal stem cells (MSCs) of different tissue origins on metabolic disorders can be varied in many ways but remains poorly defined. Here we report a comprehensive comparison of human MSCs derived from umbilical cord Wharton's jelly (UC-MSCs), dental pulp (PU-MSCs), and adipose tissue (AD-MSCs) on the treatment of glucose and lipid metabolic disorders in type II diabetic mice.

Methods: Fourteen-to-fifteen-week-old male C57BL/6 db/db mice were intravenously administered with human UC-MSCs, PU-MSCs, and AD-MSCs at various doses or vehicle control once every 2 weeks for 6 weeks. Read More

View Article and Full-Text PDF

Benfotiamine reduced collagen IV contents of sciatic nerve in hyperglycemic rats.

J Diabetes Metab Disord 2021 Jun 20;20(1):21-30. Epub 2021 Feb 20.

Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Azadi Square, Mashhad, Iran.

Background: Neuropathy as a common complication of hyperglycemia in diabetic patients is probably caused by metabolic and structural changes in extracellular matrix (ECM) of peripheral nerves. This study was designed to evaluate the effects of benfotiamine (BT) on the structural, biological and mechanical characteristics of rat sciatic nerve in hyperglycemic condition.

Materials And Methods: Forty eight adult male Wistar rats were assigned to 6 groups (n = 8): control (healthy rats with no treatment; C), positive control (healthy rats received BT treatment; B), negative control groups 1&2 (hyperglycemic rats kept for 4 and/or 8 weeks; 4WD and 8WD, respectively) and experimental groups 1&2 (hyperglycemic rats treated by daily oral gavage of 100 mg kg body weight BT for 4 and/or 8 weeks; 4WD + BT and 8WD + BT, respectively). Read More

View Article and Full-Text PDF

Mangosteen Hinders Gamma Radiation-Mediated Oxidative Stress and Liver Injury by Down-Regulating TNF-α/NF-κB and Pro-Fibrotic Factor TGF-β1 Inducing Inflammatory Signaling.

Dose Response 2021 Apr-Jun;19(2):15593258211025190. Epub 2021 Jun 21.

Department of Radiation Biology, National Center for Radiation Research & Technology, (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt.

Background: Liver injury due to ionizing radiation exposure either accidental or after radiotherapy treatment, may lead to many alterations in proteins expression related to inflammation or apoptosis. Our study investigated the curative effect of Mangosteen (MGS) extract (fruit rind) against ionizing radiation (IR) induced liver damage.

Methods: Hepatotoxicity was induced in Wister rats by exposure to an acute single dose (6 Gy) of IR while MGS was given orally to rats (500 mg/kg bwt) and administered daily for 30 days after irradiation. Read More

View Article and Full-Text PDF

The protective role of curcumin against toxic effect of nonylphenol on bone development.

Hum Exp Toxicol 2021 Jul 5:9603271211030548. Epub 2021 Jul 5.

Department of Histology and Embryology, Erciyes University, Faculty of Medicine, Kayseri, Turkey.

Introduction: In the study, it was aimed to investigate the possible protective effects of curcumin, a potent antioxidant, against the toxic effect of nonylphenol on bone development.

Methods: Thirty pregnant female Wistar albino rats were used. The rats were randomly divided into the following five groups; the control group, corn oil group (150 µl/kg/day), nonylphenol group (50 µl/kg/day), curcumin group (100 mg/kg/day) and curcumin + nonylphenol group (100 mg/kg/day + 50 µl/kg/day). Read More

View Article and Full-Text PDF

Local recurrence of the atypical fibrous histiocytoma - a case report.

Pol Merkur Lekarski 2021 Jun;49(291):221-223

Institute of Hematology and Transfusiology Medicine, Warsaw, Poland: Department of General, Oncological and Metabolic Surgery.

Atypical fibrous histiocytoma (AFH) is an uncommon variant of benign skin neoplasm, fibrous histiocytoma. Despite having pseudosarcomatous histological features, atypical fibrous histiocytoma is characterized by a benign clinical course.

Aim: The aim of the study was to present the case of local recurrence of atypical fibrous histiocytoma in scar after the primary excision. Read More

View Article and Full-Text PDF

Noninvasive, objective evaluation of lower extremity lymphedema severity using shear wave elastography: A preliminary study.

J Plast Reconstr Aesthet Surg 2021 Jun 6. Epub 2021 Jun 6.

Department of Plastic, Reconstructive, and Aesthetic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.

Background: Increased skin and subcutaneous tissue stiffness in patients with early-stage lymphedema has been reported. The purpose of this study was to examine the use of shear wave elastography (SWE) for evaluating lower extremity lymphedema (LEL).

Methods: For 10 lower extremities of normal controls and 72 limbs of patients with gynecological cancer whose lymphatic function was categorized into six stages based on the range of dermal backflow (DBF) observed in indocyanine green (ICG) lymphography, SWE was performed and shear wave velocity (SWV) of the dermis and three layers of subcutaneous tissue at the thigh and calf were recorded. Read More

View Article and Full-Text PDF

RGD-modified multifunctional nanoparticles encapsulating salvianolic acid A for targeted treatment of choroidal neovascularization.

J Nanobiotechnology 2021 Jul 2;19(1):196. Epub 2021 Jul 2.

Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, 200080, People's Republic of China.

Background: The development of alternative anti-angiogenesis therapy for choroidal neovascularization (CNV) remains a great challenge. Nanoparticle systems have emerged as a new form of drug delivery in ocular diseases. Here, we report the construction and characterization of arginine-glycine-aspartic acid (RGD)-conjugated polyethyleneimine (PEI) as a vehicle to load antioxidant salvianolic acid A (SAA) for targeted anti-angiogenesis therapy of CNV. Read More

View Article and Full-Text PDF

Baicalin Magnesium Salt Attenuates Lipopolysaccharide-Induced Acute Lung Injury via Inhibiting of TLR4/NF-B Signaling Pathway.

J Immunol Res 2021 8;2021:6629531. Epub 2021 Jun 8.

College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China.

Baicalin (BA) magnesium salt (BA-Mg) is a good water-soluble ingredient extracted from , a commonly used traditional Chinese medicine. This study is aimed at investigating whether BA-Mg could exert a better protective effect on lipopolysaccharide- (LPS-) induced acute lung injury (ALI) in mice and illuminate the underlying mechanisms in vivo and in vitro. Mice were intraperitoneally administrated with equimolar BA-Mg, BA, and MgSO before LPS inducing ALI. Read More

View Article and Full-Text PDF

Severe onset of inflammatory myositis in a child: think to paraneoplastic myositis.

Ital J Pediatr 2021 Jul 1;47(1):146. Epub 2021 Jul 1.

University of Trieste, Via dell'Istria 65/1, Trieste, Italy.

Background: Juvenile idiopathic inflammatory myopathies (JIIMs) are a group of heterogenous, acquired, autoimmune disorders that affect the muscle. While the association between IIMs and malignancy has been widely reported in adults, cancer-associated myositis (CAM) is rare in children, so that routine malignancy screening is not generally performed. This report shows a case of severe CAM in a child. Read More

View Article and Full-Text PDF