20,957 results match your criteria histologic lesions

Anti-Tumor Necrosis Factor-Alpha Withdrawal in Children With Inflammatory Bowel Disease in Endoscopic and Histologic Remission.

Inflamm Bowel Dis 2021 Apr 9. Epub 2021 Apr 9.

Gastroenterology and Nutrition Unit, Meyer Children's Hospital, Florence, Italy.

Background: The aim of the present study was to investigate outcomes of anti-TNF-alpha (ATA) withdrawal in selected pediatric patients with inflammatory bowel disease who achieved clinical remission and mucosal and histological healing (MH and HH).

Methods: A retrospective analysis was performed on children and adolescents affected by Crohn disease (CD) and ulcerative colitis (UC) who were followed up at 2 tertiary referral centers from 2008 through 2018. The main outcome measure was clinical relapse rates after ATA withdrawal. Read More

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Fatal Coronary Artery Vasculitis With Mixed Features.

Am J Forensic Med Pathol 2021 Apr 7. Epub 2021 Apr 7.

From the University of South Carolina School of Medicine, Columbia, SC Edward Via College of Osteopathic Medicine, Auburn, AL Volusia County Medical Examiner's Office, Daytona Beach, FL Pathology Associates of Greenville, Greenville Office of the Medical Examiner, Greenville County University of South Carolina School of Medicine Greenville, Greenville, SC.

Abstract: Atherosclerotic cardiovascular disease (ASCVD) is often investigated by medical examiners as a cause of sudden death. Because of the variation in presentation of atherosclerotic cardiovascular disease, the examiner must be cautious when assigning a final diagnosis. The presented case depended upon histologic examination of coronary artery lesions to reach an appropriate final diagnosis of vasculitis with mixed features. Read More

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Comparison of programmed death-ligand 1 protein expression between primary and metastatic lesions in patients with lung cancer.

J Immunother Cancer 2021 Apr;9(4)

Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA.

Assessment of programmed cell death-ligand 1 (PD-L1) expression by immunohistochemistry (IHC) is the definite diagnostic test to guide treatment for patients with advanced-stage non-small cell lung cancer. Intratumoral heterogeneity and discrepancy of PD-L1 expression between primary and metastatic lesions may increase the risk of tumor misclassification. We performed a retrospective study of the Foundation Medicine, Inc clinical database on lung cancer cases that were evaluated for PD-L1 expression by IHC in the context of routine care. Read More

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Bronchial Washing Fluid Versus Plasma and Bronchoscopy Biopsy Samples for Detecting Epidermal Growth Factor Receptor Mutation Status in Lung Cancer.

Front Oncol 2021 22;11:602402. Epub 2021 Mar 22.

Department of Respiratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.

Background: Bronchial washing fluid (BWF) is a common specimen collected during bronchoscopy and has been suggested to contain both tumor cells and cell-free DNA. However, there is no consensus on the feasibility of BWF in epidermal growth factor receptor (EGFR) genetic analysis because of the limited sample size and varying results in previous studies. This study compared the feasibility, sensitivity, and specificity of detecting EGFR mutation using BWF, bronchoscopy biopsy, and plasma samples in patients with lung cancer (LC). Read More

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J Zoo Wildl Med 2021 Apr;52(1):332-336

College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA,

Giraffes () are commonly managed in zoos and conservation programs worldwide, but the current understanding of the occurrence and progression of neoplastic disease in this species is limited by the scarcity of published reports. This study collated documented cases of neoplasia on the basis of gross and histologic evaluation of ante- and postmortem samples. In total, 30 giraffes from 22 institutions across the United States were included. Read More

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J Zoo Wildl Med 2021 Apr;52(1):103-116

Department of Veterinary Medicine and Epidemiology, University of California Davis, School of Veterinary Medicine, Davis, CA 95616, USA,

Skin lesions are frequently diagnosed in fish medicine. Although systemic fish treatments exist, little is known about the efficacy of topical drugs on fish skin lesions. This study aimed to investigate the efficacy of medical-grade honey and silver sulfadiazine on skin lesions using common carp () as a model. Read More

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J Zoo Wildl Med 2021 Apr;52(1):28-37

Institute of Virology, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland.

Equine sarcoids (ES) were diagnosed in 12 Somali wild asses (SWA) () from 10 different institutions of the SWA European Endangered Species Programme from 1976 to 2019. Samples of surgically excised masses, biopsies, or necropsy samples were submitted for histologic and virologic analysis. In addition, tissue samples from one onager (), one kulan (), and two Hartmann's mountain zebras (HMZ) () were examined. Read More

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[Updated WHO classification of tumors of the breast: the most important changes].

Pathologe 2021 Apr 6. Epub 2021 Apr 6.

Institut für Pathologie, Philipps-Universität Marburg und Universitätsklinikum Marburg, Marburg, Deutschland.

The development of the WHO classification of tumors of the breast is driven by new knowledge from research whose translation into daily practice is considered clinically relevant. The fifth edition represents an update of the fourth edition and essentially follows the previously known systematics. The histologic features of the lesions continue to form the basis of the classification in the update. Read More

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Inflammatory Pseudotumor: A 20-Year Single Institutional Experience.

Adv Biomed Res 2020 28;9:68. Epub 2020 Nov 28.

Department of Pathology, University College Hospital, Ibadan, Oyo State, Nigeria.

Background: Inflammatory pseudotumor (IPT) is a relatively rare benign disease. The aim of the study was to demonstrate the demographic distribution, clinical presentation, and histomorphological characteristics of IPT while highlighting its associated diagnostic challenges.

Materials And Methods: A retrospective cross-sectional review of all the IPT diagnosed in our institution between January 1999 and December 2018 was conducted. Read More

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November 2020

Case Report: Paratesticular Rhabdomyosarcoma.

Front Oncol 2021 17;11:629878. Epub 2021 Mar 17.

Department of Urology, Jinhua Hospital Affiliated to Zhejiang University School of Medicine, Jinhua, China.

Paratesticular rhabdomyosarcoma (RMS) accounts for only 7% of all the RMS cases. Due to the limited available data, there is no consensus on the diagnosis and management of the paratesticular tumors. Here, we interrogated two paratesticular RMS cases in 25 and 27-year-old men presenting with painless and rapidly growing mass in the scrotum. Read More

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Histologic heterogeneity and syndromic associations of non-ampullary duodenal polyps and superficial mucosal lesions.

Dig Liver Dis 2021 Apr 1. Epub 2021 Apr 1.

First Department of Internal Medicine, University of Pavia, IRCCS San Matteo Hospital Foundation, Viale Golgi 19, 27100, Italy.

Background: Duodenal polyps and superficial mucosal lesions (DP/SMLs) are poorly characterised.

Aims: To describe a series of endoscopically-diagnosed extra-ampullary DPs/SMLs.

Methods: This is a retrospective study conducted in a tertiary referral Endoscopy Unit, including patients who had DPs or SMLs that were biopsied or removed in 2010-2019. Read More

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Postinflammatory Medial Meatal Fibrosis: Histopathologic Features and Outcomes of Surgical Management.

Ear Nose Throat J 2021 Apr 5:1455613211001134. Epub 2021 Apr 5.

Department of Otolaryngology, Head and Neck Surgery, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany.

Objectives: The aims of our study were to investigate the clinical and audiometric outcome of the surgical treatment of postinflammatory medial meatal fibrosis (PIMMF) and to review the histopathologic changes in the specimens of the fibrotic plug, in order to try to shed light on the pathogenesis of the disease.

Materials And Methods: The clinical records and the histopathologic specimens of all patients who underwent tympanomeatoplasty for PIMMF at the ENT Clinic of the University of Erlangen between 2006 and 2020 were evaluated retrospectively.

Results: Thirty-four patients (41 primary surgical procedures) made up our study cohort. Read More

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Bilateral Diffuse Nodular Pulmonary Ossification Mimicking Metastatic Disease in a Patient with Fibrolamellar Hepatocellular Carcinoma.

Children (Basel) 2021 Mar 16;8(3). Epub 2021 Mar 16.

Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

Pulmonary ossification (PO) is a rare finding, characterized by mature bone formation in the lung parenchyma. We report a 20-year-old female patient diagnosed with fibrolamellar hepatocellular carcinoma (FL-HCC) and bilateral diffuse nodular PO. The patient presented with a unifocal left liver mass and multiple bilateral pulmonary lesions, which were treated as metastatic disease. Read More

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The Use of Platelet-Rich Plasma for Treatment of Tenodesmic Lesions in Horses: A Systematic Review and Meta-Analysis of Clinical and Experimental Data.

Animals (Basel) 2021 Mar 12;11(3). Epub 2021 Mar 12.

Department of Veterinary Medicine and Animal Production, University of Napoli "Federico II", Via Federico Delpino 1, 80137 Napoli, Italy.

The use of platelet-rich plasma (PRP) to enhance tenodesmic lesion healing has been questioned over the years. The aim of this study was to evaluate current literature to establish the effectiveness of PRP for treating tenodesmic lesions through a systematic review, in accordance with the PRISMA guidelines, and a meta-analysis. Studies comparing PRP with placebo or other treatments for horses with tenodesmic injuries or evaluated PRP effect on tendon and ligament explants were included. Read More

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Field evaluation of feeding spray-dried plasma in the starter period on final performance and overall health of broilers.

Poult Sci 2021 Mar 3;100(5):101080. Epub 2021 Mar 3.

ISI institute, Curitiba, Parana, Brazil.

The effect of feeding spray-dried plasma (SDP) during the starter period was evaluated with a commercial broiler integrator on performance and overall health of broilers. The I See Inside (ISI) methodology assessing gut health in broilers was used as a tool to evaluate the impact of dietary interventions under commercial conditions. One hundred farms with approximately 1. Read More

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Tumor Resection, Optical Molecular Imaging, and the Potential Synergy of the Combination of the Two Techniques in Bladder Cancer.

Front Oncol 2021 16;11:638083. Epub 2021 Mar 16.

First Clinical Medical College, Shanxi Medical University, Taiyuan, China.

Although transurethral resection of bladder tumor is the golden standard for the treatment of non-muscle invasive bladder cancer, this surgical procedure still has some serious drawbacks. For example, piecemeal resection of tumor tissue results in exfoliated tumor cells dissemination and implantation, and fragmented tumor specimens make it difficult for pathologists to accurately assess the pathological stage and histologic grade. En bloc tumor resection follows the basic principle of oncological surgery and provides an intact tumor specimen containing detrusor muscle for pathologists to make accurate histopathological assessment. Read More

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Hyperspectral autofluorescence characterization of drusen and sub-RPE deposits in age-related macular degeneration.

Ann Eye Sci 2021 Mar 15;6. Epub 2021 Mar 15.

Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Background: Soft drusen and basal linear deposit (BLinD) are two forms of the same extracellular lipid rich material that together make up an Oil Spill on Bruch's membrane (BrM). Drusen are focal and can be recognized clinically. In contrast BLinD is thin and diffusely distributed, and invisible clinically, even on highest resolution OCT, but has been detected on hyperspectral autofluorescence (AF) imaging . Read More

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A Holistic Approach to Bone Tumors in Dogs and Cats: Radiographic and Histologic Correlation.

Vet Pathol 2021 Mar 29:300985821999832. Epub 2021 Mar 29.

6420Massey University, Palmerston North, New Zealand.

The skeletal system is a common site for neoplasia in dogs and cats, and primary bone tumors may develop from any of the mesenchymal tissues present in bone. Imaging and histopathology are routinely used in the diagnosis of bone tumors, and the 2 techniques are highly complementary. While imaging may be highly suggestive of a specific diagnosis and treatment may be instituted based on this, definitive diagnosis requires histopathology of either incisional or excisional biopsies or an amputation specimen. Read More

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H MR Spectroscopy of Fine-Needle Aspiration Biopsy Specimens for the Discrimination of Breast Cancer.

Radiol Imaging Cancer 2020 Nov 27;2(6):e200033. Epub 2020 Nov 27.

Department of Psychiatry and Behavioral Neuroscience (R.A.K., J.H.L., J.A.W., W.J.C.) and Department of Radiology (M.C.M.), College of Medicine, University of Cincinnati, 234 Goodman St, ML 761, Cincinnati, OH 45267; Department of Biomedical Engineering, College of Engineering and Applied Science, University of Cincinnati, Cincinnati, Ohio (J.H.L.); and Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio (J.A.D.).

Purpose: To determine whether MR spectroscopic assessment of fine-needle aspiration (FNA) biopsy specimens from suspicious breast lesions could be used to improve the diagnostic utility of FNA biopsies for the characterization of breast lesions.

Materials And Methods: In this prospective study, a previously reported technique using high-spatial-resolution proton MR spectroscopy was modified and used to examine the utility of FNA biopsies in the evaluation of suspicious breast lesions. Tissue samples from 115 lesions (from 102 women; average age, 54 years) were excised by using FNA and core biopsies and were collected between September 7, 2012, and April 11, 2014. Read More

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November 2020

Prognostic factors and impact of surgery in patients with metastatic soft tissue sarcoma at diagnosis: A population-based cohort study.

Jpn J Clin Oncol 2021 Mar 29. Epub 2021 Mar 29.

Department of Orthopedic Surgery, The University of Tokyo, Tokyo, Japan.

Background: Approximately 10% of the patients with soft tissue sarcoma show metastasis at initial diagnosis, and hence, poorer prognosis. However, the prognostic factors and whether definitive surgery for the primary lesion improves overall survival, especially when complete resection of metastasis is difficult, remain unclear.

Methods: This retrospective analysis was based on the Bone and Soft Tissue Tumor Registry in Japan. Read More

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PD-L1 expression and surgical outcomes of adenosquamous carcinoma of the pancreas in a single-centre study of 56 lesions.

Pancreatology 2021 Mar 17. Epub 2021 Mar 17.

Department of Pathology and Molecular Diagnostic Laboratory, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.

Objective: Adenosquamous carcinoma of the pancreas (ASCP) is a rare histologic subtype of pancreatic carcinoma. The clinicopathologic characteristics and surgical outcomes of ASCP are poorly understood due to the rarity of this disease. Recently, promising clinical responses in patients with pancreatic cancer have been obtained for antibodies against programmed death-1/programmed death-ligand 1 (PD-1/PD-L1). Read More

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Melanocytic lesions with blue nevus-like (dendritic) morphology: an update with emphasis on histopathologic, immunophenotypic and molecular features.

Histopathology 2021 Mar 27. Epub 2021 Mar 27.

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston.

An accurate diagnosis of melanocytic lesions requires a thorough histopathologic evaluation accompanied by appropriate correlation with clinical examination findings. Although most melanocytic lesions can readily be classified as one of the defined diagnostic entities using well-established diagnostic criteria, a subset of melanocytic lesions, particularly those with blue nevus-like (pigmented dendritic) morphology, have notoriously been an enduring challenge for pathologists. These lesions are rare and often demonstrate histologic ambiguities with features of both benignity and malignancy, thereby making accurate risk assessment and prediction of their biological behaviors difficult on histologic grounds alone. Read More

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Mesonephric and mesonephric-like carcinomas of the female genital tract: molecular characterization including cases with mixed histology and matched metastases.

Mod Pathol 2021 Mar 26. Epub 2021 Mar 26.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Mesonephric carcinoma of the cervix is a rare tumor derived from Wolffian remnants. Mesonephric-like carcinomas of the ovary and endometrium, while morphologically similar, do not have obvious Wolffian derivation. Here, we sought to characterize the repertoire of genetic alterations in primary mesonephric and mesonephric-like carcinomas, in the distinct histologic components of mixed cases, as well as in matched primary tumors and metastases. Read More

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Retrospective and prospective studies of transmissible viral proventriculitis in broiler chickens in Brazil.

J Vet Diagn Invest 2021 Mar 26:10406387211004106. Epub 2021 Mar 26.

Departments of Veterinary Clinic and Surgery, Veterinary School, Universidade Federal de Minas Gerais-UFMG, Belo Horizonte, Minas Gerais, Brazil.

We investigated the occurrence and pathologic findings of transmissible viral proventriculitis (TVP) associated with the chicken proventricular necrosis virus (CPNV) in commercial broiler chickens in southeastern Brazil. Seventy-three broilers, 25-36 d old, with a history of reduced growth, were referred to our veterinary pathology services from 2013 to 2017. Broilers were clinically examined, weighed, and euthanized for postmortem examination. Read More

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Towards harmony in defining and reporting glomerular diseases on kidney biopsy.

Mark Haas

Curr Opin Nephrol Hypertens 2021 May;30(3):280-286

Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Purpose Of Review: To review recent efforts to develop uniformity and precision in defining individual glomerular histologic and ultrastructural lesions and proposals for developing greater uniformity in reporting of glomerular diseases.

Recent Findings: Over the past 2 decades, scoring systems for multiple glomerular diseases have emerged, as have several consortia for the study of glomerular diseases. However, one important limitation faced by renal pathologists and nephrologists has been a lack of uniformity and precision in defining the morphologic lesions seen by light and electron microscopy on which the scoring systems are based. Read More

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Analysis of PET parameters as prognosticators of survival and tumor extent in Oropharyngeal Cancer treated with surgery and postoperative radiotherapy.

BMC Cancer 2021 Mar 25;21(1):317. Epub 2021 Mar 25.

Department of Radiation Oncology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Background: Positron-emission tomography (PET) is widely used to detect malignancies, but consensus on its prognostic value in oropharyngeal cancer has not been established. The purpose of this study was to analyze the PET parameters associated with tumor extent and survival in resectable oropharyngeal cancer.

Methods: The PET parameters in oropharyngeal cancer patients with regional node metastasis who underwent surgery and postoperative radiotherapy between January 2005 and January 2019 were analyzed. Read More

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Allogeneic epithelial cell sheet transplantation for preventing esophageal stricture after circumferential ESD in a porcine model: preliminary results.

Scand J Gastroenterol 2021 Mar 25:1-6. Epub 2021 Mar 25.

Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Objectives: Circumferential endoscopic submucosal dissection (ESD) for large lesions induces severe stricture, requiring subsequent treatment. We aimed to evaluate the efficacy of allogeneic epithelial cell sheet transplantation in preventing esophageal stricture after circumferential ESD in a porcine model.

Materials And Methods: A total of 15 conventional pigs underwent a 4 cm long circumferential ESD in the mid-esophagus. Read More

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Patient on Immunomodulatory Therapy Experiencing Joint Pain and Skin Lesions: A Case Report.

J Prim Care Community Health 2021 Jan-Dec;12:21501327211005894

Mayo Clinic, Rochester, MN, USA.

A woman in her late fifties was admitted to the Family Medicine Inpatient Service directly from Rheumatology clinic for polyarticular pain and erythema with concern for infection. She was taking immunosuppressant medications for a history of multiple autoimmune diseases. Examination showed increasing erythema and tenderness on the upper and lower extremity joints. Read More

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Hidradenitis suppurativa lesions are associated with decreased collagen, decreased elastin, and increased neovascularization.

J Histotechnol 2021 Mar 24:1-10. Epub 2021 Mar 24.

Department of Diagnostic and Health Science, University of Tennessee Health Science Center, Memphis, TN, USA.

Hidradenitis suppurativa (HS) is a dermatological condition characterized by ruptured hair follicles inducing a localized, but massive chronic inflammatory response. Analysis of 104 HS lesions in formalin-fixed paraffin-embedded tissues identified the most common histologic features found associated with HS were migrating epithelial sheets, acute and chronic inflammation, perivascular chronic inflammation in regions adjacent to active lesions, and granulation tissue. Additionally, using a modified Masson's trichrome stain principally for collagen, Verhoeff van Gieson elastic stain, and CD34 immunohistochemistry assay for endothelium, lesional areas in the dermis with chronic inflammation exhibited a significant decrease in collagen and elastin, and an increase in neovascularization. Read More

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Clinical presentation, treatment, and outcomes associated with vaginal intraepithelial neoplasia: A retrospective study of 118 patients.

J Obstet Gynaecol Res 2021 Mar 23. Epub 2021 Mar 23.

Department of Obstetrics & Gynecology, Tianjin Medical University, Tianjin, China.

The incidence of vaginal intraepithelial neoplasia (VAIN) is increasing annually; however, the reported values are likely underestimated. Risk factors for VAIN include advanced age, human papillomavirus (HPV) infection, history of hysterectomy, and simultaneous or previous cervical intraepithelial neoplasia (CIN) or cervical cancer cervical cancer. The most common presentation is abnormal cytology without clinical symptoms. Read More

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