Neurosci Lett 2021 Jun 4:136011. Epub 2021 Jun 4.
Libin Cardiovascular Institute, Department of Physiology and Pharmacology, University of Calgary, Calgary, AB, Canada; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada. Electronic address:
Neuronal hyperactivity is an early, common manifestation of Alzheimer's disease (AD), and is believed to drive AD progression. Neuronal hyperactivity in the form of baseline activity (or spontaneous Ca transients) has consistently been demonstrated in mouse models of AD using two-photon in vivo Ca imaging of cortical or hippocampal neurons in anesthetized animals. Notably, these AD-related spontaneous Ca transients were hardly detected in acute hippocampal slices, probably due to neuronal damage during brain slicing. Read More