3,800 results match your criteria hippo pathway


Unraveling the Complex Interplay Between Transcription Factors and Signaling Molecules in Thyroid Differentiation and Function, From Embryos to Adults.

Front Endocrinol (Lausanne) 2021 20;12:654569. Epub 2021 Apr 20.

Instituto de Investigaciones Biomédicas "Alberto Sols", Consejo Superior de Investigaciones Científicas (CSIC) y Universidad Autónoma de Madrid (UAM), Madrid, Spain.

Thyroid differentiation of progenitor cells occurs during embryonic development and in the adult thyroid gland, and the molecular bases of these complex and finely regulated processes are becoming ever more clear. In this , we describe the most recent advances in the study of transcription factors, signaling molecules and regulatory pathways controlling thyroid differentiation and development in the mammalian embryo. We also discuss the maintenance of the adult differentiated phenotype to ensure the biosynthesis of thyroid hormones. Read More

View Article and Full-Text PDF

Parthenolide plays a protective role in the liver of mice with metabolic dysfunction‑associated fatty liver disease through the activation of the HIPPO pathway.

Mol Med Rep 2021 Jul 6;24(1). Epub 2021 May 6.

Department of Hepatology, Liaocheng People's Hospital, Liaocheng, Shandong 252000, P.R. China.

Metabolic dysfunction‑associated fatty liver disease (MAFLD) is a serious threat to human health. Parthenolide (PAR) displays several important pharmacological activities, including the promotion of liver function recovery during hepatitis. The aim of the present study was to assess the effect of PAR on MAFLD in a mouse model. Read More

View Article and Full-Text PDF

A Noncanonical Hippo Pathway Regulates Spindle Disassembly and Cytokinesis During Meiosis in Saccharomyces cerevisiae.

Genetics 2020 Oct;216(2):447-462

Department of Biology, University of Massachusetts Boston, Massachusetts 02125.

Meiosis in the budding yeast Saccharomyces cerevisiae is used to create haploid yeast spores from a diploid mother cell. During meiosis II, cytokinesis occurs by closure of the prospore membrane, a membrane that initiates at the spindle pole body and grows to surround each of the haploid meiotic products. Timely prospore membrane closure requires SPS1, which encodes an STE20 family GCKIII kinase. Read More

View Article and Full-Text PDF
October 2020

Promoter Proximal Pausing Limits Tumorous Growth Induced by the Yki Transcription Factor in Drosophila.

Genetics 2020 Sep;216(1):67-77

Indian Institute of Science Education and Research (IISER), Pashan, Pune 411008.

Promoter proximal pausing (PPP) of RNA polymerase II has emerged as a crucial rate-limiting step in the regulation of gene expression. Regulation of PPP is brought about by complexes 7SK snRNP, P-TEFb (Cdk9/cycT), and the negative elongation factor (NELF), which are highly conserved from Drosophila to humans. Here, we show that RNAi-mediated depletion of bin3 or Hexim of the 7SK snRNP complex or depletion of individual components of the NELF complex enhances Yki-driven growth, leading to neoplastic transformation of Drosophila wing imaginal discs. Read More

View Article and Full-Text PDF
September 2020

The Hippo Pathway Is Essential for Maintenance of Apicobasal Polarity in the Growing Intestine of Caenorhabditis elegans.

Genetics 2019 Oct;213(2):501-515

Department of Biological Sciences, Seoul National University, Gwanak-gu 08826, Korea.

Although multiple determinants for establishing polarity in membranes of epithelial cells have been identified, the mechanism for maintaining apicobasal polarity is not fully understood. Here, we show that the conserved Hippo kinase pathway plays a role in the maintenance of apicobasal polarity in the developing intestine of Caenorhabditis elegans. We screened suppressors of the mutation in wts-1-the gene that encodes the LATS kinase homolog, deficiency of which leads to disturbance of the apicobasal polarity of the intestinal cells and to eventual death of the organism. Read More

View Article and Full-Text PDF
October 2019

The Hippo Pathway Is Essential for Maintenance of Apicobasal Polarity in the Growing Intestine of Caenorhabditis elegans.

Genetics 2019 Oct;213(2):501-515

Department of Biological Sciences, Seoul National University, Gwanak-gu 08826, Korea.

Although multiple determinants for establishing polarity in membranes of epithelial cells have been identified, the mechanism for maintaining apicobasal polarity is not fully understood. Here, we show that the conserved Hippo kinase pathway plays a role in the maintenance of apicobasal polarity in the developing intestine of Caenorhabditis elegans. We screened suppressors of the mutation in wts-1-the gene that encodes the LATS kinase homolog, deficiency of which leads to disturbance of the apicobasal polarity of the intestinal cells and to eventual death of the organism. Read More

View Article and Full-Text PDF
October 2019

Pits and CtBP Control Tissue Growth in Drosophila melanogaster with the Hippo Pathway Transcription Repressor Tgi.

Genetics 2020 May;215(1):117-128

Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia 3000.

The Hippo pathway is an evolutionarily conserved signaling network that regulates organ size, cell fate, and tumorigenesis. In the context of organ size control, the pathway incorporates a large variety of cellular cues, such as cell polarity and adhesion, into an integrated transcriptional response. The central Hippo signaling effector is the transcriptional coactivator Yorkie, which controls gene expression in partnership with different transcription factors, most notably Scalloped. Read More

View Article and Full-Text PDF

Fascin Regulates the Hippo Pathway and Is Important for Melanoma Development.

Anticancer Res 2021 May;41(5):2403-2410

Department of Pathology, College of Medicine, Chosun University, Gwangju, Republic of Korea

Background/aim: Fascin, an actin-bundling protein, plays an essential role in cancer metastasis. The Hippo pathway is critical for carcinogenesis and cancer stem cell self-renewal. Mammalian STE20-like kinase (MST) is a core component of the Hippo pathway. Read More

View Article and Full-Text PDF

The long noncoding RNA AATBC promotes breast cancer migration and invasion by interacting with YBX1 and activating the YAP1/Hippo signaling pathway.

Cancer Lett 2021 May 2. Epub 2021 May 2.

NHC Key Laboratory of Carcinogenesis, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China; Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address:

Long noncoding RNAs (lncRNAs) play an important role in the regulation of gene expression and are involved in several pathological responses. However, many important lncRNAs in breast cancer have not been identified and their expression levels and functions in breast cancer remain unknown. In this study, the lncRNA apoptosis-associated transcript in bladder cancer (AATBC) was found to be significantly highly expressed in breast cancer patients. Read More

View Article and Full-Text PDF

Moderate DNA hypomethylation suppresses intestinal tumorigenesis by promoting caspase-3 expression and apoptosis.

Oncogenesis 2021 May 4;10(5):38. Epub 2021 May 4.

Shanghai Key Laboratory of Regulatory Biology, Fengxian District Central Hospital-ECNU Joint Center of Translational Medicine, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.

Global DNA hypomethylation is a most common epigenetic alteration in human neoplasia. However, accumulative evidence shows that global DNA hypomethylation impacts tumorigenesis in a tissue-specific manner, promoting tumorigenesis in some but suppressing tumorigenesis in others including colorectal cancer. The underlying mechanisms, especially how DNA hypomethylation suppresses tumorigenesis, remain largely unknown. Read More

View Article and Full-Text PDF

YWHAE-NUTM2 oncoprotein regulates proliferation and cyclin D1 via RAF/MAPK and Hippo pathways.

Oncogenesis 2021 May 4;10(5):37. Epub 2021 May 4.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 20 Shattuck Street, Thorn 528, Boston, MA, 02115, USA.

Endometrial stromal sarcoma (ESS) is the second most common subtype of uterine mesenchymal cancer, after leiomyosarcoma, and oncogenic fusion proteins are found in many ESS. Our previous studies demonstrated transforming properties and diagnostic relevance of the fusion oncoprotein YWHAE-NUTM2 in high-grade endometrial stromal sarcoma (HG-ESS) and showed that cyclin D1 is a diagnostic biomarker in these HG-ESS. However, YWHAE-NUTM2 mechanisms of oncogenesis and roles in cyclin D1 expression have not been characterized. Read More

View Article and Full-Text PDF

Targeted Quantification of Phosphorylation Sites Identifies STRIPAK-Dependent Phosphorylation of the Hippo Pathway-Related Kinase SmKIN3.

mBio 2021 05 4;12(3). Epub 2021 May 4.

Allgemeine und Molekulare Botanik, Ruhr-Universität, Bochum, Germany

We showed recently that the erminal enter inase III (GCKIII) SmKIN3 from the fungus is involved in sexual development and hyphal septation. Our recent extensive global proteome and phosphoproteome analysis revealed that SmKIN3 is a target of the iatin-nteracting hosphatase nd inase (STRIPAK) multisubunit complex. Here, using protein samples from the wild type and three STRIPAK mutants, we applied absolute quantification by arallel-eaction onitoring (PRM) to analyze phosphorylation site occupancy in SmKIN3 and other eptation nitiation etwork (SIN) components, such as CDC7 and DBF2, as well as BUD4, acting downstream of SIN. Read More

View Article and Full-Text PDF

Hippo signaling pathway in companion animal diseases, an under investigated signaling cascade.

Vet Q 2021 May 4:1-14. Epub 2021 May 4.

Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 104, 3584 CM, Utrecht, the Netherlands.

The Hippo pathway is a highly conserved kinase cascade in mammals with the proteins YAP and TAZ as its most important downstream effectors that shuttle between cytoplasma and nucleus. It has a crucial role in processes such as embryogenesis, organ size control, homeostasis and tissue regeneration, where mechanosensing and/or cell-cell interactions are involved. As the pathway is associated with many essential functions in the body, its dysregulation is related to many diseases. Read More

View Article and Full-Text PDF

LATS1 K751 acetylation blocks activation of Hippo signalling and switches LATS1 from a tumor suppressor to an oncoprotein.

Sci China Life Sci 2021 Apr 29. Epub 2021 Apr 29.

Department of Human Anatomy, Histology and Embryology, MOE Key Laboratory of Carcinogenesis and Translational Research and State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing, 100191, China.

Large tumor suppressor 1 (LATS1) is the key kinase controlling activation of Hippo signalling pathway. Post-translational modifications of LATS1 modulate its kinase activity. However, detailed mechanism underlying LATS1 stability and activation remains elusive. Read More

View Article and Full-Text PDF

Wallenda-Nmo Axis Regulates Growth via Hippo Signaling.

Front Cell Dev Biol 2021 16;9:658288. Epub 2021 Apr 16.

Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China.

Both Hippo signaling pathways and cell polarity regulation are critical for cell proliferation and the maintenance of tissue homeostasis, despite the well-established connections between cell polarity disruption and Hippo inactivation, the molecular mechanism by which aberrant cell polarity induces Hippo-mediated overgrowth remains underexplored. Here we use wing discs as a model and identify the Wnd-Nmo axis as an important molecular link that bridges loss-of-cell polarity-triggered Hippo inactivation and overgrowth. We show that Wallenda (Wnd), a MAPKKK (mitogen-activated protein kinase kinase kinase) family member, is a novel regulator of Hippo pathways in and that overexpression of Wnd promotes growth via Nemo (Nmo)- mediated Hippo pathway inactivation. Read More

View Article and Full-Text PDF

Promotes Proliferation and Metastasis by Targeting Hippo/YAP Signalling in Colorectal Cancer.

Front Cell Dev Biol 2021 15;9:656359. Epub 2021 Apr 15.

Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China.

The complex in which scribble planar cell polarity protein () is located is one of the three main polar protein complexes that play an important role in maintaining epithelial polarity and affecting tumour growth. However, the role of in colorectal cancer (CRC) remains largely unknown. This study used date from The Cancer Genome Atlas (TCGA) and clinical samples to determine the expression of in CRC and explored its mechanism through bioinformatics analysis and and experiments. Read More

View Article and Full-Text PDF

Abnormal Expression of YAP Is Associated With Proliferation, Differentiation, Neutrophil Infiltration, and Adverse Outcome in Patients With Nasal Inverted Papilloma.

Front Cell Dev Biol 2021 15;9:625251. Epub 2021 Apr 15.

Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Background: Nasal inverted papilloma (NIP) is a common benign tumor. Yes-associated protein (YAP) is the core effector molecule of the Hippo pathway, which regulates the proliferation and differentiation of airway epithelium. While its role in proliferation may be connected to NIP formation, no definitive association has been made between them. Read More

View Article and Full-Text PDF

Luteolin Ameliorates Experimental Pulmonary Arterial Hypertension via Suppressing Hippo-YAP/PI3K/AKT Signaling Pathway.

Front Pharmacol 2021 15;12:663551. Epub 2021 Apr 15.

Department of Cardiovascular Medicine, The Second Xiangya Hospital of Central South University, Hunan, China.

Luteolin is a flavonoid compound with a variety of pharmacological effects. In this study, we explored the effects of luteolin on monocrotaline (MCT) induced rat pulmonary arterial hypertension (PAH) and underlying mechanisms. A rat PAH model was generated through MCT injection. Read More

View Article and Full-Text PDF

New insights into the Hippo/YAP pathway in idiopathic pulmonary fibrosis.

Pharmacol Res 2021 Apr 27;169:105635. Epub 2021 Apr 27.

State Key Laboratory of Toxicology and Medical Countermeasures, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, No 27, Taiping Road, Haidian District, Beijing 100850, China. Electronic address:

Idiopathic pulmonary fibrosis (IPF) is a progressive disease characterised by an inexorable decline in lung function. The development of IPF involves multiple positive feedback loops; and a strong support role of the Hippo/YAP signalling pathway, which is essential for regulating cell proliferation and organ size, in IPF pathogenesis has been unveiled recently in cell and animal models. YAP/TAZ contributes to both pulmonary fibrosis and alveolar regeneration via the conventional Hippo/YAP signalling pathway, G protein-coupled receptor signalling, and mechanotransduction. Read More

View Article and Full-Text PDF

Hepatocytes Induce Change in Their Neighbors by YAP-ing at Them.

Hepatology 2021 Apr 30. Epub 2021 Apr 30.

Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA.

Inhibition of the Hippo pathway in mice, typically by genetic deletion of one or more components, is associated with hepatomegaly and eventually development of hepatocellular carcinoma. This process is marked by increased activity of the transcriptional co-activators YAP and TAZ, which are negatively regulated by the Hippo pathway. Hippo/YAP signaling has been a focus of research into mechanisms of hepatocarcinogenesis and responses to HCC-directed therapy however the majority of studies have focused on cell intrinsic signaling pathways and Hippo dysregulation (leading to YAP activation). Read More

View Article and Full-Text PDF

Antisense Oligos May Hit "Undruggable" YAP1.

Authors:

Cancer Discov 2021 Apr 29. Epub 2021 Apr 29.

An antisense oligonucleotide that targets the Hippo pathway protein YAP1, long thought "undruggable," has shown preclinical promise and is under evaluation in a phase I trial. Read More

View Article and Full-Text PDF

New Insights into YES-Associated Protein Signaling Pathways in Hematological Malignancies: Diagnostic and Therapeutic Challenges.

Cancers (Basel) 2021 Apr 20;13(8). Epub 2021 Apr 20.

School and Operative Unit of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy.

The Hippo/YES-associated protein (YAP) signaling pathway is a cell survival and proliferation-control system with its main activity that of regulating cell growth and organ volume. YAP operates as a transcriptional coactivator in regulating the onset, progression, and treatment response in numerous human tumors. Moreover, there is evidence suggesting the involvement of YAP in the control of the hematopoietic system, in physiological conditions rather than in hematological diseases. Read More

View Article and Full-Text PDF

Isomer-Specific Effects of -9,-11- and -10,-12-CLA on Immune Regulation in Ruminal Epithelial Cells.

Animals (Basel) 2021 Apr 19;11(4). Epub 2021 Apr 19.

Institute of Food Sciences, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China.

In this study, we used transcriptomics and qPCR to investigate the potential immunoprotective effects of different conjugated linoleic acid (CLA) isomers, the natural rumen microbial metabolites, on lipopolysaccharide (LPS)-induced inflammation of ruminal epithelial cells (RECs) in vitro. The results showed that 100 μM -10,-12-CLA exerted higher anti-inflammatory effects than -9,-11-CLA by significantly downregulating the expression of genes related to inflammation, cell proliferation and migration in RECs upon LPS stimulation. Transcriptomic analyses further indicated that pretreatment with -10,-12-CLA, but not -9,-11-CLA, significantly suppressed the biological signals of GO terms' response to LPS, the regulation of signal transduction and cytokine production and KEGG pathways NF-κB, chemokine, NOD-like receptor, Hippo, PI3K-Akt, TGF-β and Rap1 signaling in RECs upon LPS stimulation. Read More

View Article and Full-Text PDF

Misshapen Disruption Cooperates with to Drive Tumorigenesis.

Cells 2021 Apr 14;10(4). Epub 2021 Apr 14.

School of Medicine, Zhejiang University, Hangzhou 310058, China.

Although family genes play essential roles in tumorigenesis, effective treatments targeting -related tumors are lacking, partly because of an incomplete understanding of the complex signaling crosstalk within -related tumors. Here, we performed a large-scale genetic screen in eye imaginal discs and identified () as a tumor suppressor that synergizes with oncogenic () to induce c-Jun N-terminal kinase (JNK) activation and Hippo inactivation, then subsequently leads to tumor overgrowth and invasion. Moreover, ectopic Msn expression activates Hippo signaling pathway and suppresses Hippo signaling disruption-induced overgrowth. Read More

View Article and Full-Text PDF

Reconciling the Biological and Transcriptional Variability of Hepatoblastoma with Its Mutational Uniformity.

Cancers (Basel) 2021 Apr 21;13(9). Epub 2021 Apr 21.

Division of Hematology/Oncology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA.

Hepatoblastoma (HB), the most common childhood liver cancer, is associated with seven distinct histologic subtypes and variable degrees of clinical aggressiveness and presentation. Yet it is among the least genomically altered tumors known, with about half of HBs showing mutation and/or dysregulation of the Wnt/β-catenin and Hippo pathways. This raises the question of how this mutational simplicity can generate such biological and histologic complexity. Read More

View Article and Full-Text PDF

In Vitro Activation Early Follicles: From the Basic Science to the Clinical Perspectives.

Int J Mol Sci 2021 Apr 6;22(7). Epub 2021 Apr 6.

Department of Obstetrics and Gynecology, School of Medicine, International University of Health and Welfare, Narita, Chiba 286-8686, Japan.

Development of early follicles, especially the activation of primordial follicles, is strictly modulated by a network of signaling pathways. Recent advance in ovarian physiology has been allowed the development of several therapies to improve reproductive outcomes by manipulating early folliculogenesis. Among these, in vitro activation (IVA) has been recently developed to extend the possibility of achieving genetically related offspring for patients with premature ovarian insufficiency and ovarian dysfunction. Read More

View Article and Full-Text PDF

Elaborating the Physiological Role of YAP as a Glucose Metabolism Regulator:A Systematic Review.

Cell Physiol Biochem 2021 Apr;55(2):193-205

Department of Biomedical Science, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia,

Yes-associated protein (YAP) is one of the Hippo pathway's two effectors, a pathway associated with organ size control. Research on YAP has focused on its oncogenic potential. However, in cancer cells, aside from inducing growth, YAP was also found to regulate glucose metabolism. Read More

View Article and Full-Text PDF

Heterozygous ANKRD17 loss-of-function variants cause a syndrome with intellectual disability, speech delay, and dysmorphism.

Am J Hum Genet 2021 Apr 21. Epub 2021 Apr 21.

Institute for Human Genetics, University of California, San Francisco, San Francisco, CA 94143, USA.

ANKRD17 is an ankyrin repeat-containing protein thought to play a role in cell cycle progression, whose ortholog in Drosophila functions in the Hippo pathway as a co-factor of Yorkie. Here, we delineate a neurodevelopmental disorder caused by de novo heterozygous ANKRD17 variants. The mutational spectrum of this cohort of 34 individuals from 32 families is highly suggestive of haploinsufficiency as the underlying mechanism of disease, with 21 truncating or essential splice site variants, 9 missense variants, 1 in-frame insertion-deletion, and 1 microdeletion (1. Read More

View Article and Full-Text PDF

PKM2 regulates proliferation and apoptosis through the Hippo pathway in oral tongue squamous cell carcinoma.

Oncol Lett 2021 Jun 11;21(6):461. Epub 2021 Apr 11.

Department of Oral and Maxillofacial Surgery, Suining Central Hospital, Suining, Sichuan 629000, P.R. China.

Oral tongue squamous cell carcinoma (OTSCC) is a highly malignant type of tumor. The 5-year survival rate of patients with advanced tongue squamous cell carcinoma is only ~50%. Pyruvate kinase M2 (PKM2) is the key rate-limiting enzyme of glycolysis, maintaining the Warburg effect in tumor cells. Read More

View Article and Full-Text PDF

KIBRA Connects Hippo Signaling and Cancer.

Exp Cell Res 2021 Apr 23:112613. Epub 2021 Apr 23.

Department of Human Genetics, Faculty of Biomedical Sciences, Technology & Research, Sri Ramachandra Institute of Higher Education, Chennai, 600116, Tamil Nadu, India. Electronic address:

The Hippo signaling pathway is a tumor suppressor pathway that plays an important role in tissue homeostasis and organ size control. KIBRA is one of the many upstream regulators of the Hippo pathway. It functions as a tumor suppressor by positively regulating the core Hippo kinase cascade. Read More

View Article and Full-Text PDF