108,346 results match your criteria highly sensitive


[Norms of the German Version of the Highly Sensitive Person Scale (HSPS-G) - Self-Assessment Scale on a German-Speaking Sample].

Psychother Psychosom Med Psychol 2021 Sep 20. Epub 2021 Sep 20.

Professur für Persönlichkeitspsychologie und Psychologische Diagnostik, Helmut-Schmidt-Universität Universität der Bundeswehr Hamburg, Deutschland.

Problem: The German version of the Highly Sensitive Person Scale (HSPS-G) is an instrument for the assessment of sensitivity. Validity of the scale was confirmed in prior research (Konrad & Herzberg, 2017). This paper provides norm values of the HSPS-G for German-speaking countries. Read More

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September 2021

Plasmon-Assisted Polarization-Sensitive Photodetection with Tunable Polarity for Integrated Silicon Photonic Communication Systems.

Nanotechnology 2021 Sep 20. Epub 2021 Sep 20.

Institute of Solid State Electronics, Technische Universität Wien, Gußhausstraße 25-25a, Vienna, 1040, AUSTRIA.

To establish high-bandwidth chip-to-chip interconnects in optoelectronic integrated circuits (OEICs), it requires high-performance photon emitters and signal receiving components. Regarding the photodetector fast device concepts like Schottky junction devices, large carrier mobility materials and shrinking the channel length will enable higher operation speed. However, integrating photodetectors in highly scaled ICs technologies is challenging due to the efficiency-speed trade-off. Read More

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September 2021

Insight into sulfur dioxide and its derivatives metabolism in living system with visualized evidences via ultra-sensitive fluorescent probe.

J Hazard Mater 2021 Sep 11;423(Pt B):127179. Epub 2021 Sep 11.

CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Shandong Key Laboratory of Coastal Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China; Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao 266071, China; Laboratory for Marine Biology and Biotechnology, Pilot National Laboratory for Marine Science and Technology, Qingdao 266237, China; School of Pharmacy, Binzhou Medical University, Yantai 264003, China. Electronic address:

Sulfur dioxide (SO) and its derivatives have long been considered as hazardous environmental pollutants but commonly used as food additives in safe dose range. They also could be produced from biological metabolism process of sulfur-containing amino acids. However, their physiological roles remain extremely obscure mainly due to lack of efficient tools for monitoring and imaging strategy establishment. Read More

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September 2021

TRAP transporter TakP: a key player in the resistance against selenite-induced oxidative stress in Rhodobacter sphaeroides.

Microbiol Res 2021 Aug 8;252:126828. Epub 2021 Aug 8.

Institute of Pharmacy, Pharmaceutical Microbiology, University of Greifswald, Germany; Institute of infection medicine, Kiel University, Germany. Electronic address:

Almost one-third of all proteins require metal ions as an essential component in key biological processes and approximately half of all enzymes are associated with one or more metal ions. The naturally occurring selenium is very toxic at higher levels, but few bacteria can reduce it into the less toxic insoluble elemental selenium. Selenium is required for the synthesis of selenocysteine, an essential residue involved in the active sites of various enzymes. Read More

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Immobile crystallization of radioactive iodide by redox transformation of a low crystalline copper phase.

Chemosphere 2021 Sep 16;287(Pt 3):132266. Epub 2021 Sep 16.

Disposal Performance Demonstration Research Division, Korea Atomic Energy Research Institute (KAERI), Daejeon, 34057, Republic of Korea.

Here we show an innovative way to effectively scavenge highly mobile radioiodide and to dramatically reduce its waste volume through a spontaneous phase transformation. Under an anaerobic condition, as metallic copper (II) was favorably associated with bicarbonate (HCO) in solution, a cupriferous carbonate compound (malachite) quickly formed, which was redox-sensitive and transformable to a compact crystal of CuI (marshite). The formation of CuI crystal was principally led by the spontaneous Cu-I redox reaction centering around the copper phase over the presence of sulfate (SO). Read More

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September 2021

Aptamer-functionalized metal-organic framework-based electrospun nanofibrous composite coating fiber for specific recognition of ultratrace microcystin in water.

J Chromatogr A 2021 Sep 10;1656:462542. Epub 2021 Sep 10.

Institute of Food Safety and Environment Monitoring, Fuzhou University, Fuzhou 350108, People's Republic of China; Engineering Technology Research Center on Reagent and Instrument for Rapid Detection of Product Quality and Food Safety, Fuzhou, Fujian 350108, People's Republic of China.

A novel [email protected]@UiO-66-NH electrospun nanofibrous coating fiber for specific recognition of microcystin-LR (MC-LR) was proposed by using electrospinning, metal-organic frameworks (MOF) seed growth and AuNPs bridging aptamer strategies. Characterization of morphology, structure and stability of the obtained affinity nanofibrous coating fiber were investigated. High loading of MOFs and aptamers on the nanofibrous fiber were achieved and successfully applied for accurate identification of MC-LR by solid-phase microextraction (SPME) coupled with LC-MS. Read More

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September 2021

Amplification-free smartphone-based attomolar HBV detection.

Biosens Bioelectron 2021 Sep 11;194:113622. Epub 2021 Sep 11.

Joint International Research Laboratory of Animal Health and Food Safety of Ministry of Education & Single Molecule Nanometry Laboratory (Sinmolab), Nanjing Agricultural University, Nanjing, Jiangsu, 210095, China. Electronic address:

Classical gold standard HBV detection relies on expensive devices and complicated procedures, thus is always restricted in large-scale hospitals and centers for disease control and prevention. To extend HBV detection to primary clinics especially in underdeveloped areas, we design amplification-free smartphone-based attomolar HBV detecting technique based on single molecule sensing. Verified by synthesized HBV target DNA, this technique reaches a detection limit at attomolar concentration (100 aM); and verified by 110 clinical samples, it also reaches a rather high sensitivity of 10 copy/mL (≈2000 IU/mL) with a high accuracy of 93. Read More

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September 2021

Complex effects of moisture conditions and temperature enhanced vegetation growth in the Arid/humid transition zone in Northern China.

Sci Total Environ 2021 Sep 7;805:150152. Epub 2021 Sep 7.

Henan Province Development and Reform Commission, Zhengzhou 450018, China.

Ecosystems in the arid/humid transition zone (AHTZ) of northern China are highly sensitive to climate change and human activities. Accurately assessing the impact of climate change on these ecosystems is important for effectively reducing the risks faced by them under future climate change. In this study, the leaf area index during the selected growing season (LAI) was used as an indicator for vegetation activity. Read More

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September 2021

A multiplex nanoparticle-assisted polymerase chain reaction assay for detecting three canine epidemic viruses using a dual priming oligonucleotide system.

J Virol Methods 2021 Sep 17:114290. Epub 2021 Sep 17.

Innovation Team of Small Animal Infectious Disease, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences (CAAS), Shanghai, 200241, China. Electronic address:

A rapid and accurate diagnosis of mixed viral infections is important for providing timely therapeutic interventions. The aim of this study was to develop a highly sensitive and specific method for the simultaneous detection of canine distemper virus (CDV), canine parvovirus (CPV) and canine coronavirus (CCV) in mixed infections by combining the high specificity of a dual priming oligonucleotide (DPO) primer system with the high sensitivity of a nanoparticle-assisted PCR (nanoPCR) assay. Under the optimized assay conditions, the multiplex DPO-nanoPCR assay developed using DPO primers was 100-fold more sensitive than the multiplex PCR assay using conventional primers. Read More

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September 2021

Highly Sensitive CRISPR/Cas12a-Based Fluorescence Detection of Porcine Reproductive and Respiratory Syndrome Virus.

ACS Synth Biol 2021 Sep 20. Epub 2021 Sep 20.

Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture & Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518000, PR China.

Porcine reproductive and respiratory syndrome (PRRS) is an economically important disease of swine that is caused by PRRS virus (PRRSV). In this study, we established a fluorescence assay for highly sensitive detection of PRRSV through integration of the reverse transcription-recombinase polymerase amplification (RT-RPA)-coupled Cas12a system with an optical property of single stranded DNA-fluorescently quenched (ssDNA-FQ) reporter. This technique can achieve isothermal and visual detection of PRRSV in 25 min. Read More

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September 2021

Predictors of unfavorable responses to therapy in rifampicin-sensitive pulmonary tuberculosis using an integrated approach of radiological presentation and sputum mycobacterial burden.

PLoS One 2021 20;16(9):e0257647. Epub 2021 Sep 20.

Department of Clinical Research, National Institute for Research in Tuberculosis (formerly Tuberculosis Research Centre), Indian Council of Medical Research, Chennai, Tamil Nadu, India.

Introduction: Despite the exalted status of sputum mycobacterial load for gauging pulmonary tuberculosis treatment and progress, Chest X-rays supplement valuable information for taking instantaneous therapeutic decisions, especially during the COVID-19 pandemic. Even though literature on individual parameters is overwhelming, few studies have explored the interaction between radiographic parameters denoting severity with mycobacterial burden signifying infectivity. By using a sophisticated approach of integrating Chest X-ray parameters with sputum mycobacterial characteristics, evaluated at all the three crucial time points of TB treatment namely pre-treatment, end of intensive phase and completion of treatment, utilizing the interactive Cox Proportional Hazards model, we aimed to precisely deduce predictors of unfavorable response to TB treatment. Read More

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September 2021

Ethics, Integrity and Retributions of Digital Detection Surveillance Systems on Infectious Diseases: Systematic literature review.

J Med Internet Res 2021 Sep 14. Epub 2021 Sep 14.

Department of Family Medicine and Primary Care, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 3/F, Ap Lei Chau Clinic161 Main Street, Ap Lei Chau, Hong Kong, HK.

Background: The COVID-19 pandemic has raised the importance of the deployment of digital detection surveillance systems to support early warning and monitoring of infectious diseases (ID). These opportunities create a "double-edge sword" as the ethical governance of such approaches often lag behind technological achievements.

Objective: The aim was to investigate ethical issues identified from utilizing AI-augmented surveillance or early warning systems to monitor and detect common or novel ID outbreaks. Read More

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September 2021

Reaction between a NO Dimer and Dissolved SO: A New Mechanism for ONSO Formation and its Fate in Aerosol.

Authors:
Bo Tang Zhenyu Li

J Phys Chem A 2021 Sep 20. Epub 2021 Sep 20.

Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, Anhui 230026, China.

Experimental observations indicate that sulfate formation in aerosol is sensitive to the concentrations of nitric oxide (NO). While it also widely exists as a dimer in the gas phase, previous studies focus on the monomer of NO. In this study, we employ quantum chemical calculations and molecular dynamics simulations to investigate the reaction between the NO dimer (ONONO) and sulfite (HSO/SO) in the gas phase and in an aerosol. Read More

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September 2021

Photocatalytic Hydroaminoalkylation of Styrenes with Unprotected Primary Alkylamines.

J Am Chem Soc 2021 Sep 20. Epub 2021 Sep 20.

Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, U.K.

Catalytic, intermolecular hydroaminoalkylation (HAA) of styrenes provides a powerful disconnection for pharmacologically relevant γ-arylamines, but current methods cannot utilize unprotected primary alkylamines as feedstocks. Metal-catalyzed HAA protocols are also highly sensitive to α-substitution on the amine partner, and no catalytic solutions exist for α-tertiary γ-arylamine synthesis via this approach. We report a solution to these problems using organophotoredox catalysis, enabling a direct, modular, and sustainable preparation of α-(di)substituted γ-arylamines, including challenging electron-neutral and moderately electron-rich aryl groups. Read More

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September 2021

Purification of Cytoskeletal Proteins by Fast Protein Liquid Chromatography (FPLC) Using an ÄKTA Start System.

Methods Mol Biol 2022 ;2364:237-249

Protein Purification, Kemp Proteins, Frederick, MD, USA.

Actin, myosin, and tubulin are ubiquitous components of the fibrous network known as the cytoskeleton. Cytoskeletal proteins are involved in a plethora of intracellular processes such as maintenance of cellular organization, organelle translocation, and various nuclear roles including chromosome separation during mitosis. Early methods for protein extraction primarily relied on the salting-out method which was performed in conjunction with biochemical assays. Read More

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January 2022

Tuneable time delay in the burst release from oxidation sensitive polymersomes made by PISA.

Angew Chem Int Ed Engl 2021 Sep 20. Epub 2021 Sep 20.

Friedrich-Schiller-Universitat Jena, Laboratory for Organic and Macromolecular Chemistry, Humboldtstrasse 10, 07743, Jena, GERMANY.

The confinement in and the selective release from vesicular structures is an elementary part of biological transport processes and highly attractive for drug delivery systems. Reactive polymersomes represent a versatile artificial cargo carrier system, which can facilitate an immediate release in response to a specific stimulus. The herein presented oxidation-sensitive polymersomes feature a time delayed release mechanism in an oxidative environment, which can be precisely adjusted by either tuning the membrane thickness or partial pre-oxidation. Read More

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September 2021

Iron, Nitrogen-Doped Carbon Aerogels for Fluorescent and Electrochemical Dual-Mode Detection of Glucose.

Langmuir 2021 Sep 19. Epub 2021 Sep 19.

Department of Chemistry and Biochemistry, University of California, 1156 High Street, Santa Cruz, California 95064, United States.

Due to their effective catalytic activity and maximum atom utilization, single metal atoms dispersed in carbon matrices have found diverse applications in electrocatalysis, photocatalysis, organic catalysis, and biosensing. Herein, iron is atomically dispersed into nitrogen-doped porous carbon aerogel by a facile pyrolysis procedure, and the resulting nanocomposite behaves both as a peroxidase mimic for the sensitive detection of glucose by fluorescence spectroscopy and as an effective catalyst for the electrochemical oxidation of glucose. The glucose concentration can be quantified within the millimolar to micromolar range with a limit of detection of 3. Read More

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September 2021

Direction-Adjustable Single-Mode Lasing via Self-Assembly 3D-Curved Microcavities for Gas Sensing.

ACS Appl Mater Interfaces 2021 Sep 19. Epub 2021 Sep 19.

College of Physics and Optoelectronics, Faculty of Science, Beijing University of Technology, Beijing 100124, China.

Drop-based microcavity lasers emerged as a promising tool in modern physics investigation and chemical detection owing to their cost-effective fabrication, high luminescence, and sensitive molecule sensing. However, it is of great challenge to achieve highly directional emission along with high quality () factors via traditional droplet self-assembly behavior of the gain medium on a planar substrate. In this work, a single-mode microcavity laser with directional far-field emission is first proposed via droplet self-assembly 3D-curved microcavities, and simultaneously, acetic acid (AcOH) gas sensing is realized. Read More

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September 2021

Evaluation of Plasmid Stability by Negative Selection in Gram-negative Bacteria.

Bio Protoc 2017 May 5;7(9):e2261. Epub 2017 May 5.

Department of Cell and Developmental Biology, University College London, London, UK.

Plasmid stability can be measured using antibiotic-resistance plasmid derivatives by positive selection. However, highly stable plasmids are below the sensitivity range of these assays. To solve this problem we describe a novel, highly sensitive method to measure plasmid stability based on the selection of plasmid-free cells following elimination of plasmid-containing cells. Read More

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RNase Sensitivity Screening for Nuclear Bodies with RNA Scaffolds in Mammalian Cells.

Bio Protoc 2017 Apr 20;7(8):e2232. Epub 2017 Apr 20.

Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan.

The mammalian cell nucleus is highly organized and contains membraneless nuclear bodies (NBs) characterized by distinct resident factors. The NBs are thought to serve as sites for biogenesis and storage of certain RNA and protein factors as well as assembly of ribonucleoprotein complexes. Some NBs are formed with architectural RNAs (arcRNAs) as their structural scaffolds and additional NBs likely remain unidentified in mammalian cells. Read More

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Neutral Comet Assay to Detect and Quantitate DNA Double-Strand Breaksin Hematopoietic Stem Cells.

Bio Protoc 2021 Aug 20;11(16):e4130. Epub 2021 Aug 20.

School of Biology, Indian Institute of Science Education and Research Thiruvananthapuram, Kerala, 695 551, India.

In vertebrates, hematopoietic stem cells (HSCs) regulate the supply of blood cells throughout the lifetime and help to maintain homeostasis. Due to their long lifespan, genetic integrity is paramount for these cells, and accordingly, a number of stem cell-specific mechanisms are employed. However, HSCs tend to show more DNA damage with increasing age due to an imbalance between proliferation rates and DNA damage responses. Read More

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Restoration of dental services after COVID-19: The fallow time determination with laser light scattering.

Sustain Cities Soc 2021 Nov 9;74:103134. Epub 2021 Jul 9.

Faculty of Dentistry, The University of Hong Kong, Pok Fu Lam, Hong Kong Island, Hong Kong, China.

In time, dental health care has slowly expanded beyond emergency treatment to treat oral diseases. How to reduce the cross-transmission risk in dental surgery has raised much more attention. Considering the lack of consistency of fallow time (FT) in its necessity and duration, the highly sensitive laser light scattering method has been proposed to visualize the airborne lifetime and decay rate of suspended particles in the dental surgery environment. Read More

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November 2021

The Validity of the American Diabetes Association's Diabetes Risk Test in a Saudi Arabian Population.

Cureus 2021 Sep 16;13(9):e18018. Epub 2021 Sep 16.

Health Sciences, Johns Hopkins University, Baltimore, USA.

Introduction The prevalence of type 2 diabetes (T2D) is growing worldwide. This study aimed to assess the sensitivity and specificity of the American Diabetes Association (ADA) and the United States Centers for Disease Control and Prevention's diabetes risk test in identifying Saudi Arabian patients at risk of developing T2D. Methods We conducted a one-month cross-sectional study that included patients older than 18 years who visited primary care facilities for any health concern in Riyadh City, Saudi Arabia. Read More

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September 2021

The relationship between CHADS-VASc score and isolated coronary artery ectasia.

Am J Blood Res 2021 15;11(4):391-398. Epub 2021 Aug 15.

Department of Cardiology, Institute of Cardiology, Istanbul University-Cerrahpaşa Istanbul, Turkey.

Introduction: Coronary artery ectasia (CAE) is defined as localized or diffuse dilatation of the epicardial coronary arteries. We aimed to elucidate the relationship between the CHADS-VASc score and CAE.

Methods: The study population consisted of 122 patients with isolated CAE and 87 sex- and age-matched control subjects. Read More

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Bioactive Hexapeptide Reduced the Resistance of Ovarian Cancer Cells to DDP by Affecting HSF1/HSP70 Signaling Pathway.

J Cancer 2021 24;12(20):6081-6093. Epub 2021 Aug 24.

School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui 230032, P.R. China.

Ovarian cancer is the leading cause of death in gynecologic malignancies. Ovarian cancer as a metastatic malignant tumor is highly recurrent and prone to drug resistance. Bioactive peptides are an emerging area of biomedical research in reducing resistance of tumor cell to drugs. Read More

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Mitochondria in Injury, Inflammation and Disease of Articular Skeletal Joints.

Front Immunol 2021 3;12:695257. Epub 2021 Sep 3.

Department of Anatomy and Regenerative Medicine and Tissue Engineering Research Group, Royal College of Surgeons in Ireland, Dublin, Ireland.

Inflammation is an important biological response to tissue damage caused by injury, with a crucial role in initiating and controlling the healing process. However, dysregulation of the process can also be a major contributor to tissue damage. Related to this, although mitochondria are typically thought of in terms of energy production, it has recently become clear that these important organelles also orchestrate the inflammatory response multiple mechanisms. Read More

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September 2021

A Nonclinical Spectroscopic Approach for Diagnosing Covid-19: A Concise Perspective.

J Appl Spectrosc 2021 Sep 12:1-7. Epub 2021 Sep 12.

Coordination, Metallopharmaceutical and Computational Chemistry Laboratory, Department of PG Studies and Research in Chemistry and Pharmacy, RD University, Jabalpur, MP India.

With the COVID-19 outbreak, many challenges are posed before the scientific world to curb this pandemic. The diagnostic testing, treatment, and vaccine development for this infection caught the scientific community's immediate attention. Currently, despite the global proliferation of COVID-19 vaccination, the specific treatment for this disease is yet unknown. Read More

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September 2021

Ultrasensitive electrochemical detection of CYFRA 21-1 via in-situ initiated ROP signal amplification strategy.

Anal Chim Acta 2021 Oct 27;1180:338889. Epub 2021 Jul 27.

Department of Endocrinology, The First Affiliated Hospital, Henan University of Chinese Medicine, Zhengzhou, 450000, PR China. Electronic address:

The cytokeratin19 fragment (CYFRA 21-1) is an essential biomarker for non-small cell lung cancer (NSCLC). This work proposed a novel electrochemical immunosensor with a high selective and sensitive detection of CYFRA 21-1via the ring-opening polymerization (ROP) signal amplification strategy. Specifically, 3-mercaptopropionic (MPA) was employed as a cross-linking agent to immobilize cAb on the electrode surface for subsequent specific capture of CYFRA 21-1. Read More

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October 2021

PREDICTORS OF ATRIAL FIBRILLATION RECURRENCE AFTER RADIOFREQUENCY ABLATION IN PATIENTS WITH CHRONIC HEART FAILURE.

Wiad Lek 2021 ;74(8):1850-1855

V. N. KARAZIN KHARKIV NATIONAL UNIVERSITY, KHARKIV, UKRAINE.

Objective: The aim: To study the predictive power of demographic, hemodynamic and electrocardiographic factors for atrial fibrillation recurrence after radiofrequency ablation (RFA) in patients with chronic heart failure.

Patients And Methods: Materials and methods: Study included 120 patients, aged 59,80±10,08 years old with chronic heart failure with preserved left ventricular ejection fraction who were undergo RFA due to atrial fibrillation (AF). A standard 12-lead electrocardiogram (ECG) was registered. Read More

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January 2021

DNA dendrimer-templated copper nanoparticles: self-assembly, aggregation-induced emission enhancement and sensing of lead ions.

Mikrochim Acta 2021 09 19;188(10):346. Epub 2021 Sep 19.

State Key Lab of Food Science and Technology, Jiangnan University, Wuxi, 214122, People's Republic of China.

Copper nanomaterials based on DNA scaffold (DNA-Cu NMs) are becoming a novel fluorescent material, but it is still challenging to obtain highly fluorescent DNA-Cu NMs with excellent stability. In this work, we report a kind of copper nano-assemblies (Cu NASs) with aggregation-induced emission enhancement (AIEE) property using DNA dendrimers with sticky end as template. The sticky end of the DNA dendrimers induced the formation of much bigger Cu NASs with average size ranging from 131 to 264 nm, depending on the length of the DNA dendrimer sticky end from 6 bases to 27 bases. Read More

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September 2021