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Hydrothermal aging affects the three-dimensional fit and fatigue lifetime of zirconia abutments.

J Mech Behav Biomed Mater 2021 Sep 8;124:104832. Epub 2021 Sep 8.

Department of Prosthodontics and Periodontology, Bauru School of Dentistry - University of Sao Paulo, 9-75 Octavio Pinheiro Brizolla, 17012-901, Bauru, SP, Brazil.

Objective: Evaluate the effect of aging using two different methods on the three-dimensional fit of zirconia abutments at the implant-abutment connection and estimate the probability of survival of anterior crowns supported by straight and 17-degree angled abutments.

Materials And Methods: Two different zirconia abutment designs, straight and 17-degree angled abutments (n = 63/group), were evaluated in the current study. The abutments were randomly allocated into three experimental groups according to laboratory aging condition (134°C, 2. Read More

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September 2021

Racial and ethnic disparities in treatment response and tolerability in multiple sclerosis: A comparative study.

Mult Scler Relat Disord 2021 Sep 9;56:103248. Epub 2021 Sep 9.

Division of Multiple Sclerosis and Neuroimmunology, Department of Neurology, University of Texas Health Science Center at Houston, Houston, TX, USA.

Background: Inter-individual response and tolerability profiles associated with available disease-modifying treatments (DMTs) are an important aspect of the therapeutic decision-making process in multiple sclerosis (MS). In the absence of racially diverse clinical studies, the possible effect of race and ethnicity on treatment outcome remains uncertain. This study aims to compare disease outcome among Hispanic, Black, and White patients with MS, and assess the impact of race/ethnicity on long-term outcome. Read More

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September 2021

Mutual effects of fine particulate matter, nitrogen dioxide, and fireworks on cause-specific acute cardiovascular mortality: A case-crossover study in communities affected by aircraft noise.

Environ Pollut 2021 Aug 30;291:118066. Epub 2021 Aug 30.

Swiss Tropical and Public Health Institute (SwissTPH), Basel, Switzerland; University of Basel, Basel, Switzerland. Electronic address:

Ambient air pollution is the leading cause of environmental mortality and morbidity worldwide. However, the individual contributions to acute mortality of traffic-related air pollutants such as nitrogen dioxide (NO) and fine particulate matter (PM) are still debated. We conducted a time-stratified case-crossover study for a population located around Zurich airport in Switzerland, including 24,886 adult cardiovascular deaths from the Swiss National Cohort. Read More

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Chronic Hypertension, Perinatal Mortality, and the Impact of Preterm Delivery: A Population-Based Study.

BJOG 2021 Sep 18. Epub 2021 Sep 18.

Division of Epidemiology and Biostatistics, Department of Obstetrics, Gynecology and Reproductive Sciences, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.

Objectives: To estimate the association between chronic hypertension and perinatal mortality and to evaluate the extent to which risks are impacted by preterm delivery.

Design: Cross-sectional analysis.

Setting: United States, 2015-2018. Read More

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September 2021

BRAF V600E potentially determines "Oncological Resectability" for "Technically Resectable" colorectal liver metastases.

Cancer Med 2021 Sep 18. Epub 2021 Sep 18.

Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

Despite reports on poor survival outcomes after hepatectomy for colorectal liver metastases (CRLM) with BRAF V600E mutation (mBRAF) exist, the role of mBRAF testing for technically resectable cases remains unclear. A single-center retrospective study was performed to investigate the survival outcomes of patients who underwent upfront hepatectomy for solitary resectable CRLM with mBRAF between January 2005 and December 2017 and to compare them with those of unresectable cases with mBRAF. Of 172 patients who underwent initial hepatectomy for solitary resectable CRLM, mBRAF, RAS mutations (mRAS), and wild-type RAS/BRAF (wtRAS/BRAF) were observed in 5 (2. Read More

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September 2021

IL-6 Is Associated with Progression of Coronary Artery Calcification and Mortality in Incident Dialysis Patients.

Am J Nephrol 2021 Sep 15:1-8. Epub 2021 Sep 15.

Kidney and Hypertension Unit, Joslin Diabetes Center, Boston, Massachusetts, USA.

Introduction: Inflammation is important in the pathogenesis of atherosclerosis. Elevated interleukin-6 (IL-6) is associated with cardiovascular events and also predicts mortality in individuals with CKD. Our goal was to determine the association between IL-6, FGF23, and high-sensitivity C-reactive protein (hsCRP) on coronary artery calcification (CAC) progression and mortality in incident dialysis patients without prior coronary events. Read More

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September 2021

Risk prediction of covid-19 related death and hospital admission in adults after covid-19 vaccination: national prospective cohort study.

BMJ 2021 Sep 17;374:n2244. Epub 2021 Sep 17.

Division of Primary Care, School of Medicine, University of Nottingham, Nottingham, UK.

Objectives: To derive and validate risk prediction algorithms to estimate the risk of covid-19 related mortality and hospital admission in UK adults after one or two doses of covid-19 vaccination.

Design: Prospective, population based cohort study using the QResearch database linked to data on covid-19 vaccination, SARS-CoV-2 results, hospital admissions, systemic anticancer treatment, radiotherapy, and the national death and cancer registries.

Settings: Adults aged 19-100 years with one or two doses of covid-19 vaccination between 8 December 2020 and 15 June 2021. Read More

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September 2021

Pertussis antibody levels in infants and their mothers receiving combined tetanus-diphtheria toxoid and acellular pertussis vaccine during pregnancy in Turkey.

Eur J Obstet Gynecol Reprod Biol 2021 Sep 2;265:212-216. Epub 2021 Sep 2.

Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Department of Neonatology, Istanbul, Turkey.

Objective: Pertussis is an important cause of morbidity and mortality in infants under two months of age and these high risk babies are dependent on maternally derived antibodies until completion of their first immunization series. This study aimed to evaluate the vaccine response of late preterm and term newborns as well as their mothers who underwent combined tetanus-diphtheria toxoid and acellular pertussis (Tdap) vaccination during pregnancy.

Study Design: A total of 70 pregnant women were administered Tdap vaccine (Boostrix®, GSK) between 27 and 33 gestational weeks of pregnancy. Read More

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September 2021

All-cause and cause-specific mortality of patients with rheumatoid arthritis in Korea: A nation-wide population-based study.

Joint Bone Spine 2021 Sep 14:105269. Epub 2021 Sep 14.

Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea. Electronic address:

Objective: To compare all-cause and cause-specific mortality between rheumatoid arthritis (RA) patients versus the general population of Korea Methods: A nationally representative RA population aged ≥40 years was identified from Korea National Health Insurance Service (KNHIS) database. We estimated age- and sex-adjusted all-cause and cause-specific standardized mortality ratios (SMRs) with 95% confidence intervals (CIs), comparing RA patients to the general population. Subgroup analyses were done by sex, age group, calendar year, and biologics use. Read More

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September 2021

Post-operative Renal Failure, Shunt Type and Mortality after Norwood Palliation.

Ann Thorac Surg 2021 Sep 14. Epub 2021 Sep 14.

Department of Pediatrics, Duke University Medical Center, 2301 Erwin Road, Durham, North Carolina 27710; Duke Clinical Research Institute, Duke University Medical Center, 2301 Erwin Road, Durham, North Carolina 27710.

Background: The Single Ventricle Reconstruction (SVR) trial demonstrated increased risk of death or heart transplant one year post-Norwood in subjects randomized to Blalock-Taussig shunts (mBTS) compared to right ventricle-to-pulmonary artery (RV-PA) shunts. We used the SVR public use database to evaluate incidence and risk factors for post-operative renal failure and relationships between renal failure, shunt type and outcomes post-Norwood.

Methods: Post-operative renal failure was defined a-priori as a 3-fold rise in creatinine from baseline, or dialysis use, within 7 days of Norwood. Read More

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September 2021

All-cause and cause-specific mortality during and following incarceration in Brazil: A retrospective cohort study.

PLoS Med 2021 Sep 17;18(9):e1003789. Epub 2021 Sep 17.

Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford, California, United States of America.

Background: Mortality during and after incarceration is poorly understood in low- and middle-income countries (LMICs). The need to address this knowledge gap is especially urgent in South America, which has the fastest growing prison population in the world. In Brazil, insufficient data have precluded our understanding of all-cause and cause-specific mortality during and after incarceration. Read More

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September 2021

Accurate Distinction of Ovarian Clear Cell From Endometrioid Carcinoma Requires Integration of Phenotype, Immunohistochemical Predictions, and Genotype: Implications for Lynch Syndrome Screening.

Am J Surg Pathol 2021 Sep 16. Epub 2021 Sep 16.

Department of Pathology, University of Calgary Division of Gynecologic Oncology, Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB Cancer Control Research, BC Cancer Agency Department of Pathology and Laboratory Medicine, BC Cancer, Vancouver, BC, Canada Division of Epidemiology, Biostatistics and Preventative Medicine, Department of Internal Medicine, University of New Mexico, Albuquerque, NM Department of Pathology and Laboratory Medicine, University of California Davis, Davis, CA.

Ovarian clear cell carcinoma (OCCC) and ovarian endometrioid carcinoma (OEC) are both associated with endometriosis but differ in histologic phenotype, biomarker profile, and survival. Our objectives were to refine immunohistochemical (IHC) panels that help distinguish the histotypes and reassess the prevalence of mismatch repair deficiency (MMRd) in immunohistochemically confirmed OCCC. We selected 8 candidate IHC markers to develop first-line and second-line panels in a training set of 344 OCCC/OEC cases. Read More

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September 2021

Descriptive Epidemiology and Outcomes of Nonventilated Hospital-Acquired, Ventilated Hospital-Acquired, and Ventilator-Associated Bacterial Pneumonia in the United States, 2012-2019.

Crit Care Med 2021 Sep 16. Epub 2021 Sep 16.

Division of Health Services Research, EviMed Research Group, LLC, Goshen, MA. OptiStatim, LLC, Longmeadow, MA. Merck, Kenilworth, NJ. Department of Pulmonary and Critical Care Medicine, Washington Hospital Center, Washington, DC.

Objectives: Multiple randomized controlled trials exploring the outcomes of patients with ventilator-associated bacterial pneumonia and hospital-acquired bacterial pneumonia have noted that hospital-acquired bacterial pneumonia patients who require subsequent ventilated hospital-acquired bacterial pneumonia suffered higher mortality than either those who did not (nonventilated hospital-acquired bacterial pneumonia) or had ventilator-associated bacterial pneumonia. We examined the epidemiology and outcomes of all three conditions in a large U.S. Read More

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September 2021

Day-to-day variation in sleep duration is associated with increased all-cause mortality.

J Clin Sleep Med 2021 Sep 17. Epub 2021 Sep 17.

Department of Medicine, NYC Health + Hospitals/Jacobi, Albert Einstein College of Medicine.

Study Objectives: There is paucity of data on association between day-to-day variation in sleep pattern and all-cause mortality. We aim to investigate if day-to-day variation in sleep duration and onset of sleep are associated with cardiovascular and all-cause mortality.

Methods: Data belonging to 388 unique subjects from the Midlife in the United States (MIDUS) 2 Biomarker study (2004-09) was used in our study. Read More

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September 2021

Comparison of assessment tools in acute upper gastrointestinal bleeding: which one for which decision.

Scand J Gastroenterol 2021 Sep 17:1-7. Epub 2021 Sep 17.

Gastroenterology Unit, Nuovo Regina Margherita Hospital, Rome, Italy.

Background: Upper GI bleeding (UGIB) remains a common emergency with significant mortality. Scores help triage patients, but it is still unclear which score should be used in the different decision-making moments to identify patients at high or low death risk. We aimed to compare the overall performances of the most validated scores and their cut-off performance to identify patients at low and high death risk. Read More

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September 2021

Risk factors, epidemiology and prognosis of cholangiocarcinoma in Finland.

United European Gastroenterol J 2021 Sep 17. Epub 2021 Sep 17.

Department of Gastroenterology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Background: Cholangiocarcinoma (CCA) is a cancer arising from the intra- and extrahepatic bile ducts. The early stages are often asymptomatic, CCA is frequently diagnosed in an advanced stage and the prognosis of CCA is often dismal.

Objective: Our objective was to estimate the incidence of CCA in Finland and to identify risk factors for CCA, with a special interest in primary sclerosing cholangitis (PSC). Read More

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September 2021

Combined association of cognitive impairment and poor oral health on mortality risk in older adults: results from the NHANES with 15 years of follow-up.

J Periodontol 2021 Sep 17. Epub 2021 Sep 17.

Center for Dentistry and Oral Hygiene, University Medical Center Groningen, University of Groningen, China.

Background: Cognitive impairment and poor oral health are frequently seen among older adults. Both conditions have been identified as risk factors for mortality. However, the combined associations of cognitive impairment and poor oral health with mortality have not been well studied and are therefore the aim of this cohort study. Read More

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September 2021

It is time for TEG in pediatric trauma: unveiling meaningful alterations in children who undergo massive transfusion.

Pediatr Surg Int 2021 Sep 17. Epub 2021 Sep 17.

Division of Pediatric Surgery, Children's Hospital Colorado, Aurora, CO, USA.

Background: Hemorrhage is the leading cause of preventable death in pediatric trauma patients. In adults, goal-directed thrombelastography (TEG) has been shown to reduce mortality when used to guide massive transfusion (MT) resuscitation. There remains a paucity of data on the utility of TEG in directing resuscitation of pediatric trauma patients. Read More

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September 2021

Influence of changes in body fat on clinical outcomes in a general population: a 12-year follow-up report on the Ansan-Ansung cohort in the Korean Genome Environment Study.

Ann Med 2021 Dec;53(1):1646-1658

Division of Cardiology, Department of Internal Medicine, Hanyang University Medical Center, Seoul, South Korea.

Background: The impact of the changes in the obesity status on mortality has not been established; thus, we investigated the long-term influence of body fat (BF) changes on all-cause deaths and cardiovascular outcomes in a general population.

Methods: A total of 8374 participants were observed for 12 years. BF was measured at least two times using a bioimpedance method. Read More

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December 2021

Risk Assessment of the Door-In-Door-Out Process at Primary Stroke Centers for Patients With Acute Stroke Requiring Transfer to Comprehensive Stroke Centers.

J Am Heart Assoc 2021 Sep 17:e021803. Epub 2021 Sep 17.

Department of Neurology Biological Sciences Division University of Chicago Chicago IL.

Background Patients with acute stroke at non- or primary stroke centers (PSCs) are transferred to comprehensive stroke centers for advanced treatments that reduce disability but experience significant delays in treatment and increased adjusted mortality. This study reports the results of a proactive, systematic, risk assessment of the door-in-door-out process and its application to solution design. Methods and Results A learning collaborative (clinicians, patients, and caregivers) at 2 PSCs and 3 comprehensive stroke centers in Chicago, Illinois participated in a failure modes, effects, and criticality analysis to identify steps in the process; failures of each step, underlying causes; and to characterize each failure's frequency, impact, and safeguards using standardized scores to calculate risk priority and criticality numbers for ranking. Read More

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September 2021

New-Onset Postoperative Atrial Fibrillation After Total Arch Repair Is Associated With Increased In-Hospital Mortality.

J Am Heart Assoc 2021 Sep 17:e021980. Epub 2021 Sep 17.

Department of Vascular Surgery Fuwai HospitalState Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical College Beijing China.

Background It is well established that postoperative atrial fibrillation (POAF) is associated with adverse postoperative outcomes after major cardiac operations. The purpose of this study was to investigate the incidence of new-onset POAF after successful total arch repair surgery and the association between POAF and in-hospital mortality. Methods and Results All consecutive patients undergoing total arch repair from September 2012 to December 2019 in Fuwai hospital were enrolled (n=1280). Read More

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September 2021

Flame burns.

Dermatol Ther 2021 Sep 16:e15133. Epub 2021 Sep 16.

Gazi Yasargil Training and Research Hospital Department of General Surgery, Diyarbakır, Turkey.

Introduction: Flame burns lead to significant long-term morbidity and functional consequences. This study analysed the mortality-related factors in patients with flame burns to compare with the existing literature.

Methods: This retrospective descriptive study was carried out at the General Surgery Clinic, Gazi YaŞargil Training and Research Hospital, Turkey, to include 131 patients admitted and treated with emergency surgery for flame burns between January 2016 and December 2019. Read More

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September 2021

Shock in China 2018 (SIC-study): a cross-sectional survey.

Ann Transl Med 2021 Aug;9(15):1219

Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.

Background: Shock is a critical illness that seriously threatens the lives of patients. This study explains the epidemiology of shock, mortality of shock, and identify factors that related to hospital death.

Methods: This is a multi-centre cross-sectional survey, which included 1,064 tertiary hospitals in 31 provinces, municipalities, and autonomous regions across China mainland. Read More

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Baseline Neutrophil-to-Lymphocyte Ratio Is Independently Associated With 90-Day Transplant-Free Mortality in Patients With Cirrhosis.

Front Med (Lausanne) 2021 31;8:726950. Epub 2021 Aug 31.

Department of Infectious Diseases, Institute of Infection and Immunology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Patients with cirrhosis have an increased risk of short-term mortality, however, few studies quantify the association between neutrophil-to-lymphocyte ratio (NLR) and 90-day transplant-free mortality in cirrhotic patients. We prospectively analyzed 3,970 patients with chronic liver diseases from two multicenter cohorts in China (January 2015 to December 2016 and July 2018 to January 2019). Restricted cubic splines (RCS) were used to analyze the relation of NLR and all-causes 90-day transplant-free mortality in cirrhosis. Read More

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Bioinformatics analysis reveals biomarkers with cancer stem cell characteristics in kidney renal clear cell carcinoma.

Transl Androl Urol 2021 Aug;10(8):3501-3514

College of Life Sciences and Technology, Beijing University of Chemical Technology, Beijing, China.

Background: Kidney renal clear cell carcinoma (KIRC) is a renal cortical tumor. KIRC is the most common subtype of kidney cancer, accounting for 70%-80% of kidney cancer. Early identification of the risk of KIRC patients can facilitate more accurate clinical treatment, but there is a lack of effective prognostic markers. Read More

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Differences in malaria and haematocrit presentation in children living in different settings, North West Region, Cameroon.

Malariaworld J 2021 1;12. Epub 2021 Jun 1.

Department of Biological Sciences, Faculty of Science, University of Bamenda, P.O. Box 39, Bambili, North West Region, Cameroon.

Background: Malaria continues to be a major cause of morbidity and mortality in Cameroon. With all efforts being made to eliminate malaria, it is imperative to describe the epidemiology of the disease in different parts of the country in order to inform control policies. This study aimed to present the differences in the prevalence and intensity of malaria and the anaemic status of children living in different areas of the North West region of Cameroon. Read More

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Clinical value of lymph node dissection for stage T1b mid-thoracic esophageal squamous cell carcinoma.

J Gastrointest Oncol 2021 Aug;12(4):1223-1227

Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fujian Provincial Key Laboratory of Tumor Biotherapy, Department of Thoracic Tumor Surgery, Fujian Cancer Hospital, Fuzhou, China.

Background: Surgery remains the mainstay of treatment for esophageal squamous cell carcinoma (ESCC), during which lymph node (LN) dissection, especially recurrent laryngeal nerve (RLN) LN dissection, is particularly important and challenging. This study aimed to investigate the LN metastasis of stage T1b mid-thoracic ESCC and explore the clinical value of RLN LN dissection.

Methods: The clinicopathological data of 254 patients with stage T1b mid-thoracic ESCC who underwent the McKeown procedure ("tri-incisional esophagectomy") and three-field LN dissection (3FD) at Fujian Cancer Hospital from January 2010 to December 2015 were retrospectively analyzed. Read More

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CircPTCH1 Promotes Migration in Lung Cancer by Regulating MYCN Expression Through miR-34c-5p.

Onco Targets Ther 2021 10;14:4779-4789. Epub 2021 Sep 10.

Pulmonology and Critical Care Medicine Department, The Third Xiangya Hospital of Central South University, Changsha, 410013, People's Republic of China.

Background: The incidence rate and mortality rate of lung cancer are the highest in the world. Therefore, further studies are needed to reveal the molecular mechanism of lung cancer progression and development. Previous study demonstrated that the deregulation of circRNAs can regulate cell biological functions in tumorigenesis and development. Read More

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September 2021

Neural encoding of perceived patch value during competitive and hazardous virtual foraging.

Nat Commun 2021 Sep 16;12(1):5478. Epub 2021 Sep 16.

Department of Humanities and Social Sciences and California Institute of Technology, 1200 E California Blvd, HSS 228-77, Pasadena, CA, 91125, USA.

Natural observations suggest that in safe environments, organisms avoid competition to maximize gain, while in hazardous environments the most effective survival strategy is to congregate with competition to reduce the likelihood of predatory attack. We probed the extent to which survival decisions in humans follow these patterns, and examined the factors that determined individual-level decision-making. In a virtual foraging task containing changing levels of competition in safe and hazardous patches with virtual predators, we demonstrate that human participants inversely select competition avoidant and risk diluting strategies depending on perceived patch value (PPV), a computation dependent on reward, threat, and competition. Read More

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September 2021

Development and presentation of an objective risk stratification tool for healthcare workers when dealing with the COVID-19 pandemic in the UK: risk modelling based on hospitalisation and mortality statistics compared with epidemiological data.

BMJ Open 2021 Sep 16;11(9):e042225. Epub 2021 Sep 16.

Department of Primary Care and Public Health, Imperial College London, London, UK.

Objectives: Healthcare workers have greater exposure to SARS-CoV-2 and an estimated 2.5-fold increased risk of contracting COVID-19 than the general population. We wished to explore the predictive role of basic demographics to establish a simple tool that could help risk stratify healthcare workers. Read More

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September 2021