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Antimicrobial use, biosecurity, herd characteristics, and antimicrobial resistance in indicator Escherichia coli in ten Finnish pig farms.

Prev Vet Med 2021 Jun 10;193:105408. Epub 2021 Jun 10.

Department of Production Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Finland.

We investigated connections between antimicrobial use (AMU), biosecurity, and the numbers of pigs and staff in ten Finnish farrow-to-finish herds. Data on AMU in each herd were collected for 12 months. AMU was quantified as treatment incidences per 1000 days at risk (TI) using the consensus defined daily dose calculation. Read More

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Use of a Tourniquet and Spinal Anesthesia Increases Satisfactory Outcomes After Total Knee Arthroplasty: A Randomized Study.

J Bone Joint Surg Am 2021 Jun 15. Epub 2021 Jun 15.

Department of Anesthesiology, Intensive Care, and Pain Medicine, Peijas Hospital, HUS Helsinki University Hospital, Helsinki, Finland.

Background: Total knee arthroplasty (TKA) is usually performed successfully with or without a tourniquet and under spinal anesthesia (SA) or general anesthesia (GA). However, 10% to 34% of patients experience dissatisfaction and pain after TKA. We aimed to compare the effects of tourniquet use and SA or GA on TKA outcomes. Read More

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Impact of the model of long-term follow-up care on adherence to guideline-recommended surveillance among survivors of adolescent and young adult cancers.

Cancer Med 2021 Jun 15. Epub 2021 Jun 15.

University of Toronto, Institute of Medical Science, Toronto, Canada.

Purpose: Adolescent and young adult cancer survivors require lifelong healthcare to address the late effects of therapy. We examined the impact of different provider models of long-term follow-up (LTFU) care on adherence to recommended surveillance.

Methods: We conducted a retrospective cohort study using administrative health databases in Ontario, Canada. Read More

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Black Patients With Cirrhosis Have Higher Mortality and Lower Transplant Rates: Results From a Metropolitan Cohort Study.

Hepatology 2021 Jun 15. Epub 2021 Jun 15.

Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Northwestern University Transplant Outcomes Research Collaborative (NUTORC), Chicago, IL.

Background And Aims: Estimates of racial disparity in cirrhosis have been limited by lack of large-scale, longitudinal data, which track patients from diagnosis to death and/or transplant.

Approach And Results: We analyzed a large, metropolitan, population-based electronic health record data set from seven large health systems linked to the state death registry and the national transplant database. Multivariate competing risk analyses, adjusted for sex, age, insurance status, Elixhauser score, etiology of cirrhosis, HCC, portal hypertensive complication, and Model for End-Stage Liver Disease-Sodium (MELD-Na), examined the relationship between race, transplant, and cause of death as defined by blinded death certificate review. Read More

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Epidemiology and prognosis of patients with a history of cancer admitted to intensive care. A multicenter observational study.

Med Intensiva (Engl Ed) 2021 Jun 11. Epub 2021 Jun 11.

Unidad Clínica de Cuidados Intensivos, Hospital Universitario Virgen Macarena, Sevilla, Spain.

Objective: To assess the epidemiology and outcome at discharge of cancer patients requiring admission to the Intensive Care Unit (ICU).

Design: A descriptive observational study was made of data from the ENVIN-HELICS registry, combined with specifically compiled variables. Comparisons were made between patients with and without neoplastic disease, and groups of cancer patients with a poorer outcome were identified. Read More

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National Estimates of the Reserve Capacity of Registered Nurses Not Currently Employed in Nursing and Emergency Nursing Job Mobility in the United States.

Ann Emerg Med 2021 Jun 11. Epub 2021 Jun 11.

College of Nursing, University of New Mexico, Albuquerque, NM.

Study Objective: In a large-scale disaster, recruiting from all retired and nonworking registered nurses is one strategy to address surge demands in the emergency nursing workforce. The purpose of this research was to estimate the workforce capacity of all registered nurses who are not currently working in the nursing field in the United States by state of residence and to describe the job mobility of emergency nurses.

Methods: Weighted population estimates were calculated using the 2018 National Sample Survey of Registered Nurses. Read More

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Quantifying Psychopathology in Rapid Readmissions.

CNS Spectr 2021 Apr;26(2):165-166

The Loretto Hospital, Chicago, IL, USA.

Psychiatric readmissions contribute to a significant cost and healthcare burden to physicians, hospitals, and the healthcare system as an entity. Furthermore, as part of the Affordable Care Act, the Centers for Medicare and Medicaid Services (CMS) began to reduce financial coverage to hospitals with overwhelming rehospitalization rates. The purpose of this study was to do a systematic analysis on inpatient psychiatric readmission data and identify co-morbidities and risk factors that lead to high readmission rates. Read More

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Public support for healthy supermarket initiatives focused on product placement: a multi-country cross-sectional analysis of the 2018 International Food Policy Study.

Int J Behav Nutr Phys Act 2021 Jun 14;18(1):78. Epub 2021 Jun 14.

Global Obesity Centre (GLOBE), Institute for Health Transformation, Deakin University, 221 Burwood Highway, Burwood VIC, Geelong, 3125, Australia.

Background: Food retail environments have an influential role in shaping purchasing behavior and could contribute to improving dietary patterns at a population level. However, little is known about the level of public support for different types of initiatives to encourage healthy food choices in supermarkets, and whether this varies across countries or context. The current study aimed to explore the level of support for three potential supermarket initiatives focused on product placement across five countries, and factors that may influence this support. Read More

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Evidence-based oral antiplatelet therapy among hospitalized Chinese patients with acute myocardial infarction: results from the Chinese acute myocardial infarction registry.

BMC Cardiovasc Disord 2021 Jun 14;21(1):299. Epub 2021 Jun 14.

Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Science and Peking Union Medical College, No. 167 North Lishi Road, Xicheng District, Beijing, 100037, China.

Background: Oral antiplatelet therapy is the cornerstone of treatment for acute myocardial infaction (AMI). However, detailed usage data on oral antiplatelet therapy are lacking.

Methods: Using data from a nationally representative sample of patients with AMI, the detailed usage of oral antiplatelet therapy was analyzed in 40,202 consecutive eligible patients. Read More

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Enhanced solubility of Albendazole in Cyclodextrin Inclusion Complex: A Molecular Modeling Approach and Physicochemical Evaluation.

Curr Drug Deliv 2021 Jun 13. Epub 2021 Jun 13.

Laboratório de Tecnologia dos Medicamentos, Universidade Federal de Pernambuco, Recife/PE, Brazil.

Background: Albendazole (ABZ) is the drug of choice for the treatment of a variety of human and veterinary parasites. However, it has low aqueous solubility and low bioavailability. Cyclodextrins (CD) are pharmaceutical excipients with the ability to modulate the solubilization property of hydrophobic molecules. Read More

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[Cross sectional study of familial hypercholesterolemia in dyslipidemia patients receiving lipid-lowering therapy: DYSIS-China subgroup analysis].

Zhonghua Xin Xue Guan Bing Za Zhi 2021 Jun;49(6):564-571

Department of Cardiology, the Tenth People's Hospital Affiliated to Tongji University, Shanghai 200040, China.

To analyze the incidence, blood lipid levels and cardiovascular disease of familial hypercholesterolemia (FH) in dyslipidemia patients receiving lipid-lowing therapy from the DYSIS-China. Dyslipidemia International Study-China (DYSIS-China) database was re-analyzed according to the criteria of "Chinese guidelines for prevention and treatment of dyslipidemia in adults-2016 version". DYSIS-China database included 25 317 dyslipidemia out-patients who received at least one lipid-lowering drug for at least three months. Read More

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[Reoperation rate and related factors in patients with Crohn's disease].

Zhonghua Yi Xue Za Zhi 2021 Jun;101(22):1683-1689

Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

To analyze the cumulative reoperation rate of postoperative Crohn's disease (CD) patients and investigate the operation reasons and the effects of drugs on surgical recurrence. Patients with Crohn's disease who had undergone intestinal resection from January 2000 to March 2020 in Peking Union Medical College Hospital were enrolled. Patients were divided into reoperation and non-reoperation group according to whether they had a second operation. Read More

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Gun Violence and Firearm Injuries in West Michigan: Targeting Prevention.

West J Emerg Med 2021 May 19;22(3):488-497. Epub 2021 May 19.

University of Michigan, Department of Urology, Ann Arbor, Michigan.

Introduction: Firearm-related deaths and injuries are ongoing public health issues in the United States. We reviewed a series of gun violence- and firearm-related injuries treated at a multi-campus community healthcare system in West Michigan to better understand the demographic and clinical characteristics of these injuries. We also studied hospital charges, and payers responsible, in an effort to identify stakeholders and opportunities for community- and hospital-based prevention. Read More

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Visual or visual-tactile examination to detect and inform the diagnosis of enamel caries.

Cochrane Database Syst Rev 2021 Jun 14;6:CD014546. Epub 2021 Jun 14.

Dundee Dental School, University of Dundee, Dundee, UK.

Background: The detection and diagnosis of caries at the initial (non-cavitated) and moderate (enamel) levels of severity is fundamental to achieving and maintaining good oral health and prevention of oral diseases. An increasing array of methods of early caries detection have been proposed that could potentially support traditional methods of detection and diagnosis. Earlier identification of disease could afford patients the opportunity of less invasive treatment with less destruction of tooth tissue, reduce the need for treatment with aerosol-generating procedures, and potentially result in a reduced cost of care to the patient and to healthcare services. Read More

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SARS-Cov2: a meta-analysis of symptom distribution by continent in 7310 adult COVID-19 infected patients.

Virusdisease 2021 Jun 9:1-10. Epub 2021 Jun 9.

Department of Otorhinolaryngology, Infirmary Square, University Hospital of Leicester, Leicester, UK.

There is recent evidence that suggests that there are multiple strains of coronavirus in different parts of the world. Moreover, scientist have noted multiple mutations and postulated that these changes might increase the infective rate of the virus. However literature on varying severity of disease based on these strains is absent. Read More

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Antibiotic Prescription in Veterinary Consultations in Bhutan: A Retrospective Cross-Sectional Study.

Front Vet Sci 2021 28;8:641488. Epub 2021 May 28.

Department of Infectious Diseases, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia.

The veterinary prescription of antibiotics in low- and middle-income countries (LMIC) remains largely undocumented. In Bhutan, however, the national veterinary service keeps records of their activities and prescriptions, which offer an opportunity to establish a benchmark to assess the use of these agents in this and other LMIC. A cross-sectional retrospective study was designed and 2,266 handwritten veterinary records from 2017 were sampled from 23 animal health premises (AHPs) to estimate individual and an overall proportion of consultations that resulted in an antibiotic prescription. Read More

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Stanozolol and Danazol Have Different Effects on Hematopoiesis in the Murine Model of Immune-Mediated Bone Marrow Failure.

Front Med (Lausanne) 2021 28;8:615195. Epub 2021 May 28.

Department of Hematology, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Science, Beijing, China.

Stanozolol and danazol are widely used in the treatment of aplastic anemia; however, their mechanisms of action are unclear. Bone marrow mononuclear cells from 10 patients newly diagnosed with aplastic anemia and 10 healthy volunteers were collected and cultured together with stanozolol, danazol, or blank control separately for marrow colony assays. K562 cell lines that had been incubated with stanozolol, danazol, or blank control were tested for erythroid or megakaryocytic differentiation. Read More

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Prevalence of Growth Restriction at Birth for Newborns With Congenital Heart Defects: A Population-Based Prospective Cohort Study EPICARD.

Front Pediatr 2021 28;9:676994. Epub 2021 May 28.

Université de Paris, CRESS, INSERM, INRA, Paris, France.

Congenital heart defects (CHD) and growth restriction at birth are two major causes of childhood and adult morbidity and mortality. The aim of this study was to assess the overall risk of growth restriction at birth, as measured by its imperfect proxy small (< 10th percentile) for gestational age (SGA), for newborns with CHD. Using data from a population-based cohort of children born with CHD, we assessed the risk of growth restriction at birth using SGA and severe SGA (3rd percentile). Read More

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A cross--sectional study of mental wellbeing with practice of yoga and meditation during COVID-19 pandemic.

J Family Med Prim Care 2021 Apr 29;10(4):1576-1581. Epub 2021 Apr 29.

Community Medicine, Lady Hardinge Medical College and Associated Hospitals, New Delhi, India.

Background: COVID-19 pandemic has resulted in increased mental health issues. Yoga and meditation can help in alleviating mental stress and improving psychological wellbeing.

Methods: It was a community-based online cross-sectional study involving adult general population. Read More

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Histopathological Account of Obstetrical and Gynecological Specimens: Retrospective Study at a Tertiary Care Center of Peshawar.

Cureus 2021 May 11;13(5):e14950. Epub 2021 May 11.

Cardiothoracic Surgery, Rehman Medical Institute, Peshawar, PAK.

Introduction Histopathologic specimen examination of surgically isolated organs and tissues yields valuable information regarding a disease process and plays a vital role in the future management of a patient. Our aim was to account for the common diagnosis yielded from histopathological specimens of the obstetrics and gynecology department and to determine if all the obstetric and gynecological specimens should be routinely sent for histopathology. Methods A retrospective, cross-sectional study was conducted at the histopathology unit of a tertiary care hospital in Peshawar. Read More

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The Indirect Effect of Death Anxiety on Experienced Meaning in Life Search for Meaning and Prosocial Behavior.

Front Psychol 2021 28;12:673460. Epub 2021 May 28.

Department of Neuroscience, Faculty of Medicine, Uppsala University, Uppsala, Sweden.

This study investigated the relationship between death anxiety and experienced meaning in life. Six hundred and forty-eight Chinese college students were surveyed using the Death Anxiety Scale, the Prosocial Behavior Scale, and the Meaning in Life Scale. The results showed that death anxiety predicted experienced meaning through three pathways: the first one was through search for meaning singly; the second one was through prosocial behavior singly; and the third one was through search for meaning and prosocial behavior serially, which accounted for the highest proportion of the total effect. Read More

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Evaluation of population-level pharmacogenetic actionability in Alabama.

Clin Transl Sci 2021 Jun 13. Epub 2021 Jun 13.

Department of Neurology.

The evolution of evidence and availability of Clinical Pharmacogenetic Implementation Consortium (CPIC) guidelines have enabled assessment of pharmacogenetic actionability and clinical implementation. However population-level actionability is not well characterized. We leveraged the Alabama Genomic Health Initiative (AGHI) to evaluate population-level pharmacogenetic actionability. Read More

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Current status of antenatal care of pregnant women-8 provinces in China, 2018.

BMC Public Health 2021 Jun 14;21(1):1135. Epub 2021 Jun 14.

National Center for Women and Children's Health, Chinese Center for Disease Control and Prevention, No.12, Dahuisi Road, Beijing, 100081, China.

Background: Antenatal care (ANC) played a crucial role in ensuring maternal and child safety and reducing the risk of complications, disability, and death in mothers and their infants. The objective of this study was to evaluate the current status of ANC emphasizing the number, timing, and content of examinations on a national scale.

Methods: The data was collected from maternal and newborn's health monitoring system at 8 provinces in China. Read More

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Hospital Board of Directors' Composition and Financial Performance: Empirical Evidence from Taiwan.

Inquiry 2021 Jan-Dec;58:469580211024897

Executive master program of business administration in Biotechnology, College of management, Taipei Medical University, Taipei city, Taiwan.

The board of directors of a nonprofit proprietary hospital is responsible for supervising and managing major operational matters and reviewing operational results. This study investigates how hospital financial performance is influenced by director and supervisor characteristics among the board members of nonprofit proprietary hospitals in Taiwan. Data were obtained from the Division of Medical Services of the Ministry of Health and Welfare. Read More

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Pertussis seroprevalence among adults of reproductive age (20-39 years) in fourteen European countries.

APMIS 2021 Jun 12. Epub 2021 Jun 12.

The Public Health Agency of Sweden, SE-171 82, Solna, Sweden.

The reported incidence of pertussis in European countries varies considerably. We aimed to study specific Bordetella pertussis seroprevalence in Europe by measuring serum IgG antibody levels to pertussis toxin (anti-PT IgG). Fourteen national laboratories participated in this study including Belgium, Denmark, Finland, Greece, Hungary, Italy, Lithuania, Malta, Norway, Poland, Portugal, Romania, Spain and Sweden. Read More

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Enhanced bioelectricity output of microbial fuel cells via electrospinning zeolitic imidazolate framework-67/polyacrylonitrile carbon nanofiber cathode.

Bioresour Technol 2021 Jun 2;337:125358. Epub 2021 Jun 2.

College of Environmental Science and Engineering, State Environmental Protection Engineering Center for Pollution Treatment and Control in Textile Industry, Donghua University, Shanghai 201620, China.

In this study, the zeolitic imidazolate framework-67 (ZIF-67) and electrospinning polyacrylonitrile membrane were combined to prepare electrospinning carbon nanofibers composite cathode (ZIF-67/CNFs) which could enhance the oxygen reduction reaction (ORR) performance of microbial fuel cells (MFCs) cathode. The optimum electrode 3 wt% ZIF-67/CNFs revealed the excellent ORR performance with a half-wave potential of -0.03 V vs. Read More

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Synthesis and characterization of glycol chitosan coated selenium nanoparticles acts synergistically to alleviate oxidative stress and increase ginsenoside content in Panax ginseng.

Carbohydr Polym 2021 Sep 13;267:118195. Epub 2021 May 13.

Department of Food Science and Biotechnology, Sejong University, Seoul 05006, Republic of Korea. Electronic address:

The objective of the present study is synthesis of glycol chitosan coated selenium nanoparticles (GC-Se NPs) and evaluation of oxidative stress and ginsenoside accumulation in P. ginseng C. A. Read More

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September 2021

Implementation of a Palliative Oncology Tumor Board.

J Pain Symptom Manage 2021 Jun 9. Epub 2021 Jun 9.

Penn Medicine Lancaster General Health Ann B Barshinger Cancer Institute, Lancaster, Pennsylvania, USA.

Context: The integration of palliative care into standard oncologic care has been shown to improve multiple outcomes in patients with advanced cancer. Ideal methods for integrating these disciplines is an ongoing area of discussion. One method of integration is a palliative oncology tumor board (POTB). Read More

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Intra and peridomiciliary comparison of density, sex ratio and gonotrophic stage of Phlebotomus sergenti in an active anthroponotic cutaneous leishmaniasis focus in Morocco.

Acta Trop 2021 Jun 9:106005. Epub 2021 Jun 9.

Department of Parasitology, Faculty of Pharmacy, University of Granada, Spain.

Cutaneous leishmaniasis due to Leishmania tropica represents a major public health problem due to its ability to spread into non-endemic areas by means of its vectors, and the associated dramatic psychosocial impact. The objective of this work was to compare the intra and extradomiciliary density, sex ratio and gonotrophic stage of sand flies from a recent active focus in Morocco. This field study is based on the need to optimize the effectiveness of control programs. Read More

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