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Ultrasound-guided dynamic needle tip positioning technique for radial artery cannulation in elderly patients: A prospective randomized controlled study.

PLoS One 2021 14;16(5):e0251712. Epub 2021 May 14.

Department of Anesthesiology and Pain Medicine, Hanyang University Hospital, College of Medicine, Seoul, Republic of Korea.

Background: Radial artery cannulation, which is a useful procedure for anesthetic management, is often challenging in elderly patients. Recently, the dynamic needle tip positioning (DNTP) technique was introduced to facilitate ultrasound-guided vascular catheterization. Therefore, we performed this prospective, parallel group, randomized, controlled trial to compare the ultrasound-guided DNTP technique with the palpation method in elderly patients. Read More

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Propargylic Amination Enabled the Access to Enantioenriched Acyclic α-Quaternary α-Amino Ketones.

J Am Chem Soc 2021 May 14. Epub 2021 May 14.

Department of Chemistry, Shantou University, Shantou 515063, China.

A propargylic amination approach toward chiral acyclic α-quaternary α-amino ketones is described. This Cu-catalyzed procedure could be performed open to air using commercially available amines as nucleophiles. The key to success is the use of rationally designed propargylic cyclic carbonates as substrates, which can generate a Cu-bonded enolate zwitterionic intermediate upon decarboxylation. Read More

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Regenerative medicine for end-stage fibrosis and tissue loss in the upper aerodigestive tract: a twenty-first century review.

J Laryngol Otol 2021 May 14:1-13. Epub 2021 May 14.

Head and Neck Academic Department, Division of Surgery and Interventional Science, University College London.

Objective: This review assesses regenerative medicine of the upper aerodigestive tract during the first two decades of the twenty-first century, focusing on end-stage fibrosis and tissue loss in the upper airways, salivary system, oropharynx and tongue.

Method: PubMed, Embase, Google Scholar, Cochrane Library, Medline and clinicaltrials.org were searched from 2000 to 2019. Read More

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Insights to enhance the examination of tool marks in human cartilage.

Int J Legal Med 2021 May 13. Epub 2021 May 13.

Institute of Legal Medicine, Faculty of Medicine, University of Cologne, Melatengürtel 60-62, 50823, Cologne, Germany.

This work deals with the examination of tool marks in human cartilage. We compared the effectiveness of several cleaning methods on cut marks in porcine cartilage. The method cleaning by multiple casts achieved the significantly highest scores (P = 0. Read More

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Memory precision of object-location binding is unimpaired in ε4-carriers with spatial navigation deficits.

Brain Commun 2021 23;3(2):fcab087. Epub 2021 Apr 23.

Department of Psychology, University of Cambridge, Cambridge CB2 3EB, UK.

Research suggests that tests of memory fidelity, feature binding and spatial navigation are promising for early detection of subtle behavioural changes related to Alzheimer's disease. In the absence of longitudinal data, one way of testing the early detection potential of cognitive tasks is through the comparison of individuals at different genetic risk for Alzheimer's dementia. Most studies have done so using samples aged 70 years or older. Read More

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Estimating the amplitude spectrum area of ventricular fibrillation during cardiopulmonary resuscitation using only ECG waveform.

Ann Transl Med 2021 Apr;9(8):619

Department of Biomedical Engineering and Imaging Medicine, Army Medical University, Chongqing, China.

Background: Amplitude spectrum area (AMSA) calculated from ventricular fibrillation (VF) can be used to monitor the effectiveness of chest compression (CC) and optimize the timing of defibrillation. However, reliable AMSA can only be obtained during CC pause because of artifacts. In this study, we sought to develop a method for estimating AMSA during cardiopulmonary resuscitation (CPR) using only the electrocardiogram (ECG) waveform. Read More

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The Dark Side of High-Fliers: The Dark Triad, High-Flier Traits, Engagement, and Subjective Success.

Front Psychol 2021 27;12:647676. Epub 2021 Apr 27.

Thomas International, Marlow, United Kingdom.

The aim of this study was to understand the relationship between bright-side, High Potential and dark-side Dark Triad traits, as well as work engagement on judgements of perceived success. In all, 290 working adults completed questionnaires assessing their High Potential Personality Traits (HPTI), their dark-triad traits, job engagement and self-rated success at work. The data showed that the three dark-triad traits (Narcissism, Psychopathy, Machiavellianism) were systematically and significantly correlated with High Potential traits Adjustment/neuroticism, Tolerance of Ambiguity and Conscientiousness. Read More

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De novo transcriptome analysis for examination of the nutrition metabolic system related to the evolutionary process through which stick insects gain the ability of flight (Phasmatodea).

BMC Res Notes 2021 May 13;14(1):182. Epub 2021 May 13.

Database Center for Life Science (DBCLS), Joint Support-Center for Data Science Research, Research Organization of Information and Systems (ROIS), Mishima, Shizuoka, 411-8540, Japan.

Objective: Insects are the most evolutionarily successful groups of organisms, and this success is largely due to their flight ability. Interestingly, some stick insects have lost their flight ability despite having wings. To elucidate the shift from wingless to flying forms during insect evolution, we compared the nutritional metabolism system among flight-winged, flightless-winged, and flightless-wingless stick insect groups. Read More

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Can we successfully predict the outcome for extracorporeal shock wave lithotripsy (ESWL) for medium size renal stones? A single-center experience.

Urologia 2021 May 13:3915603211016355. Epub 2021 May 13.

Department of Urology, Ain Shams University, Cairo, Egypt.

Background: Extracorporeal shock wave lithotripsy (ESWL) is one of the most used modalities in treatment of renal stones, but its effectiveness can be influenced by many factors related to the patient or the stone itself which may affect the success of stone disintegration. The aim of our study was to investigate the predictive value of some patient and stone-related factors for ESWL success for renal stones.

Methods: A total of 100 patients with single radiopaque renal stone 10-20 mm in diameter, undergoing ESWL were enrolled in this study. Read More

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Clinical impacts of endothelium-dependent flow-mediated vasodilation assessment on primary aldosteronism.

Endocr Connect 2021 May 1. Epub 2021 May 1.

A Ichihara, Department of Endocrinology and Hypertension, Tokyo Women's Medical University, Shinjuku-ku, Japan.

Objective: Primary aldosteronism (PA) is divided into two major subtypes, aldosterone-producing adenoma (APA) and bilateral idiopathic hyperplasia (IHA), and is associated with a higher risk of cardiovascular events. However, the nature of vascular function in PA patients remains to be determined. The aim of this study was to determine vascular function and investigate the implications of vascular function assessments in these patients. Read More

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Knowledge, barriers and facilitators regarding COVID-19 vaccine and vaccination programme among the general population: A cross-sectional survey from one thousand two hundred and forty-nine participants.

Diabetes Metab Syndr 2021 May 1;15(3):987-992. Epub 2021 May 1.

Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.

Background And Aims: The success of the COVID-19 vaccination program is dependent on people's knowledge and attitude regarding the vaccination program. Higher vaccine acceptance can be ensured by strengthening the facilitators and limiting the barriers being observed among the general population.

Material And Methods: Indexed study is a cross-sectional web-based survey using a pre-validated questionnaire to assess knowledge, barriers and facilitators of COVID-19 vaccine and vaccination programme administered on adults across India using a Google online survey platform. Read More

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A randomized controlled study of the effect of hyoscine butylbromide on duration of labor in primigravida women with prolonged labor.

Arch Gynecol Obstet 2021 May 13. Epub 2021 May 13.

Obstetrics and Gynecology Department, Kasr AlAini Hospital Cairo University, 11 Eid Mostafa from King Faisal Street Haram Giza, Cairo, 12111, Egypt.

Objective: To assess the safety and efficacy of hyoscine butyl bromide (HBB) in primipara with prolonged 1st stage of labor.

Materials And Methods: A double-blinded randomized controlled trial included 100 primiparas diagnosed with prolonged labor. They were randomly divided two equal groups. Read More

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Nurse-Administered Propofol Continuous Infusion Sedation: A New Paradigm for Gastrointestinal Procedural Sedation.

Am J Gastroenterol 2021 Apr;116(4):710-716

1Digestive Disease Institute, Virginia Mason Medical Center, Seattle; 2Department of Anesthesia, Virginia Mason Medical Center, Seattle.

Introduction: Nurse-Administered Propofol Continuous Infusion Sedation (NAPCIS) is a new nonanesthesia propofol delivery method for gastrointestinal endoscopy. NAPCIS is adopted from the computer-assisted propofol sedation (CAPS) protocol. We evaluated the effectiveness, efficiency, and safety of NAPCIS in low-risk subjects. Read More

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Direct Endoscopic Necrosectomy With and Without Hydrogen Peroxide for Walled-off Pancreatic Necrosis: A Multicenter Comparative Study.

Am J Gastroenterol 2021 Apr;116(4):700-709

1Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA; 2Division Gastroenterology and Hepatology, University of Utah School of Medicine, Salt Lake City, Utah, USA; 3Division Gastroenterology and Hepatology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA; 4Borland-Groover Clinic, Jacksonville, Florida, USA; 5Division of Gastroenterology and Hepatology, Medical University of South Carolina, Charleston, South Carolina, USA; 6Division of Gastroenterology, Washington University School of Medicine, St. Louis, Missouri, USA; 7Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburg, Pennsylvania, USA; 8Division of Gastroenterology, Hepatology and Nutrition, The Ohio state University Wexner Medical Center, Columbus, Ohio, USA; 9Section of Gastroenterology and Hepatology, Baylor College of Medicine, Houston, Texas, USA; 10Biostatistics & Bioinformatics Shared Resource, Winship Cancer Institute of Emory University, Atlanta, Georgia, USA; 11Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Introduction: Endoscopic necrosectomy has emerged as the preferred treatment modality for walled-off pancreatic necrosis. This study was designed to evaluate the safety and efficacy of direct endoscopic necrosectomy with and without hydrogen peroxide (H2O2) lavage.

Methods: Retrospective chart reviews were performed for all patients undergoing endoscopic transmural management of walled-off pancreatic necrosis at 9 major medical centers from November 2011 to August 2018. Read More

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Four-Strand Hamstring Diamond Braid Technique for Anterior Cruciate Ligament Reconstruction.

Arthrosc Tech 2021 Apr 22;10(4):e1173-e1177. Epub 2021 Mar 22.

Advanced Orthopaedics and Sports Medicine, San Francisco, California, U.S.A.

Several factors affect the success of an anterior cruciate ligament reconstruction, including graft origin, type, and morphology. Hamstring and bone-patellar tendon-bone autografts are the most widely used, and there are many different techniques of graft preparation with each. In this Technical Note and accompanying video, a 4-strand hamstring autograft technique is described that uses a simple diamond-type braid to produce a more ovoid morphology with increased cross-sectional area. Read More

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Association between depression and HIV treatment outcomes in a US military population with HIV infection.

AIDS Res Ther 2021 May 12;18(1):29. Epub 2021 May 12.

Brooke Army Medical Center, 3551 Roger Brooke Drive, Fort Sam Houston, TX, 78234-6200, USA.

Background: Depression is common among HIV-infected individuals and may contribute to suboptimal adherence to antiretroviral therapy (ART) and subsequent inability to attain viral load (VL) suppression. We evaluated associations between depression, self-reported adherence, and longitudinal HIV treatment outcomes in US Military HIV Natural History Study (NHS) participants with and without depression.

Methods: Male NHS participants with available ICD-9 data for mental health diagnoses, Center for Epidemiological Studies Depression (CES-D) measures, and self-reported adherence (SRA) were included. Read More

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The impact of epicardial adipose tissue in patients with acute myocardial infarction.

Clin Res Cardiol 2021 May 12. Epub 2021 May 12.

Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany.

Aims: Epicardial adipose tissue (EAT) has been linked to impaired reperfusion success after percutaneous coronary intervention (PCI). Whether EAT predicts myocardial damage in the early phase after acute myocardial infarction (MI) is unclear. Therefore, we investigated whether EAT in patients with acute MI is associated with more microvascular obstruction (MVO), greater ST-deviation, larger infarct size and reduced myocardial salvage index (MSI). Read More

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[CT-guided pain management of specific low back pain : Disc impairment vs. osseous degeneration].

Radiologe 2021 May 12. Epub 2021 May 12.

Fakultät für Gesundheit, Universität Witten/Herdecke, Witten, Deutschland.

Background: Back pain is common and leads the patient to the radiologist both for diagnosis and in specific cases for therapy.

Objectives: The current study compares the pain-reducing effect of microinvasive computed tomography (CT)-guided pain therapy for specific back pain caused by herniated discs or spondylarthrosis.

Materials And Methods: Over a period of 3. Read More

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InterEvDock3: a combined template-based and free docking server with increased performance through explicit modeling of complex homologs and integration of covariation-based contact maps.

Nucleic Acids Res 2021 May 12. Epub 2021 May 12.

Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France.

The InterEvDock3 protein docking server exploits the constraints of evolution by multiple means to generate structural models of protein assemblies. The server takes as input either several sequences or 3D structures of proteins known to interact. It returns a set of 10 consensus candidate complexes, together with interface predictions to guide further experimental validation interactively. Read More

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Outcomes of Conventional External Dacryocystorhinostomy with and without Mitomycin C: Experience from Eastern Nepal.

Nepal J Ophthalmol 2020 Jul;12(24):209-215

Bharatpur Eye Hospital, Bharatpur, Chitwan, Nepal.

Introduction: Dacryocystorhinostomy (DCR) is the commonest surgery for nasolacrimal duct obstruction. Inhibition of the scarring process within the anastomosis and rhinostomy site which has been attributed to the failure of this procedure, might improve the success rate of DCR. The objective of this study was to evaluate the outcomes of DCR with Mitomycin-C (MMC) and to compare the results of DCR with and without MMC. Read More

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Neurocognitive basis of deductive reasoning in children varies with parental education.

Hum Brain Mapp 2021 May 12. Epub 2021 May 12.

Department of Psychology and Human Development, Vanderbilt University, Nashville, Tennessee, USA.

The neurocognitive basis of elementary academic skills varies with parental socioeconomic status (SES). Little is known, however, about SES-related differences underlying higher-order cognitive skills that are critical for school success, such as reasoning. Here we used fMRI to examine how the neurocognitive basis of deductive reasoning varies as a function of parental education in school-aged children. Read More

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The outcomes of endoscopic third ventriculostomy in the treatment of hydrocephalus: 317 pediatric and adult cases.

Turk Neurosurg 2020 Sep 14. Epub 2020 Sep 14.

Adana City Training and Research Hospital, Department of Neurosurgery, Adana, Turkey.

Aim: We aimed to evaluate the role of ETV as a primary or secondary treatment for hydrocephalus and factors affecting ETV success.

Material And Methods: Pediatric and adult patients with symptomatic hydrocephalus treated with ETV during 11 years (2008-2019) in our clinic were retrospectively evaluated. Patients were divided into primary ETV group, in which ETV was the first method of hydrocephalus treatment, and secondary ETV group, in which cerebrospinal fluid (CSF) drainage procedures were initially attempted. Read More

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September 2020

Biosense Webster's QDOT Micro™ radiofrequency ablation catheter.

Future Cardiol 2021 May 12. Epub 2021 May 12.

Department of Cardiology, Sint-Jan Hospital, Bruges, Belgium.

The QDOT Micro™ catheter (Biosense Webster, Inc., CA, USA) is a new radiofrequency ablation catheter based on the SmartTouch SF™ (Biosense Webster, Inc.). Read More

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Efficacy and safety of ultrasound-guided above-knee lateral approach for popliteal sciatic nerve block in surgeries below the knee: a randomized controlled trial.

Ann Palliat Med 2021 May 10. Epub 2021 May 10.

Department of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.

Background: Ultrasound guidance has become a standard method for detection of nerve structures in regional anesthesia. During ultrasound-guided blockade, to identify anatomical structures is crucial but can be challenging. In clinical practice, we find a wide difference in the visibility score of the sciatic nerve (SN) through different approaches. Read More

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Needling and open filtering bleb revision after XEN-45 implantation-a retrospective outcome comparison.

Graefes Arch Clin Exp Ophthalmol 2021 May 11. Epub 2021 May 11.

Department of Ophthalmology and Optometry, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.

Purpose: To compare efficacy and safety of needling and open bleb revision after XEN-45 surgery.

Methods: This retrospective study represents real-life data of patients who underwent XEN-45 surgery between November 2014 and June 2018 in the Vienna General Hospital. The following groups were formed for data evaluation: (PSEA) primary surgery secondary intervention allowed (n = 268); (PS) primary surgery until secondary intervention (n = 268); (N) first needling until additional secondary intervention (n = 55); (BR) first bleb revision until additional secondary intervention (n = 105). Read More

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Comparative evaluation of retrograde intrarenal surgery, antegrade ureterorenoscopy and laparoscopic ureterolithotomy in the treatment of impacted proximal ureteral stones larger than 1.5 cm.

Cent European J Urol 2021 23;74(1):57-63. Epub 2021 Jan 23.

Department of Urology, Haseki Traning and Research Hospital, Haseki, Turkey.

Introduction: The aim of this article was to compare retrograde intrarenal surgery (RIRS), antegrade ureterorenoscopy (URS), and laparoscopic ureterolithotomy (LU) for impacted proximal ureter stones larger than 1.5 cm in terms of operative data, success, complications, auxiliary treatment rates, and visual analog scale (VAS) scores.

Material And Methods: Medical records of patients undergoing RIRS, antegrade URS, or LU were retrospectively reviewed. Read More

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January 2021

Novel high-affinity EGFRvIII-specific chimeric antigen receptor T cells effectively eliminate human glioblastoma.

Clin Transl Immunology 2021 9;10(5):e1283. Epub 2021 May 9.

Immunology Division The Walter and Eliza Hall Institute of Medical Research Parkville VIC Australia.

Objectives: The increasing success of Chimeric Antigen Receptor (CAR) T cell therapy in haematological malignancies is reinvigorating its application in many other cancer types and with renewed focus on its application to solid tumors. We present a novel CAR against glioblastoma, an aggressive, malignant glioma, with a dismal survival rate for which treatment options have remained unchanged for over a decade.

Methods: We use the human Retained Display (ReD) antibody platform (Myrio Therapeutics) to identify a novel single-chain variable fragment (scFv) that recognises epidermal growth factor receptor mutant variant III (EGFRvIII), a common and tumor-specific mutation found in glioblastoma. Read More

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Interactive effects of body mass changes and species-specific morphology on flight behavior of chick-rearing Antarctic fulmarine petrels under diurnal wind patterns.

Ecol Evol 2021 May 6;11(9):4972-4991. Epub 2021 Apr 6.

Department of Agriculture, Water and the Environment Australian Antarctic Division Kingston Tas. Australia.

For procellariiform seabirds, wind and morphology are crucial determinants of flight costs and flight speeds. During chick-rearing, parental seabirds commute frequently to provision their chicks, and their body mass typically changes between outbound and return legs. In Antarctica, the characteristic diurnal katabatic winds, which blow stronger in the mornings, form a natural experimental setup to investigate flight behaviors of commuting seabirds in response to wind conditions. Read More

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Considering sampling bias in close-kin mark-recapture abundance estimates of Atlantic salmon.

Ecol Evol 2021 May 6;11(9):3917-3932. Epub 2021 Apr 6.

Norwegian Institute for Nature Research Trondheim Norway.

Genetic methods for the estimation of population size can be powerful alternatives to conventional methods. Close-kin mark-recapture (CKMR) is based on the principles of conventional mark-recapture, but instead of being physically marked, individuals are marked through their close kin. The aim of this study was to evaluate the potential of CKMR for the estimation of spawner abundance in Atlantic salmon and how age, sex, spatial, and temporal sampling bias may affect CKMR estimates. Read More

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The Postnatal Risk, Resuscitation Success Rate and Outcomes of Pediatric Sudden Death in Taiwan.

Acta Cardiol Sin 2021 May;37(3):296-304

Graduate Institute of Clinical Medicine, National Taiwan University Hospital and Medical College, National Taiwan University, Taiwan e Administration of National Health Insurance, Taipei, Taiwan.

Background: The epidemiology of pediatric potentially sudden death (SD) events and the rescue rate remain unclear.

Methods: We established a birth cohort (2000-2014) from a national database 2000-2015.

Results: Of 3,097,277 live births, we identified 3126 children (56. Read More

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