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8-Hydroxy-2'-Deoxyguanosine and Reactive Oxygen Species as Biomarkers of Oxidative Stress in Mental Illnesses: A Meta-Analysis.

Psychiatry Investig 2021 Jul 22;18(7):603-618. Epub 2021 Jul 22.

Department of Chemical Engineering, Lee Kong Chian Faculty of Engineering and Science, Universiti Tunku Abdul Rahman, Kajang, Malaysia.

Objective: Mental illnesses may be caused by genetic and environmental factors. Recent studies reported that mental illnesses were accompanied by higher oxidative stress level. However, the results were inconsistent. Read More

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Phase II study of azacitidine with pembrolizumab in patients with intermediate-1 or higher-risk myelodysplastic syndrome.

Br J Haematol 2021 Aug 2. Epub 2021 Aug 2.

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Programmed cell death protein 1 (PD-1) and PD-ligand 1 (PD-L1) expression is upregulated in cluster of differentiation 34 (CD34) bone marrow cells from patients with myelodysplastic syndromes (MDS). Hypomethylating agent (HMA) treatment results in further increased expression of these immune checkpoints. We hypothesised that combining an anti-PD-1 antibody with HMAs may have efficacy in patients with MDS. Read More

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The Association between Sarcopenia as a Comorbid Disease and Incidence of Institutionalisation and Mortality in Geriatric Rehabilitation Inpatients: REStORing health of acutely unwell adulTs (RESORT).

Gerontology 2021 Aug 2:1-11. Epub 2021 Aug 2.

Department of Medicine and Aged Care, @AgeMelbourne, The Royal Melbourne Hospital, The University of Melbourne, Melbourne, Victoria, Australia.

Introduction: Sarcopenia is associated with poor health outcomes and highly prevalent in individuals with age-related diseases. This study aimed to determine whether sarcopenia as a comorbid disease is associated with the incidence of institutionalisation and mortality in geriatric rehabilitation inpatients.

Methods: REStORing health of acutely unwell adulTs (RESORT) includes geriatric rehabilitation patients assessed for sarcopenia (the European Working Group on Sarcopenia in Older People [EWGSOP, 2010], EWGSOP2 [2018], and the Asian Working Group for Sarcopenia [AWGS 2019]), multimorbidity, disease severity, and specific diseases (Charlson Comorbidity Index and Cumulative Illness Rating Scale) at admission. Read More

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Body Adiposity Index Is Predictive of Weight Loss after Roux-en-Y Gastric Bypass.

Ann Nutr Metab 2021 Aug 2:1-10. Epub 2021 Aug 2.

Department of Endocrinology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.

Background/aims: Roux-en-Y gastric bypass (RYGB) is one of the most effective therapies for morbid obesity, yet some patients who have taken the surgery still undergo insufficient weight loss. Visceral adiposity index (VAI), lipid accumulation product (LAP), body adiposity index (BAI), and cardiometabolic index (CMI) have been regarded as clinical indicators of adiposity phenotypes that associated closely with obesity-related metabolic diseases. However, no studies have evaluated the relationship between these indexes and weight loss after bariatric surgery. Read More

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Quantitative evaluation of trunk function and the StartReact effect during reaching in patients with cervical and thoracic spinal cord injury.

J Neural Eng 2021 Aug 2. Epub 2021 Aug 2.

Institut Guttmann, Camí de Can Ruti, s/n, Badalona, Catalunya, 08916, SPAIN.

Objective: Impaired trunk stability is frequent in spinal cord injury (SCI), but there is a lack of quantitative measures for assessing trunk function. Our objectives were to: 1) evaluate trunk muscle activity and movement patterns during a reaching task in SCI patients, 2) compare the impact of cervical (cSCI) and thoracic (tSCI) injuries in trunk function, and 3) investigate the effects of a startling acoustic stimulus (SAS) in these patients.

Approach: Electromyographic (EMG) and smartphone accelerometer data were recorded from 15 cSCI patients, 9 tSCI patients, and 24 healthy controls, during a reaching task requiring trunk tilting. Read More

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Coupled harmonic oscillator models for correlated plasmons in one-dimensional and quasi-one-dimensional systems.

J Phys Condens Matter 2021 Aug 2. Epub 2021 Aug 2.

Department of Physics, National University of Singapore, Kent Ridge, SINGAPORE 119260, Singapore, 119260, SINGAPORE.

A new phenomenon of correlated plasmons was first observed in the insulating phase of the Sr1-xNb1-yO3+ family [T. C. Asamara et al. Read More

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Chemotherapy-Induced Peripheral Neurotoxicity in Cancer Survivors: Predictors of Long-Term Patient Outcomes.

J Natl Compr Canc Netw 2021 Jul 28;19(7):821-828. Epub 2021 Jul 28.

5Brain and Mind Centre, Faculty of Medicine and Health, University of Sydney, Camperdown, Australia.

Background: Chemotherapy-induced peripheral neurotoxicity (CIPN) is a major adverse effect of cancer treatment. However, its impact remains poorly understood. This study aimed to investigate the impact associated with CIPN on the lives of cancer survivors. Read More

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Transfer learning artificial intelligence for automated detection of atrial fibrillation in patients undergoing evaluation for suspected obstructive sleep apnoea: a feasibility study.

Sleep Med 2021 Jul 17;85:166-171. Epub 2021 Jul 17.

School of Medicine, The University of Notre Dame Australia, 21 Henry St., Fremantle, WA, 6160, Australia; Bendat Respiratory Research and Development Fund, SJOG Subiaco, WA, 6008, Australia.

Background: Individuals with obstructive sleep apnoea (OSA) experience a higher burden of atrial fibrillation (AF) than the general population, and many cases of AF remain undetected. We tested the feasibility of an artificial intelligence (AI) approach to opportunistic detection of AF from single-lead electrocardiograms (ECGs) which are routinely recorded during in-laboratory polysomnographic sleep studies.

Methods: Using transfer learning, an existing ECG AI model was applied to 1839 single-lead ECG traces recorded during in-laboratory sleep studies without any training of the algorithm. Read More

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Proton beam therapy in rectal cancer: A systematic review and meta-analysis.

Surg Oncol 2021 Jul 27;38:101638. Epub 2021 Jul 27.

Department of Colorectal Surgery, Countess of Chester NHS Foundation Trust, UK; Institute of Systems, Molecular and Integrative Biology, University of Liverpool, 200 London Road, Liverpool, L3 9TA, UK. Electronic address:

Introduction: Locally advanced rectal cancer is often treated with neoadjuvant chemoradiotherapy and surgery. Radiotherapy carries significant risk of toxicity to organs at risk (OAR). Proton beam therapy (PBT) has demonstrated to be effective in other cancers, delivering equivalent dosimetric radiation but with the benefit of improved sparing of OAR. Read More

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Fate of dioxins in a municipal solid waste incinerator with state-of-the-art air pollution control devices in China.

Environ Pollut 2021 Jul 21;289:117798. Epub 2021 Jul 21.

Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China; School of Environment, Tsinghua University, Beijing, 100084, China. Electronic address:

The variation of municipal solid waste (MSW) components and the improvement of incinerators have an obvious effect on dioxin emissions. However, there is a knowledge gap on dioxin distribution characteristics following China's implementation of MSW classification. To reveal the fate of dioxins under ultra-low emission standards in leading cities in China, a systematic investigation was carried out in a typical modern MSW incinerator in Shenzhen, China. Read More

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BDNF genotype Val66Met interacts with acute plasma BDNF levels to predict fear extinction and recall.

Behav Res Ther 2021 Jul 30;145:103942. Epub 2021 Jul 30.

School of Psychological Sciences, University of Melbourne, Australia.

Brain-derived neurotropic factor (BDNF) is a potent regulator of memory processes and is believed to influence the consolidation of fear extinction memories. No previous human study has tested the effect of unstimulated BDNF on fear extinction recall, and no study has tested the association between plasma BDNF levels and psychophysiological responding during an extinction paradigm. We tested the association between fear responses during a 2-day differential conditioning, extinction and extinction recall paradigm and Val66Met genotype in a group of healthy participants (N = 191). Read More

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Refining diagnostic criteria for paediatric bronchiectasis using low-dose CT scan.

Respir Med 2021 Jul 24;187:106547. Epub 2021 Jul 24.

Department of Respiratory and Sleep Medicine, The Royal Children's Hospital, Melbourne, VIC, Australia; Infection and Immunity, Murdoch Children's Research Institute, Melbourne, VIC, Australia; Department of Paediatrics, The University of Melbourne, Melbourne, VIC, Australia. Electronic address:

Background: There is a current lack of consensus amongst paediatric radiologists and respiratory paediatricians as to the correct CT definition of bronchiectasis in children. Using contemporary low-dose CT, our objectives were to determine the upper limit of normal for broncho-arterial ratio (BAR) in children and to evaluate the effect of age and general anaesthesia.

Methods: Measurements of 330 broncho-arterial ratios from 51 children (0-19 years) undergoing low-dose CT chest for non-respiratory indications were performed by 3 blinded observers (two radiologists, one respiratory physician) using four different methods. Read More

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The uptake of foil from needle and syringe provision services and its role in smoking or snorting heroin among people who inject drugs in Scotland.

Int J Drug Policy 2021 Jul 30;98:103369. Epub 2021 Jul 30.

School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, Scotland; Public Health Scotland, NHS National Services Scotland, Glasgow, Scotland.

Background: In the UK, legislation was implemented in 2014 allowing needle and syringe provision (NSP) services to offer foil to people who inject drugs (PWID) to encourage smoking rather than injecting. This paper aims to examine the association between foil uptake and smoking or snorting heroin among PWID. This is the first large scale national study to examine foil uptake and smoking or snorting heroin among PWID post legislative change. Read More

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Posttraumatic stress symptom clusters differentially predict late positive potential to cocaine imagery cues in trauma-exposed adults with cocaine use disorder.

Drug Alcohol Depend 2021 Jul 28;227:108929. Epub 2021 Jul 28.

Department of Psychology, University of Houston, Houston, TX, United States.

Background: While studies have investigated the effects of posttraumatic stress disorder (PTSD) symptoms on substance use, information on these associations in the context of drug cue reactivity is lacking, which can provide meaningful information about risk for relapse. The current study assessed the associations between PTSD symptom clusters and reactivity to cues in trauma-exposed adults with cocaine use disorder.

Methods: We recorded electroencephalogram on 52 trauma-exposed participants (M = 51. Read More

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The effect of next day responsibilities and an adaptive purchase task on cannabis demand.

Drug Alcohol Depend 2021 Jul 28;227:108919. Epub 2021 Jul 28.

Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA; Center for Pain Research and Behavioral Health, University of Florida, Gainesville, FL, USA. Electronic address:

Background: The marijuana purchase task (MPT) is a commonly used behavioral economic measure of relative cannabis value (i.e. demand) that presents specific methodological concerns due to non-standardized measurement, variability in modality of use, and evolving legalization policies. Read More

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Sustained-release modeling of clove essential oil in brine to improve the shelf life of Iranian white cheese by bioactive electrospun zein.

Int J Food Microbiol 2021 Jul 24;355:109337. Epub 2021 Jul 24.

Department of Food Nanotechnology, Research Institute of Food Science and Technology (RIFST), km 12 Mashhad-Quchan Highway, P.O. Box: 91895-157-356, Mashhad, Iran. Electronic address:

In this study, the sustained-release of clove essential oil (CEO) loaded into the structure of electrospun zein was used as a biopreservative to extend the shelf life of Iranian white cheese. CEO was loaded at levels of 5, 7.5, and 10% w/w in the structure of electrospun nanofibers. Read More

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Effects of three essential oils and their nano-emulsions on Listeria monocytogenes and Shigella flexneri in Egyptian Talaga cheese.

Int J Food Microbiol 2021 Jul 27;355:109334. Epub 2021 Jul 27.

Certified Food Lab, Animal Health Research Institute, Agriculture Research Center, Egypt.

Talaga cheese is a soft Egyptian cheese that has been associated with foodborne pathogens such as Listeria monocytogenes and Shigella flexneri. Essential oils (EOs) play a pivotal role in sustainably controlling foodborne diseases and as a potential preservative in soft cheeses. However, limited data is available comparing the antibacterial activity of EOs and their nano-emulsions (NEs) when inoculated into Talaga cheese. Read More

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The partitioning behavior of PAHs between settled dust and its extracted water phase: Coefficients and effects of the fluorescent organic matter.

Ecotoxicol Environ Saf 2021 Jul 30;223:112573. Epub 2021 Jul 30.

School of Geography and Environment, Key Laboratory of Poyang Lake Wetland and Watershed Research, Ministry of Education, Jiangxi Normal University, 99 Ziyang Road, Nanchang 330022, China.

The occurrence and distribution of polycyclic aromatic hydrocarbons (PAHs) in a city of Central China were determined in the settled dust and its extracted water phase from different land use types and bus stops in Nanchang City. The physicochemical properties of its water extracted dissolved organic matter (WEOM) were characterized to investigate the effect of fluorescence organic matter on the dust-water partitioning coefficients (K) using three-dimensional excitation-emission matrix fluorescence spectroscopy combined parallel factor analysis. Results showed that the range of ∑PAHs in settled dust and the extracted water phase was 0. Read More

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Distribution and antimicrobial resistance of Vibrio parahaemolyticus isolated from fish and shrimp aquaculture farms along the Korean coast.

Mar Pollut Bull 2021 Jul 30;171:112785. Epub 2021 Jul 30.

West Sea Fisheries Research Institute, National Institute of Fisheries Science, Incheon 22383, Republic of Korea.

The present study investigated the distribution and antimicrobial susceptibility patterns of Vibrio parahaemolyticus in water samples and aquatic animals (fish and shrimp) from major aquaculture farms along the Korean coast in 2018. V. parahaemolyticus is the most common pathogen causing seafood-borne illness. Read More

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First report on embryonic and larval development of 2n/3n mosaic sterlet.

Animal 2021 Jul 30;15(9):100317. Epub 2021 Jul 30.

Department of Ichthyology and Aquaculture, Faculty of Animal Bioengineering, University of Warmia and Mazury in Olsztyn, 10-718 Olsztyn, Poland.

Mosaicism is frequently observed in aquaculture practices, and it adversely affects the production as well as the restoration programme of the sturgeon. The purpose of the present study was the induction of 2n/3n mosaic in sterlet, Acipenser ruthenus L., and compare their embryonic and larval development with diploid control sterlet. Read More

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Effects of oxygen concentration during incubation and broiler breeder age on embryonic heat production, chicken development, and 7-day performance.

Animal 2021 Jul 30;15(9):100323. Epub 2021 Jul 30.

Adaptation Physiology Group, Wageningen University and Research, P.O. Box 338, 6700 AH Wageningen, the Netherlands.

Older breeder flocks produce eggs with a relatively larger yolk and thereby a higher nutrient availability than young breeder flocks. To optimise nutrient utilisation and embryonic development throughout incubation and posthatch period, embryos originating from older breeder flocks may require a higher oxygen availability. The current study investigated effects of broiler breeder flock age and incubational oxygen concentration on embryonic metabolism and chicken development until 7-day posthatch. Read More

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Diverse trauma profiles of youth in group care settings: A cluster analysis.

Child Abuse Negl 2021 Jul 30;120:105221. Epub 2021 Jul 30.

McMaster University, Department of Pediatrics, 1280 Main Street West, Room 3A, Hamilton L8S 4K1, Ontario, Canada.

Background: Many adolescents in group care have experienced higher rates of traumatic event exposure, behavior problems, and severe trauma sequelae compared to those outside of group care. Yet, little research has examined from a person-centered perspective their diverse trauma profiles and corresponding service needs.

Objective: This exploratory study aimed to examine the heterogeneity of trauma-related profiles among youth in group care to highlight potential distinct service needs among subgroups. Read More

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At-risk gambling in patients with severe psychiatric illness and in community subjects matched for age and sex.

Psychiatry Res 2021 Jul 26;304:114142. Epub 2021 Jul 26.

Institute of Clinical Physiology, National Council of Research (CNR), Rome, Italy.

In the recent literature the rates of gambling in psychiatric patients have been compared only indirectly with those found in community samples and no study has so far matched a clinical sample with community controls. We selected 875 outpatients attending two community mental health centers and 3.500 community subjects, matched for age and sex. Read More

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Effects of dietary protein, energy and β-mannanase on laying performance, egg quality, and ileal amino acid digestibility in laying hens.

Poult Sci 2021 Jun 5;100(9):101312. Epub 2021 Jun 5.

Department of Poultry Science, University of Georgia, Athens, GA, USA. Electronic address:

β-mannan is a nonstarch polysaccharide found in hulled and dehulled soybeans that can survive drying-toasting phase of processing soybeans and have antinutritive effects in poultry. β-mannanase is an active enzyme (endohydrolase) that can hydrolyze β-mannan to reduce its antinutritional effects. Two experiments were conducted to evaluate the effects of β-mannanase supplementation in low energy/protein diets on egg production, egg quality, and apparent ileal digestibility of the dry matter (DM), crude protein (CP), and amino acids in 21-week-old Single Comb White Leghorn hens (Hy-Line W-36). Read More

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First report of organochlorine pesticides (OCPs) in coral tissues and the surrounding air-seawater system from the South China Sea: Distribution, source, and environmental fate.

Chemosphere 2021 Jul 29;286(Pt 2):131711. Epub 2021 Jul 29.

Guangxi Laboratory on the Study of Coral Reefs in the South China Sea, Coral Reef Research Center of China, School of Marine Sciences, Guangxi University, Nanning, 530004, China.

The levels, fate, and potential sources of 22 organochlorine pesticides (OCPs) in coral tissues and the surrounding air-seawater system from the South China Sea (SCS) were elucidated for the first time. ∑OCPs (total concentration of 22 OCPs) (16.1-223 pg L) was relatively higher in coastal seawater than in offshore seawater, which may be the widespread influence of coastal pollution inputs under the western boundary current. Read More

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The impact of indomethacin on the number of oocytes retrieved and IVF outcomes in patients with poor ovarian response.

Eur J Obstet Gynecol Reprod Biol 2021 Jul 24;264:266-270. Epub 2021 Jul 24.

Center for Assisted Reproduction, Department of Obstetrics and Gynecology, Ankara University Faculty of Medicine, Ankara, Turkey.

Objective: The aim of this retrospective case-control study was to analyze the effect of administering indomethacin after triggering final oocyte maturation in patients with poor ovarian response (POR) on the cycle cancellation rate due to premature ovulation (PO), the number of oocytes retrieved and the clinical outcomes of IVF cycles.

Study Design: A total of 214 patients with POR, diagnosed according to the Bologna criteria, who underwent fresh IVF cycle via flexible gonadotrophin-releasing hormone antagonist (GnRH-ant) protocol were enrolled in the study. The control group consisted of 100 patients, whereas the indomethacin group included 114 patients who received 100 mg rectal indomethacin administered twice within the same day (twelve hours apart) -starting at twelve hours after triggering. Read More

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Self-efficacy, coping strategies and quality of life in women and men requiring assisted reproductive technology treatments for anatomical or non-anatomical infertility.

Eur J Obstet Gynecol Reprod Biol 2021 Jul 21;264:241-246. Epub 2021 Jul 21.

Infertility and IVF Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy; University of Bologna - DIMEC, Bologna, Italy.

Objective: To examine the magnitude and the predictors of emotional reactions to an infertility diagnosis, comparing women and men who were clinically diagnosed with an anatomical cause of infertility or non-anatomical cause of infertility.

Study Design: Cross-sectional study involving a total of 133 adults waiting for infertility treatment at the IVF and Infertility Unit of the S. Orsola University Hospital in Bologna (Italy). Read More

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Knockout of FER decreases cadmium concentration in roots of Arabidopsis thaliana by inhibiting the pathway related to iron uptake.

Sci Total Environ 2021 Jul 28;798:149285. Epub 2021 Jul 28.

State Key Laboratory of Plant Physiology and Biochemistry, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address:

Identifying the genes that affect cadmium (Cd) accumulation in plants is a prerequisite for minimizing dietary Cd uptake from contaminated edible parts of plants by genetic engineering. This study showed that Cd stress inhibited the expression of FERONIA (FER) gene in the roots of wild-type Arabidopsis. Knockout of FER in fer-4 mutants downregulated the Cd-induced expression of several genes related to iron (Fe) uptake, including IRT1, bHLH38, NRAMP1, NRAMP3, FRO2 andFIT. Read More

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Reverse osmosis concentrate treatment by microbubble ozonation-biological activated carbon process: Organics removal performance and environmental impact assessment.

Sci Total Environ 2021 Jul 28;798:149289. Epub 2021 Jul 28.

National University of Singapore, Sembcorp-NUS Corporate Laboratory c/o FoE, Block E1A, #04-01, 1 Engineering Drive 2, 117576, Singapore; Department of Civil & Environmental Engineering, Faculty of Engineering, National University of Singapore, Block E1A, #07-01, 1 Engineering Drive 2, 117576, Singapore. Electronic address:

Reverse osmosis (RO) is being used in many water reclamation facilities to produce high quality water that can be reused for different purposes. As a part of the RO process, a reject stream is produced as the reverse osmosis concentrate (ROC), which contains elevated levels of contaminants compared to the source water. Effective treatment and safe disposal of ROC via cost-effective means is very challenging. Read More

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Concentrations and geographical patterns of persistent organic pollutants (POPs) in meat from semi-domesticated reindeer (Rangifer tarandus tarandus L.) in Norway.

Sci Total Environ 2021 Jul 29;798:149278. Epub 2021 Jul 29.

Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, N-9037 Tromsø, Norway; NILU - Norwegian Institute for Air Research, Fram Centre, N-9296 Tromsø, Norway.

The study aimed at investigating the concentrations and geographical patterns of 11 polychlorinated biphenyls (PCBs) and 15 organochlorine pesticides (OCPs) in reindeer muscle samples (n = 100) collected from 10 grazing districts in Norway, 2009. Concentrations were examined for patterns related to geographical region as well as age and sex of animals. Concentrations measured for PCBs and OCPs in reindeer meat samples were generally low. Read More

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