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ILEOSIGMOID POUCH AS A URINARY DIVERSION APPROACH FOLLOWING RADICAL CYSTECTOMY IN PATIENTS WITH MUSCLE-INVASIVE BLADDER CANCER.

Georgian Med News 2021 Mar(312):36-42

National Cancer Institute, Kyiv, Ukraine.

Goal - to determine efficacy of the Ileosigmo-pouch (ISP) as a method of transrectal urinary diversion in invasive bladder cancer (BC) treatment. Retrospective analysis of clinical data of patients that undergone radical cystectomy (RC), followed by ISP method of urinary diversion. Study compared two groups of patients: the first group of 22 (23. Read More

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Mitigation of membrane biofouling in membrane bioreactor treating sewage by novel quorum quenching strain of Acinetobacter originating from a full-scale membrane bioreactor.

Bioresour Technol 2021 May 1;334:125242. Epub 2021 May 1.

School of Engineering, Newcastle University, Newcastle NE1 7RU, UK.

A novel quorum quenching (QQ) strain, Acinetobacter guillouiae ST01, was isolated from a full-scale membrane bioreactor (MBR) and characterized for its QQ activities. Batch reactor studies at lab-scale showed that A. guillouiae ST01 exhibited higher QQ activity against acyl homoserine lactones (AHLs) with an oxo group compared to those without an oxo group. Read More

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Mixtures of chelating agents to enhance photo-Fenton process at natural pH: Influence of wastewater matrix on micropollutant removal and bacterial inactivation.

Sci Total Environ 2021 Apr 29;786:147416. Epub 2021 Apr 29.

Department of Chemical Engineering and Analytical Chemistry, Faculty of Chemistry, Universitat de Barcelona, C/Martí i Franqués 1, 08028 Barcelona, Spain.

Three organic fertilizers (EDTA (Ethylenedinitrilotetraacetic acid), EDDS (Ethylenediamine-N, N'-disuccinic acid) and DTPA (Diethylene triamine pentaacetic acid)) were tested as Fe-complexes in photo-Fenton process at natural pH for micropollutants (MPs) abatement and simultaneous E.coli inactivation. Less stable Fe-complexes show high iron precipitation, stopping MPs degradation. Read More

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Organic carbon bioavailability: Is it a good driver to choose the best biological nitrogen removal process?

Sci Total Environ 2021 Apr 29;786:147390. Epub 2021 Apr 29.

Western Paraná State University, 85819-110 Cascavel, PR, Brazil; Federal University of Fronteira Sul, 99700-000 Erechim, Brazil; Embrapa Suínos e Aves, 89715-899 Concórdia, SC, Brazil. Electronic address:

Organic carbon can affect the biological nitrogen removal process since the Anammox, heterotrophic and denitrifying bacteria have different affinities and feedback in relation to carbon/nitrogen ratio. Therefore, we reviewed the wastewater carbon concentration, its biodegradability and bioavailability to choose the appropriate nitrogen removal process between conventional (nitrification-denitrification) and Anammox-based process (i.e. Read More

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Firearm-Related Injuries: A Single Center Experience.

J Surg Res 2021 May 5;265:289-296. Epub 2021 May 5.

Division of Trauma, Critical Care, Emergency Surgery, and Burns, Department of Surgery, College of Medicine, University of Arizona, Tucson, Arizona. Electronic address:

Introduction: Firearm-related injuries (FRI) are an important public health crisis in the US. There is relatively less city level data examining the injury-related trends in Tucson, Arizona. Our study aims to examine FRI, in Southern Arizona's only Level I trauma center. Read More

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Iatrogenic Ureteral Injury and Prophylactic Stent Use in Veterans Undergoing Colorectal.

J Surg Res 2021 May 5;265:272-277. Epub 2021 May 5.

Michael and Marian Ilitch Department of Surgery, Wayne State University School of Medicine / Detroit Medical Center, Detroit, Michigan; John D. Dingell VA Medical Center, Detroit, Michigan. Electronic address:

Introduction: Iatrogenic ureteral injury (IUI) is an uncommon complication in colorectal surgery. Prophylactic ureteral stenting (PUS) gained acceptance to aid in intraoperative identification of the ureter. Despite its use, the benefit of pus to avoid IUI remains debatable. Read More

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Stormwater retention and detention performance of green roofs with different substrates: Observational data and hydrological simulations.

J Environ Manage 2021 May 5;291:112682. Epub 2021 May 5.

School of Soil and Water Conservation, Beijing Forestry University, 35 Qinghua East Road, Beijing, 100083, China.

Green roofs are widely considered as a promising nature-based solution for urban stormwater management. In this study, the stormwater retention and detention performance of 6 green roof modules with different types and depth of substrates at Beijing, China was investigated through 3-year continuous monitoring. The Hydrus-1D was applied to further explore the stormwater management performance of green roofs under extreme storms. Read More

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Mechanical thrombectomy in distal residual occlusions of the middle cerebral artery after large vessel recanalization in acute stroke: 2b or not 2b? A pragmatic approach in real-life scenarios.

World Neurosurg 2021 May 5. Epub 2021 May 5.

Hopital Foch, Department of Diagnostic and Interventional Neuroradiology, Suresnes, Île-de-France, FR.

Background: AND PURPOSE: Recent studies have suggested that a recanalization grade of modified thrombolysis in cerebral infarction (mTICI) ≥2c is strongly related with good clinical outcome rather than the current therapeutic angiography target ≥2b. In order to achieve better recanalization, additional further maneuvers on distal residual vessel occlusion may be required. The aim of this paper was to evaluate the safety and efficacy of rescue treatment in residual vessel occlusions (RVOs) after recanalization of large vessel occlusions in the anterior circulation. Read More

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Delayed egress of CD8 T cells contributes to long-term pathology after ischemic stroke in male mice.

Brain Behav Immun 2021 May 5. Epub 2021 May 5.

Department of Neurology & Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, Texas, United States; Department of Neurology, Center for Advanced Translational Stroke Science, University of Kentucky, Lexington, Kentucky, USA. Electronic address:

Objective: Stroke is a debilitating disorder with significant annual mortality and morbidity rates worldwide. Immune cells are recruited to the injured brain within hours after stroke onset and can exhibit either protective or detrimental effects on recovery. However, immune cells, including CD8 T cells, persist in the injured brain for weeks, suggesting a longer-term role for the adaptive immune system during functional recovery. Read More

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Outcomes of Posterior Labral Repair with or without Concomitant High-Grade Glenohumeral Chondral Pathology: a retrospective cohort with minimum 2-year follow-up.

J Shoulder Elbow Surg 2021 May 5. Epub 2021 May 5.

Carolinas Medical Center, Atrium Musculoskeletal Institute, 1025 Morehead Medical Dr., Suite #300, Charlotte, NC, 28204, USA. Electronic address:

Background: The purpose of this study was to compare outcomes of patients who underwent posterior labral repair with and without concomitant glenohumeral chondral pathology.

Methods: A retrospective review was performed on patients ≥ 18 years of age who underwent primary posterior labral repair over 5 years. Charts were reviewed to determine the presence and location of high-grade (Outerbridge Grade III/IV) pathology. Read More

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Sex Differences, Sleep Disturbance and Risk of Persistent Pain Associated With Groin Hernia Surgery: A Nationwide Register-Based Cohort Study.

J Pain 2021 May 5. Epub 2021 May 5.

Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden; Department of Surgery, Skåne University Hospital, Malmö, Sweden.

Persistent pain after groin hernia repair is a major health problem. Sleep disturbance is associated with heightened pain sensitivity. The main objective of this study was to examine the role of sleep disturbance in the development and long-term maintenance of chronic postherniorrhaphy inguinal pain (CPIP), with exploration of sex differences. Read More

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Comparison of clinical efficacy of neoadjuvant chemoradiotherapy between lower and higher radiation dose for carcinoma of the esophagus and gastroesophageal junction: a systematic review.

Int J Radiat Oncol Biol Phys 2021 May 5. Epub 2021 May 5.

Department of Radio-Chemotherapy, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou City, Jiangsu Province, China. Electronic address:

Background: Neoadjuvant concurrent chemoradiotherapy (nCRT) plus surgery has been a standard treatment for locoregionally advanced esophageal cancer and carcinoma of the gastroesophageal junction (EC/GEJ), but an optimal preoperative radiation dose is still unclear.

Purpose: We performed this systematic review to explore the treatment efficacy and toxicity of different radiation dose levels and find an optimal dose-fractionation strategy in EC/GEJ patients receiving nCRT.

Methods: Embase and Ovid Medline were searched for articles involving operable squamous and adenocarcinoma of the esophagus and GEJ receiving nCRT up to a dose of 50. Read More

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Systematic evaluation of activated carbon-FeO composites for removing and degrading emerging organic pollutants.

Environ Res 2021 May 5:111187. Epub 2021 May 5.

Civil and Environmental Engineering Faculty, Technion, Haifa, 32000 Israel. Electronic address:

In this study, a comparative activity assessment of several activated carbon (AC) and AC-FeO composites was performed to evaluate their efficiency and versatility as Fenton-like catalysts. Although many studies have demonstrated the advantages of AC-based materials as Fenton-like catalysts, most have been developed using only one oxidant and/or one pollutant. Here, untreated (AC) and acid-treated AC (AC) iron-oxide composites were synthesized, characterized, and compared in terms of activity to bare ACs using several oxidants and pollutants, the activation efficiency of hydrogen peroxide (HO) and ammonium persulfate ((NH)SO), and the subsequent oxidation extent and kinetics of bisphenol-A, atrazine, and carbamazepine by the AC-based materials were studied in depth. Read More

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Pediatric Asthma Incidence Rates in the United States from 1980-2017.

J Allergy Clin Immunol 2021 May 5. Epub 2021 May 5.

Background: Few studies have examined longitudinal asthma incidence rates from a public health surveillance perspective.

Objective: Calculate descriptive asthma incidence rates in children over time considering demographics and parental asthma history.

Methods: Data from nine US birth cohorts were pooled into one population covering 1980-2017. Read More

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Is the Diagnostic rate for the Common subtypes of A1AT Deficiency Consistent across Two Canadian Provinces?

Clin Biochem 2021 May 5. Epub 2021 May 5.

Department of Pathology and Laboratory Medicine, St Paul's Hospital, 1081 Burrard St, Vancouver, BC, V6Z 1Y6, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Rm. G227 - 2211 Westbrook Mall, Vancouver, BC, V6T 2B5, Canada. Electronic address:

Background: The diagnosis of alpha-1-antitrypsin (A1AT) deficiency has been hindered by obscurity concerning the testing process and treatment implications. In this study, we aimed to identify regional differences in the diagnostic rates for A1AT deficiency in the western Canadian provinces of British Columbia (BC) and Alberta (AB).

Methods: The number of A1AT deficiency variant genotype (ZZ, SZ, MZ, SS, and MS) diagnoses were reviewed for BC and AB. Read More

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Frequency of health-care service use and severity of illness in undocumented migrants in Catalonia, Spain: a population-based, cross-sectional study.

Lancet Planet Health 2021 May;5(5):e286-e296

Institut Català de la Salut, Barcelona, Spain.

Background: In Spain, legislation was passed in 2012 excluding undocumented migrants from the public health-care system. Catalonia was one of the Spanish regions that did not implement this legislation, and continued to guarantee access to health care to the whole population. We aimed to analyse health-care use and health status among undocumented migrants in Catalonia, and compare health-care use and health status with legal residents classified according to their socioeconomic position (SEP). Read More

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Food Access and Cardiovascular Outcomes in Metropolitan Atlanta Census Tracts With Residents at Low Risk and High Risk of Cardiovascular Disease: The Morehouse-Emory Cardiovascular Center for Health Equity Study.

Prev Chronic Dis 2021 May 6;18:E42. Epub 2021 May 6.

Community Health and Preventive Medicine, Morehouse School of Medicine, Atlanta, Georgia.

Introduction: Perceived and actual access to healthy foods may differ in urban areas, particularly among Black people. We assessed the effect of objective and perceived neighborhood food access on self-reported cardiovascular disease (CVD) among Black people living in areas of high risk and low risk for the disease in Atlanta, Georgia. We hypothesized that perceived and objective food access would independently predict self-reported CVD. Read More

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Property modelling of lysozyme-crosslinker-alginate complexes using latent variable methods.

J Biomed Mater Res A 2021 May 8. Epub 2021 May 8.

Department of Chemical Engineering, McMaster University, Hamilton, Ontario, Canada.

Statistical methods were used to provide insight into a polymer complex system composed of lysozyme and alginate to quantify the effects of such parameters as pH, and ionic composition of the mixing solution on the properties of the complexes including composition, particle diameter, and zeta potential. Various crosslinkers (calcium, barium, iron[III], and bovine serum albumin), were used with lysozyme for complex formation to investigate the effect of crosslinker charge density on protein release kinetics, modelled using kt . Multivariate statistical analysis showed that the kinetic parameters associated with the release were, not surprisingly highly dependent on the ionic strength of the release media, with higher ionic strength leading to faster release. Read More

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Rural and racial disparities in colorectal cancer incidence and mortality in South Carolina, 1996 - 2016.

J Rural Health 2021 May 8. Epub 2021 May 8.

Department of Epidemiology & Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA.

Purpose: Colorectal cancer (CRC) is the third leading cause of cancer mortality among men and women in the United States and South Carolina (SC). Since SC has one of the highest proportions of Black (27.9%) and rural residents (33. Read More

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Predictors of Colorectal Cancer Screening Among African American Men Living with HIV.

J Community Health 2021 May 8. Epub 2021 May 8.

University Pennsylvania Annenberg School of Communication, Philadelphia, USA.

African American men living with HIV are at high risk of colorectal cancer (CRC). Screening to detect CRC is associated with a reduced risk of CRC mortality. However, little is known about CRC screening predictors in this population. Read More

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Conscious rat PET imaging with soft immobilization for quantitation of brain functions: comprehensive assessment of anesthesia effects on cerebral blood flow and metabolism.

EJNMMI Res 2021 May 8;11(1):46. Epub 2021 May 8.

Preeminent Medical Photonics Education and Research Center, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka, 431-3192, Japan.

Background: Animal brain functions evaluated by in vivo imaging under anesthesia can be affected by anesthetic agents, resulting in incorrect assessment of physiological brain function. We therefore performed dynamic positron emission tomography (PET) imaging of conscious rats using recently reported soft immobilization to validate the efficacy of the immobilization for brain function assessments. We also determined the effects of six anesthetic agents-a mixed anesthetic agent (MMB), ketamine + xylazine (KX), chloral hydrate (Chloral), pentobarbital (PTB), propofol (PF), and isoflurane (IFL)-on brain function by comparison with conscious rats. Read More

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The Impact of Intensifying Prostate Cancer Screening in Black Men: A Model-Based Analysis.

J Natl Cancer Inst 2021 May 8. Epub 2021 May 8.

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Background: Black men in the United States have markedly higher rates of prostate cancer than the general population. National guidelines for prostate-specific antigen (PSA) screening do not provide clear guidance for this high-risk population. The purpose of this study is to estimate the benefit and harm of intensified PSA screening in Black men. Read More

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Exposure to stressful and traumatic life events in hoarding: Comparison to clinical controls.

J Clin Psychol 2021 May 8. Epub 2021 May 8.

Anxiety Treatment and Research Clinic, St. Joseph's Healthcare, Hamilton, Ontario, Canada.

Background: Individuals with hoarding report stressful and traumatic life events at an elevated rate compared with those with obsessive-compulsive disorder and healthy controls, but have not been compared with other clinical groups. This study compared rates of traumatic life events between those with clinically significant hoarding, anxiety disorders, or posttraumatic stress disorder (PTSD), hypothesizing that rates would be higher in the hoarding and PTSD groups than the anxiety group.

Methods: Rates of traumatic and stressful events were compared across groups. Read More

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Treating high-risk moderate acute malnutrition using therapeutic food compared with nutrition counseling (Hi-MAM Study): a cluster-randomized controlled trial.

Am J Clin Nutr 2021 May 8. Epub 2021 May 8.

Project Peanut Butter, Freetown, Sierra Leone.

Background: There is a lack of consensus on what is the most appropriate treatment of moderate acute malnutrition (MAM).

Objectives: We aimed to determine if provision of ready-to-use-therapeutic food (RUTF) and antibiotics to "high-risk" MAM (HR-MAM) children in addition to nutritional counseling would result in higher recovery and less deterioration than nutrition counseling alone.

Methods: At the 11 intervention clinics, HR-MAM children were given RUTF and amoxicillin along with standard nutrition counseling, for 2-12 wk. Read More

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[Effect of FVIII doses on joint structure and function in adolescents with severe hemophilia A: mid-term results of a prospective cohort study].

Nan Fang Yi Ke Da Xue Xue Bao 2021 Apr;41(4):536-542

Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

Objective: To explore the clinical phenotype and changes in joint structure and function in adolescent patients with severe hemophilia A under different doses of FVIII.

Objective: Forty- three adolescents with severe hemophilia A aged 4-18 years were divided into on-demand group (=7), low-dose group (FVIII dose of 10-15 U/kg, 2-3 times a week, and ≤30 U/kg a week; =17), and intermediate-dose group (FVIII dose of 15-20 U/kg, 2-3 times a week, and 45-60 U/kg a week (=19). The 3 groups were compared for their clinical bleeding phenotype, annual bleeding rate (ABR), annual joint bleeding rate (AJBR), annual the most severe joint bleeding rate, joint imaging scores (ultrasound HEAD-US score and IPSG MRI score), Hemophilia Joint Health Score (HJHS) and Functional Independence Score in Hemophilia (FISH) within 24 months. Read More

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Diagnostic Accuracy of Axillary Ultrasound for Prediction of Axillary Pathologic Response after Neoadjuvant Treatment in Breast Cancer.

Chirurgia (Bucur) 2021 Mar-Apr;116(2 Suppl):45-58

In the era of NAT, to accurately predict pathologic response is a great challenge, which might influence surgical approach for breast and axilla. Axillary staging via imaging methods as an adjunct have long been used with various reported accuracy rates. However, the role of preoperative axillary ultrasonography (AUS) in clinical N0 patients after NAT is still controversial. Read More

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Risk Factor Analysis for Flap and Donor Site Related Complications in 1274 DIEP Flaps - Retrospective Single Center Study.

Chirurgia (Bucur) 2021 Mar-Apr;116(2 Suppl):5-15

Breast cancer is the most common cancer affecting women worldwide. In Germany, in almost 70% of cases, women require a complete mastectomy and wish for breast reconstruction which is especially difficult when the breast was previously irradiated. The DIEP flap is then the gold standard for autologous breast reconstruction and shows an overall low complication rate. Read More

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Temporal variations in maternal treatment requirements and early neonatal outcomes in patients with gestational diabetes.

Diabet Med 2021 May 8:e14596. Epub 2021 May 8.

School of Clinical Medicine, Addenbrooke's Hospital, Box 281, Hills Road, Cambridge, CB2 0QQ, United Kingdom.

Aims: There is seasonal variation in the incidence of gestational diabetes and delivery outcomes of affected patients. We assessed if there was also evidence of temporal variation in maternal treatment requirements and early neonatal outcomes.

Methods: We performed a retrospective analysis of women diagnosed with gestational diabetes (75g OGTT, 0hr ≥5. Read More

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Hepatic Arterioportal Fistula Is Associated with Decreased Future Liver Remnant Regeneration after Stage-I ALPPS for Hepatocellular Carcinoma.

J Gastrointest Surg 2021 May 7. Epub 2021 May 7.

Department of Hepatobiliary Surgery and Liver transplantation, the First Affiliated Hospital of Guangxi Medical University, Shuangrong Raod 6, Nanning, 530021, China.

Background: Hepatocellular carcinoma (HCC) patients often developed hepatic arterioportal fistula (APF). The aim of this study is to evaluate the impact of APF on future liver remnant (FLR) regeneration and surgical outcomes after the first stage of associating liver partition and portal vein ligation for staged hepatectomy (stage-I ALPPS).

Methods: Consecutive HCC patients who underwent ALPPS at our center between March 2017 and May 2019 were retrospectively studied. Read More

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A Pilot RCT Evaluating InThistoGether, an mHealth HIV Prevention Program for Ugandan Youth.

AIDS Behav 2021 May 7. Epub 2021 May 7.

Internet Solutions for Kids Uganda, Mbarara, Uganda.

Despite data suggesting that older adolescence is an important period of risk for HIV acquisition in Uganda, tailored HIV prevention programming is lacking. To address this gap, we developed and tested nationally, InThistoGether (ITG), a text messaging-based HIV prevention program for 18-22 year-old Ugandan youth. To assess feasibility and acceptability, and preliminary indications of behavior change, a randomized controlled trial was conducted with 202 youth. Read More

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