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Impact of Plasmatic Progesterone on the Day of Frozen Embryo Transfer in Hormone-induced Cycles.

Rev Bras Ginecol Obstet 2021 Aug 21;43(8):608-615. Epub 2021 Sep 21.

Instituto Valenciano de Infertilidad, Lisboa, Portugal.

Objective:  To establish a relationship between serum progesterone values on the day of frozen blastocyst transfer in hormone-replaced cycles with the probability of pregnancy, miscarriage or delivery.

Methods:  This was an ambispective observational study including all frozen-thawed embryo transfer cycles performed at our department following in vitro fecundation from May 2018 to June 2019. The outcomes evaluated were β human chorionic gonadotropin (β-hCG)-positive pregnancy and delivery. Read More

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Perineal Lacerations: A Retrospective Study in a Habitual-Risk Public Maternity.

Rev Bras Ginecol Obstet 2021 Aug 21;43(8):588-594. Epub 2021 Sep 21.

Medical School, Universidade Franciscana, Santa Maria, Rio Grande do Sul, RS, Brazil.

Objective:  In around 85% of vaginal births, the parturients undergo perineal lacerations and/or episiotomy. The present study aimed to determine the incidence of lacerations and episiotomies among parturients in 2018 in a habitual-risk public maternity hospital in southern Brazil, and to determine the risk and protective factors for such events.

Methodology:  A retrospective cross-sectional study. Read More

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Developmental pathways linking the quality and intensity of organized afterschool activities in middle school to academic performance in high school.

J Adolesc 2021 Sep 18;92:152-164. Epub 2021 Sep 18.

University of California, Irvine, USA. Electronic address:

Introduction: Adolescents' organized afterschool activities have been linked to their academic performance, but processes contributing to these relations are not well understood. This study tested two pathways linking activity intensity and activity quality in 6th grade to high school academic performance: adolescents' activities in 9th grade and adolescents' academic skills in 9th grade.

Methods: Data were from the Study of Early Child Care and Youth Development, a longitudinal study conducted at 10 sites in the United States. Read More

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September 2021

Nonlinear tensor train format for deep neural network compression.

Neural Netw 2021 Sep 8;144:320-333. Epub 2021 Sep 8.

Department of Precision Instrumentation, Center for Brain Inspired Computing Research and Beijing Innovation Center for Future Chip, Tsinghua University, Beijing 100084, China. Electronic address:

Deep neural network (DNN) compression has become a hot topic in the research of deep learning since the scale of modern DNNs turns into too huge to implement on practical resource constrained platforms such as embedded devices. Among variant compression methods, tensor decomposition appears to be a relatively simple and efficient strategy owing to its solid mathematical foundations and regular data structure. Generally, tensorizing neural weights into higher-order tensors for better decomposition, and directly mapping efficient tensor structure to neural architecture with nonlinear activation functions, are the two most common ways. Read More

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September 2021

Combined chemical exposure using exposure loads on human biomonitoring data of the 4th Flemish Environment and Health Study (FLEHS-4).

Int J Hyg Environ Health 2021 Sep 18;238:113849. Epub 2021 Sep 18.

VITO, Flemish Institute for Technological Research, Unit Health, Boeretang 200, 2400, Mol, Belgium; Department of Biomedical Sciences, University of Antwerp, 2610, Wilrijk, Belgium.

To improve our understanding of internal exposure to multiple chemicals, the concept exposure load (EL) was used on human biomonitoring (HBM) data of the 4th FLEHS (Flemish Environment and Health Study; 2016-2020). The investigated chemicals were per- and polyfluoroalkyl substances (PFASs), bisphenols, phthalates and alternative plasticizers, flame retardants, pesticides, toxic metals, organochlorine compounds and polycyclic aromatic hydrocarbons (PAHs). The EL calculates "the number of chemicals to which individuals are internally exposed above a predefined threshold". Read More

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September 2021

Which is the best alternative to estimate muscle mass for sarcopenia diagnosis when DXA is unavailable?

Arch Gerontol Geriatr 2021 Sep 3;97:104517. Epub 2021 Sep 3.

FCNAUP - Faculdade de Ciências da Nutrição e Alimentação, Universidade do Porto, 4150-180 Porto, Portugal; LAETA-INEGI - Faculdade de Engenharia, Universidade do Porto, Porto, Portugal.

Background: Dual x-ray absorptiometry (DXA) is widely adopted to estimate muscle mass for research, but for daily practice is only available in a limited number of facilities.

Aim: To elucidate if it is anthropometry or bioelectrical impedance analysis (BIA) the method more concordant with DXA in estimating muscle mass for sarcopenia diagnosis among older adults, and to investigate the impact of several cut-off points in sarcopenia frequency.

Methods: 159 older adults (≥65 years) were included in a cross-sectional analysis. Read More

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September 2021

Pregnancy after stillbirth: Maternal and neonatal outcomes and health service utilisation.

Am J Obstet Gynecol MFM 2021 Sep 18:100486. Epub 2021 Sep 18.

Pregnancy Loss Research Group, the Irish Centre for Maternal and Child Health Research (INFANT), University College Cork; Department of Obstetrics and Gynaecology, Cork University Maternity Hospital, Cork, Ireland.

Background: Stillbirth occurs in every 3.5 of 1,000 pregnancies in Ireland and is a devastating event for a family. Women who have a pregnancy after stillbirth require increased antenatal support. Read More

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September 2021

Stick to Milan: Infeasibility of the Brazil-Milan Criteria in recommending patients with hepatocellular carcinoma for liver transplantation.

Authors:
Alexander Ng

Ann Hepatol 2021 Sep 18:100537. Epub 2021 Sep 18.

University College London, London, United Kingdom, WC1E 6BT. Electronic address:

This article discusses the infeasibility of adhering to the Brazil-Milan Criteria for determining whether patients with hepatocellular carcinoma (HCC) should be offered liver transplantation. The Criteria are currently used widely in Brazil. However, since they expand the net of the transplant-eligible population, and that transplantation is shown to improve clinical outcomes in HCC patients relative to other treatments, they are inherently attractive and may be adopted by other countries in determining whether HCC patients should receive liver transplantation. Read More

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September 2021

Are Patient-Reported Drug Allergies Associated with Prosthetic Joint Infections and Functional Outcomes Following Total Hip and Knee Arthroplasty?

J Arthroplasty 2021 Sep 18. Epub 2021 Sep 18.

NYU Langone Orthopedic Hospital, 301 E 17th St, Suite 1402, New York, NY, 10003, USA.

Background: The purpose of this study is to determine if the number and types of patient-reported drug allergies are associated with prosthetic joint infection (PJI) and functional outcomes following total joint arthroplasty (TJA).

Methods: This was a retrospective review of all patients who underwent a primary, elective total hip (THA) or knee arthroplasty (TKA) over a 10-year period at a single academic institution. Demographic, clinical information, and number and type of patient-reported drug allergy was collected. Read More

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September 2021

Indirect effects of social activity on appetite via depressive symptoms in community-dwelling older adults: A cross-sectional study.

Appetite 2021 Sep 18:105705. Epub 2021 Sep 18.

Department of Public Health, Kobe University Graduate School of Health Sciences, Kobe, Japan. Electronic address:

Depressive symptoms have a strong effect on appetite decline in older adults. There is also an association between social activity and decreased depressive symptoms, but the mechanism between appetite and social activity with respect to depressive symptoms is unclear. This cross-sectional study examined the direct and indirect effects of social activity on appetite, via depressive symptoms. Read More

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September 2021

Characterizing Standardized Letters of Recommendation in Urology Residency Applications.

Urology 2021 Sep 18. Epub 2021 Sep 18.

Department of Urology, University of California San Francisco, San Francisco, California, USA; Department of Biostatistics and Epidemiology, University of California San Francisco, San Francisco, California, USA. Electronic address:

Objective: To identify the current formats of standardized letters of recommendation (SLORs) and evaluate their characteristics, the distribution of applicants' ratings, correlation between SLOR domain ratings and conventional application metrics, and potential biases.

Methods: We evaluated all applications submitted to our residency program for the 2020-2021 urology match. Two main formats of SLOR were identified. Read More

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September 2021

What Is the Effect of Pre-Emptive Oral Montelukast on Postoperative Pain Following Bimaxillary Orthognathic Surgery? A Triple-Blind Randomized Clinical Trial.

J Oral Maxillofac Surg 2021 Aug 20. Epub 2021 Aug 20.

Associate Professor, Oral and Maxillofacial Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Purpose: The aim of this study was to assess the effect of preoperative administration of oral montelukast on the amount of postoperative pain following bimaxillary orthognathic surgery.

Methods And Materials: All healthy skeletal class III deformity candidates for bimaxillary orthognathic surgery were included in this triple-blind randomized clinical trial. The subjects were randomly divided into placebo and montelukast groups. Read More

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Rare and de novo variants in 827 congenital diaphragmatic hernia probands implicate LONP1 as candidate risk gene.

Am J Hum Genet 2021 Sep 14. Epub 2021 Sep 14.

Department of Surgery, Boston Children's Hospital, Boston, MA 02115, USA.

Congenital diaphragmatic hernia (CDH) is a severe congenital anomaly that is often accompanied by other anomalies. Although the role of genetics in the pathogenesis of CDH has been established, only a small number of disease-associated genes have been identified. To further investigate the genetics of CDH, we analyzed de novo coding variants in 827 proband-parent trios and confirmed an overall significant enrichment of damaging de novo variants, especially in constrained genes. Read More

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September 2021

DcCCD4 catalyzes the degradation of α-carotene and β-carotene to affect carotenoid accumulation and taproot color in carrot.

Plant J 2021 Sep 21. Epub 2021 Sep 21.

State Key Laboratory of Crop Genetics and Germplasm Enhancement, Ministry of Agriculture and Rural Affairs Key Laboratory of Biology and Germplasm Enhancement of Horticultural Crops in East China, College of Horticulture, Nanjing Agricultural University, 1 Weigang, Nanjing, 210095, China.

Carotenoids are important natural pigments that give bright colors to plants. The difference in the accumulation of carotenoids is one of the key factors in the formation of various colors in carrot taproots. Carotenoid cleavage dioxygenases (CCDs), including CCD and nine-cis epoxycarotenoid dioxygenase (NCED), are the main enzymes involved in the cleavage of carotenoids in plants. Read More

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September 2021

Social Role, Behavior, and Belief Changes Associated With Driving After Using Marijuana Among U.S. Young Adults, and Comparisons With Driving After 5+ Drinking.

J Stud Alcohol Drugs 2021 Sep;82(5):584-594

Institute for Social Research, University of Michigan, Ann Arbor, Michigan.

Objective: This study examined past-2-week driving after marijuana use (DMU) and driving after having five or more drinks (D5D) during young adulthood, specifically focusing on associations between within-person change in social roles (living situation, marriage, parenthood, education, employment) and mediators (perceived risk, evenings out, and religiosity) from modal ages 19 to 30.

Method: Multilevel analyses were conducted using survey data collected from 2013 to 2019 from 1,873 adults (1,060 women; total number of data collection waves = 7,037) participating in the longitudinal Monitoring the Future study.

Results: Change across waves from not being married to married was associated with lower DMU likelihood at any particular wave both directly and via mediation through wave-level change in evenings out. Read More

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September 2021

Preparations of exploration of immediate hypersensitivity to antineoplastic agents: An oncology pharmacy perspective.

J Oncol Pharm Pract 2021 Sep 21:10781552211035695. Epub 2021 Sep 21.

Groupement Hospitalier Sud, Clinical Oncology Pharmacy Department, 26900Hospices Civils de Lyon, France.

Background: Cancer patients are being exposed to antineoplastic drugs more frequently and for longer periods, resulting in a higher risk of hypersensitivity reactions. The aim of this study was to assess the pharmaceutical time and direct cost of drug allergy explorations following immediate hypersensitivity reactions to antineoplastic agents.

Methods: A micro-costing method was used to collect data on consumption of human and material resources for allergy exploration preparations. Read More

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September 2021

Autologous Adipose Tissue Injection of Vocal Cords in Presbyphonia.

Otolaryngol Head Neck Surg 2021 Sep 21:1945998211045292. Epub 2021 Sep 21.

Department of Otolaryngology, Hospital Universitario de Fuenlabrada, Madrid, Spain.

Objective: This series evaluates the long-term results of autologous adipose injection (AAI) in patients older than 65 years with presbyphonia.

Study Design: Retrospective cohort study.

Setting: Academic secondary medical center. Read More

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September 2021

Number of prior concussions predict poorer concussion care seeking in military cadets.

Brain Inj 2021 Sep 21:1-9. Epub 2021 Sep 21.

Department of Behavioral Sciences and Leadership, USAF Academy, Colorado, USA.

Primary Objective: To determine whether concussion history predicts concussion care seeking, self-management practices, or confidence to recognize/report.

Research Design: Cross-sectional.

Methods & Procedures: 706 United States Air Force Academy (USAFA) cadets completed survey items regarding concussion history (0,1,2,3+), likelihood of reporting a concussion, self-management, and confidence to recognize/report. Read More

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September 2021

Characteristics of Japanese Electrolaryngeal Speech Produced by Untrained Speakers: An Observational Study Involving Healthy Volunteers.

J Speech Lang Hear Res 2021 Sep 21:1-8. Epub 2021 Sep 21.

Intensive Care Unit, Kanazawa University Hospital, Japan.

Purpose The aim of this study was to investigate the characteristics of electrolaryngeal (EL) speech among untrained speakers to aid in its effective introduction and to identify syllables and words that are easy or difficult to pronounce. Method A total of 21 healthy individuals who had never used an EL were included. The participants were briefed, and tests comprising 100 Japanese syllables and 50 single words were conducted to evaluate EL speech intelligibility. Read More

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September 2021

Naomi: a new modelling tool for estimating HIV epidemic indicators at the district level in sub-Saharan Africa.

J Int AIDS Soc 2021 Sep;24 Suppl 5:e25788

Division of Global HIV and Tuberculosis, Centers for Disease Control and Prevention, Lilongwe, Malawi.

Introduction: HIV planning requires granular estimates for the number of people living with HIV (PLHIV), antiretroviral treatment (ART) coverage and unmet need, and new HIV infections by district, or equivalent subnational administrative level. We developed a Bayesian small-area estimation model, called Naomi, to estimate these quantities stratified by subnational administrative units, sex, and five-year age groups.

Methods: Small-area regressions for HIV prevalence, ART coverage and HIV incidence were jointly calibrated using subnational household survey data on all three indicators, routine antenatal service delivery data on HIV prevalence and ART coverage among pregnant women, and service delivery data on the number of PLHIV receiving ART. Read More

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September 2021

Enhanced Extracellular Matrix Degradation in Growth Plate Contributes to Manganese Deficiency-Induced Tibial Dyschondroplasia in Broiler Chicks.

Biol Trace Elem Res 2021 Sep 21. Epub 2021 Sep 21.

College of Animal Science and Veterinary Medicine, Shandong Agricultural University, 61 Daizong Street, Tai'an City, 271018, Shandong Province, China.

Manganese (Mn) is a crucial trace element for poultry nutrition, and its deficiency compromises tibial cartilage development, leading to perosis and a higher incidence of slipped tendon. Tibial dyschondroplasia (TD) is a metabolic cartilage disease characterized by disruption of endochondral bone formation, which is closely related to extracellular matrix (ECM) degradation, in which Mn deficiency plays an important role. Previous studies have confirmed the role of matrix metalloproteinases (MMPs) in the pathogenesis of TD, but whether dysregulated ECM degradation and MMP expression profiles in growth plate are involved in Mn deficiency-induced avian TD has not been fully elucidated yet. Read More

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September 2021

Survival and spawning success of American shad (Alosa sapidissima) in varying temperatures and levels of glochidia infection.

Fish Physiol Biochem 2021 Sep 21. Epub 2021 Sep 21.

U.S. Geological Survey, Eastern Ecological Science Center, Conte Anadromous Fish Research Laboratory, One Migratory Way, Turners Falls, MA, 01376, USA.

Temperature fluctuations and climate change impacts may substantially affect spawning success of fish, especially migratory species with a limited spawning window. Factors affecting American shad (Alosa sapidissima) spawning success and survival were investigated at different temperatures and periods (peak- and late-spawning periods) during the Connecticut River, USA, spawning migration in 2017. Wild caught American shad were exposed to constant temperatures regimes of 15, 18, 21, 24 and 27 °C for 2 weeks. Read More

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September 2021

Low-level laser treatment promotes skin wound healing by activating hair follicle stem cells in female mice.

Lasers Med Sci 2021 Sep 21. Epub 2021 Sep 21.

Ninth Department of Plastic Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 33, Badachu Road, Shijingshan District, Beijing, 100144, China.

The aim of the study was to explore the effect and mechanism of a low-level laser on hair follicle stem cells in full-thickness skin wound healing in mice. Full-thickness skin defects were generated by a 5-mm punch biopsy tool on the backs of depilated C57/BL6N mice, which were randomly divided thereafter into a low-dose laser treatment group (LLLT-Low), a high-dose laser treatment group (LLLT-High), and a control group (control). From the day of modeling to the day before the skin samples were taken, the wound area and wound edge of the mice in the LLLT-Low and LLLT-High groups were irradiated with a laser comb every 24 h, and the energy density was 1 J/cm and 10 J/cm, respectively. Read More

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September 2021

Features of the Population of Mouse Peritoneal Macrophages Isolated after Stimulation with Concanavalin A and Thioglycolate.

Bull Exp Biol Med 2021 Sep 21. Epub 2021 Sep 21.

National Research Center for Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia.

Murine peritoneal macrophages isolated from the lavage fluid after administration of thioglycolate and concanavalin A are presented by two populations of cells of different diameters. Polarization of macrophages into a proinflammatory (M1) phenotype is accompanied by an increase in number of small cells. Macrophages obtained after administration of thioglycolate demonstrate higher tendency to anti-inflammatory (M2) phenotype, while macrophages isolated after administration of concanavalin A are committed in the proinflammatory direction. Read More

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September 2021

Physiology and whole-plant carbon partitioning during stem sugar accumulation in sweet dwarf sorghum.

Planta 2021 Sep 21;254(4):80. Epub 2021 Sep 21.

Divisions of Plant and Biological Sciences, University of Missouri, Columbia, MO, 65211, USA.

Main Conclusion: A greater rate of phloem unloading and storage in the stem, not a higher rate of sugar production by photosynthesis or sugar export from leaves, is the main factor that results in sugar accumulation in sweet dwarf sorghum compared to grain sorghum. At maturity, the stem internodes of sweet sorghum varieties accumulate high concentrations of fermentable sugars and represent an efficient feedstock for bioethanol production. Although stem sugar accumulation is a heritable trait, additional factors that drive sugar accumulation in sorghum have not been identified. Read More

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September 2021

Variation in Diagnosis, Treatment, and Outcome of Esophageal Cancer in a Regionalized Care System in Ontario, Canada.

JAMA Netw Open 2021 Sep 1;4(9):e2126090. Epub 2021 Sep 1.

Ontario Health (Cancer Care Ontario), Toronto, Canada.

Importance: Esophageal cancer remains one of the most deadly cancers, ranking sixth highest among cancers leading to the greatest years of life lost.

Objective: To determine how patients with esophageal cancer are diagnosed and treated in Ontario's regionalized thoracic surgery centers.

Design, Setting, And Participants: This cohort study included patients diagnosed with esophageal cancer between January 1, 2010, and December 31, 2018, identified from the Ontario Cancer Registry, in a single-payer health care system with regionalization of thoracic surgery in the province of Ontario, Canada. Read More

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September 2021

Improving Low-Density Fat by Condensing Cellular and Collagen Content through a Mechanical Process: Basic Research and Clinical Applications.

Plast Reconstr Surg 2021 Sep 20. Epub 2021 Sep 20.

From the Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University.

Background: Large-volume fat grafting results in high absorption and complication rates. Low-density fat includes small numbers of viable cells and considerable oil, resulting in nodules and oil cysts. This study evaluated a strategy for large-volume fat grafting using a mechanical process to condense low-density fat and transplanting it with high-density fat. Read More

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September 2021

Remote Corticospinal Tract Degeneration After Cortical Stroke in Rats May Not Preclude Spontaneous Sensorimotor Recovery.

Neurorehabil Neural Repair 2021 Sep 21:15459683211041318. Epub 2021 Sep 21.

Biomedical MR Imaging and Spectroscopy Group, Center for Image Sciences, University Medical Center Utrecht and Utrecht University, Utrecht, The Netherlands.

Recovery of motor function after stroke appears to be related to the integrity of axonal connections in the corticospinal tract (CST) and corpus callosum, which may both be affected after cortical stroke. In the present study, we aimed to elucidate the relationship of changes in measures of the CST and transcallosal tract integrity, with the interhemispheric functional connectivity and sensorimotor performance after experimental cortical stroke. We conducted in vivo diffusion magnetic resonance imaging (MRI), resting-state functional MRI, and behavior testing in twenty-five male Sprague Dawley rats recovering from unilateral photothrombotic stroke in the sensorimotor cortex. Read More

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September 2021

Incidence, Predictor, and Clinical Outcomes of Multiple Resheathing With Self-Expanding Valves During Transcatheter Aortic Valve Replacement.

J Am Heart Assoc 2021 Sep 3;10(18):e020682. Epub 2021 Sep 3.

Instituto do Coração Hospital das Clinicas HCFMUSP Faculdade de MedicinaUniversidade de Sao Paulo Sao Paulo Brazil.

Background No study has evaluated the impact of the additional manipulation demanded by multiple resheathing (MR) in patients undergoing transcatheter aortic valve replacement with repositionable self-expanding valves. Methods and Results This study included a real-world, multicenter registry involving 16 centers from Canada, Germany, Latin America, and Spain. All consecutive patients who underwent transcatheter aortic valve replacement with the Evolut R, Evolut PRO, and Portico valves were included. Read More

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September 2021

Engineering T4 Bacteriophage for Display by Type V CRISPR-Cas Genome Editing.

ACS Synth Biol 2021 Sep 21. Epub 2021 Sep 21.

Key Laboratory of Development of Veterinary Diagnostic Products, Ministry of Agriculture, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.

Bacteriophage T4 has enormous potential for biomedical applications due to its large size, capsid architecture, and high payload capability for protein and DNA delivery. However, it is not very easy to genetically engineer its genome heavily modified by cytosine hydroxymethylation and glucosylation. The glucosyl hydroxymethyl cytosine (ghmC) genome of phage is completely resistant to most restriction endonucleases and exhibits various degrees of resistance to CRISPR-Cas systems. Read More

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September 2021