649,627 results match your criteria higher levels

Increased lipocalin 2 levels in adolescents with type 2 diabetes mellitus.

J Pediatr Endocrinol Metab 2021 Jun 14. Epub 2021 Jun 14.

Department of Pediatrics, Kansai Medical University, Hirakata, Osaka, Japan.

Objectives: Bone can act as an endocrine organ through the secretion of bone-specific hormones, i.e., osteokines. Read More

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Urinary bisphenol A in women with polycystic ovary syndrome - a possible suppressive effect on steroidogenesis?

Horm Mol Biol Clin Investig 2021 Jun 14. Epub 2021 Jun 14.

First Department of Internal Medicine, Medical Faculty, P.J. Šafárik University, Košice, Slovakia.

Objectives: There is a growing evidence indicating an impact of endocrine distrupting chemicals such as bisphenol A (BPA) on human reproduction. Its higher levels in serum or urine have been documented in women with polycystic ovary syndrome (PCOS), however the relationship to ovarian steroidogenesis remains unclear. of the study was to compare urinary BPA (U-BPA) concentrations among PCOS women and control group. Read More

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Characteristics and outcomes of cancer patients with covid-19 at a safety-net hospital.

Cancer Treat Res Commun 2021 Jun 10;28:100418. Epub 2021 Jun 10.

Department of Hematology and Oncology, Capital Health Regional Medical Center, Trenton, NJ, United States.

Patients with cancer are a vulnerable population during the COVID-19 pandemic due to underlying immunosuppression, pre-existing comorbidities, and poor nutrition. There is a lack of data describing the disease course of cancer patients with COVID-19 disease. Therefore, we analyzed data from cancer patients with COVID-19 who were admitted to our hospital. Read More

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Seasonal variation in oestrogenic potency and biological effects of wastewater treatment works effluents assessed using ERE-GFP transgenic zebrafish embryo-larvae.

Aquat Toxicol 2021 May 19;237:105864. Epub 2021 May 19.

Biosciences, College of Life and Environmental Sciences, University of Exeter, Exeter, United Kingdom. Electronic address:

Effluents from wastewater treatment works (WwTW) exhibit both temporal and spatial variation in oestrogenicity, however few studies have attempted to quantify how this variation affects biological responses in fish. Here we used an oestrogen-responsive green fluorescent protein (ERE-GFP) transgenic zebrafish (Danio rerio) to quantify oestrogenic activity and health effects for exposure to three different WwTW effluents. Endpoints measured included survival/hatching rate, GFP induction (measured in target tissues or gfp mRNA induction in whole embryos) and vtg mRNA induction in whole embryos. Read More

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Epidemiological feature, viral shedding, and antibody seroconversion among asymptomatic SARS-CoV-2 carriers and symptomatic/presymptomatic COVID-19 patients.

J Infect Public Health 2021 May 27;14(7):845-851. Epub 2021 May 27.

Department of Epidemiology, Second Military Medical University, Shanghai 200433, China. Electronic address:

Background: Novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is pandemic. However, data concerning the epidemiological features, viral shedding, and antibody dynamics between asymptomatic SARS-CoV-2 carriers and COVID-19 patients remain controversial.

Methods: We enrolled 193 SARS-CoV-2 infected subjects in Ningbo and Zhoushan, Zhejiang, China, from January 21 to March 6, 2020. Read More

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Development and validation of the Soweto Stress Scale: Mixed-methods, population-based study of adults living in Soweto, South Africa.

Soc Sci Med 2021 May 12;281:114023. Epub 2021 May 12.

SAMRC Developmental Pathways for Health Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Edmund A. Walsh School of Foreign Service, Georgetown University, Washington, DC, USA. Electronic address:

This article moves from ethnography to epidemiology to generate a locally specific assessment of stress and evaluates it correlates with general psychiatric morbidity. We conducted two related ethnographic studies of stress and distress in Soweto, South Africa (N=107). We then used these studies to develop the Soweto Stress Scale, piloted the scale, and then evaluated its use in an epidemiological surveillance study of stress and health (N=933). Read More

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A sensing network involving citizens for high spatio-temporal resolution monitoring of fugitive emissions from a petroleum pre-treatment plant.

Sci Total Environ 2021 May 29;791:148135. Epub 2021 May 29.

Biology Department, University of Bari, via Orabona, 4, 70126 Bari, Italy.

In this study an innovative sensing network consisting of eight photoionization detectors, meteorological sensors, a video camera and a telephonic system able to systematize the population complaints was developed for the monitoring of odor emissions. The development of monitoring approaches with high temporal and spatial resolution and actively involving citizens, is strategic in areas where relevant and also short-term emissive events frequently occur and the conventional approaches fail due to the high variability of fugitive emissions. Moreover, even if unpleasant odors are not necessarily direct triggers of health effects, they could be associated with the release of other harmful compounds. Read More

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Driving mechanisms of gross primary productivity geographical patterns for Qinghai-Tibet Plateau lake systems.

Sci Total Environ 2021 Jun 5;791:148286. Epub 2021 Jun 5.

Key Laboratory of Ecosystem Network Observation and Modeling, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China. Electronic address:

Being a fundamental property of aquatic systems, gross primary productivity (GPP) is affected by complex environmental factors, such as salinity, nutrients, pH, and sunlight. Under conditions of intensified anthropogenic activity and climate change, it is critical to understand the driving mechanisms of GPP in alpine lakes. In this study, we investigated GPP and associated environmental factors of 23 lake systems in the Qinghai-Tibet Plateau (QTP) along an altitudinal range (from 2500 m to 4500 m). Read More

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Cross-sectional associations of leisure and transport related physical activity with depression and anxiety.

J Psychiatr Res 2021 Jun 4;140:228-234. Epub 2021 Jun 4.

Departmento de Clínica Médica, Faculdade de Medicina da USP & Hospital Universitário, Universidade de São Paulo, São Paulo, Brazil; Laboratory of Neurosciences (LIM-27), Institute of Psychiatry, Hospital das Clínicas da Faculdade de Medicina da USP, Brazil.

Background: Previous evidence supports the notion that the physical activity (PA) domain (leisure-time or transport), and the amount of time spent in PA, influence the association of PA with depressive and anxiety symptoms. However, no study evaluated the associations of different volumes of leisure-time PA (LTPA) and transport PA (TPA) with prevalent depression, anxiety, and co-occurring depression and anxiety (D&A) disorders.

Aim: To investigate the associations between different volumes of LTPA and TPA with prevalent depression, anxiety, and D&A. Read More

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The physiological role of guanidinoacetic acid and its relationship with arginine in broiler chickens.

Poult Sci 2021 Apr 20;100(7):101203. Epub 2021 Apr 20.

Alzchem Trostberg GmbH, Dr.-Albert-Frank-Straße 32, 83308 Trostberg, Germany.

The role of guanidinoacetic acid (GAA) and its relationship with arginine was reviewed in order to define a replacement ratio between GAA and arginine for broiler diet formulation, the ratio being of how much arginine could be spared, or replaced by GAA. Guanidionoacetic acid, the precursor of creatine, can be synthesized de novo from the amino acids arginine and glycine, whereby 1 mol of arginine creates 1 mol of GAA; that is a weight:weight (w:w) ratio of 1.49:1 (arginine:GAA). Read More

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The effect of Raphanus sativus L. seeds on regulation of intestinal motility in rats consuming a high-calorie diet.

Biomed Pharmacother 2021 Jun 9;140:111705. Epub 2021 Jun 9.

School of Basic Medical Science, Beijing University of Chinese Medicine, Beijing, PR China. Electronic address:

Purpose: The purpose of this study was to explore the effects of a short-term high-calorie diet and the regulation mechanism of Raphanus sativus L. seeds (RSL seeds) on the intestinal motility of young rats.

Methods: We fed 20 Specific Pathogen Free (SPF) 4-week-old male Sprague-Dawley (SD) rats special high-calorie diet for 3 days and then randomized them to a high-calorie diet group (HCG, 10 rats) and an RSL seeds treatment group (TG, 10 rats). Read More

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Toxic mechanism on phenanthrene-induced cytotoxicity, oxidative stress and activity changes of superoxide dismutase and catalase in earthworm (Eisenia foetida): A combined molecular and cellular study.

J Hazard Mater 2021 Jun 9;418:126302. Epub 2021 Jun 9.

School of Environmental Science and Engineering, Shandong University, China-America CRC for Environment & Health, Shandong Province, 72# Jimo Binhai Road, Qingdao, Shandong 266237, PR China. Electronic address:

Phenanthrene (PHE) is an important organic compound, which is widespread in the soil environment and exhibits potential threats to soil organisms. Toxic effects of PHE to earthworms have been extensively studied, but toxic mechanisms on PHE-induced cytotoxicity and oxidative stress at the molecular and cellular levels have not been reported yet. Therefore, we explored the cytotoxicity and oxidative stress caused by PHE in earthworm coelomocytes and the interaction mechanism between PHE and the major antioxidant enzymes SOD/CAT. Read More

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Clonal osteoblastic cell lines with CRISPR/Cas9-mediated ablation of Pit1 or Pit2 show enhanced mineralization despite reduced osteogenic gene expression.

Bone 2021 Jun 9;151:116036. Epub 2021 Jun 9.

Department of Bone and Mineral Research, Research Institute, Osaka Women's and Children's Hospital, Osaka Prefectural Hospital Organization, Izumi, Osaka 594-1101, Japan. Electronic address:

Multiple actions of extracellular Pi on the skeletal cells are likely to be partly mediated by type III sodium/phosphate (Na/Pi) cotransporters Pit1 and Pit2, although the details are not fully understood. In the current study, to determine the roles of Pit1 and Pit2 in osteoblasts, we generated Pit1-knockout (KO) and Pit2-KO osteoblastic cells by applying CRISPR/Cas9 genome editing to an osteoblastic cell line MC3T3-E1 subclone 4. The extracellular Pi level was increased in the Pit1-KO and Pit2-KO clones due to the reduced Pi uptake. Read More

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Level of Maternal Respiratory Syncytial Virus (RSV) F Antibodies in Hospitalized Children and Correlates of Protection.

Int J Infect Dis 2021 Jun 9. Epub 2021 Jun 9.

Biomedical Research Center, Qatar University, Qatar; College of Health Sciences, Qatar University, Qatar. Electronic address:

Background: RSV is a major cause of lower respiratory infections among children, where no vaccine is available. The stabilized form of the fusion (F) protein, pre-F, is a leading vaccine candidate targeting different populations, including pregnant women. This study aimed to determine the magnitude and nature of RSV-directed maternal antibodies (matAbs) in hospitalized children with RSV infection. Read More

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The miRNA expression profile directly reflects the energy metabolic differences between slow and fast muscle with nutritional regulation of the Chinese perch (Siniperca chuatsi).

Comp Biochem Physiol A Mol Integr Physiol 2021 Jun 9:111003. Epub 2021 Jun 9.

Hunan Provincial Key Laboratory of Nutrition and Quality Control of Aquatic Animals, Department of Biological and Environmental Engineering, Changsha University, Changsha 410022, China. Electronic address:

Fish skeletal muscles are composed of two distinct types, slow and fast muscles, and they play important roles in maintaining the body's movement and energy metabolism. The two types of muscle are easy to separate, so they are often used as the model system for studies on their physiological and functional characteristics. In this study, we revealed that the carbohydrate and lipid metabolic KEGG pathways are different between slow and fast muscles of Chinese perch with transcriptome analysis. Read More

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Seroprevalence and SARS-CoV-2 cross-reactivity of endemic coronavirus OC43 and 229E antibodies in Finnish children and adults.

Clin Immunol 2021 Jun 9:108782. Epub 2021 Jun 9.

Vaccine Development and Immunology/Vaccine Research Center, Faculty of Medicine and Health Technology, Tampere University, Arvo Ylpön katu 34, FI-33520 Tampere, Finland. Electronic address:

Endemic human coronaviruses (hCoVs) are common causative agents of respiratory tract infections, affecting especially children. However, in the ongoing SARS-CoV-2 pandemic, children are the least affected age-group. The objective of this study was to investigate the magnitude of endemic hCoVs antibodies in Finnish children and adults, and pre-pandemic antibody cross-reactivity with SARS-CoV-2. Read More

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TikTok browsing for anxiety relief in the preoperative period: a randomized clinical trial.

Complement Ther Med 2021 Jun 9:102749. Epub 2021 Jun 9.

Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. Electronic address:

Objective: The purpose of this study was to determine the effect of browsing TikTok for 20 minutes on patients' preoperative anxiety.

Method: A randomized controlled trial was conducted at the Department of Anesthesiology of The First Affiliated Hospital, Zhejiang University School of Medicine from January 2021 to March 2021. The 80 patients were randomly divided into two groups. Read More

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Serum HMGB1 Associates with Liver Disease and Predicts Readmission and Mortality in Patients with Alcohol Use Disorder.

Alcohol 2021 Jun 9. Epub 2021 Jun 9.

MGH Alcohol Liver Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA; Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA, 02114, USA. Electronic address:

Identifying the minority of patients with Alcohol Use Disorder (AUD) who develop the wide spectrum of Alcohol-associated Liver Disease (ALD), and risk stratifying these patients, is of critical importance. High-Mobility Group Box 1 protein (HMGB1) is an alarmin that has been implicated in the pathogenesis of multiple liver diseases. Its use as a biomarker for liver disease in those with AUD has not been studied. Read More

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Essential and toxic elements in sustainable and underutilized seafood species and derived semi-industrial ready-to-eat products.

Food Chem Toxicol 2021 Jun 9:112331. Epub 2021 Jun 9.

Istituto Superiore di Sanità - National Institute of Health, Department of Food Safety, Nutrition and Veterinary Public Health, Viale Regina Elena 299, 00161 Rome, Italy. Electronic address:

Blue whiting (Micromesistius poutassou), pouting (Trisopterus luscus) and common dab (Limanda limanda) are underutilized fish species attractive in terms of sustainability. However, there is limited information about their nutritional characteristics as well as potential presence of environmental contaminants. Specimens caught in European waters were characterised for their content of essential and toxic elements. Read More

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Arsenic disrupts neuronal insulin signaling through increasing free PI3K-p85 and decreasing PI3K activity.

Toxicol Lett 2021 Jun 9. Epub 2021 Jun 9.

Laboratory of Pharmacology, Chulabhorn Research Institute, 54 Kamphaeng Phet 6 Rd, Bangkok, 10210, Thailand; Environmental Toxicology Program, Chulabhorn Graduate Institute, 54 Kamphaeng Phet 6 Rd, Bangkok, 10210, Thailand; Center of Excellence on Environmental Health and Toxicology (EHT), Ministry of Higher Education, Science, Research and Innovation, Thailand.

Previously, we reported that prolonged arsenic exposure impaired neuronal insulin signaling. Here we have further identified novel molecular mechanisms underlying neuronal insulin signaling impairment by arsenic. Arsenic treatment altered insulin dose-response curve and reduced maximum insulin response in differentiated human neuroblastoma SH-SY5Y cells, suggesting that arsenic hindered neuronal insulin signaling in a non-competitive like manner. Read More

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New Insight To The Rol Of Α-Enolase (Eno-1) As Immunological Marker In Rainbow Trout Fry.

Dev Comp Immunol 2021 Jun 9:104163. Epub 2021 Jun 9.

Grupo de Marcadores Inmunológicos, Laboratorio de Genética e Inmunología Molecular, Instituto de Biología, Pontificia Universidad Católica de Valparaíso, Avenida Universidad #330, 2373223, Valparaíso, Chile; Núcleo Biotecnológico de Curauma (NBC), Pontificia Universidad Católica de Valparaíso, Avenida Universidad #330, 2373223, Valparaíso, Chile. Electronic address:

α-Enolase is an enzyme of the glycolytic pathway that has also been involved in vertebrate inflammatory processes through its interaction with plasminogen. However, its participation in the immune response of lower vertebrates during early life development is unknown. Opportunistic pathogens in salmon farming are the principal cause of mortality in the fry stage. Read More

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Contraception 2021 Jun 9. Epub 2021 Jun 9.

Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Objective: To assess how women's reproductive history, contraceptive experience and need of abortion care are associated with priorities for contraception.

Study: Design In this cross-sectional survey study, we gathered information on women's history of births and abortions, previous use and satisfaction with contraceptive methods, and features of contraceptive methods they value most. Women were recruited at public family planning and outpatient abortion clinics in the capital region of Helsinki, Finland. Read More

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Nurse turnover: A longitudinal survival analysis of the Korea Nurses' Health Study.

J Adv Nurs 2021 Jun 12. Epub 2021 Jun 12.

College of Nursing, University of Illinois at Chicago, Chicago, IL, USA.

Aims: To identify factors influencing turnover among Korean female nurses from a longitudinal perspective.

Design: A national cohort study called the Korea Nurses' Health Study (2013-2020) was used.

Methods: A national sample of female nurses from module 1 (N = 20,613, 2013-2014), module 5 (N = 11,527, 2016-2017), module 7 (N = 8,658, 2018-2019) and module 8 (N = 10,253, 2019-2020) was used. Read More

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Investigating the inflammatory cascade effect of basophil activation in children with allergic rhinitis or asthma, via the IgE-FcεRI-NF-κB signaling pathway.

Yi Qiao Jie Chen

Adv Clin Exp Med 2021 Jun 11. Epub 2021 Jun 11.

Department of Otorhinolaryngology, National Children's Medical Center, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, China.

Background: Allergic rhinitis (AR) is a type I allergic reaction mediated by serum immunoglobulin E (IgE).

Objectives: This study aimed to investigate the basophil activation rate and serum expression of inflammatory factors in AR patients and rats. The involvement of the IgE-FcεRI-nuclear factor kappa B (NF-κB) signaling pathway in the pathogenesis of AR was also explored. Read More

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The association of triglyceride and glucose index, and triglyceride to high-density lipoprotein cholesterol ratio with prehypertension and hypertension in normoglycemic subjects: A large cross-sectional population study.

J Clin Hypertens (Greenwich) 2021 Jun 12. Epub 2021 Jun 12.

Tianjin Chest Hospital, Tianjin, China.

Insulin resistance (IR) plays an important role in the development of hypertension. Triglyceride and glucose index (TyG index), and triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-c) as effective IR surrogate indexes have been verified in numerous studies. Therefore, the authors conducted a large cross-sectional study to explore the association of TyG index and TG/HDL-c with prehypertension and hypertension in the same normoglycemic subjects from Tianjin, China. Read More

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Prognostic impacts of peripheral blood erythroblasts after single-unit cord blood transplantation.

Int J Lab Hematol 2021 Jun 12. Epub 2021 Jun 12.

Department of Hematology/Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

Introduction: The appearance of erythroblasts (EBLs) in peripheral blood occurs in a variety of serious conditions and has been associated with mortality in critically ill patients. However, the incidence, risk factor, and outcomes of EBLs after cord blood transplantation (CBT) remain unclear.

Methods: We have investigated the impact of EBLs on transplant outcomes on 225 adult patients who underwent single-unit CBT at our single institute. Read More

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Systemic Jak1 activation causes extrarenal calcitriol production and skeletal alterations provoking stunted growth.

FASEB J 2021 Jul;35(7):e21721

Institute of Physiology, University of Zurich, Zurich, Switzerland.

Mineral homeostasis is regulated by a complex network involving endocrine actions by calcitriol, parathyroid hormone (PTH), and FGF23 on several organs including kidney, intestine, and bone. Alterations of mineral homeostasis are found in chronic kidney disease and other systemic disorders. The interplay between the immune system and the skeletal system is not fully understood, but cytokines play a major role in modulating calcitriol production and function. Read More

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The effects of vitamin D supplementation on types of falls.

J Am Geriatr Soc 2021 Jun 12. Epub 2021 Jun 12.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Background/objectives: To assess whether vitamin D supplementation prevents specific fall subtypes and sequelae (e.g., fracture). Read More

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