2,180,879 results match your criteria higher eukaryotes

A unique AtSar1D-AtRabD2a nexus modulates autophagosome biogenesis in .

Proc Natl Acad Sci U S A 2021 Apr;118(17)

School of Life Sciences, Centre for Cell & Developmental Biology, State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China;

In eukaryotes, secretory proteins traffic from the endoplasmic reticulum (ER) to the Golgi apparatus via coat protein complex II (COPII) vesicles. Intriguingly, during nutrient starvation, the COPII machinery acts constructively as a membrane source for autophagosomes during autophagy to maintain cellular homeostasis by recycling intermediate metabolites. In higher plants, essential roles of autophagy have been implicated in plant development and stress responses. Read More

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Bacterial biosilicification: A new insight into the global silicon cycle.

Takeshi Ikeda

Biosci Biotechnol Biochem 2021 Apr 20. Epub 2021 Apr 20.

Unit of Biotechnology, Graduate School of Integrated Sciences for Life, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-8530, Japa.

Biosilicification is the process by which organisms incorporate soluble, monomeric silicic acid, Si(OH)4, in the form of polymerized insoluble silica, SiO2. Biosilicifying eukaryotes, including diatoms, siliceous sponges, and higher plants, have been the targets of intense research to study the molecular mechanisms underlying biosilicification. By contrast, prokaryotic biosilicification has been less well studied, partly because the biosilicifying capability of well-known bacteria was not recognized until recently. Read More

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Variations of radon and airborne particulate matter near three large phosphogypsum stacks in Florida.

Environ Monit Assess 2021 Apr 19;193(5):284. Epub 2021 Apr 19.

Jiann-Ping Hsu College of Public Health, Georgia Southern University, Statesboro, GA, USA.

Approximately 1 billion tons of phosphogypsum (PG), a by-product of the fertilizer industry, are currently stacked in Florida. PG emits radon gas, which is a risk factor for lung cancer and can also increase particulate matter (PM) associated non-cancer mortality in exposed individuals. We measured concentrations of atmospheric radon and particulate matter near PG stacks and their short-term variations at different distances to estimate exposures in nearby communities. Read More

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Job Satisfaction, Burnout, and Intention to Leave among Dental Hygienists in Clinical Practice.

J Dent Hyg 2021 Apr;95(2):28-35

Associate professor; all at the Forsyth School of Dental Hygiene, MCPHS University, Boston, MA, USA.

: There is limited research about the job satisfaction (JS), burnout (BO), and intention to leave (ITL) amongst dental hygienists in clinical practice providing patient care. The purpose of this study was to explore current trends and the factors influencing JS, BO, and ITL among dental hygienists in their current positions. A cross-sectional research study was conducted with a convenience sample of dental hygienists recruited via social media sites. Read More

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Impact of Oral Health Education on the Knowledge, Behaviors, Attitudes, and Self-Efficacy of Caregivers for Individuals with Intellectual and Developmental Disabilities.

J Dent Hyg 2021 Apr;95(2):21-27

Associate professor and Interim Dental Hygiene Program Dean, all at Forsyth School of Dental Hygiene, MCPHS University, Boston, MA, USA.

Individuals with intellectual and developmental disabilities (IDD) have a higher risk of oral disease and require assistance in performing oral self-care. The purpose of this study was to measure the impact of an oral health education program in improving caregivers' oral health knowledge, attitudes, behavior, and self-efficacy in providing oral health care to clients with IDD, residing in intermediate care facilities. A non-probability sample of new hire caregivers (n=47) for clients with IDD residing in an intermediate care facility was used for this quasi-experimental study. Read More

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The Effects of the Traditional Scaling Technique Versus a Modified Scaling Technique on Muscle Activity and Pinch Force Generation: A pilot study.

J Dent Hyg 2021 Apr;95(2):6-13

Department of Exercise and Sport Science at the University of North Carolina, Chapel Hill, NC, USA.

Dental hygienists perform precision instrumentation tasks repetitively throughout the workday, placing them at increased risk for developing a musculoskeletal disorder. The purpose of this pilot study was to determine differences in muscle activity and pinch force generation between the traditional scaling technique and a modified scaling technique. A convenience sample of dental hygienists (n=12) acted as their own controls in this counterbalance-designed pilot study. Read More

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Interferon Regulatory Factor 5 siRNA-Loaded Folate-Modified Cationic Liposomes for Acute Lung Injury Therapy.

J Biomed Nanotechnol 2021 Mar;17(3):466-476

Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is an overwhelming pulmonary inflammation with limited clinical treatment strategies. Interferon regulatory factor 5 (IRF5) is a crucial regulator of inflammation factors, which can be upregulated under an inflammatory state and related to the efferocytosis of macrophages. Herein, IRF5 was knockdown by small interfering RNA (siIRF5) to promote the anti-inflammatory effect of macrophages. Read More

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Anti-Human Epidermal Growth Factor Receptor 2 Single-Chain Fv Fragment-Decorated DM1 Nanoparticles for Specific Targeting of Human Epidermal Growth Factor Receptor 2-Positive Breast Tumor Cells.

Ling Ni You-Xin Li

J Biomed Nanotechnol 2021 Mar;17(3):447-455

Purpose: Although monoclonal antibodies are used to decorate nanoparticles to target specific cells, penetration of tumor tissues by monoclonal antibodies is limited by their large size. Therefore, we prepared DM1 nanoparticles decorated with the small anti-HER2 single-chain Fv fragment (scFvHER2) of trastuzumab (TMAB) for targeting to human epidermal growth factor receptor 2 (HER2) overexpressing in breast cancer effectively.

Methods: ScFvHER2 fragment was coupled with DM1 nanoparticles (NPs) via covalent thiol-maleimide linkages. Read More

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Outcomes of Calcium Hydroxide with Iodoform Pulpectomies in Primary Teeth.

J Dent Child (Chic) 2021 Jan;88(1):46-51

Dr. Moskovitz is a clinical associate professor, Department of Pediatric Dentistry, Hebrew University - Hadassah School of Dental Medicine, Jerusalem, Israel;, Email:

To assess retrospectively the success rate of calcium hydroxide with iodoform as a filling material in pulpectomies of primary molars with irreversible pulpitis or pulp necrosis, and to evaluate factors that affect outcomes.
This study consisted of records of 73 patients with primary molars treated with pulpectomy with high quality radiographs. Treatment was considered successful clinically if the tooth was not extracted and radiographs showed a decrease or no change in preexisting pathologic radiolucent defects. Read More

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January 2021

Developmental Enamel Defects and Dental Caries in the Primary Dentition of Preterm Children.

J Dent Child (Chic) 2021 Jan;88(1):40-45

Dr. Martins is an associate professor, Department of Pediatric Dentistry, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil;, Email:

To assess developmental enamel defects (DED) and dental caries of preterm (PT) and/or low birth weight (LBW) children compared to full term (FT) and/or normal birth weight (NBW) infants, and to evaluate the association of DED with socioeconomic factors, gestational health, and postnatal factors.
This study included 84 two- to five-year-old children. The PT/LBW group included 42 children who received medical care at a university hospital, while FT/ NBW group included 42 subjects. Read More

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January 2021

Predicting Negative Outcomes While Awaiting Dental Treatment Under General Anesthesia.

J Dent Child (Chic) 2021 Jan;88(1):3-10

Ms. Lin is a fourth-year dental student, Harvard School of Dental Medicine, Harvard University, Boston, Mass., USA.

To determine the wait time for dental treatment under general anesthesia (GA) and its impact on clinical outcomes in a pediatric population at federally qualified health centers in the United States.
Data were collected from 566 pediatric subjects who underwent dental rehabilitation under GA between July 1, 2013, and June 30, 2014. One-way analysis of variance and linear regression analyses were performed. Read More

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January 2021

[Effect of placental vascular distribution on residual anastomoses after fetoscopic laser surgery for twin to twin transfusion syndrome].

Zhonghua Fu Chan Ke Za Zhi 2021 Mar;56(3):171-177

Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China.

To investigate the effect of placental vascular distribution on residual anastomoses (RA) after fetoscopic laser occlusion of chorioangiopagous ressels (FLOC) for twin to twin transfusion syndrome (TTTS). A total of 57 cases of TTTS after laser surgery were retrospectively analyzed from April 2014 to April 2019 in Peking University Third Hospital. The patients were divided into RA group (24 cases) and non-RA group (33 cases) according to whether RA occurred in the placenta after laser surgery. Read More

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[Metabolic bone tissue markers dynamics as criteria for periodontal disease treatment efficiency].

Stomatologiia (Mosk) 2021 ;100(2):44-49

Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation, Nizhniy Novgorod, Russia.

The of the study was to investigate the evolution of the tissue metabolism parameters in the course of the treatment of aggressive periodontitis forms.

Materials And Methods: The paper presents the results of the treatment of 68 patients with chronic generalized periodontitis. The control group comprised 10 healthy individuals. Read More

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[Plasma Exosomes in Inherited Forms of Parkinson's Disease].

Mol Biol (Mosk) 2021 Mar-Apr;55(2):338-345

Konstantinov Petersburg Nuclear Physics Institute, National Research Center Kurchatov Institute, Gatchina, 188300 Russia.

Parkinson's disease (PD) is the second most common neurodegenerative disorder. Alpha-synuclein misfolding and aggregation resulting in neurototoxicity is a hallmark of PD. The prion properties of alpha-synuclein are still under discussion. Read More

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Marine endophytic fungal metabolites: A whole new world of pharmaceutical therapy exploration.

Heliyon 2021 Mar 8;7(3):e06362. Epub 2021 Mar 8.

Faculty of Medicine, Cairo University, Kasr Al Ainy, Cairo 11562, Egypt.

The growing threat arises due to diseases such as cancer and the infections around the world leading to a critical requirement for novel and constructive compounds with unique ways of action capable of combating these deadly diseases. At present, it is evident that endophytic fungi constitute an enormous as well as comparatively untapped source of great biodiversity that can be considered as a wellspring of effective novel natural products for medical, agricultural and industrial use. Marine endophytic fungi have been found in every marine plants (algae, seagrass, driftwood, mangrove plants), marine vertebrates (mainly, fish) or marine invertebrates (mainly, sponge and coral) inter- and intra-cellular without causing any palpable symptoms of illness. Read More

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Changes in the Community Structure of Under-Ice and Open-Water Microbiomes in Urban Lakes Exposed to Road Salts.

Front Microbiol 2021 31;12:660719. Epub 2021 Mar 31.

Département de Biologie and Institut de Biologie Intégrative et des Systèmes (IBIS), Université Laval, Quebec City, QC, Canada.

Salinization of freshwater is increasingly observed in regions where chloride de-icing salts are applied to the roads in winter, but little is known about the effects on microbial communities. In this study, we analyzed the planktonic microbiomes of four lakes that differed in degree of urbanization, eutrophication and salinization, from an oligotrophic reference lake with no surrounding roads, to a eutrophic, salinized lake receiving runoff from a highway. We tested the hypothesis that an influence of road salts would be superimposed on the effects of season and trophic status. Read More

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Classic Kaposi sarcoma in a patient of Miao ethnicity followed up for 7 years: a case report.

J Med Case Rep 2021 Apr 19;15(1):179. Epub 2021 Apr 19.

Department of Dermatology, The Affiliated Hospital, Guizhou Medical University, Beijing Road 4, Yunyan District, Guiyang, China.

Background: Classic Kaposi sarcoma (CKS) is a vascular sarcoma associated with human herpesvirus 8 (HHV-8), which is known to be more common in Mediterranean elderly men and is characterized by indolent clinical behavior. Xinjiang province in China is considered an endemic region for Kaposi's sarcoma-associated herpesvirus (KSHV), with higher incidence among adults of Kazak and Uyghur ethnicities. Cases of CKS are rarely reported in inland China. Read More

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Prognostic value of lymphovascular invasion in stage II colorectal cancer patients with an inadequate examination of lymph nodes.

World J Surg Oncol 2021 Apr 18;19(1):125. Epub 2021 Apr 18.

Department of General Surgery, The Third Affiliated Hospital of Soochow University and The First People's Hospital of Changzhou, 185 Juqian Street, Changzhou, 213000, Jiangsu, China.

Background: Lymphovascular invasion (LVI) is defined as the presence of cancer cells in lymphatics or blood vessels. This study aimed to evaluate the prognostic value of LVI in stage II colorectal cancer (CRC) patients with inadequate examination of lymph nodes (ELNs) and further combined LVI with the TNM staging system to determine the predictive efficacy for CRC prognosis. Adjuvant chemotherapy (ACT) was then evaluated for stage II CRC patients with LVI positivity (LVI+). Read More

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Vascular resection for locally advanced pancreatic ductal adenocarcinoma: analysis of long-term outcomes from a single-centre series.

World J Surg Oncol 2021 Apr 18;19(1):126. Epub 2021 Apr 18.

Unit of General Surgery 2, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Viale San Pietro 43, 07100, Sassari, Italy.

Background: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with poor prognosis. Radical surgery is the best option for cure and, nowadays, it is performed by many surgeons also in cases of vascular infiltration. Whether this aggressive approach to a locally advanced PDAC produces a survival benefit is under debate. Read More

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Worldwide research tendency and hotspots on hip fracture: a 20-year bibliometric analysis.

Arch Osteoporos 2021 04 17;16(1):73. Epub 2021 Apr 17.

Clinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin, 300070, China.

We analyzed the overall knowledge structure, development trends, and research hotspots of 7684 publications related to hip fracture through the bibliometric method. Our results indicate this area has received more and more attention from researchers. Prevention of complications will be the focus of future studies. Read More

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Development of a tailor-made surgical online learning platform, ensuring surgical education in times of the COVID19 pandemic.

BMC Surg 2021 Apr 17;21(1):196. Epub 2021 Apr 17.

Department for General, Visceral and Transplantation Surgery, University Hospital RWTH Aachen, Pauwelsstr. 30, 52074, Aachen, Germany.

Background: During the worldwide COVID-19 pandemic, the quality of surgical education experiences sudden major restrictions. Students' presence in the operating theater and on wards is reduced to a bare minimum and face-to-face teaching is diminished. Aim of this study was therefore to evaluate alternative but feasible educational concepts, such as an online-only-platform for undergraduates. Read More

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Comparison of clinical features on admission between coronavirus disease 2019 and influenza a among children: a retrospective study in China.

BMC Infect Dis 2021 Apr 17;21(1):365. Epub 2021 Apr 17.

Clinical Data Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510623, Guangdong, China.

Background: Coronavirus disease 2019 (COVID-19) share similar symptoms with influenza A (IA), but it is more worthwhile to understand the disparities of the two infections regarding their clinical characteristics on admission.

Methods: A total of 71 age-matched pediatric IA and COVID-19 patient pairs were formed and their clinical data on admission were compared.

Results: Fever, cough, nasal congestion and nausea/vomiting were the most common symptoms on admission for both infections but occurred less often in COVID-19. Read More

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The Demographic Analysis of the Probable COVID-19 Cases in Terms of RT-PCR Results and Age.

Clin Lab 2021 Apr;67(4)

Background: Despite global prevention and quarantine efforts, the incidence of COVID-19 disease continues to increase. As a possible cause, our aim was to investigate which parameters increase the sensitivity or protection against COVID-19 between RT-PCR positive and RT-PCR negative cases in patients admitted to the emergency department.

Methods: In the pandemic process, patients admitted to the hospital with suspicion of COVID-19 were evaluated retrospectively. Read More

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[Phosphorus MR spectroscopy and 18F-FDG PET/CT in the study of energy metabolism of glial tumors].

Zh Vopr Neirokhir Im N N Burdenko 2021 ;85(2):26-33

Burdenko Neurosurgical Center, Moscow, Russia.

Objective: To study energy metabolism in glial tumors using dynamic MR spectroscopy and F-FDG PET/CT.

Material And Methods: The study included 19 patients (9 women and 10 men) with newly diagnosed supratentorial glial tumors WHO Grade I-IV (diffuse astrocytoma - 4 cases, oligodendroglioma - 4 cases, anaplastic astrocytoma - 5 cases, glioblastoma - 6 cases). All patients underwent examination and surgical treatment at the Burdenko Neurosurgery Center. Read More

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Development and validation of a simple-to-use nomogram to predict the deterioration and survival of patients with COVID-19.

BMC Infect Dis 2021 Apr 16;21(1):356. Epub 2021 Apr 16.

Department of Neurosurgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, China.

Background: COVID-19 pandemic has forced physicians to quickly determine the patient's condition and choose treatment strategies. This study aimed to build and validate a simple tool that can quickly predict the deterioration and survival of COVID-19 patients.

Methods: A total of 351 COVID-19 patients admitted to the Third People's Hospital of Yichang between 9 January to 25 March 2020 were retrospectively analyzed. Read More

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The nucleolus as a polarized coaxial cable in which the rDNA axis is surrounded by dynamic subunit-specific phases.

Curr Biol 2021 Apr 8. Epub 2021 Apr 8.

Department of Biological Sciences, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA.

In ribosomal DNA (rDNA) repeats, sequences encoding small-subunit (SSU) rRNA precede those encoding large-subunit (LSU) rRNAs. Processing the composite transcript and subunit assembly requires >100 subunit-specific nucleolar assembly factors (AFs). To investigate the functional organization of the nucleolus, we localized AFs in S. Read More

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A comparison of the release of phosphorus by a phytase enzyme in pigs fed diets deficient or adequate in phosphorus content.

J Anim Sci 2021 Apr;99(4)

Department of Animal Science, Iowa State University, Ames, IA 50011-1178.

Previous research indicated that phytase may release less phosphorus (P) from phytate when it is evaluated using diets with P levels above requirement as compared with diets below requirement. The objectives of this experiment were to further test the hypothesis that the P release values determined for phytase are higher when pigs are fed diets that are deficient (DE) in P compared with when they are fed diets that are adequate (AD) in P, and that phytase will increase the digestibility of dry matter (DM), gross energy (GE), nitrogen (N), and calcium (Ca) independent of dietary P status. Twenty-four barrows (body weight: 23. Read More

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Protective Effects of Intravenous Magnesium Sulfate in Stroke Patients Receiving Amiodarone: A Randomized Controlled Trial.

Adv Exp Med Biol 2021 ;1308:579-588

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Anti-arrhythmic agents, like amiodarone, interfere at different stages of the ischemic stroke. However, amiodarone was accompanied with immunological pulmonary complications and adverse neurological effects. We hypothesize that magnesium sulfate in combination with amiodarone holds promise for stroke treatment. Read More

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The Effect of Curcumin Phytosome on the Treatment of Patients with Non-alcoholic Fatty Liver Disease: A Double-Blind, Randomized, Placebo-Controlled Trial.

Adv Exp Med Biol 2021 ;1308:25-35

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Non-alcoholic fatty liver disease (NAFLD) is a global health problem with increasing prevalence among overweight and obese patients. It is strongly associated with conditions of insulin resistance including type 2 diabetes mellitus (T2DM) and obesity. It has detrimental consequences ranged from simple steatosis to irreversible hepatic fibrosis and cirrhosis. Read More

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[Effect of 5-hydroxypyrimidine derivatives on tumor growth and cytokine concentration in blood serum of female CBA mice with cervical cancer (RSHM-5)].

Biomed Khim 2021 Mar;67(2):158-161

Zakusov Institute of Pharmacology, Moscow, Russia.

The effects of intraperitoneal administration of SNK-411 (2-isobutyl-4,6-dimethyl-5-hydroxypyrimidine) in a dose of 25 mg/kg (the total dose of 350 mg/kg) and SNK-578 (hydrochloride of 2-isobutyl-4,6-dimethyl-5- hydroxypyrimidine) in a dose of 10 mg/kg (the total dose of 140 mg/kg) on tumor growth and concentration of cytokines in the blood serum were studied in female CBA mice. Substances were administrated from the 2nd to 15th days of tumor development. Tumor growth inhibition (TGI) and serum cytokine level were studied on the 7th day after the end of compounds administration (21st day of tumor growth). Read More

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