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Within-Person Associations of Self-Reports of Memory Impairment and Depressive Symptoms in Older Adults: Moderation of Relationships Over Time by Personality.

J Gerontol B Psychol Sci Soc Sci 2021 May 7. Epub 2021 May 7.

College of Nursing, The Pennsylvania State University, University Park, PA.

Objectives: The current study examined within-person associations of self-reports of impaired current memory functioning and perceived decline with depressive symptoms in older adults without cognitive impairment, and whether these associations were moderated by individuals' levels of neuroticism, conscientiousness, and extraversion.

Methods: Samples were drawn from the Einstein Aging Study (EAS), Rush Memory and Aging Project (MAP), Minority Aging Research Study (MARS), Health and Retirement Study (HRS), and National Health and Aging Trends Study (NHATS), with over 8,000 participants (65+ years) included across datasets. In a series of coordinated analyses, multilevel linear models tested within-person relationships over periods of up to 22 years. Read More

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Type 2 diabetes is causally associated with reduced serum osteocalcin: A genome-wide association and Mendelian randomization study.

J Bone Miner Res 2021 May 6. Epub 2021 May 6.

Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China.

Recent advances indicate that bone and energy metabolism are closely related. However, little direct evidence on causality has been provided in humans. We aimed to assess the association of three bone-related biomarkers 25 hydroxyvitamin D (25OHD), parathyroid hormone (PTH) and osteocalcin (OCN) with several metabolic phenotypes, and investigate any causal relevance to the associations using a Mendelian randomization (MR) study. Read More

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Elastic AlignedSENSE for Dynamic MR Reconstruction: A Proof of Concept in Cardiac Cine.

Entropy (Basel) 2021 Apr 29;23(5). Epub 2021 Apr 29.

Laboratorio de Procesado de Imagen, E.T.S.I. Telecomunicación, Universidad de Valladolid, Paseo Belén 15, 47011 Valladolid, Spain.

Numerous methods in the extensive literature on magnetic resonance imaging (MRI) reconstruction exploit temporal redundancy to accelerate cardiac cine. Some of them include motion compensation, which involves high computational costs and long runtimes. In this work, we proposed a method-elastic alignedSENSE (EAS)-for the direct reconstruction of a motion-free image plus a set of nonrigid deformations to reconstruct a 2D cardiac sequence. Read More

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Detection of the First Epoxyalcohol Synthase/Allene Oxide Synthase (CYP74 Clan) in the Lancelet (, Chordata).

Int J Mol Sci 2021 Apr 29;22(9). Epub 2021 Apr 29.

Kazan Institute of Biochemistry and Biophysics, FRC Kazan Scientific Center of RAS, P.O. Box 30, 420111 Kazan, Russia.

The CYP74 clan cytochromes (P450) are key enzymes of oxidative metabolism of polyunsaturated fatty acids in plants, some Proteobacteria, brown and green algae, and Metazoa. The CYP74 enzymes, including the allene oxide synthases (AOSs), hydroperoxide lyases, divinyl ether synthases, and epoxyalcohol synthases (EASs) transform the fatty acid hydroperoxides to bioactive oxylipins. A novel CYP74 clan enzyme CYP440A18 of the Asian (Belcher's) lancelet (, Chordata) was biochemically characterized in the present work. Read More

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Inhibitors of Protein Convertase Subtilisin/Kexin 9 (PCSK9) and Acute Coronary Syndrome (ACS): The State-of-the-Art.

J Clin Med 2021 Apr 5;10(7). Epub 2021 Apr 5.

Department of Translational Medical Sciences, "Federico II" University of Naples, Via S. Pansini 5, 80131 Naples, Italy.

Acute Coronary Syndrome (ACS) remains one of the most frequent causes of morbidity and mortality in the world. Although the age- and gender-adjusted incidence of ACS is decreasing, the mortality associated with this condition remains high, especially 1-year after the acute event. Several studies demonstrated that PCSK9 inhibitors therapy determine a significant reduction of major adverse cardiovascular events (MACE) in post-ACS patients, through a process of plaque modification, by intervening in lipid metabolism and platelet aggregation and finally determining an improvement in endothelial function. Read More

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Novel 2D allotropic forms and nanoflakes of silicon, phosphorus, and germanium: a computational study.

J Mol Model 2021 Apr 28;27(5):142. Epub 2021 Apr 28.

Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México, Apartado Postal 70-360, CU, Coyoacán, 04510, Mexico, DF, Mexico.

The structural variability offered by 2D materials is an essential feature in materials design. Despite its significance, obtaining assemblies with suitable stability remains a challenge. In this work, we theoretically explore novel silicon, phosphorus, and germanium, analogues of haeckelites at hybrid DFT level. Read More

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Genetic analysis of 32 InDels in four ethnic minorities from Chinese Xinjiang.

PLoS One 2021 22;16(4):e0250206. Epub 2021 Apr 22.

Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.

The present study used the previously constructed 32-plex InDels panel to investigated the genetic diversity of four ethnic minorities (Hui, Mongol, Uygur and Kazakh) from Xinjiang, and analyzed the genetic relationships between the four populations and 27 reference populations. No significant deviations were observed from the Hardy-Weinberg equilibrium (HWE) at the 32 InDels for each population. The average observed heterozygosity (Hexp), average polymorphic information content (PIC), combined power of discrimination (CPD) and cumulative probability of exclusion (CPE) for the 32 InDels were all higher than the Qiagen Investigator DIPplex kit in the four populations from Xinjiang. Read More

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Cushing's Syndrome With Nocardiosis: A Case Report and a Systematic Review of the Literature.

Front Endocrinol (Lausanne) 2021 29;12:640998. Epub 2021 Mar 29.

Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China.

Objective: To analyze and summarize the clinical characteristics, treatments, and prognosis of Cushing's syndrome (CS) with nocardiosis.

Methods: A patient in our hospital and additional 17 patients of CS with nocardiosis in the English literature were included in this study. Clinical characteristics, laboratory data, imaging studies, treatments, and prognosis were evaluated. Read More

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Prospective multicenter study on the incidence of surgical site infection after emergency abdominal surgery in China.

Sci Rep 2021 Apr 8;11(1):7794. Epub 2021 Apr 8.

Department of Emergency Medicine, The Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, 266000, People's Republic of China.

There is still a lack of relevant studies on surgical site infection (SSI) after emergency abdominal surgery (EAS) in China. This study aims to understand the incidence of SSI after EAS in China and discuss its risk factors. All adult patients who underwent EAS in 47 hospitals in China from May 1 to 31, 2018, and from May 1 to June 7, 2019, were enrolled in this study. Read More

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The potential of microbes and sulfate in reducing arsenic phytoaccumulation by maize (Zea mays L.) plants.

Environ Geochem Health 2021 Apr 2. Epub 2021 Apr 2.

State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang, 550081, China.

Arsenic (As) contamination in soil-plant system is an important environmental, agricultural and health issue globally. The microbe- and sulfate-mediated As cycling in soil-plant system may depend on soil sulfate levels, and it can be used as a potential strategy to reduce plant As uptake and improve plant growth. Here, we investigated the role of soil microbes (SMs) to examine As phytoaccumulation using maize as a test plant, under varying sulfate levels (S-0, S-5, S-25 mmol kg) and As stress. Read More

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Higher cardiac vagal activity predicts lower peripheral resistance 6 years later in European but not African Americans.

Am J Physiol Heart Circ Physiol 2021 May 26;320(5):H2058-H2065. Epub 2021 Mar 26.

Department of Medicine, Georgia Prevention Institute, Medical College of Georgia, Augusta University, Augusta, Georgia.

African American (AA) individuals are at a greater risk for the development of cardiovascular complications, such as hypertension, compared with European Americans (EAs). Higher vagally mediated heart rate variability (HRV) is typically associated with lower blood pressure (BP) and total peripheral resistance (TPR). However, research has yet to examine the differential impact of HRV on longitudinal hemodynamic activity between AAs and EAs. Read More

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Population genetic variation of gene, associated with neurophysiological development.

J Genet 2021 ;100

Department of Anatomy, Melaka Manipal Medical College, Manipal Campus, Manipal Academy of Higher Education, Manipal 576 104, India.

The serotonin transporter 5-HTT is encoded by a single gene . Polymorphisms in has been associated with a wide variety of neurological and psychiatric disorders including increased risk of posttraumatic stress disorder, higher likelihood for depression, obsessive-compulsive disorder (OCD), increased hostility and criminal behaviour. Genes associated with complex diseases often exhibit strong signatures of purifying selection compared to others. Read More

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January 2021

Incorporating European GWAS findings improve polygenic risk prediction accuracy of breast cancer among East Asians.

Genet Epidemiol 2021 Mar 19. Epub 2021 Mar 19.

Department of Molecular Physiology & Biophysics, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, Tennessee, USA.

Previous genome-wide association studies (GWASs) have been largely focused on European (EUR) populations. However, polygenic risk scores (PRSs) derived from EUR have been shown to perform worse in non-EURs compared with EURs. In this study, we aim to improve PRS prediction in East Asians (EASs). Read More

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Adherence to diagnosis followed by selective treatment of schistosomiasis mansoni and related knowledge among schoolchildren in an endemic area of Minas Gerais, Brazil, prior to and after the implementation of educational actions.

Parasite Epidemiol Control 2021 May 2;13:e00208. Epub 2021 Mar 2.

Environmental and Health Education Laboratory, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil.

Introduction: Brazilian guidelines for schistosomiasis elimination recommend regular search of infection carriers and their timely treatment. This study evaluates the effect of educational actions (EAs) among schoolchildren on adherence to diagnosis and treatment, as well as on knowledge of the disease.

Methods: In April/2013, a questionnaire was applied to 6th-to-8th-grade pupils of eight public schools to evaluate prior knowledge of disease and self-reported risk behavior. Read More

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Radiological and Audiological Outcomes of the LISTENT LCI-20PI Cochlear Implant Device.

Otol Neurotol 2021 04;42(4):524-531

Department of Otolaryngology Head and Neck Surgery, Sino-French Joint Clinic Research Center on Otology and Neuro-Otology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University.

Objective: To study the surgical results, intracochlear position of the electrode array (EA) and auditory performance of the LISTENT LCI-20PI cochlear implant device, and daily use status at 3 years.

Study Design: A retrospective study.

Setting: A single-tertiary referral center. Read More

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Experience of Ectopic Adrenocorticotropin Syndrome: 88 Cases With Identified Causes.

Endocr Pract 2021 Mar 9. Epub 2021 Mar 9.

Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

Objective: Ectopic adrenocorticotropic hormone syndrome (EAS) is a rare cause of Cushing's syndrome and diagnosis and management remain challenging. The aim of this study was to present the clinical spectrum of a group of EAS cases in a single center to explore better management strategies.

Methods: A retrospective study was conducted to identify 88 confirmed EAS cases at our hospital from 1984 to 2019. Read More

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Steering clear: Traffic violations among emerging adults who engage in habitual or casual cannabis use.

Accid Anal Prev 2021 Apr 1;153:106059. Epub 2021 Mar 1.

School of Public Health and Health Systems, University of Waterloo, Waterloo, Canada. Electronic address:

While some research has shown that cannabis use can impair driving ability, evidence to the degree and impact of impairment are lacking. This study examined the association between habitual or casual cannabis use and past-year traffic violations among emerging adults (EAs). Data come from the 2012 Canadian Community Health Survey-Mental Health. Read More

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The prevalence of psychological distress during pregnancy in Miyagi Prefecture for 3 years after the Great Eas t Japan Earthquake.

Environ Health Prev Med 2021 Feb 26;26(1):27. Epub 2021 Feb 26.

Environment and Genome Research Center, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8573, Japan.

Background: To examine changes in psychological distress prevalence among pregnant women in Miyagi Prefecture, which was directly affected by the Great East Japan Earthquake and tsunami, and compare it with the other, less damaged areas of Japan.

Methods: This study was conducted in conjunction with the Japan Environment and Children`s Study. We examined 76,152 pregnant women including 8270 in Miyagi Regional Center and 67,882 in 13 other regional centers from the all-birth fixed data of the Japan Environment and Children's Study. Read More

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February 2021

Atopic skin diathesis rather than atopic dermatitis is associated with specific contact allergies.

J Dtsch Dermatol Ges 2021 02;19(2):231-240

Department of Dermatology, Venereology and Allergology, University Medical Centre Göttingen, Germany.

Background: The association of atopic dermatitis (AD) and allergic contact dermatitis has been a matter of considerable uncertainty. Study results range from lack of any association to increased sensitization for multiple allergens, but fail to identify consistent allergen associations.

Objective: We studied a large patch test cohort of patients stratified by their atopic skin diathesis using the Erlangen Atopy Score (EAS), independent of active skin disease. Read More

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February 2021

Evaluation of three microhaplotypes in individual identification and ancestry inference.

Forensic Sci Int 2021 Mar 10;320:110681. Epub 2021 Jan 10.

Central Laboratory, Affiliated Haikou Hospital of Xiangya Medical College, Central South University, Haikou, Hainan, 570208, China. Electronic address:

Microhaplotype as an emerging genetic marker has attracted more attention in forensic field. The purpose of this study was to evaluate the potential of microhaplotypes in individual identification and ancestry inference in Chinese Hainan Li and 26 1000 G populations. Three microhaplotypes were genotyped from 100 Li individuals using Agena MassARRAY. Read More

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Efficient Protocol for Improving the Development of Cryopreserved Embryonic Axes of Chestnut ( Mill.) by Encapsulation-Vitrification.

Plants (Basel) 2021 Jan 25;10(2). Epub 2021 Jan 25.

Institute of BioEconomy, National Research Council (CNR/IBE), Sesto Fiorentino, 50019 Florence, Italy.

An optimized cryopreservation protocol for embryonic axes (EAs) of chestnut ( Mill.) has been developed based on the encapsulation-vitrification procedure. EAs of mature seeds were aseptically dissected and encapsulated in alginate beads with or without 0. Read More

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January 2021

Self-Esteem, Self-Monitoring, and Temperamental Traits in Action: Who Is Involved in Humanitarian, Political, and Religious Non-profit Organizations?

Front Psychol 2020 8;11:573689. Epub 2021 Jan 8.

Institute of Psychology, University of Wrocław, Wrocław, Poland.

Self-esteem, self-monitoring, and temperamental traits are important factors that influence human behavior. The purpose of the present study was to compare groups involved in humanitarian ( = 61), political ( = 68), and religious ( = 54) activities in terms of intergroup differences in self-esteem, self-monitoring, and temperamental traits. There are two research questions that we sought to address: "What are the relationships between self-esteem, self-monitoring, and temperamental traits among those involved in social, religious, and humanitarian aid activities?" and "Do temperamental traits affect self-esteem and self-monitoring among volunteers?" The study was conducted in Poland among adults aged 18 years and older, during meetings of six selected non-profit organizations, consisting of two organizations each in the humanitarian, political, and religious areas. Read More

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January 2021

Association of Epileptiform Abnormality on Electroencephalography with Development of Epilepsy After Acute Brain Injury.

Neurocrit Care 2021 Jan 20. Epub 2021 Jan 20.

Department of Neurology, Emory University School of Medicine and Grady Memorial Hospital, Atlanta, GA, USA.

Background/objectives: Epileptiform abnormalities (EA) on continuous electroencephalography (cEEG) are associated with increased risk of acute seizures; however, data on their association with development of long-term epilepsy are limited. We aimed to investigate the association of EA in patients with acute brain injury (ABI): ischemic or hemorrhagic stroke, traumatic brain injury, encephalitis, or posterior reversible encephalopathy syndrome, and subsequent development of epilepsy.

Methods: This was a retrospective, single-center study of patients with ABI who had at least 6 hours of cEEG during the index admission between 1/1/2017 and 12/31/2018 and at least 12 months of follow-up. Read More

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January 2021

Reaching LDL-C Targets in Patients with Moderate, High, and Very High Risk for Cardiovascular Disease After Bariatric Surgery According to Different Guidelines.

Obes Surg 2021 May 19;31(5):2087-2096. Epub 2021 Jan 19.

Clinic for Nutrition and Obesity, ABC Medical Center, 116, Sur 136, Las Américas, Álvaro Obregón, 01120, Mexico City, Mexico.

Background: Cardiovascular disease (CVD) is highly prevalent in obese patients and is the leading cause of death. High levels of plasma low-density lipoprotein cholesterol (LDL-C) are associated with higher coronary artery disease (CAD) risk. The aim of the study was to assess the impact of the Roux-en-Y gastric bypass on the achievement of the currently proposed cardiovascular prevention goals after 1 year. Read More

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Formulation and Optimization of Nanospanlastics for Improving the Bioavailability of Green Tea Epigallocatechin Gallate.

Pharmaceuticals (Basel) 2021 Jan 15;14(1). Epub 2021 Jan 15.

Department of Pharmaceutical Technology, Faculty of Pharmacy, Horus University, New Damietta 34518, Egypt.

The present study aimed to investigate the potential of nanospanlastics for boosting the bioavailability of epigallocatechin gallate‎ (EGCG). EGCG has valuable effects like anti-inflammation, anti-oxidation, and anti-tumorigenesis. Unfortunately, it has a low oral bioavailability due to its limited permeation and poor stability. Read More

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January 2021

[Management of dyslipidaemias: The New 2019 ESC/EAS-Guideline].

Dtsch Med Wochenschr 2021 01 19;146(2):75-84. Epub 2021 Jan 19.

The updated guidelines for the management of dyslipidaemias 2019 sticks to the concept of individual risk-based intervention strategies, but intensifies LDL-C goals. Next to the established SCORE system non-invasive imaging techniques such as coronary CT or ultrasound of carotid or femoral arteries are now recommended for improved risk stratification. Screening for lipoprotein(a) identifies persons at higher cardiovascular risk. Read More

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January 2021

Predictive and Incremental Validity of Parental Representations During Pregnancy on Child Attachment.

Front Public Health 2020 2;8:439449. Epub 2020 Dec 2.

Department of Dynamic and Clinical Psychology, "Sapienza" University of Rome, Rome, Italy.

Parental pre-natal representations predict the interactive patterns that parents will put in place after childbirth. Early interactions defined by high parental emotional availability (EA) influence the development of security in children. To date, research on the predictive role of parental pre-natal representations on child attachment is still poor. Read More

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December 2020

Diabetes and liver cancer risk: A stronger effect in Whites than Blacks?

J Diabetes Complications 2021 Mar 1;35(3):107816. Epub 2020 Dec 1.

Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, United States of America.

Background: Both diabetes and liver cancer are overrepresented among African Americans, but limited information is available on the interrelationship of these two diseases among African Americans. We examined the association of diabetes with the incidence of liver cancer and whether this varied by participant self-reported race/ethnicity.

Methods: Using the Southern Community Cohort Study, we conducted a cancer follow up (2002-2016) of a cohort of mostly low-income participants aged 40-79 with diabetes (n = 15,879) and without diabetes (n = 59,077) at study baseline. Read More

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Exceptional nexus with a hybrid topological invariant.

Science 2020 11;370(6520):1077-1080

Department of Physics, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China.

Branch-point singularities known as exceptional points (EPs), which carry a nonzero topological charge, can emerge in non-Hermitian systems. We demonstrate with both theory and acoustic experiments an "exceptional nexus" (EX), which is not only a higher-order EP but also the cusp singularity of multiple exceptional arcs (EAs). Because the parameter space is segmented by the EAs, the EX possesses a hybrid topological invariant (HTI), which consists of distinct winding numbers associated with Berry phases accumulated by cyclic paths on different complex planes. Read More

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November 2020