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Increased lipocalin 2 levels in adolescents with type 2 diabetes mellitus.

J Pediatr Endocrinol Metab 2021 Jun 14. Epub 2021 Jun 14.

Department of Pediatrics, Kansai Medical University, Hirakata, Osaka, Japan.

Objectives: Bone can act as an endocrine organ through the secretion of bone-specific hormones, i.e., osteokines. Read More

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Urinary bisphenol A in women with polycystic ovary syndrome - a possible suppressive effect on steroidogenesis?

Horm Mol Biol Clin Investig 2021 Jun 14. Epub 2021 Jun 14.

First Department of Internal Medicine, Medical Faculty, P.J. Šafárik University, Košice, Slovakia.

Objectives: There is a growing evidence indicating an impact of endocrine distrupting chemicals such as bisphenol A (BPA) on human reproduction. Its higher levels in serum or urine have been documented in women with polycystic ovary syndrome (PCOS), however the relationship to ovarian steroidogenesis remains unclear. of the study was to compare urinary BPA (U-BPA) concentrations among PCOS women and control group. Read More

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Melatonin protects against focal cerebral ischemia-reperfusion injury in diabetic mice by ameliorating mitochondrial impairments: involvement of the Akt-SIRT3-SOD2 signaling pathway.

Aging (Albany NY) 2021 Jun 11;13. Epub 2021 Jun 11.

Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China.

Diabetic patients are more vulnerable to cerebral ischemia-reperfusion (CIR) injury and have a worse prognosis and higher mortality after ischemic stroke than non-diabetic counterparts. Melatonin can exert neuroprotective effects against CIR injury in nondiabetic animal models. However, its effects on diabetic CIR injury and the underlying mechanisms remain unclarified. Read More

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Characteristics and outcomes of cancer patients with covid-19 at a safety-net hospital.

Cancer Treat Res Commun 2021 Jun 10;28:100418. Epub 2021 Jun 10.

Department of Hematology and Oncology, Capital Health Regional Medical Center, Trenton, NJ, United States.

Patients with cancer are a vulnerable population during the COVID-19 pandemic due to underlying immunosuppression, pre-existing comorbidities, and poor nutrition. There is a lack of data describing the disease course of cancer patients with COVID-19 disease. Therefore, we analyzed data from cancer patients with COVID-19 who were admitted to our hospital. Read More

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Transient neural network dynamics in cognitive ageing.

Neurobiol Aging 2021 May 14;105:217-228. Epub 2021 May 14.

MRC Cognition & Brain Sciences Unit, University of Cambridge, Cambridge, UK; Department of Psychiatry, University of Cambridge, Cambridge, UK.

It is important to maintain cognitive function in old age, yet the neural substrates that support successful cognitive ageing remain unclear. One factor that might be crucial, but has been overlooked due to limitations of previous data and methods, is the ability of brain networks to flexibly reorganize and coordinate over a millisecond time-scale. Magnetoencephalography (MEG) provides such temporal resolution, and can be combined with Hidden Markov Models (HMMs) to characterise transient neural states. Read More

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Seasonal variation in oestrogenic potency and biological effects of wastewater treatment works effluents assessed using ERE-GFP transgenic zebrafish embryo-larvae.

Aquat Toxicol 2021 May 19;237:105864. Epub 2021 May 19.

Biosciences, College of Life and Environmental Sciences, University of Exeter, Exeter, United Kingdom. Electronic address:

Effluents from wastewater treatment works (WwTW) exhibit both temporal and spatial variation in oestrogenicity, however few studies have attempted to quantify how this variation affects biological responses in fish. Here we used an oestrogen-responsive green fluorescent protein (ERE-GFP) transgenic zebrafish (Danio rerio) to quantify oestrogenic activity and health effects for exposure to three different WwTW effluents. Endpoints measured included survival/hatching rate, GFP induction (measured in target tissues or gfp mRNA induction in whole embryos) and vtg mRNA induction in whole embryos. Read More

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Meliponinae and Apis mellifera honey in southern Brazil: Physicochemical characterization and determination of pesticides.

Food Chem 2021 May 24;363:130175. Epub 2021 May 24.

Post-graduate Program in Food Engineering and Science, Escola de Química e Alimentos, Laboratório de Análise de Compostos Orgânicos e Metais (LACOM), Universidade Federal do Rio Grande, Av Itália, km 8, Rio Grande, Rio Grande do Sul State 96201-900, Brazil. Electronic address:

This study evaluated the physicochemical parameters and the occurrence of pesticides in multi-flower honey produced by six species of Meliponinae and Apis mellifera and collected in different seasons, floral species and sites in southern Brazil. Meliponinae honey were found to exhibit higher moisture, free acidity and sucrose concentration and lower concentration of reducing sugars than the standard of Apis mellifera honey in Brazil. Regarding Apis mellifera honey, reducing sugars and sucrose did not comply with the legislation. Read More

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Hormonal stress responses of growth hormone and insulin-like growth factor-I in highly resistance trained women and men.

Growth Horm IGF Res 2021 Jun 6;59:101407. Epub 2021 Jun 6.

Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, USA.

The purpose of this study was to examine the responses of growth hormone (GH) and insulin-like growth factor-I (IGFI) to intense heavy resistance exercise in highly trained men and women to determine what sex-dependent responses may exist. Subjects were highly resistance trained men (N = 8, Mean ± SD; age, yrs., 21 ± 1, height, cm, 175. Read More

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Emerging biomarkers of delayed graft function in kidney transplantation.

Transplant Rev (Orlando) 2021 May 26;35(4):100629. Epub 2021 May 26.

Nephrology, Dialysis and Transplantation Unit, Advanced Research Center on Kidney Aging (A.R.K.A.), Department of Medical and Surgical Sciences, University of Foggia, Italy. Electronic address:

Delayed Graft Function (DGF) is one of the most common early complications in kidney transplantation, associated with poor graft outcomes, prolonged post-operative hospitalization and higher rejection rates. Given the severe shortage of high-quality organs for transplantation, DGF incidence is expected to raise in the next years because of the use of nonstandard kidneys from Extended Criteria Donors (ECD) and from Donors after Circulatory Death (DCD). Alongside conventional methods for the evaluation of renal allograft [e. Read More

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Co-production of functional xylo-oligosaccharides and fermentable sugars from corn stover through fast and facile ball mill-assisted alkaline peroxide pretreatment.

Bioresour Technol 2021 May 24;337:125327. Epub 2021 May 24.

State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou 510640, China. Electronic address:

The aim of this work was to develop a feasible ball mill-assisted alkaline peroxide pretreatment followed by stepwise hydrolysis to improve the yield of xylo-oligosaccharides (XOS) and fermentable sugars. The hydrogen peroxide charge, ball-milling time, and solid-to-liquid ratio affected the compositions, particle sizes, morphology, and crystallinity of the corn stover, directly improving the following hydrolytic efficiency. The optimal pretreatment was with 0. Read More

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Large variations in disease severity, death and ICU admission of 2993 patients infected with SARS-CoV-2: The potential impact of genetic vulnerability.

J Infect Public Health 2021 Apr 22;14(7):886-891. Epub 2021 Apr 22.

Health Informatics and Smart Health Department, Health Regulation Sector, Dubai Health Authority, Dubai, United Arab Emirates. Electronic address:

Background: The COVID-19 pandemic has had an immeasurable impact, affecting healthcare systems, the global economy, and society. Exploration of trends within the existing COVID-19 data may guide directions for further study and novel treatment development. As the world faces COVID-19 disease, it is essential to study its epidemiological and clinical characteristics further to better understand and aid in its detection and containment. Read More

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Epidemiological feature, viral shedding, and antibody seroconversion among asymptomatic SARS-CoV-2 carriers and symptomatic/presymptomatic COVID-19 patients.

J Infect Public Health 2021 May 27;14(7):845-851. Epub 2021 May 27.

Department of Epidemiology, Second Military Medical University, Shanghai 200433, China. Electronic address:

Background: Novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is pandemic. However, data concerning the epidemiological features, viral shedding, and antibody dynamics between asymptomatic SARS-CoV-2 carriers and COVID-19 patients remain controversial.

Methods: We enrolled 193 SARS-CoV-2 infected subjects in Ningbo and Zhoushan, Zhejiang, China, from January 21 to March 6, 2020. Read More

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Nationwide Seroprevalence of SARS-CoV-2 in Saudi Arabia.

J Infect Public Health 2021 Apr 24;14(7):832-838. Epub 2021 Apr 24.

King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

Background: Estimated seroprevalence of Coronavirus Infectious Disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) is a critical evidence for a better evaluation of the virus spread and monitoring the progress of COVID-19 pandemic in a population. In the Kingdom of Saudi Arabia (KSA), SARS-CoV-2 seroprevalence has been reported in specific regions, but an extensive nationwide study has not been reported. Here, we report a nationwide study to determine the prevalence of SARS-CoV-2 in the population of KSA during the pandemic, using serum samples from healthy blood donors, non-COVID patients and healthcare workers (HCWs) in six different regions of the kingdom, with addition samples from COVID-19 patients. Read More

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Improved SARS-CoV-2 M inhibitors based on feline antiviral drug GC376: Structural enhancements, increased solubility, and micellar studies.

Eur J Med Chem 2021 May 30;222:113584. Epub 2021 May 30.

Department of Chemistry, University of Alberta, Edmonton AB, T6G 2G2, Canada. Electronic address:

Replication of SARS-CoV-2, the coronavirus causing COVID-19, requires a main protease (M) to cleave viral proteins. Consequently, M is a target for antiviral agents. We and others previously demonstrated that GC376, a bisulfite prodrug with efficacy as an anti-coronaviral agent in animals, is an effective inhibitor of M in SARS-CoV-2. Read More

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Using daily diary methods to understand how college students in recovery use social support.

J Subst Abuse Treat 2021 Apr 14;130:108406. Epub 2021 Apr 14.

NLW Partners, Lubbock, TX, USA. Electronic address:

Collegiate Recovery Communities (CRCs) are important sources of support for college students building and maintaining recovery from substance use disorders. The current study used daily diary data from members of a CRC to examine with which sources of social support students engaged daily, and whether students connected with these sources more on days when they indicated higher-than-usual recovery difficulty, negative affect, and/or school stress. Results indicate that on days when students reported having greater difficulty with recovery maintenance than usual, they had higher odds of being in contact with family members and were expected to talk or spend time with family for longer than usual. Read More

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Sorption of sulfadiazine and flow modeling in an alluvial deposit of a dry riverbed in the Brazilian semiarid.

J Contam Hydrol 2021 May 4;241:103818. Epub 2021 May 4.

Department of Nuclear Energy, Federal University of Pernambuco, Recife, Brazil.

The Brazilian semiarid region is subjected to irregular rainfall, prolonged droughts, and high temperatures, hampering the surface water accumulation. The water access is restricted to the alluvium in the valleys, which are used for cattle and poultry livestock development. These activities trigger the excessive use of veterinary antibiotics. Read More

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Development and validation of the Soweto Stress Scale: Mixed-methods, population-based study of adults living in Soweto, South Africa.

Soc Sci Med 2021 May 12;281:114023. Epub 2021 May 12.

SAMRC Developmental Pathways for Health Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Edmund A. Walsh School of Foreign Service, Georgetown University, Washington, DC, USA. Electronic address:

This article moves from ethnography to epidemiology to generate a locally specific assessment of stress and evaluates it correlates with general psychiatric morbidity. We conducted two related ethnographic studies of stress and distress in Soweto, South Africa (N=107). We then used these studies to develop the Soweto Stress Scale, piloted the scale, and then evaluated its use in an epidemiological surveillance study of stress and health (N=933). Read More

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In vitro tetraploidy induction creates enhancements in morphological, physiological and phytochemical characteristics in the fig tree (Ficus Carica L.).

Plant Physiol Biochem 2021 Jun 1;166:191-202. Epub 2021 Jun 1.

Department of Horticultural Science, College of Agriculture, Shiraz University, Shiraz, P.O. Box 65186-71441, Iran. Electronic address:

Fig tree (Ficus carica L.) is a precious fruit tree in semi-arid and arid areas worldwide which has difficulties in its conventional breeding programs. This study was carried out to make new genotypes with superior features based on the ploidy induction method. Read More

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Temporal transition of racial/ethnic disparities in COVID-19 outcomes in 3108 counties of the United States: Three phases from January to December 2020.

Sci Total Environ 2021 Jun 1;791:148167. Epub 2021 Jun 1.

School of the Environment, Yale University, New Haven, CT, United States of America.

Early studies reported higher risk of COVID-19 outcomes for racial/ethnic minorities in the early phase of the pandemic in the United States. While the initial surge of COVID-19 was concentrated in some areas, COVID-19 became pervasive across the entire continent with high impacts in the northern region and central region in the end of 2020. With this geographical transition, we aim to investigate patterns of these racial/ethnic disparities over time. Read More

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Nanoplastics adsorption and removal efficiency by granular activated carbon used in drinking water treatment process.

Sci Total Environ 2021 Jun 1;791:148175. Epub 2021 Jun 1.

Group of Environmental Physical Chemistry, Department F.-A. Forel for Environmental and Aquatic Sciences, University of Geneva, Uni Carl Vogt, 66, boulevard Carl-Vogt, CH-1211 Geneva 4, Switzerland. Electronic address:

In this study Granular Activated Carbon (GAC) used in drinking water treatment processes is evaluated for its capacity to adsorb and remove polystyrene (PS) nanoplastics. Batch experiments are conducted in ultrapure and surface water from Lake Geneva, currently used as drinking water resources. Equilibrium and kinetic studies are conducted to understand adsorption mechanisms and limiting factors. Read More

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Trophic interactions of reef-associated predatory fishes (Hexagrammos otakii and Sebastes schlegelii) in natural and artificial reefs along the coast of North Yellow Sea, China.

Sci Total Environ 2021 Jun 6;791:148250. Epub 2021 Jun 6.

Research and Development Center for Efficient Utilization of Coastal Bioresources, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, People's Republic of China; Muping Coastal Environment Research Station, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, People's Republic of China. Electronic address:

Large reef-associated predatory fishes play important roles in aquatic ecosystem along coast because of their ecological functions and economic values to recreational and commercial fisheries. This study was carried out to assess the function of artificial reefs as alternative habitats for two common reef-associated predatory fishes in the north of Yellow Sea, China, Fat Greenling Hexagrammos otakii and Korean rockfish Sebastes schlegelii. According to the catch per unit effort (CPUE), the biomass of predatory fishes at the artificial reef was comparable (H. Read More

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Co-hydrothermal carbonization of swine manure and cellulose: Influence of mutual interaction of intermediates on properties of the products.

Sci Total Environ 2021 May 29;791:148134. Epub 2021 May 29.

School of Material Science and Engineering, University of Jinan, Jinan 250022, China. Electronic address:

Co-hydrothermal carbonization (HTC) of livestock manure and biomass might improve the fuel properties of the hydrochar due to the high reactivity of the biomass-derived intermediates with the abundant oxygen-containing functionalities. However, the complicated compositions make it difficult to explicit the specific roles of the individual components of biomass played in the co-HTC process. In this study, cellulose was used for co-HTC with swine manure to investigate the influence on the properties of the hydrochar. Read More

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Generation of hydroxyl radicals by metal-free bifunctional electrocatalysts for enhanced organics removal.

Sci Total Environ 2021 May 31;791:148107. Epub 2021 May 31.

Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University, Guangzhou 511443, China. Electronic address:

Low yields of HO and a narrow range of appropriate pH values have been two major drawbacks for electro-Fenton (EF) process. Herein, metal-free electrochemical advanced oxidation processes (EAOPs) were developed with nitrogen and sulfur co-doped electrochemically exfoliated graphene (N, S-EEGr) electrocatalysts, which was confirmed as an outstanding bifunctional catalyst for synchronous generation and activation of HO via (2 + 1) e consecutive reduction reactions. Specifically, two elements (N, S) in metal-free N, S-EEGr-CF cathode synergize to promote the formation of HO followed by its activation. Read More

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A sensing network involving citizens for high spatio-temporal resolution monitoring of fugitive emissions from a petroleum pre-treatment plant.

Sci Total Environ 2021 May 29;791:148135. Epub 2021 May 29.

Biology Department, University of Bari, via Orabona, 4, 70126 Bari, Italy.

In this study an innovative sensing network consisting of eight photoionization detectors, meteorological sensors, a video camera and a telephonic system able to systematize the population complaints was developed for the monitoring of odor emissions. The development of monitoring approaches with high temporal and spatial resolution and actively involving citizens, is strategic in areas where relevant and also short-term emissive events frequently occur and the conventional approaches fail due to the high variability of fugitive emissions. Moreover, even if unpleasant odors are not necessarily direct triggers of health effects, they could be associated with the release of other harmful compounds. Read More

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Improved agricultural Water management in data-scarce semi-arid watersheds: Value of integrating remotely sensed leaf area index in hydrological modeling.

Sci Total Environ 2021 Jun 1;791:148177. Epub 2021 Jun 1.

University of Maryland, College Park, USA. Electronic address:

In watersheds located in semi-arid regions, vegetation dynamics, evapotranspiration (ET), and associated water and energy balances collectively play a major role in controlling hydrological regimes and crop yield. As such, it is challenging to predict the complex hydrological processes and biophysical dynamics. This challenge increases in areas with limited data availability. Read More

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Degradation of antibiotic Cephalosporin C in different water matrices by ionizing radiation: Degradation kinetics, pathways, and toxicity.

Sci Total Environ 2021 Jun 4;791:148253. Epub 2021 Jun 4.

Laboratory of Environmental Technology, INET, Tsinghua University, Beijing 100084, PR China; Beijing Key Laboratory of Radioactive Waste Treatment, Tsinghua University, Beijing 100084, PR China. Electronic address:

Cephalosporin antibiotics are ubiquitous emerging pollutants in various aquatic environments due to their extensive production and application. Herein, the radiolytic degradation of antibiotic Cephalosporin C (CEP-C) in different water matrices was comprehensively investigated using gamma radiation at various experimental conditions. The results revealed that CEP-C oxidation obeyed pseudo first-order kinetics, and 100%, 94. Read More

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Driving mechanisms of gross primary productivity geographical patterns for Qinghai-Tibet Plateau lake systems.

Sci Total Environ 2021 Jun 5;791:148286. Epub 2021 Jun 5.

Key Laboratory of Ecosystem Network Observation and Modeling, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China. Electronic address:

Being a fundamental property of aquatic systems, gross primary productivity (GPP) is affected by complex environmental factors, such as salinity, nutrients, pH, and sunlight. Under conditions of intensified anthropogenic activity and climate change, it is critical to understand the driving mechanisms of GPP in alpine lakes. In this study, we investigated GPP and associated environmental factors of 23 lake systems in the Qinghai-Tibet Plateau (QTP) along an altitudinal range (from 2500 m to 4500 m). Read More

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Using Sr-Nd-Pb isotope systems to trace sources of sediment and trace metals to the Weser River system (Germany) and assessment of input to the North Sea.

Sci Total Environ 2021 Jun 3;791:148127. Epub 2021 Jun 3.

Institute of Coastal Research, Helmholtz-Zentrum Geesthacht Center for Materials and Coastal Research, Max-Planck Str.1, 21502 Geethacht, Germany. Electronic address:

In order to trace the sources of sediment materials and trace metals in the Weser River system (Germany), and the riverine input to the North Sea, Sr, Nd and Pb isotopes, together with multi-elemental compositions, were measured for sediments collected over the entire Weser River Basin, from headwaters to the estuary. Mass fractions of metals, including Ag, Cd, and Pb, and of one metalloid, Sb, higher than their crustal abundance, were observed within the entire Weser Basin. Isotope-amount ratio n(Sr)/n(Sr) and ε ranged from 0. Read More

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Assessment of dust trace elements in an e-waste recycling area and related children's health risks.

Sci Total Environ 2021 May 31;791:148154. Epub 2021 May 31.

Laboratory of Environmental Medicine and Developmental Toxicology, Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University, Guangzhou 511443, Guangdong, China. Electronic address:

Children from Guiyu, an electronic waste (e-waste) recycling town, are exposed to trace elements via dust. However, the source, pathways, and influence factors of house dust and the association of house dust with child inflammation in an e-waste recycling area are not well-known. This study investigated dust trace elements in children's living environment and the associations of house dust trace elements with influence factors and child inflammation. Read More

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