2,785,653 results match your criteria higher

Changes in drug use in European cities during early COVID-19 lockdowns - A snapshot from wastewater analysis.

Environ Int 2021 Mar 26;153:106540. Epub 2021 Mar 26.

Environmental and Public Health Analytical Chemistry, Research Institute for Pesticides and Water, University Jaume I, Castellón, Spain; Institute for Biodiversity and Ecosystem Dynamics, University of Amsterdam, the Netherlands. Electronic address:

The COVID-19 outbreak has forced countries to introduce severe restrictive measures to contain its spread. In particular, physical distancing and restriction of movement have had important consequences on human behaviour and potentially also on illicit drug use and supply. These changes can be associated with additional risks for users, in particular due to reduced access to prevention and harm reduction activities. Read More

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Maternal exposure to ambient air pollution and congenital heart defects in China.

Environ Int 2021 Apr 7;153:106548. Epub 2021 Apr 7.

Guangdong Provincial Engineering Technology Research Center of Environmental and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. Electronic address:

Background: Evidence of maternal exposure to ambient air pollution on congenital heart defects (CHD) has been mixed and are still relatively limited in developing countries. We aimed to investigate the association between maternal exposure to air pollution and CHD in China.

Method: This longitudinal, population-based, case-control study consecutively recruited fetuses with CHD and healthy volunteers from 21 cities, Southern China, between January 2006 and December 2016. Read More

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Home alone? Effect of weather-induced behaviour on spread of SARS-CoV-2 in Germany.

Slava Yakubenko

Econ Hum Biol 2021 Apr 1;42:100998. Epub 2021 Apr 1.

University of Goettingen, Germany.

In early 2020 the world was struck by the epidemic of novel SARS-CoV-2 virus. Like many others, German government has introduced severe contact restrictions to limit the spread of infection. This paper analyses effects of weather on the spread of the disease under the described circumstances. Read More

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Recent developments in emerging technologies for beetroot pigment extraction and its food applications.

Food Chem 2021 Mar 19;356:129611. Epub 2021 Mar 19.

Department of Food Science, College of Food and Agriculture, United Arab Emirates University, Al Ain 15551, United Arab Emirates. Electronic address:

Beetroot is well known for its deep red-purple colouring pigments called betalains. Betalains also found its application in the preparation of functional foods and drinks. Therefore, extraction of pigments with higher recovery and stability is the prime need for the industry. Read More

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Red and processed meat consumption and cancer outcomes: Umbrella review.

Food Chem 2021 Mar 27;356:129697. Epub 2021 Mar 27.

Department of Urology/Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address:

The purpose of this umbrella review was to evaluate the quality of evidence, validity and biases of the associations between red and processed meat consumption and multiple cancer outcomes according to existing systematic reviews and meta-analyses. The umbrella review identified 72 meta-analyses with 20 unique outcomes for red meat and 19 unique outcomes for processed meat. Red meat consumption was associated with increased risk of overall cancer mortality, non-Hodgkin lymphoma (NHL), bladder, breast, colorectal, endometrial, esophageal, gastric, lung and nasopharyngeal cancer. Read More

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Effects of acetylation on dissociation and phosphorylation of actomyosin in postmortem ovine muscle during incubation at 4 °C in vitro.

Food Chem 2021 Mar 27;356:129696. Epub 2021 Mar 27.

Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences/Key Laboratory of Agro-Products Processing, Ministry of Agriculture and Rural Affairs, Beijing 100193, PR China.

This study aimed to assess the effects of acetylation levels on actomyosin disassociation and phosphorylation of lamb during incubation at 4 °C. Samples of whole proteins from lamb longissimus thoracis muscles were prepared and assigned into three treatments (high, middle and low acetylation groups). The results showed that deacetylation of myosin heavy chain and actin was inhibited by lysine deacetylase inhibitor trichostatin A and nicotinamide in this study. Read More

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Sleep quality and daytime sleepiness in epilepsy: Systematic review and meta-analysis of 25 studies including 8,196 individuals.

Sleep Med Rev 2021 Mar 13;57:101466. Epub 2021 Mar 13.

Department of Neurology, Medical University Innsbruck, Austria. Electronic address:

We sought to gain a better understanding of the relationship between epilepsy and sleep quality and daytime sleepiness by performing a literature search of PubMed for case-control studies that compared patients with epilepsy to controls and reported the Pittsburgh sleep quality index (PSQI) and/or the Epworth sleepiness scale (ESS). Study-specific mean differences in the PSQI and ESS between cases and controls were extracted from the publications and pooled using random-effects meta-analysis. Twenty-five studies (2964 cases, 5232 controls) were included. Read More

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How important is price variation between health insurers?

J Health Econ 2021 Feb 16;77:102423. Epub 2021 Feb 16.

Kellogg School of Management, Northwestern University and NBER, United States.

Prices negotiated between payers and providers affect a health insurance contract's value via enrollees' cost-sharing and self-insured employers' costs. However, price variation across payers is difficult to observe. We measure negotiated prices for hospital-payer pairs in Massachusetts and characterize price variation. Read More

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February 2021

Effect of ozone treatment on glutathione (GSH) status in selected berry fruit.

Phytochemistry 2021 Apr 7;187:112767. Epub 2021 Apr 7.

Department of Chemistry and Food Toxicology, Institute of Food Technology and Nutrition, University of Rzeszow, St. Cwiklinskiej 1a, 35-601, Rzeszow, Poland. Electronic address:

The major aim of this study was to investigate the effect of one-time ozone elicitation on glutathione metabolism in selected berry fruit. Raspberry, highbush blueberry, strawberry, blackberry and blackcurrant fruit was ozonated with an ozone concentration of 15 ppm for 30 min. Research showed that ozonation process causes clear and positive changes in the metabolism of glutathione in berries. Read More

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Antiviral zinc oxide nanoparticles mediated by hesperidin and in silico comparison study between antiviral phenolics as anti-SARS-CoV-2.

Colloids Surf B Biointerfaces 2021 Mar 26;203:111724. Epub 2021 Mar 26.

Department of Phytochemistry and Plant Systematics, Pharmaceutical Division, National Research Centre, Dokki, Cairo, Egypt. Electronic address:

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which caused the coronavirus (COVID-19), is the virus responsible for over 69,613,607 million infections and over 1,582,966 deaths worldwide. All treatment measures and protocols were considered to be supportive only and not curative. During this current coronavirus pandemic, searching for pharmaceutical or traditional complementary and integrative medicine to assist with prevention, treatment, and recovery has been advantageous. Read More

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Clinical Features and Outcomes of Anti-N-Methyl-d-Aspartate Receptor Encephalitis in Infants and Toddlers.

Pediatr Neurol 2021 Mar 12;119:27-33. Epub 2021 Mar 12.

Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Department of Neurology, Beijing, China. Electronic address:

Objective: We describe the clinical features and outcomes of anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis in infants and toddlers.

Methods: This was a single-center retrospective study. Infants and toddlers who met the diagnostic criteria for anti-NMDAR encephalitis were recruited for the study. Read More

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Shyness and susceptibility to social influence: Stronger concordance between norms and drinking among shy individuals.

Addict Behav 2021 Mar 26;119:106922. Epub 2021 Mar 26.

Rowan University, United States. Electronic address:

Despite a large body of work exploring associations between perceived norms and drinking and norms-based interventions for drinking, less work has examined moderators of associations between norms and drinking outcomes to determine potential sub-groups that might benefit most from brief norms-based interventions. The present study investigates shyness as a moderator of associations between drinking norms and alcohol use. We hypothesized that shyness would moderate associations between drinking norms and alcohol use such that individuals who are higher in shyness might be more sensitive to social influence and thus show stronger associations between drinking norms and alcohol use. Read More

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Anxiety symptoms are the strongest predictor of quality of life in temporal lobe epilepsy.

Seizure 2021 Mar 23;88:78-82. Epub 2021 Mar 23.

Department of Psychiatry, Hospital das Clínicas, University of São Paulo Medical School (IPq/HCFMUSP), Brazil.

Purpose: It is established that the severity of depressive and anxiety symptoms is associated with poorer quality of life (QOL) in persons with drug-resistant epilepsy. We aimed to verify the presence of subsyndromic depressive episodes (SDEs) and subsyndromic anxiety episodes (SAEs) in persons with temporal lobe epilepsy with hippocampal sclerosis (TLE-HS) compared to healthy controls and to determine the impact of depressive and anxiety symptoms on patients' QOL.

Methods: We prospectively evaluated 35 persons with TLE-HS and 90 healthy controls. Read More

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Exploring ambivalent rape acknowledgment and posttraumatic stress symptoms among college women who have experienced rape: What's in a name?

J Anxiety Disord 2021 Apr 3;80:102389. Epub 2021 Apr 3.

The University of Memphis, 400 Innovation Drive, Memphis, TN 38152, United States.

The present study explored rape acknowledgment among 131 college women survivors of rape utilizing three subgroups: acknowledged rape, unacknowledged rape, and ambivalent acknowledgment. Posttraumatic stress disorder (PTSD) symptom clusters and parameters of victimization and were compared between the subgroups. Of the participants, 28. Read More

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A multicenter survey on access to care in Multiple Sclerosis-related trigeminal neuralgia.

J Neurol Sci 2021 Mar 27;424:117430. Epub 2021 Mar 27.

Rehabilitation Department, Mons. L. Novarese, Moncrivello, Vercelli, Italy.

The prevalence of trigeminal neuralgia (TN) in patients with Multiple Sclerosis (MS) is higher than in the general population and its management can be particularly challenging due to a number of reasons including high recurrence rates, lack of MS-specific treatment guidelines and uncertainties about pain pathophysiology. Aim of this cross-sectional, multicentre survey was to gather information on the current treatment modalities and options of MS-related TN across 23 Italian MS centres. Initial medical management (carbamazepine or oxcarbazepine) of MS-related TN was fairly homogeneous throughout Italian centres. Read More

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Conversion of AML-blasts to leukemia-derived dendritic cells (DCleu) in 'DC-culture-media' shifts correlations of released chemokines with antileukemic T-cell reactions.

Immunobiology 2021 Mar 20;226(3):152088. Epub 2021 Mar 20.

Department for Hematopoietic Transplantations, Med III, University Hospital of Munich, Germany; Helmholtz Center, Munich, Clinical Cooperative Group Human Cell Transplantation (CCG-HCT), Germany. Electronic address:

Dendritic cells (DC) and T-cells are mediators of CTL-responses. Autologous (from patients with acute myeloid leukaemia (AML) or myelodysplasia (MDS)) or allogeneic (donor)-T-cells stimulated by DC, gain an efficient lysis of naive blasts, although not in every case. CXCL8, -9, -10, CCL2, -5 and Interleukin (IL-12) were quantified by Cytometric Bead Array (CBA) in supernatants from 5 DC-generating methods and correlated with AML-/MDS-patients' serum-values, DC-/T-cell-interactions/antileukemic T-cell-reactions after mixed lymphocyte culture (MLC) and patients' clinical course. Read More

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Intramammary infection caused by Staphylococcus aureus increases IgA antibodies to iron-regulated surface determinant-A, -B, and -H in bovine milk.

Vet Immunol Immunopathol 2021 Mar 31;235:110235. Epub 2021 Mar 31.

Dairy Hygiene Research Division, National Institute of Animal Health, National Agriculture and Food Research Organization, 4 Hitsujigaoka, Toyohira, Sapporo, Hokkaido, 062-0045, Japan. Electronic address:

The aim of this study was to identify virulence factors that have high immunogenicity. An in vivo-expressed Staphylococcus aureus antigen was identified by probing bacteriophage expression libraries of S. aureus with antibodies in bovine mastitis milk. Read More

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Mannosylated gelatin nanoparticles enhanced inactivated PRRSV targeting dendritic cells and increased T cell immunity.

Vet Immunol Immunopathol 2021 Apr 5;235:110237. Epub 2021 Apr 5.

College of Life Science and Technology, Dalian University, Dalian, 116622, PR China; Institute of Immunology, Dalian University, Dalian, 116622, PR China. Electronic address:

The objective of the present work was to evaluate the efficacy of a novel antigen carrier using mannosylated gelatin nanoparticles with entrapped inactivated porcine reproductive and respiratory syndrome virus (PRRSV) in inducing T cell mediated immunity in vitro. Gelatin nanoparticles (GNP) were modified with mannose to form mannosylated gelatin nanoparticles (MnGNP), which can efficiently and specifically target monocyte derived dendritic cells (MoDCs). The inactivated PRRSV was encapsulated in the MnGNP and GNP, referred to as MnGNP-PRRSV and GNP-PRRSV, respectively. Read More

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Ultrasound-guided erector spinae plane block for postoperative analgesia in patients undergoing open radical prostatectomy: A randomized, placebo-controlled trial.

J Clin Anesth 2021 Apr 7;72:110277. Epub 2021 Apr 7.

Department of Urology, Ondokuz Mayis University Faculty of Medicine, Samsun, Turkey.

Study Objective: The aim of this study was to evaluate the effect of ultrasound-guided erector spinae plane (ESP) block on postoperative pain in radical prostatectomy, which leads to both visceral and somatic pain.

Design: Prospective, randomized, placebo controlled, double-blinded.

Setting: University hospital. Read More

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Perioperative high inspired oxygen fraction induces atelectasis in patients undergoing abdominal surgery: A randomized controlled trial.

J Clin Anesth 2021 Apr 7;72:110285. Epub 2021 Apr 7.

Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine in Seoul, South Korea. Electronic address:

Study Objective: We evaluated the feasibility of use and effects on postoperative atelectasis and complications of lower inspired oxygen fraction (FIO) compared to conventional oxygen therapy.

Design: Single center, randomized clinical trial.

Setting: University hospital, operating room and postoperative recovery area. Read More

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A co-delivery platform for synergistic promotion of angiogenesis based on biodegradable, therapeutic and self-reporting luminescent porous silicon microparticles.

Biomaterials 2021 Mar 26;272:120772. Epub 2021 Mar 26.

Institute of Analytical Chemistry, Department of Chemistry, Zhejiang University, Hangzhou, 310058, China. Electronic address:

Insufficient angiogenesis happened in body defects such as ulceration, coronary heart disease, and chronic wounds constitutes a major challenge in tissue regeneration engineering. Owing to the poor bioactivity and maintenance of pro-angiogenic cells and factors during transplantation, new bioactive materials to tackle the barrier are highly desirable. Herein, we demonstrate a co-delivery platform for synergistic promotion of angiogenesis based on biodegradable, therapeutic, and self-reporting luminescent porous silicon (PSi) microparticles. Read More

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The role of depression in the prediction of a "late" remission in first-episode psychosis: An analysis of the OPTiMiSE study.

Schizophr Res 2021 Apr 7;231:100-107. Epub 2021 Apr 7.

Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad Complutense, Madrid, Spain.

Objective: The identification of predictors of psychosis remission could guide early clinical decision-making for treatment of first-episode schizophrenia (FES).

Methods: We analyzed two non-independent subsamples of patients with FES ages 18-40 years from the OPTiMiSE study dataset to investigate the demographic and clinical factors that might help to differentiate "late" remitters (i.e. Read More

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Mean Platelet Volume is a Prognostic Marker in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis.

J Stroke Cerebrovasc Dis 2021 Apr 6;30(6):105718. Epub 2021 Apr 6.

Stroke Unit, Department of Neurosciences and Mental Health (Neurology), Hospital Santa Maria; Faculty of Medicine, University of Lisbon, Lisbon, Portugal; Instituto de Medicina Molecular, Lisbon, Portugal.

Background And Objectives: There is conflicting data regarding the association between platelet parameters and prognosis of stroke patients treated with intravenous thrombolysis. We aimed to analyze this association in a cohort of patients treated with rtPA.

Material And Methods: Retrospective, observational study in adult ischemic stroke patients treated with rtPA between January 2015 and February 2017. Read More

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Thermal stability of arsenic complexes in soils.

J Hazard Mater 2021 Mar 25;416:125715. Epub 2021 Mar 25.

Czech Geological Survey, Geologicka 6, 152 00 Prague 5, Czech Republic.

The release of soil arsenic (As) in an unsaturated zone under oxidative conditions and at two temperatures simulating the seasonal effect (15 °C and 23 °C) was studied in four cultivated soils from the Elbe River catchment (Czech Republic, Central Europe). The soils with a low geogenic As background contained from 10 to 50 µg.g of As, mostly originating from atmospheric deposition in the past. Read More

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Subclinical upper motor neuron involvement at the diagnosis may predict disease progression in a cohort of lower motor neuron syndromes from Southern Italy.

J Neurol Sci 2021 Mar 16;425:117392. Epub 2021 Mar 16.

Neurology Unit, Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari "Aldo Moro", Piazza Giulio Cesare 11, 70100 Bari, Italy.

Background: Only few epidemiological studies on survival of Lower Motor Neuron (LMN) phenotype (LMNP) are available and with controversial results.

Aims: To prospectively evaluate a cohort of LMNP patients and assess the possible contribute on survival or disease's progression according to the presence of subclinical Upper Motor Neuron (UMN) impairment at the diagnosis.

Methods: Forty LMNP among 176 consecutive incident ALS cases observed in our tertiary center from the ALS-Apulia Register were enrolled in the study. Read More

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Thrombin generation is associated with ischemic stroke at a young age.

Thromb Res 2021 Mar 29;202:139-144. Epub 2021 Mar 29.

Erasmus MC, University Medical Center Rotterdam, Department of Hematology, the Netherlands. Electronic address:

Introduction: Understanding the underlying mechanisms in ischemic stroke (IS) in young adults remains challenging. Thrombin activates processes that contribute to the development and progression of arterial diseases. We investigated the association between thrombin generation (TG) and a first IS or transient ischemic attack (TIA) in young adults. Read More

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The impact of prenatal stressful life events on adverse birth outcomes: A systematic review and meta-analysis.

J Affect Disord 2021 Mar 31;287:406-416. Epub 2021 Mar 31.

Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, Anhui, China; Centre for Evidence-Based Practice, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, Anhui, China. Electronic address:

Background: Stressful life events as important stressors have gradually been recognized as the potential etiology that may lead to adverse birth outcomes such as preterm birth (PTB), low birth weight (LBW), and small for gestational age (SGA). However, researches on this topic have shown relatively inconsistent results. This systematic review and meta-analysis was performed to synthesize available data on the association between prenatal stressful life events and increased risks of PTB, LBW, and SGA. Read More

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Cognitive correlates of impulsive aggression in youth with pediatric bipolar disorder and bipolar offspring.

J Affect Disord 2021 Mar 23;287:387-396. Epub 2021 Mar 23.

Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA; Department of Psychiatry, Texas Children's Hospital, Houston, TX, USA. Electronic address:

Background: Youth with bipolar disorder (BD) and offspring of individuals with BD (BD-OFF) are characterized by higher levels of impulsive and overt aggression. The cognitive basis underlying these aggressive behaviors are not clarified in this population. The aim of this study was to investigate the relationship between cognitive alterations and aggressive behavior in youth with BD and BD-OFF. Read More

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The role of the BUN/albumin ratio in predicting mortality in COVID-19 patients in the emergency department.

Am J Emerg Med 2021 Apr 5;48:33-37. Epub 2021 Apr 5.

Emergency Department, Necmettin Erbakan University, Meram School of Medicine, Konya, Turkey.

Introduction: Due to the high mortality and spread rates of coronavirus disease 2019 (COVID-19), there are currently serious challenges in emergency department management. As such, we investigated whether the blood urea nitrogen (BUN)/albumin ratio (BAR) predicts mortality in the COVID-19 patients in the emergency department.

Methods: A total of 602 COVID-19 patients who were brought to the emergency department within the period from March to September 2020 were included in the study. Read More

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Biological effects of multimetal (Ni, Cd, Pb, Cu, Cr, Zn) mixture in rainbow trout Oncorhynchus mykiss: Laboratory exposure and recovery study.

Ecotoxicol Environ Saf 2021 Apr 7;216:112202. Epub 2021 Apr 7.

Nature Research Centre, Laboratory of Geoenvironmental Research, Akademijos St. 2, LT-08412 Vilnius, Lithuania; Vilnius University, Faculty of Chemistry and Geosciences, Naugarduko St. 24, LT-03225 Vilnius, Lithuania.

The present study tested the biological consequences of exposure to a multimetal mixture as a multiple chemical stressor on Oncorhynchus mykiss at molecular, cellular, physiological and whole-organism levels and on biomarker responses of this fish during the depuration period. To represent environmentally relevant multiple chemical stressors, in our study, we used the mixture of Zn, Cu, Ni, Cr, Pb and Cd at the concentrations corresponding to Maximum-Permissible-Concentrations (MPCs) acceptable for the EU inland waters. This study was undertaken with a view to elucidate if changes in the MPC of the test mixture components (Ni, Pb, Cd) could cause significantly different biomarker responses in O. Read More

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