174,122 results match your criteria high-risk procedures


Mindfulness-based interventions for medication adherence: A systematic review and narrative synthesis.

J Psychosom Res 2021 Jul 26;149:110585. Epub 2021 Jul 26.

Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, RI, United States. Electronic address:

Objective: Inadequate medication adherence is a significant limitation for achieving optimal health outcomes across chronic health conditions. Mindfulness-based interventions (MBIs) have been increasingly applied to promote medical regimen adherence as MBIs have been shown to improve patient-level barriers to adherence (i.e. Read More

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The joint effects of clinically relevant depressive symptoms and cardiovascular risk factors on incident cardiovascular disease among older adults in the community.

J Psychosom Res 2021 Jul 16;149:110572. Epub 2021 Jul 16.

Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam Public Health Research Institute, Amsterdam, the Netherlands; GGZ inGeest Specialized Mental Health Care, Amsterdam, the Netherlands. Electronic address:

Objective: To determine if there is a synergistic effect between clinically relevant depressive symptoms and cardiovascular risk factors that disproportionately increases the risk of cardiovascular disease (CVD) among older adults with depressive symptoms.

Methods: Data were obtained from the Longitudinal Aging Study Amsterdam, a longitudinal cohort study. N = 3091 respondents with up to seven years of follow-up were included. Read More

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Are oral lichen planus patients at high risk of hepatitis C? A case-control study.

J Stomatol Oral Maxillofac Surg 2021 Jul 28. Epub 2021 Jul 28.

Department of Oral and Maxillofacial Surgery, University Hospital of Giessen and Marburg, UKGM GmbH, Campus Marburg, Faculty of Medicine, Philipps-University of Marburg, Marburg, Germany.

Objective: To assess the correlation between oral lichen planus (OLP) and viral hepatitis C (HCV).

Methods: This retrospective case-control study included a sample of OLP patients in a 3-year interval. The predictor variable was the presence of OLP (yes/no). Read More

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Influence of HIV infection on the distribution of high-risk HPV types among women with cervical precancerous lesions in Yaounde, Cameroon.

Int J Infect Dis 2021 Jul 28. Epub 2021 Jul 28.

Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.

Objectives: To characterise the high-risk HPV types associated with cervical precancerous lesions in women living in Yaounde Cameroon, and to determine their distribution with HIV status.

Methods: Women with abnormal pap smears recorded from February 2015 to May 2019 at Saint Martin de Porres' Health Centre, Yaounde, Cameroon were recruited in the study after obtaining informed consent. Pap smears were collected and re-examined. Read More

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Early screening and diagnosis strategies of pancreatic cancer: a comprehensive review.

Cancer Commun (Lond) 2021 Jul 31. Epub 2021 Jul 31.

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, P. R. China.

Pancreatic cancer is a highly malignant digestive system tumor with a poor prognosis. Most pancreatic cancer patients are diagnosed at an advanced stage or even metastasis due to its highly aggressive characteristics and lack of typical early symptoms. Thus, an early diagnosis of pancreatic cancer is crucial for improving its prognosis. Read More

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Concordance Between a Mohs Surgeon and a Dermatopathologist in Evaluating Mohs Cryosections.

J Eur Acad Dermatol Venereol 2021 Jul 31. Epub 2021 Jul 31.

Department of Dermatology and Venereology, Hacettepe University, School of Medicine, Ankara, Turkey.

Background: Mohs micrographic surgery is the gold standard treatment for high-risk non-melanoma skin cancers. The success of Mohs relies on accurate histopathologic evaluation. Due to law restrictions in some European countries Mohs surgeons are not permitted to report on histopathology, therefore a pathologist evaluates the frozen sections. Read More

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Determinants for under- and overdosing of direct oral anticoagulants and physicians' implementation of clinical pharmacists' recommendations.

Br J Clin Pharmacol 2021 Jul 31. Epub 2021 Jul 31.

Research Group Clinical Pharmacology and Clinical Pharmacy; Vrije Universiteit Brussel, Jette, Belgium.

Aim: To analyze the appropriateness of DOAC dosing and determinants for under-and overdosing as well as acceptance and implementation rates of pharmacists' interventions.

Methods: Cross-sectional study in a tertiary hospital in hospitalized patients with atrial fibrillation on DOACs in 2019 (n=1688). Primary outcome was the proportion of patients with inappropriate DOAC prescribing with identification of determinants for under-and overdosing. Read More

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Development and Validation of a Simplified Risk Score for the Prediction of Critical COVID-19 Illness in Newly Diagnosed Patients.

J Med Virol 2021 Jul 31. Epub 2021 Jul 31.

Department of Nephrology, Technical University of Munich, School of Medicine, Klinikum rechts der Isar, Munich, Germany.

Objectives: Scores to identify patients at high risk of progression of coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), may become instrumental for clinical decision-making and patient management.

Methods: We used patient data from the multicentre Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS) and applied variable selection to develop a simplified scoring system to identify patients at increased risk of critical illness or death. A total of 1,946 patients who tested positive for SARS-CoV-2 were included in the initial analysis and assigned to derivation and validation cohorts (n=1,297 and n=649, respectively). Read More

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Reducing risk for gestational diabetes among American Indian and Alaska Native teens: Tribal leaders' recommendations.

Int J Gynaecol Obstet 2021 Jul 31. Epub 2021 Jul 31.

University of Pittsburgh School of Nursing, Pittsburgh, PA, USA.

Objective: To elicit feedback from tribal leaders and American Indian/Alaska Native (AI/AN) health system administrators as a national stakeholder perspective to inform the development of a gestational diabetes (GDM) risk reduction and preconception counseling intervention for AI/AN teens at high risk for GDM.

Methods: A semi-structured focus group interview guide was developed by both principal investigators and qualitative methods experts. Using open-ended questions about the READY-Girls booklet and video clips, AI/AN health care system administrators and elected tribal leaders (n=12) attending the 2015 National Indian Health Board conference in Washington, DC, made recommendations on adaptation for an AI/AN audience. Read More

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Identifying high-risk surgical patients: A study of older adults whose code status changed to Do-Not-Resuscitate.

J Am Geriatr Soc 2021 Jul 31. Epub 2021 Jul 31.

Department of Surgery, Durham VA Health Care System, Durham, North Carolina, USA.

Background: There is a paucity of data on older adults (age ≥65 years) undergoing surgery who had an inpatient do-not-resuscitate (DNR) order, and the association between timing of DNR order and outcomes.

Methods: This was a retrospective analysis of 1976 older adults in the American College of Surgeons National Surgical Quality Improvement Program geriatric-specific database (2014-2018). Patients were stratified by institution of a DNR order during their surgical admission ("new-DNR" vs. Read More

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A clinical variable-based nomogram could predict the survival for advanced NSCLC patients receiving second-line atezolizumab.

Cancer Med 2021 Jul 31. Epub 2021 Jul 31.

Department of Internal Medicine-Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.

Objective: A nomogram model based on clinical variables was conducted to predict the survival in patients with non-small cell lung cancer (NSCLC) receiving second-line atezolizumab.

Methods: Four hundred and twenty-four patients with NSCLC receiving atezolizumab from OAK study were regarded as the training cohort. Next, a nomogram model based on clinical variables in the training cohort was established to predict the survival of patients receiving atezolizumab. Read More

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The efficacy of isoniazid prophylaxis in renal transplant recipients in a high tuberculosis Burden country.

Transpl Infect Dis 2021 Jul 31. Epub 2021 Jul 31.

Sindh Institute of Urology and Transplantation, Chand Bibi Road, Karachi, 74200, Pakistan.

Introduction: Renal transplant recipients are at high risk of tuberculosis (TB). We started Isoniazid (INH) prophylaxis of 1 year duration in all renal transplant recipients from April 2009. Our aim was to assess the incidence of TB on INH prophylaxis and its tolerability. Read More

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Cost-Consequence Analysis of Using Cangrelor in High Angiographic Risk Percutaneous Coronary Intervention Patients: A US Hospital Perspective.

Am J Cardiovasc Drugs 2021 Jul 31. Epub 2021 Jul 31.

Brigham and Women's Hospital Heart and Vascular Center, and Harvard Medical School, Boston, MA, USA.

Objectives: The objective of this study was to evaluate a US hospital's cost implications and outcomes of cangrelor use in percutaneous coronary intervention (PCI) patients with two or more angiographic high-risk features (HRFs), including avoidance of oral P2Y inhibitor pretreatment in patients requiring cardiac surgery. Intravenous cangrelor provides direct, immediate onset and rapid-offset P2Y inhibition, which may reduce the necessity for oral P2Y pretreatment.

Methods: A decision analytic model was developed, estimating the annual impact over 3 years of cangrelor availability. Read More

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Portal vein thrombosis following elective laparoscopic splenectomy: incidence and analysis of risk factors.

Surg Endosc 2021 Jul 30. Epub 2021 Jul 30.

Department of Surgery, Royal Brisbane and Women's Hospital, Herston, QLD, 4029, Australia.

Background: Minimally invasive splenectomy is now well established for a wide range of pathologies. Portal vein thrombosis (PVT) is increasingly being recognised as a complication of splenectomy. The aim was to determine the incidence and risk factors for PVT after laparoscopic splenectomy. Read More

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Increasing Early Skin-to-Skin in Extremely Low Birth Weight Infants.

Neonatal Netw 2021 Jul;40(4):242-250

Background: Early skin-to-skin care (SSC) has been shown to improve outcomes after preterm birth, including improved clinical stability and establishment of breastfeeding. Recent evidence suggests the most unstable infants get the most benefit, yet these infants are not consistently offered opportunities for SSC because of safety concerns and discomfort of the care team.

Purpose: To identify barriers and implement a multidimensional approach to increase SSC within the first 72 hours of life among infants born less than 28 weeks' gestation and less than 1,000 g in a Level IV university-based regional intensive care nursery. Read More

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Measurement of galactosyl-deficient IgA1 by the monoclonal antibody KM55 contributes to predicting patients with IgA nephropathy with high risk of long-term progression.

Nefrologia 2021 Jul 27. Epub 2021 Jul 27.

Servicio de Nefrología del Hospital Universitario Marqués de Valdecilla, IDIVAL-REDINREN, Santander, Spain.

Background And Objective: About 25% of patients with IgA nephropathy (IgAN) progress to stage 5 chronic kidney disease (CKD) after years of evolution. Various tools have been developed in recent years designed to predict which of the patients will had poorer outcomes. The value of circulating galactosyl-deficient IgA1 (Gd-IgA1) has been related to a worse evolution of IgAN in several studies. Read More

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Predictive model for systemic recurrence following cisplatin-based neoadjuvant chemotherapy and radical nephroureterectomy for high risk upper tract urothelial carcinoma.

Urol Oncol 2021 Jul 28. Epub 2021 Jul 28.

Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX; Institute for Urology and Reproductive Health, Sechenov University, Moscow.

Introduction: Neoadjuvant chemotherapy (NAC) is increasingly used prior to radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). Systemic recurrence (SR) carries a dismal prognosis. We sought to determine risk factors associated with SR in this setting. Read More

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Implementation of an older adult epilepsy clinic utilizing pharmacist services.

J Am Pharm Assoc (2003) 2021 Jul 10. Epub 2021 Jul 10.

Background: Antiseizure medications are commonly associated with adverse effects including behavioral and cognitive issues, drug interactions, idiosyncratic reactions, and long-term complications, which can lead to non-adherence. At the same time, there are limited reports describing multidisciplinary models of epilepsy care that include pharmacists.

Objective: To describe the pharmacist services in an epilepsy clinic for older adults and document the patient care delivered using this design. Read More

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Is Dislocation Risk due to Posterior Pelvic Tilt Reduced With Direct Anterior Approach Total Hip Arthroplasty?

J Arthroplasty 2021 Jul 14. Epub 2021 Jul 14.

W.B. Carrell Memorial Clinic, Adult Hip and Knee Reconstruction, Dallas, TX; Department of Orthopaedic Surgery, Texas Health Presbyterian Hospital Dallas, Dallas, TX.

Background: Pelvic tilt affects acetabular anteversion, and thus total hip arthroplasty (THA) dislocation risk. The pubic symphysis-sacrococcygeal distance (PSCD) is an indicator of pelvic tilt, and a PSCD < 0 mm (ie, excessive posterior pelvic tilt) is associated with a 3.7-fold increase in postoperative dislocation rate. Read More

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Combination of Thigh Circumference and Indices of Central Obesity Helps Predict Incident Chronic Kidney Disease: A 14-Year Prospective Cohort Study Using a Three-Dimensional Body Laser Scanner.

J Ren Nutr 2021 Jul 27. Epub 2021 Jul 27.

Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan; Laboratory for Epidemiology, Department of Health Care Management, Chang Gung University, Taoyuan, Taiwan; Department of Emergency Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan; Research Center for Food and Cosmetic Safety, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan; Department of Safety, Health and Environmental Engineering, Ming Chi University of Technology, Taipei, Taiwan. Electronic address:

Objective: Obesity, high body mass index, and visceral fat accumulation are associated with renal diseases. However, the association between body measurements and chronic kidney disease (CKD) is still unclear.

Methods: A cohort of 7,825 participants scheduled for follow-up of CKD was recruited from 2000 to 2008 in Taiwan. Read More

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Clinical guide to perioperative management for videothoracoscopy lung resection (Section of Cardiac, Vascular and Thoracic Anesthesia, SEDAR; Spanish Society of Thoracic Surgery, SECT; Spanish Society of Physiotherapy).

Rev Esp Anestesiol Reanim 2021 Jul 27. Epub 2021 Jul 27.

Sección de Anestesia Cardiaca, Vascular y Torácica, SEDAR, Anestesiología, Reanimación y T. Dolor. Hospital Universitario La Fe de Valencia, Universitat de València, Valencia, España.

The introduction of video-assisted thoracoscopic (VATS) techniques has led to a new approach in thoracic surgery. VATS is performed by inserting a thoracoscope through a small incisions in the chest wall, thus maximizing the preservation of muscle and tissue. Because of its low rate of morbidity and mortality, VATS is currently the technique of choice in most thoracic procedures. Read More

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Malnutrition screening in head and neck cancer patients with oropharyngeal dysphagia.

Clin Nutr ESPEN 2021 Aug 31;44:348-355. Epub 2021 May 31.

Department of Otorhinolaryngology, Head and Neck Surgery, Maastricht University Medical Center, P.O. Box 5800, 6202, AZ, Maastricht, the Netherlands; School for Oncology and Developmental Biology - GROW, Maastricht University Medical Center, Maastricht, the Netherlands.

Background & Aims: Malnutrition in head and neck cancer (HNC) patients is associated with increased morbidity and mortality. The purpose of this study is two-fold: to identify the risk of malnutrition in patients with oropharyngeal dysphagia (OD) secondary to HNC, and to determine the relationship between the risk of malnutrition versus tumor characteristics, treatment modality, time interval (between the end of oncological treatment and swallowing assessment date), level of oral intake, body mass index (BMI), aspiration, pharyngeal pooling, and OD-related quality of life (QoL).

Methods: The Short Nutritional Assessment Questionnaire (SNAQ) was used to screen patients for the risk of malnutrition. Read More

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Efficacy of adipose tissue-derived stem cells in locomotion recovery after spinal cord injury: a systematic review and meta-analysis on animal studies.

Syst Rev 2021 Jul 31;10(1):213. Epub 2021 Jul 31.

Physiology Research Center, Iran University of Medical Sciences, Hemmat Highway, P.O Box: 14665-354, Tehran, Iran.

Background: Considerable disparities exist on the use of adipose tissue-derived stem cells (ADSCs) for treatment of spinal cord injury (SCI). Hence, the current systematic review aimed to investigate the efficacy of ADSCs in locomotion recovery following SCI in animal models.

Methods: A search was conducted in electronic databases of MEDLINE, Embase, Scopus, and Web of Science until the end of July 2019. Read More

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Novel method of real-time PCR-based screening for common fetal trisomies.

BMC Med Genomics 2021 Jul 30;14(1):195. Epub 2021 Jul 30.

Department of Obstetrics and Gynecology, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Korea.

Background: The non-invasive prenatal test (NIPT) is based on next generation sequencing (NGS) and is used for screening for fetal trisomy. However, it is time-consuming and technically difficult. Recently, peptide nucleic acid (PNA) probe-based real-time polymerase chain reaction (RT-PCR) was developed. Read More

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The 30-days hospital readmission risk in diabetic patients: predictive modeling with machine learning classifiers.

BMC Med Inform Decis Mak 2021 Jul 30;21(Suppl 2):57. Epub 2021 Jul 30.

Department of Medical Informatics, Medical School of Nantong University, 19 Qixiu Road, Nantong, 226001, Jiangsu, People's Republic of China.

Background And Objectives: Diabetes mellitus is a major chronic disease that results in readmissions due to poor disease control. Here we established and compared machine learning (ML)-based readmission prediction methods to predict readmission risks of diabetic patients.

Methods: The dataset analyzed in this study was acquired from the Health Facts Database, which includes over 100,000 records of diabetic patients from 1999 to 2008. Read More

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Utilization of ECMO in vascular surgery: A presentation of two cases.

Int J Surg Case Rep 2021 Jun 29;85:106141. Epub 2021 Jun 29.

Department of Surgery, Division of Vascular Surgery, Mayo Clinic, Jacksonville, FL, USA. Electronic address:

Introduction: Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is a form of temporary mechanical circulatory support commonly used during cardiothoracic interventions. Malperfusion during complex vascular procedures remains a significant risk that may potentially lead to multiple complications. Here, we report two cases highlighting the efficacy of VA-ECMO in both planned and emergent vascular interventions. Read More

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Are We Underestimating the Morbidity of Single Rib Fractures?

J Surg Res 2021 Jul 27;268:174-180. Epub 2021 Jul 27.

Department of Surgery, Division of Thoracic and Esophageal Surgery, University Hospitals Cleveland Medical Center, Cleveland, Ohio 44106; Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106.

Purpose: Previous studies suggest that patients with multiple rib fractures have poor outcomes, but it is unknown how isolated single rib fractures (SRF) are associated with morbidity or mortality. We hypothesized that patients with poor outcomes after SRF can be identified by demographics and comorbidities. The purpose of this study was to model adverse outcome after single rib fractures. Read More

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Genetic errors of immunity distinguish pediatric non-malignant lymphoproliferative disorders.

J Allergy Clin Immunol 2021 Jul 27. Epub 2021 Jul 27.

Department of Pediatrics, Baylor College of Medicine, Houston, TX; Department of Pediatrics, Texas Children's Hospital, Houston, TX; Division of Pediatric Hematology/Oncology, Texas Children's Hospital Cancer Center, Houston, TX. Electronic address:

Background: Pediatric non-malignant lymphoproliferative disorders (PLPD) are clinically and genetically heterogeneous. Long-standing immune dysregulation and lymphoproliferation in children may be life-threatening, and a paucity of data exists to guide evaluation and treatment of children with PLPD.

Objective: The primary objective of this study was to ascertain the spectrum of genomic immunologic defects in PLPD. Read More

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Doxycycline for community treatment of suspected COVID-19 in people at high risk of adverse outcomes in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial.

Lancet Respir Med 2021 Jul 27. Epub 2021 Jul 27.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

Background: Doxycycline is often used for treating COVID-19 respiratory symptoms in the community despite an absence of evidence from clinical trials to support its use. We aimed to assess the efficacy of doxycycline to treat suspected COVID-19 in the community among people at high risk of adverse outcomes.

Methods: We did a national, open-label, multi-arm, adaptive platform randomised trial of interventions against COVID-19 in older people (PRINCIPLE) across primary care centres in the UK. Read More

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Pulse therapy with vincristine and dexamethasone for childhood acute lymphoblastic leukaemia (CCCG-ALL-2015): an open-label, multicentre, randomised, phase 3, non-inferiority trial.

Lancet Oncol 2021 Jul 27. Epub 2021 Jul 27.

Department of Hematology/Oncology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, National Health Committee Key Laboratory of Pediatric Hematology & Oncology, Shanghai, China.

Background: Vincristine plus dexamethasone pulses are generally used throughout maintenance treatment for childhood acute lymphoblastic leukaemia. However, previous studies remain inconclusive about the benefit of this maintenance therapy and the absence of randomised, controlled trials in patients with low-risk or high-risk acute lymphoblastic leukaemia provides uncertainty. We therefore aimed to determine if this therapy could be safely omitted beyond 1 year of treatment without leading to an inferior outcome in any risk subgroup of childhood acute lymphoblastic leukaemia. Read More

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