88,244 results match your criteria high-frequency


Clinicopathological insight into self-reported hair loss with no findings: How do we manage this enigmatic condition?

J Dermatol 2021 Jun 12. Epub 2021 Jun 12.

Department of Dermatology, Faculty of Medicine, Kyorin University, Tokyo, Japan.

Patients who complain of hair loss without any supportive findings can be encountered in daily practice. To provide insight into this embarrassing condition, we retrospectively reviewed medical charts of eight cases with self-reported hair loss with no findings (SHLNOF). High frequency in middle aged women and concomitance of thyroid and gynecological problems were revealed. Read More

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High frequency of bone recurrence as an initial recurrence site after radical surgery in T1N3 gastric cancer: a propensity score matching analysis.

Langenbecks Arch Surg 2021 Jun 11. Epub 2021 Jun 11.

Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Purpose: T1 gastric cancer (GC) with seven or more metastatic lymph nodes is extremely rare, and very few clinical studies have been conducted to evaluate the clinicopathological features of their recurrence.

Methods: We retrospectively analyzed the outcomes of T1 GC and T2-4 GC patients who had multiple nodal metastases after radical surgery from 2006 to 2020. Propensity score matching was performed to compare the two groups of patients. Read More

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Hysteroscopy-assisted laparoscopic salpingectomy for interstitial pregnancy without cornual resection.

Fertil Steril 2021 Jun 8. Epub 2021 Jun 8.

Reproductive Biology Associates, Atlanta, Georgia.

Objective: To illustrate a novel surgical management technique for interstitial ectopic pregnancies (IP).

Design: Video description of the case, demonstration of the surgical technique, reevaluation at the 6-week postoperative follow-up, and review of the advantages of this surgical technique for IP.

Setting: Tertiary referral center. Read More

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Legalization of cannabis use in Canada: Impacts on the cannabis use profiles of youth seeking services for substance use.

J Subst Abuse Treat 2021 Jul 25;126:108340. Epub 2021 Feb 25.

Margaret and Wallace McCain Centre for Child, Youth and Family Mental Health, Centre for Addiction and Mental Health, Toronto, Canada; Department of Psychiatry, University of Toronto, Toronto, Canada. Electronic address:

Background: Cannabis is a highly used substance among youth, but has the potential to negatively impact the developing brain. Recreational cannabis use was legalized in Canada in October 2018. This exploratory study examines cannabis use profiles of high-risk youth before and after the national legalization of recreational cannabis use. Read More

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Chlamydia pecorum detection in aborted and stillborn lambs from Western Australia.

Vet Res 2021 Jun 11;52(1):84. Epub 2021 Jun 11.

Centre for Animal Production and Health, Murdoch University, South Street, Murdoch, WA, 6150, Australia.

Lamb survival is an important welfare and productivity issue for sheep industries worldwide. Lower lamb survival has been reported for primiparous ewes, but the causes of this are not well studied. The aim of this study was to determine causes of perinatal deaths for lambs born to primiparous ewes in Western Australia, and identify if infectious diseases are implicated. Read More

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Genotype-structurotype-phenotype correlations in pachyonychia congenita patients.

J Invest Dermatol 2021 Jun 8. Epub 2021 Jun 8.

Department of Dermatology, Stanford University, Palo Alto, CA. Electronic address:

Pachyonychia congenita (PC) is a genetic disorder of keratin that presents with nail dystrophy, painful palmoplantar keratoderma, and other clinical manifestations. We investigated genotype-structurotype-phenotype correlations seen with mutations in keratin genes (KRT6A, KRT6B, KRT6C, KRT16, KRT17) and utilized protein structure modeling of high frequency mutations to examine the functional importance of keratin structural domains in PC pathogenesis. Participants of the International PC Research Registry underwent genetic testing and completed a standardized survey on their symptoms. Read More

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Acceptance and commitment therapy for high frequency episodic migraine without aura: Findings from a randomized pilot investigation.

Headache 2021 Jun 11. Epub 2021 Jun 11.

UO Neurologia Salute Pubblica e Disabilità, Fondazione IRRCS Istituto Neurologico Carlo Besta, Milano, Italy.

Objective: We compared the incremental effects of adding acceptance and commitment therapy (ACT) to pharmacological treatment as usual (TAU) in a sample of patients with high frequency episodic migraine without aura (HFEM), assessing impact on a spectrum of measures across multiple domains.

Background: Patients with HFEM are at risk of developing chronic migraine and medication overuse headache. ACT has been shown to be effective for the treatment of various chronic pain conditions, but little attention has been given to its therapeutic value in the management of recurring headaches. Read More

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Changes in High-Frequency Intracardiac Electrogram Indicate Cardiac Ischemia.

J Cardiovasc Transl Res 2021 Jun 11. Epub 2021 Jun 11.

Department of Cardiology, Shaare Zedek Medical Center, Jerusalem, Israel.

High-frequency QRS (HFQRS) analysis of surface ECG is a reliable marker of cardiac ischemia (CI). This study aimed to assess the response of HFQRS signals from standard intracardiac electrodes (iHFQRS) to CI in swine and compare them with conventional ST-segment deviations. Devices with three intracardiac leads were implanted in three swine in a controlled environment. Read More

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Interspecific hybridization between Ganoderma lingzhi and G. applanatum through protoplast fusion.

World J Microbiol Biotechnol 2021 Jun 11;37(7):114. Epub 2021 Jun 11.

Mushroom Research Division, National Institute of Horticultural & Herbal Science, RDA, Chungbuk, Eumseong, 27709, South Korea.

Interspecific hybridization between Ganoderma lingzhi and G. applanatum was attempted through polyethylene glycol (PEG) induced fusion technique. The protoplast isolation procedure was simplified, and we obtained a significant number of protoplasts from both Ganoderma species. Read More

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Effect of Textual Features on the Success of Medical Crowdfunding: Model Development and Econometric Analysis from the Tencent Charity Platform.

J Med Internet Res 2021 Jun 11;23(6):e22395. Epub 2021 Jun 11.

School of Management, Hainan University, Haikou, Hainan, China.

Background: Medical crowdfunding utilizes the internet to raise medical funds. Medical crowdfunding has developed rapidly worldwide; however, most medical crowdfunding projects fail to raise the targeted funds. Therefore, a very important research problem that has not received sufficient attention from the existing literature is identifying which factors affect the success of medical crowdfunding projects. Read More

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Application of frequentist and Bayesian models with extensive but low-resolution data to assess status of endangered Athabasca River rainbow trout.

Conserv Biol 2021 Jun 11. Epub 2021 Jun 11.

Department of Zoology, Biodiversity Research Centre and Beaty Biodiversity Museum, University of British Columbia, 6270 University Boulevard, Vancouver, British Columbia, V6T 1Z4, Canada.

Use of extensive but low-resolution abundance data is common in the assessment of species at-risk status using quantitative decline criteria under IUCN and national endangered species legislation. Such data can be problematic for three reasons. First, statistical power to reject the null hypothesis of no change is often low because of small sample size and high sampling uncertainty leading to a high frequency of type II errors. Read More

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Engineering of stealth (maghemite/PLGA)/chitosan (core/shell)/shell nanocomposites with potential applications for combined MRI and hyperthermia against cancer.

J Mater Chem B 2021 Jun 11. Epub 2021 Jun 11.

Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, Granada, Spain. and Institute of Biopathology and Regenerative Medicine (IBIMER), Center of Biomedical Research (CIBM), University of Granada, Granada, Spain and Biosanitary Research Institute of Granada (ibs.GRANADA), Andalusian Health Service (SAS), University of Granada, Granada, Spain.

(Maghemite/poly(d,l-lactide-co-glycolide))/chitosan (core/shell)/shell nanoparticles have been prepared reproducibly by nanoprecipitation solvent evaporation plus coacervation (production performance ≈ 45%, average size ≈ 325 nm). Transmission electron microscopy, energy dispersive X-ray spectroscopy, electrophoretic determinations, and X-ray diffraction patterns demonstrated the satisfactory embedment of iron oxide nanocores within the solid polymer matrix and the formation of an external shell of chitosan in the nanostructure. The adequate magnetic responsiveness of the nanocomposites was characterized in vitro by hysteresis cycle determinations and by visualization of the nanosystem under the influence of a 0. Read More

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Endoscopic Endonasal and Supraorbital Removal of Tuberculum Sellae Meningiomas: Anatomic Guides and Operative Nuances for Keyhole Approach Selection.

Oper Neurosurg (Hagerstown) 2021 Jun 10. Epub 2021 Jun 10.

Pacific Neuroscience Institute, Santa Monica, California, USA.

Background: With growing worldwide endoscopy experience, endonasal and supraorbital removal of tuberculum sellae meningiomas (TSM) has increased.

Objective: To describe anatomic factors for guiding approach selection and outcomes.

Methods: Retrospective analysis of patients undergoing endonasal or supraorbital TSM resection: approach criteria, clinical outcomes, acute magnetic resonance imaging (MRI) fluid-attenuated inversion-recovery (FLAIR)/T2 changes. Read More

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Acupuncture at the auricular branch of the vagus nerve enhances heart rate variability in humans: An exploratory study.

Heart Rhythm O2 2020 Aug 9;1(3):215-221. Epub 2020 Jun 9.

Department of Cardiology, St. Josefs-Hospital Wiesbaden, Wiesbaden, Germany.

Background: Recent animal and human studies have shown antiarrhythmic effects inhibiting inducibility of atrial fibrillation through low-level transcutaneous electrical stimulation at the auricular branch of the vagus nerve (ABVN).

Objective: The present study investigated effects of acupuncture at the ABVN on the autonomic cardiac nervous system in humans through analysis of heart rate and heart rate variability (HRV) parameters.

Methods: We enrolled 24 healthy male volunteers and compared acupuncture at the ABVN to placebo-acupuncture performed at the Ma-35 point (an acupuncture point used in traditional Chinese medicine to treat pain caused by gonarthrosis). Read More

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Decreased anxiety after catheter ablation for paroxysmal atrial fibrillation is associated with augmented parasympathetic reactivity to stress.

Heart Rhythm O2 2020 Aug 10;1(3):189-199. Epub 2020 Jun 10.

Department of Psychiatry, Shizuoka Saiseikai General Hospital, Shizuoka, Japan.

Background: Psychological improvement after catheter ablation for atrial fibrillation (AF) has been reported, but its mechanism is unclear.

Objective: This study aimed to clarify the relationship between cardiac autonomic modification and psychological changes after catheter ablation for paroxysmal AF (PAF).

Methods: Thirty-five consecutive patients (60. Read More

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Perceived Time, Frequency, and Intensity of Engagement and Older Masters Athletes' Subjective Experiences.

Front Sports Act Living 2021 25;3:653590. Epub 2021 May 25.

School of Kinesiology, Faculty of Health Sciences, Western University, London, ON, Canada.

Masters athletes are a unique group of older adults whose experiences may provide valuable insights into the role of sport for successful aging. The purpose of this study was to explore whether masters athletes' social and psychological experiences vary with their time, frequency, and perceived exertion in training and competition. Semi-structured interviews were conducted with 40 men and women older masters athletes, aged 50-79 years (M = 66), who were active at the competitive level across a variety of sports (e. Read More

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Study on the file management method of data storage system for airborne radar.

R Soc Open Sci 2021 Jun 9;8(6):210221. Epub 2021 Jun 9.

School of Physics and Electronics, Hunan Normal University, Changsha 410081, People's Republic of China.

In order to solve the problem that the air-to-ground data transfer rate is much lower than the radar data rate, the onboard system is commonly used for storing the airborne radar data. However, there are two main problems in the data storage using the traditional file management method. The first is that the frequent data updating of the file allocation table (FAT) and the file directory table (FDT) cause a high frequency of address jumps among the discontinuous areas, which leads to a long response time. Read More

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Prediction of Successful Memory Encoding Based on Lateral Temporal Cortical Gamma Power.

Front Neurosci 2021 25;15:517316. Epub 2021 May 25.

Department of Brain and Cognitive Sciences, Seoul National University, Seoul, South Korea.

Prediction of successful memory encoding is important for learning. High-frequency activity (HFA), such as gamma frequency activity (30-150 Hz) of cortical oscillations, is induced during memory tasks and is thought to reflect underlying neuronal processes. Previous studies have demonstrated that medio-temporal electrophysiological characteristics are related to memory formation, but the effects of neocortical neural activity remain underexplored. Read More

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Updated Review on the Diagnosis and Primary Management of Psychogenic Nonepileptic Seizure Disorders.

Neuropsychiatr Dis Treat 2021 4;17:1825-1838. Epub 2021 Jun 4.

Buenos Aires University, Ramos Mejía Hospital, Epilepsy Center, Buenos Aires, Argentina.

Psychogenic nonepileptic seizures (PNES) are paroxystic and episodic events associated with motor, sensory, mental or autonomic manifestations, which resemble epileptic seizures (ES), but are not caused by epileptogenic activity. PNES affect between 20% and 30% of patients attending at epilepsy centers and constitute a serious mental health problem. PNES are often underdiagnosed, undertreated and mistaken with epilepsy. Read More

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High-frequency burst spiking in layer 5 thick-tufted pyramids of rat primary somatosensory cortex encodes exploratory touch.

Commun Biol 2021 Jun 10;4(1):709. Epub 2021 Jun 10.

Max Planck Institute for Neurobiology, Martinsried, Germany.

Diversity of cell-types that collectively shape the cortical microcircuit ensures the necessary computational richness to orchestrate a wide variety of behaviors. The information content embedded in spiking activity of identified cell-types remain unclear to a large extent. Here, we recorded spike responses upon whisker touch of anatomically identified excitatory cell-types in primary somatosensory cortex in naive, untrained rats. Read More

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Observation of a prethermal discrete time crystal.

Science 2021 06;372(6547):1192-1196

Joint Quantum Institute, Department of Physics, and Joint Center for Quantum Information and Computer Science, University of Maryland, College Park, MD 20742, USA.

Extending the framework of statistical physics to the nonequilibrium setting has led to the discovery of previously unidentified phases of matter, often catalyzed by periodic driving. However, preventing the runaway heating that is associated with driving a strongly interacting quantum system remains a challenge in the investigation of these newly discovered phases. In this work, we utilize a trapped-ion quantum simulator to observe the signatures of a nonequilibrium driven phase without disorder-the prethermal discrete time crystal. Read More

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Managing high frequency users of an electronic consultation system in primary care: a quality improvement project.

BMJ Open Qual 2021 Jun;10(2)

Whitechapel Health Centre, London, UK.

The COVID-19 pandemic prompted a rapid change in primary care provision. There was a significant shift from face-to-face appointments to remote methods such as electronic consultation (e-consultation). Patients from a primary care provider in London were actively encouraged to use an online consultation platform called 'Dr iQ'. Read More

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Selection of transcripts related to low-temperature tolerance using RNA sequencing from F2 plants between japonica and indica rice (Oryza sativa L.) cultivars.

Funct Plant Biol 2021 Jun 11. Epub 2021 Jun 11.

At low temperatures (18°C), seedlings of an indica rice (Oryza sativa L.) cultivar Kasalath showed symptoms of chlorosis, although the leaves of a japonica cultivar Arroz da Terra remained green. In this study, transcripts related to the chlorophyll content of rice seedlings grown at 18°C were investigated using RNA-sequencing (RNA-Seq) data for F2 crosses between cultivars Arroz da Terra and Kasalath, as well as their parental cultivars. Read More

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[Visual analysis of research on multidrug-resistant bacteria in intensive care unit in China].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 May;33(5):587-592

Department of Intensive Care Unit, Taian City Central Hospital, Taian 271000, Shandong, China.

Objective: To identify the distribution of research hotspots and frontiers of multidrug-resistant bacteria in intensive care units in China through the method of visualization, and to predict future research directions, analyze the research development process, so as to provide reference basis for further research in this field.

Methods: Studies related to multidrug-resistant bacteria in intensive care units published in China from 2000 to 2019 by CNKI were reviewed. According to the keywords by CiteSpace 5. Read More

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Nanobiomechanical behavior of [email protected] [email protected] over HeLa cells interfaces.

Nanotechnology 2021 Jun 10. Epub 2021 Jun 10.

Centro de Investigacion en computation del Instituto Politecnico Nacional, Mexico City, MEXICO.

In this work, we studied the impact of magnetic nanoparticles (MNPs) interactions with HeLa cells when they are exposed to high frequency alternating magnetic field (AMF). Specifically, we measured the nanobiomechanical properties of cell interfaces by using Atomic Force Microscopy (AFM). The Magnetite (FeO) MNPs were synthesized by coprecipitation and encapsulated with silica (SiO): [email protected] functionalized with amino groups (-NH): [email protected], by sonochemical processing. Read More

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Euglobulin clot lysis time reveals a high frequency of fibrinolytic activation in trauma.

Thromb Res 2021 May 31;204:22-28. Epub 2021 May 31.

Division of Hematology, Department of Medicine and Blood Research Center, University of North Carolina, Chapel Hill, NC, USA. Electronic address:

Activation of the fibrinolytic system plays a central role in the host response to trauma. There is significant heterogeneity in the degree of fibrinolysis activation at baseline that is usually assessed by whole blood thromboelastography (TEG). Few studies have focused on plasma markers of fibrinolysis that could add novel insights into the frequency and mechanisms of fibrinolytic activation in trauma. Read More

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Further Delineation of the Clinical and Pathologic Features of HIKESHI-Related Hypomyelinating Leukodystrophy.

Pediatr Neurol 2021 May 14;121:11-19. Epub 2021 May 14.

Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

Background: A recurrent homozygous missense variant, c.160G>C;p.(Val54Leu) in HIKESHI, was found to cause a hypomyelinating leukodystrophy with high frequency in the Ashkenazi Jewish population. Read More

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Specific activation of GluN1-N2B NMDA receptors underlies facilitation of cortical spreading depression in a genetic mouse model of migraine with reduced astrocytic glutamate clearance.

Neurobiol Dis 2021 Jun 7:105419. Epub 2021 Jun 7.

Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy; Padova Neuroscience Center, University of Padova, CNR Institute of Neuroscience, 35131 Padova, Italy. Electronic address:

Migraine is a common but poorly understood sensory circuit disorder. Mouse models of familial hemiplegic migraine (FHM, a rare monogenic form of migraine with aura) show increased susceptibility to cortical spreading depression (CSD, the phenomenon that underlies migraine aura and can activate migraine headache mechanisms), allowing an opportunity to investigate the mechanisms of CSD and migraine onset. In FHM type 2 (FHM2) knock-in mice with reduced expression of astrocytic Na, K-ATPases, the reduced rate of glutamate uptake into astrocytes can account for the facilitation of CSD initiation. Read More

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