Front Cardiovasc Med 2021 28;8:654670. Epub 2021 May 28.
The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Atherosclerosis is closely associated with proliferation of the adventitial vasa vasorum, leading to the atherosclerotic plaque progression and vulnerability. In this report, we investigated the role of Ginsenoside Rb (Rb) on atherosclerotic plaque stabilization and adventitial vasa vasorum (VV) along with the mechanisms involved. Apolipoprotein E-deficient (ApoE) mice were fed with a high-fat diet for 20 weeks, and then Ginsenoside Rb (50 mg/kg/d, intraperitoneal) was given for 4 weeks. Read More