577,440 results match your criteria high level


Mechanisms of Soft Tissue Injury.

Facial Plast Surg 2021 May 14. Epub 2021 May 14.

Department of Otolaryngology, Head and Neck Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.

Soft tissue trauma to the face is challenging to manage due to functional and aesthetic concerns. Management requires careful regional considerations to maintain function such as visual fields and oral competence in periorbital and perioral injuries, respectively. Basic wound management principles apply to facial soft tissue injuries including copious irrigation and tension-free closure. Read More

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A qualitative trajectory analysis of patients' experiences tapering opioids for chronic pain.

Pain 2021 May 10. Epub 2021 May 10.

Pain Management Research Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia. School of Medicine and Public Health, University of Newcastle, NSW, Australia.

Abstract: Tapering opioids for chronic pain can be challenging for both patients and prescribers, both of whom may be unsure of what to expect in terms of pain, distress, activity interference, and withdrawal symptoms over the first few weeks and months of the taper. In order to better prepare clinicians to provide patient-centred tapering support, the current research used prospective longitudinal qualitative methods to capture individual-level variation in patients' experience over the first few months of a voluntary physician-guided taper. The research aimed to identify patterns in individuals' experience of tapering, and explore whether patient characteristics, readiness to taper, opioid-tapering self-efficacy, or psychosocial context were related to tapering trajectory. Read More

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Educational level and colorectal cancer risk: the mediating roles of lifestyle and dietary factors.

Eur J Cancer Prev 2021 May 7. Epub 2021 May 7.

Department of Epidemiology, School of Public Health, Sun Yat-sen University Department of Colorectal Surgery, Department of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.

Objective: The association between the educational level and colorectal cancer risk was controversial in developed countries and evidence was limited in Chinese population. This study aimed to investigate the association between the educational level and colorectal cancer risk in Guangdong Province, China.

Methods: From July 2010 to April 2019, 2502 newly diagnosed colorectal cancer patients and 2538 sex- and age-matched controls were recruited in this case-control study. Read More

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Patient satisfaction with partial hospital telehealth treatment during the COVID-19 pandemic: Comparison to in-person treatment.

Psychiatry Res 2021 Apr 26;301:113966. Epub 2021 Apr 26.

From the Department of Psychiatry and Human Behavior, Brown Medical School, and the Department of Psychiatry, Rhode Island Hospital, 146 West River Street, Providence, RI 02904.

Most research evaluating telehealth psychiatric treatment has been conducted in outpatient settings. There is a lack of research assessing the efficacy of telehealth treatment in more acute, intensive treatment settings such as a partial hospital. In the face of the COVID-19 pandemic, much of ambulatory behavioral health treatment has transitioned to a telehealth, or virtual, format. Read More

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Screen-printed analytical strip constructed with bacteria-templated porous N-doped carbon nanorods/Au nanoparticles for sensitive electrochemical detection of dopamine molecules.

Biosens Bioelectron 2021 May 6;186:113303. Epub 2021 May 6.

Institute of Materials Science and Devices, School of Materials Science and Engineering, Suzhou University of Science and Technology, Suzhou, 215011, China; Institute for Clean Energy and Advanced Materials, Southwest University, Chongqin, 400715, China; Institute of Advanced Cross-field Science, Qingdao University, Qingdao, 266071, PR China. Electronic address:

Dopamine (DA) as an important neurotransmitter plays an important role in physiological activities, and its abnormal level can cause diseases such as Parkinson's disease. However, the clinical analysis of DA mainly relies on time-consuming and expensive liquid chromatography and molecular spectrometer. We present here a design and fabrication of inexpensive strip sensor constructed from screen printed electrodes for sensitive and selective detection of DA. Read More

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Development of a noninvasive HIFU treatment for breast adenocarcinomas using a toroidal transducer based on preliminary attenuation measurements.

Ultrasonics 2021 May 9;115:106459. Epub 2021 May 9.

LabTAU, INSERM, Centre Léon Bérard, Université Lyon 1, Univ Lyon, F-69003 Lyon, France. Electronic address:

Breast cancer is the most commonly diagnosed type of cancer among women. For the last fifteen years, treatments that are less invasive than lumpectomy, such as high-intensity focused ultrasound (HIFU) therapy, have been developed, with encouraging results. In this study, a toroidal HIFU transducer was used to create lesions of at least 2 cm in diameter within less than one minute of treatment. Read More

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CD94 expression patterns in reactive and neoplastic T-cell and NK-cell proliferations.

Leuk Res 2021 May 10;108:106614. Epub 2021 May 10.

Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

Lymphomas and leukemias of T-cell and NK-cell lineages are highly heterogeneous disorders and lack effective therapeutic strategies. Targeted therapies including anti-CD94 agents are currently under clinical investigation, but studies of CD94 expression on mature T/NK-cell neoplasms are limited. In this study, we investigated the landscape of CD94 protein expression in 15 patients with reactive T/NK-cell proliferations and 124 patients with various T/NK cell neoplasms. Read More

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Optimization of a Screening Method for Macroprolactinemia.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 Apr 25;1175:122723. Epub 2021 Apr 25.

Department of Clinical Laboratory, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, 310014, China. Electronic address:

Objective: To optimize a screening method for macroprolactinemia and improve the accuracy of free prolactin (freePRL) detection.

Method: Overall efficiency, calculated as the product of the immunoglobulin G (IgG) precipitation rate and the freePRL recovery rate were employed to determine the concentration of the precipitant polyethylene glycol (PEG). Then, an optimized screening method for macroprolactinemia was established. Read More

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What is Known About Burns in East Africa? A Scoping Review.

J Surg Res 2021 May 11;266:113-124. Epub 2021 May 11.

Program in Global Surgery and Social Change, Harvard Medical School, Boston, Massachusetts; Department of Hand Surgery, Plastic Surgery and Burns, and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.

Background: Burns are a global public health concern, with the majority of the disease burden affecting low- and middle-income countries. Yet, as suggested by previous publications, there is a widespread belief that literature about burns in low- and middle-income countries is lacking. Therefore, we aimed to assess with a scoping review, the extent of the literature output on burns in East Africa, and to investigate patient demographics, injury characteristics, treatment and outcomes, as reported from the existing publications. Read More

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Effector-independent brain network for auditory-motor integration: fMRI evidence from singing and cello playing.

Neuroimage 2021 May 11:118128. Epub 2021 May 11.

BRAMS International Laboratory for Brain, Music, and Sound Research, Montreal, QC, Canada; Centre for Interdisciplinary Research in Music Media and Technology, Montreal, QC, Canada; Department of Psychology, Concordia University, Montreal, QC, Canada. Electronic address:

Many everyday tasks share high-level sensory goals but differ in the movements used to accomplish them. One example of this is musical pitch regulation, where the same notes can be produced using the vocal system or a musical instrument controlled by the hands. Cello playing has previously been shown to rely on brain structures within the singing network for performance of single notes, except in areas related to primary motor control, suggesting that the brain networks for auditory feedback processing and sensorimotor integration may be shared (Segado et al. Read More

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Effect of synbiotic supplementation on migraine characteristics and inflammatory biomarkers in women with migraine: results of a randomised controlled trial.

Pharmacol Res 2021 May 11:105668. Epub 2021 May 11.

Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences. Electronic address:

Literature suggests a relationship between gut microbiome and migraine headache pathogenesis. However, the effect of manipulating gut microbiome on migraine remains unclear. This study aimed to investigate the effect of synbiotics on migraine characteristics and inflammatory markers in women with migraine. Read More

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Molecular Docking and Dynamic Studies of a Potential Therapeutic Target Inhibiting Glyoxalase System: metabolic action of the 3, 3 '- [3- (5-chloro-2-hydroxyphenyl) -3-oxopropane-1, 1-diyl] - bis-4-hydroxycoumarin leads overexpression of the intracellular level of methylglyoxal and induction of a pro-apoptotic phenomenon in a hepatocellular carcinoma model.

Chem Biol Interact 2021 May 11:109511. Epub 2021 May 11.

QOPNA, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal. Electronic address:

Methylglyoxal is a dicarbonyl compound recruited as a potential cytotoxic marker, initially presents in cells and considered as a metabolite of the glycolytic pathway. Our aim is to demonstrate the inhibitory effect of 3, 3'-[3-(5-chloro-2-hydroxyphenyl)-3-oxopropane-1, 1-diyl] Bis (4-hydroxycoumarin) on the glyoxalase system, and indirectly its anticancer activity. The docking of OT-55 was conducted by using Flexible docking protocol, ChiFlex and libdock tools inside the active site of Glo-I indicated that both hydrogen bonding and hydrophobic interactions contributed significantly in establishing potent binding with the active site which is selected as a strong inhibitor with high scoring values and maximum Gibbs free energy. Read More

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Body fluid matrix effect evaluation on the Hitachi Labospect 008 system.

Clin Biochem 2021 May 11. Epub 2021 May 11.

Department of Laboratory Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address:

Background: Non-standard body fluids (NSBFs) can provide essential clinical information otherwise unobtainable with conventional biological specimens. However, as most commercial chemistry reagents are only validated for serum, plasma, and urine by manufacturers, individual laboratories have to validate testing with NSBF to comply with regulatory standards. However, the heightened level of oversight and uncertainty of validation requirements to comply with regulatory standards pose a significant challenge for NSBF testing in clinical laboratories. Read More

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Genetically identified neurons in avian auditory pallium mirror core principles of their mammalian counterparts.

Curr Biol 2021 May 10. Epub 2021 May 10.

Neuroscience and Behavior, Center for Neuroendocrine Studies, University of Massachusetts, Amherst, MA 01003, USA. Electronic address:

In vertebrates, advanced cognitive abilities are typically associated with the telencephalic pallium. In mammals, the pallium is a layered mixture of excitatory and inhibitory neuronal populations with distinct molecular, physiological, and network phenotypes. This cortical architecture is proposed to support efficient, high-level information processing. Read More

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Extended Retrosigmoid Craniotomy and Approach Through the Glossopharyngeal Cochlear Triangle for Clipping of a High-Riding Vertebral-Posterior Inferior Cerebellar Artery Aneurysm: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2021 May 14. Epub 2021 May 14.

Department of Neurosurgery, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.

The far lateral transcondylar (FL) craniotomy is the standard approach for posterior inferior cerebellar artery (PICA) aneurysm exposure through microsurgical dissection in the vagoaccessory triangle (VAT).1,2 However, the extended retrosigmoid (eRS) craniotomy and dissection through the glossopharyngeal-cochlear triangle (GCT) may be more appropriate when the patient has an aneurysm arising from a high-riding vertebral artery (VA)-PICA origin.3-5 We present a case of a 41-yr-old woman with hypertension presenting with left occipital pain and left-side hearing loss and past facial spasm and pain. Read More

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Hospital frailty risk score and adverse health outcomes: evidence from longitudinal record linkage cardiac data.

Age Ageing 2021 May 15. Epub 2021 May 15.

Centre for Applied Health Economics, Griffith University, Level 1-2, N78, 170 Kessels Rd. Nathan QLD 4111, Australia.

Background: Despite recent evidence on the effect of frailty on health outcomes among those with heart failure, there is a dearth of knowledge on measuring frailty using administrative health data on a wide range of cardiovascular diseases (CVD).

Methods: We conducted a retrospective record-linkage cohort study of patients with diverse CVD in Queensland, Australia. We investigated the relationship between the risk of frailty, defined using the hospital frailty risk score (HFRS), and 30-day mortality, 30-day unplanned readmission, non-home discharge, length of hospital stay (LOS) at an emergency department and inpatient units and costs of hospitalisation. Read More

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Greater burden of risk factors and less effect of cardiac rehabilitation in elderly with low educational attainment: The Eu-CaRE study.

Eur J Prev Cardiol 2021 May;28(5):513-519

Department of Cardiology, Bispebjerg Frederiksberg University Hospital, Copenhagen, Denmark.

Aims: Socioeconomic status is a strong predictor of cardiovascular health. The aim of this study was to describe the immediate and long-term effects of cardiac rehabilitation (CR) across socioeconomic strata in elderly cardiac patients in Europe.

Methods And Results: The observational EU-CaRE study is a prospective study with eight CR sites in seven European countries. Read More

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Determinants of healthcare worker turnover in intensive care units: A micro-macro multilevel analysis.

PLoS One 2021 14;16(5):e0251779. Epub 2021 May 14.

Modélisation Epidémiologie et Surveillance des Risques Sanitaires (MESuRS) Laboratory, Conservatoire National des Arts et Métiers (Cnam), Paris, France.

Background: High turnover among healthcare workers is an increasingly common phenomenon in hospitals worldwide, especially in intensive care units (ICUs). In addition to the serious financial consequences, this is a major concern for patient care (disrupted continuity of care, decreased quality and safety of care, increased rates of medication errors, …).

Objective: The goal of this article was to understand how the ICU-level nurse turnover rate may be explained from multiple covariates at individual and ICU-level, using data from 526 French registered and auxiliary nurses (RANs). Read More

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Characterizing and predicting person-specific, day-to-day, fluctuations in walking behavior.

PLoS One 2021 14;16(5):e0251659. Epub 2021 May 14.

Center for Wireless & Population Health Systems, The Qualcomm Institute and the Department of Family Medicine and Public Health, University of California, San Diego, San Diego, CA, United States of America.

Despite the positive health effect of physical activity, one third of the world's population is estimated to be insufficiently active. Prior research has mainly investigated physical activity on an aggregate level over short periods of time, e.g. Read More

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Compounds from plantar foot sweat, nesting material, and urine show strain patterns associated with agonistic and affiliative behaviors in group housed male mice, Mus musculus.

PLoS One 2021 14;16(5):e0251416. Epub 2021 May 14.

Department of Animal Science, Purdue University, West Lafayette, Indiana, United States of America.

Excessive home cage aggression often results in severe injury and subsequent premature euthanasia of male laboratory mice. Aggression can be reduced by transferring used nesting material during cage cleaning, which is thought to contain aggression appeasing odors from the plantar sweat glands. However, neither the composition of plantar sweat nor the deposits on used nesting material have been evaluated. Read More

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Training and illness characteristics of cross-country skiers transitioning from junior to senior level.

PLoS One 2021 14;16(5):e0250088. Epub 2021 May 14.

Department of Health Sciences, Swedish Winter Sports Research Centre, Mid Sweden University, Östersund, Sweden.

Objective: This study aimed to describe the endurance training and incidence of illnesses reported by a group of well-trained cross-country (XC) skiers throughout their transition from junior to senior level.

Methods: Changes in self-reported training and performance, from 31 well-trained XC skiers, were analyzed from the start of the season they turned 16 y until the end of the season they turned 22 y, using linear mixed-effects models. Differences in the incidence of self-reported illness episodes were analyzed using incidence rate ratios, and the relationships between self-reported illness and training volumes were analyzed using linear mixed-effects models in a sub-group of 23 of the skiers. Read More

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National estimates from the Youth '19 Rangatahi smart survey: A survey calibration approach.

PLoS One 2021 14;16(5):e0251177. Epub 2021 May 14.

Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

Background: Significant progress has been made addressing adolescent health needs in New Zealand, but some areas, such as mental health issues remain, particularly for rangatahi Māori (indigenous Māori young people). Little is known about how contemporary Māori whānau (families) and communities influence health outcomes, health literacy and access to services. Previous nationally representative secondary school surveys were conducted in New Zealand in 2001, 2007 and 2012, as part of the Youth2000 survey series. Read More

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Factors affecting the seasonal distribution and biomass of E. pacifica and T. spinifera along the Pacific coast of Canada: A spatiotemporal modelling approach.

PLoS One 2021 14;16(5):e0249818. Epub 2021 May 14.

Fisheries and Oceans Canada, Pacific Biological Station, Nanaimo, British Columbia, Canada.

Euphausiids are a keystone species in coastal food webs due to their high lipid content and seasonally high biomass. Understanding the habitat and environmental drivers that lead to areas of high biomass, or 'hotspots', and their seasonal persistence, will support the identification of important foraging regions for mid- and upper- trophic level predators. We quantify the distribution of hotspots of the two dominant species of euphausiid in the north-east Pacific Ocean: Euphausia pacifica and Thysanoessa spinifera, as well as euphausiid larvae (mixed species). Read More

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A Communication Guide for Pediatric Extracorporeal Membrane Oxygenation.

Pediatr Crit Care Med 2021 May 17. Epub 2021 May 17.

Department of Cardiology, Division of Cardiovascular Critical Care, Boston Children's Hospital, Boston, MA. Department of Pediatrics, Harvard Medical School, Boston, MA. School of Medicine, University of Queensland, Brisbane, QLD, Australia. Department of Pediatrics, Boston Children's Hospital, Boston, MA. Department of Psychosocial Oncology and Palliative Care, Dana-Farber Cancer Institute, Boston, MA. Division of Critical Care Medicine, Children's National Hospital, Washington, DC.

Decision-making surrounding extracorporeal membrane oxygenation initiation and decannulation has become a key challenge in critical care. Nuanced communication skills and transparent discussions about prognosis are imperative during this lifesaving, yet high-risk and burdensome intervention. Serious illness conversation guides are proving beneficial for patients, families and staff to communicate uncertainty and facilitate shared decision-making toward goal-concordant care. Read More

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Emergency Front-of-Neck Airway Rescue Via the Cricothyroid Membrane: A High-Resolution Computed Tomography Study of Airway Anatomy in Adults.

Anesth Analg 2021 May 14. Epub 2021 May 14.

From the Department of Anesthesiology, Alfred Hospital, Melbourne, Victoria, Australia.

Background: Emergency front-of-neck airway rescue is recommended in a can't intubate, can't oxygenate clinical scenario. Cannula cricothyroidotomy has been reported as having a high failure rate. Our primary aim was to estimate the angle of the trachea in relation to the horizontal axis in a simulated emergency front-of-neck airway rescue position. Read More

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Ammonia Exposure: A Review of Six Cases.

Am J Forensic Med Pathol 2021 May 11. Epub 2021 May 11.

From the Department of Forensic Medicine, Faculty of Medicine, University of Peradeniya, Peradeniya Base Hospital, Panadura, Sri Lanka.

Abstract: Exposure to high doses of ammonia gas can result in lethal injuries to humans. This case series presents 5 fatalities and an injured individual, caused by acute ammonia exposure, which occurred in the rubber industry. One of the fatalities and the survivor were reported in an incident of ammonia gas cylinder explosion, whereas the other 4 fatalities were accidentally exposed to gaseous ammonia, where they had started working at a reopened rubber factory that had been abandoned for a long time. Read More

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TSDLPP: A Novel Two-stage Deep Learning Framework for Prognosis Prediction Based on Whole Slide Histopathological Images.

IEEE/ACM Trans Comput Biol Bioinform 2021 May 14;PP. Epub 2021 May 14.

Recently, digital pathology image-based prognosis prediction has become a hot topic in healthcare research to make early decisions on therapy and improve the treatment quality of patients. Therefore, there has been a recent surge of interest in designing deep learning method solving the problem of prognosis prediction with digital pathology images. However, whole slide histopathological images (WSIs) based prognosis prediction is still a challenge due to the large size of pathological images, the heterogeneity of tumors and the high cost of region of interests (ROIs) labeling. Read More

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VMAF Oriented Perceptual Coding based on Piecewise Metric Coupling.

IEEE Trans Image Process 2021 May 14;PP. Epub 2021 May 14.

It has been recognized that videos have to be encoded in a rate-distortion optimized manner for high coding performance. Therefore, operational coding methods have been developed for conventional distortion metrics such as Sum of Squared Error (SSE). Nowadays, with the rapid development of machine learning, the state-of-the-art learning based metric Video Multimethod Assessment Fusion (VMAF) has been proven to outperform conventional ones in terms of the correlation with human perception, and thus deserves integration into the coding framework. Read More

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Occupational exposure during metal additive manufacturing: A case study of laser powder bed fusion of aluminum alloy.

J Occup Environ Hyg 2021 May 14:1-14. Epub 2021 May 14.

Ecole des Mines de Saint-Etienne, Loire, Saint-Etienne, France.

Occupational exposure during metal additive manufacturing (Laser Powder Bed Fusion) using an aluminum alloy (AlSi10Mg) was assessed. Background aerosols before manufacturing, powder sieving, machine loading, manufacturing, machine unloading, powder unpacking, and machine cleaning were analyzed. Measurements were taken simultaneously at the source, in the near field, and on the operator during five manufacturing cycles. Read More

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Ammonium-mediated reduction in salicylic acid content and recovery of plant growth in Arabidopsis mutants is modulated by NDR1 and NPR1.

Plant Signal Behav 2021 May 14:1928819. Epub 2021 May 14.

Department of Agriculture, Forestry and Bioresources, Research Institute of Agriculture and Life Sciences, and Plant Genomics and Breeding Institute, Seoul National University, Seoul, Korea.

The mutants exhibit high SA accumulation and consequently severe dwarfism. Although mutants exhibit growth recovery upon exogenous ammonium supply, the underlying mechanism remains unknown. Here, we investigated the effect of ammonium on SA level and plant growth in SA-accumulating mutants. Read More

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