31,617 results match your criteria high input


A strategy to determine the fate of active chemical compounds in soil; applied to antimicrobially active substances.

Chemosphere 2021 Apr 7;279:130495. Epub 2021 Apr 7.

Wageningen Food Safety Research, Wageningen University & Research, Akkermaalsbos 2, 6708 WB, Wageningen, the Netherland.

Data on the fate of chemical substances in the environment after e.g. manure application is mandatory input for risk assessment in perspective of a more circular biobased economy. Read More

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Mapping functional gradients of the striatal circuit using simultaneous microelectric stimulation and ultrahigh-field fMRI in non-human primates: Mapping the dorsal and ventral striatum circuits.

Neuroimage 2021 Apr 17:118077. Epub 2021 Apr 17.

Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Republic of Korea;; Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Republic of Korea;. Electronic address:

Advances in functional magnetic resonance imaging (fMRI) have significantly enhanced our understanding of the striatal system of both humans and non-human primates (NHP) over the last few decades. However, its circuit-level functional anatomy remains poorly understood, partly because in-vivo fMRI cannot directly perturb a brain system and map its casual input-output relationship. Also, routine 3T fMRI has an insufficient spatial resolution. Read More

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Relationship between childhood physical abuse and clinical severity of treatment-resistant depression in a geriatric population.

PLoS One 2021 20;16(4):e0250148. Epub 2021 Apr 20.

Fondation FondaMental, Creteil, France.

Introduction: We assessed the correlation between childhood maltreatment (CM) and severity of depression in an elderly unipolar Treatment-Resistant Depression (TRD) sample.

Methods: Patients were enrolled from a longitudinal cohort (FACE-DR) of the French Network of Expert TRD Centres.

Results: Our sample included 96 patients (33% of the overall cohort) aged 60 years or above, with a mean age of 67. Read More

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KenDTI: an ensemble model based on network integration and CNN for drug-target interaction prediction.

IEEE/ACM Trans Comput Biol Bioinform 2021 Apr 20;PP. Epub 2021 Apr 20.

The identification of drug-target interactions (DTIs) is an essential step in the process of drug discovery. As experimental validation suffers from high cost and low success rate, various computational models have been exploited to infer potential DTIs. The performance of DTI prediction depends heavily on the features extracted from drugs and target proteins. Read More

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Design and Retrospective Application of a Spine Trauma DVT Prophylaxis Protocol on Level 1 Trauma Center Patient Database.

Global Spine J 2021 Apr 20:2192568220979139. Epub 2021 Apr 20.

22683Baylor University Medical Center, Dallas, TX, USA.

Study Design: Systematic literature review.

Objectives: The impact of thromboembolic disease on the morbidity and mortality of patients with acute spinal cord injury is well documented, with rates as high as 67%-100% among untreated patients. The efficacy of mechanical prophylaxis as a stand-alone measure has been questioned, so we sought to determine a safe perioperative window for chemical anticoagulation use after spine surgery. Read More

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Robust Lexically Mediated Compensation for Coarticulation: Christmash Time Is Here Again.

Cogn Sci 2021 Apr;45(4):e12962

Psychological Sciences, University of Connecticut.

A long-standing question in cognitive science is how high-level knowledge is integrated with sensory input. For example, listeners can leverage lexical knowledge to interpret an ambiguous speech sound, but do such effects reflect direct top-down influences on perception or merely postperceptual biases? A critical test case in the domain of spoken word recognition is lexically mediated compensation for coarticulation (LCfC). Previous LCfC studies have shown that a lexically restored context phoneme (e. Read More

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Cryo-balloon catheter localization in X-Ray fluoroscopy using U-net.

Int J Comput Assist Radiol Surg 2021 Apr 20. Epub 2021 Apr 20.

Department of Internal Medicine II, Ulm University Medical Center, Albert-Einstein-Allee 23, 89081, Ulm, Germany.

Purpose: Automatic identification of interventional devices in X-ray (XR) fluoroscopy offers the potential of improved navigation during transcatheter endovascular procedures. This paper presents a prototype implementation of fully automatic 3D reconstruction of a cryo-balloon catheter during pulmonary vein isolation (PVI) procedures by deep learning approaches.

Methods: We employ convolutional neural networks (CNN) to automatically identify the cryo-balloon XR marker and catheter shaft in 2D fluoroscopy during PVI. Read More

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An Adapted Neural-Fuzzy Inference System Model Using Preprocessed Balance Data to Improve the Predictive Accuracy of Warfarin Maintenance Dosing in Patients After Heart Valve Replacement.

Cardiovasc Drugs Ther 2021 Apr 20. Epub 2021 Apr 20.

Department of Evidence-Based Medicine and Clinical epidemiology, West China Hospital, Sichuan University, Chengdu, China.

Background: Tailoring warfarin use poses a challenge for physicians and pharmacists due to its narrow therapeutic window and substantial inter-individual variability. This study aimed to create an adapted neural-fuzzy inference system (ANFIS) model using preprocessed balance data to improve the predictive accuracy of warfarin maintenance dosing in Chinese patients undergoing heart valve replacement (HVR).

Methods: This retrospective study enrolled patients who underwent HVR between June 1, 2012, and June 1, 2016, from 35 centers in China. Read More

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Genetically Distinct Behavioral Modules Underlie Natural Variation in Thermal Performance Curves.

G3 (Bethesda) 2019 Jul;9(7):2135-2151

Department of Ecology and Evolutionary Biology, University of Toronto.

Thermal reaction norms pervade organismal traits as stereotyped responses to temperature, a fundamental environmental input into sensory and physiological systems. Locomotory behavior represents an especially plastic read-out of animal response, with its dynamic dependence on environmental stimuli presenting a challenge for analysis and for understanding the genomic architecture of heritable variation. Here we characterize behavioral reaction norms as thermal performance curves for the nematode Caenorhabditis briggsae, using a collection of 23 wild isolate genotypes and 153 recombinant inbred lines to quantify the extent of genetic and plastic variation in locomotory behavior to temperature changes. Read More

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Pretesting a poster that communicates principles of COVID-19 prevention at educational institutions in Depok City, Indonesia.

J Vis Commun Med 2021 Apr 20:1-9. Epub 2021 Apr 20.

Department of Health Education and Behavioral Sciences, Faculty of Public Health, Universitas Indonesia, Depok, Indonesia.

The Ministry of Health of the Republic of Indonesia has developed a COVID-19 prevention poster for use in educational institutions. The poster was pretested to determine the reactions of individuals at educational institutions in Depok City in relation to various aspects of communication, such as attraction, comprehension, acceptability, self-involvement and persuasion. The research was descriptive and qualitative, and informants were selected by purposive sampling. Read More

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Nitrogen leaching and grey water footprint affected by nitrogen fertilization rate in maize production: A case study of Southwest China.

J Sci Food Agric 2021 Apr 19. Epub 2021 Apr 19.

College of Resources and Environment, Academy of Agricultural Sciences, Southwest University, Chongqing, 400715, China.

Background: Effective N management measures are required to control environmental problems caused by nitrogen (N) fertilizer use in intensive maize production systems. Soil N losses associated with high precipitation and over-fertilization in maize production can cause substantial environmental problems, whereas there is a lack of quantitative data and effective study countermeasures. A 2-yr field study was conducted in the subtropical maize production system in Southwest China to quantify N leaching under varying N application rates of 0, 90, 180, 270 and 360 kg N ha yr . Read More

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Spatial tissue profiling by imaging-free molecular tomography.

Nat Biotechnol 2021 Apr 19. Epub 2021 Apr 19.

Brain Mind Institute, School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

Several techniques are currently being developed for spatially resolved omics profiling, but each new method requires the setup of specific detection strategies or specialized instrumentation. Here we describe an imaging-free framework to localize high-throughput readouts within a tissue by cutting the sample into thin strips in a way that allows subsequent image reconstruction. We implemented this framework to transform a low-input RNA sequencing protocol into an imaging-free spatial transcriptomics technique (called STRP-seq) and validated it by profiling the spatial transcriptome of the mouse brain. Read More

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Energy implications of the 21 century agrarian transition.

Nat Commun 2021 Apr 19;12(1):2319. Epub 2021 Apr 19.

Department of Environmental Science, Policy, and Management, University of California, Berkeley, Berkeley, CA, USA.

The ongoing agrarian transition from small-holder farming to large-scale commercial agriculture is reshaping systems of production and human well-being in many regions. A fundamental part of this global transition is manifested in large-scale land acquisitions (LSLAs) by agribusinesses. Its energy implications, however, remain poorly understood. Read More

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The prevalence of occupational exposure to noise: A systematic review and meta-analysis from the WHO/ILO Joint Estimates of the Work-related Burden of Disease and Injury.

Environ Int 2021 Apr 16:106380. Epub 2021 Apr 16.

Workers' Health and Human Ecology Research Center, National School of Public Health Sergio Arouca, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil. Electronic address:

Background: The World Health Organization (WHO) and the International Labour Organization (ILO) are developing joint estimates of the work-related burden of disease and injury (WHO/ILO Joint Estimates), with contributions from a large network of individual experts. Evidence from mechanistic and human data suggests that occupational exposure to noise may cause cardiovascular disease. In this paper, we present a systematic review and meta-analysis of the prevalence of occupational exposure to noise for estimating (if feasible) the number of deaths and disability-adjusted life years from cardiovascular disease that are attributable to exposure to this risk factor, for the development of the WHO/ILO Joint Estimates. Read More

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Differential expression of starch and sucrose metabolic genes linked to varying biomass yield in Miscanthus hybrids.

Biotechnol Biofuels 2021 Apr 19;14(1):98. Epub 2021 Apr 19.

Institute of Biological, Environmental & Rural Sciences (IBERS), Aberystwyth University, Aberystwyth, SY23 3EE, UK.

Background: Miscanthus is a commercial lignocellulosic biomass crop owing to its high biomass productivity and low chemical input requirements. Within an interspecific Miscanthus cross, progeny with high biomass yield were shown to have low concentrations of starch and sucrose but high concentrations of fructose. We performed a transcriptional RNA-seq analysis between selected Miscanthus hybrids with contrasting values for these phenotypes to clarify how these phenotypes are genetically controlled. Read More

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The role of active oxygen in the response of plants to water deficit and desiccation.

New Phytol 1993 Sep;125(1):27-58

University of Exeter, Department of Biological Sciences, Hatherly Laboratories, Prince of Wales Road, Exeter EX4 4PS, UK.

Water deficits cause a reduction in the rate of photosynthesis. Exposure to mild water deficits, when relative water content (RWC) remains above 70%, primarily causes limitation to carbon dioxide uptake because of stomatal closure. With greater water deficits, direct inhibition of photosynthesis occurs. Read More

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September 1993

K3.1 channels regulate the rate of critical period plasticity.

Neurosci Res 2021 Apr 16. Epub 2021 Apr 16.

Laboratory for Neuronal Circuit Development, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan; International Research Center for Neuorintelligence, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113, Japan; Center for Brain Science, Department of Molecular Cellular Biology, Harvard University, 52 Oxford Street, Cambridge, MA, 02138, USA. Electronic address:

Experience-dependent plasticity within visual cortex is controlled by postnatal maturation of inhibitory circuits, which are both morphologically diverse and precisely connected. Gene-targeted disruption of the voltage-dependent potassium channel K3.1 broadens action potentials and reduces net inhibitory function of parvalbumin (PV)-positive GABA subtypes within the neocortex. Read More

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Dielectric Polymer Property Prediction Using Recurrent Neural Networks with Optimizations.

J Chem Inf Model 2021 Apr 19. Epub 2021 Apr 19.

Argonne Leadership Computing Facility, Argonne National Laboratory, Lemont, Illinois 60439, United States.

Despite the growing success of machine learning for predicting structure-property relationships in molecules and materials, such as predicting the dielectric properties of polymers, it is still in its infancy. We report on the effectiveness of solving structure-property relationships for a computer-generated database of dielectric polymers using recurrent neural network (RNN) models. The implementation of a series of optimization strategies was crucial to achieving high learning speeds and sufficient accuracy: (1) binary and nonbinary representations of SMILES (Simplified Molecular Input Line System) fingerprints and (2) backpropagation with affine transformation of the input sequence (ATransformedBP) and resilient backpropagation with initial weight update parameter optimizations (iRPROP optimized). Read More

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Parent engagement with the New South Wales child health home-based record: A cross-sectional survey and a retrospective chart review.

Child Care Health Dev 2021 Apr 19. Epub 2021 Apr 19.

Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia.

Background: In 2018, World Health Organisation endorsed universal use of home-based records to improve care for mothers, pregnant women, newborns and children. New South Wales (NSW), Australia has had universal use of a child health home-based record since 1988, with the first major update in 2013. Since the update, limited evidence has been collected about factors influencing parent use of the record. Read More

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Corrective Shared Autonomy for Addressing Task Variability.

IEEE Robot Autom Lett 2021 Apr 8;6(2):3720-3727. Epub 2021 Mar 8.

Michael Hagenow and Michael Zinn are with the Department of Mechanical Engineering, University of Wisconsin-Madison, Madison 53706, USA.

Many tasks, particularly those involving interaction with the environment, are characterized by high variability, making robotic autonomy difficult. One flexible solution is to introduce the input of a human with superior experience and cognitive abilities as part of a shared autonomy policy. However, current methods for shared autonomy are not designed to address the wide range of necessary corrections (e. Read More

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A structural analysis of the hypoxia response network.

PeerJ 2021 6;9:e10985. Epub 2021 Apr 6.

Department of Health Service, Army Medical University, Chongqing, Shapingba, China.

Background: The hypoxia-inducible factor-1 (HIF-1) signaling pathway is an important topic in high-altitude medicine. Network analysis is a novel method for integrating information on different aspects and levels of biological networks. However, this method has not been used in research on the HIF-1 signaling pathway network. Read More

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An integrated actuating and sensing system for light-addressable potentiometric sensor (LAPS) and light-actuated AC electroosmosis (LACE) operation.

Biomicrofluidics 2021 Mar 12;15(2):024109. Epub 2021 Apr 12.

Ph.D. Program in Biomedical Engineering, Chang Gung University, Taoyuan City 333, Taiwan.

To develop a lab on a chip (LOC) integrated with both sensor and actuator functions, a novel two-in-one system based on optical-driven manipulation and sensing in a microfluidics setup based on a hydrogenated amorphous silicon (a-Si:H) layer on an indium tin oxide/glass is first realized. A high-intensity discharge xenon lamp functioned as the light source, a chopper functioned as the modulated illumination for a certain frequency, and a self-designed optical path projected on the digital micromirror device controlled by the digital light processing module was established as the illumination input signal with the ability of dynamic movement of projected patterns. For light-addressable potentiometric sensor (LAPS) operation, alternating current (AC)-modulated illumination with a frequency of 800 Hz can be generated by the rotation speed of the chopper for photocurrent vs bias voltage characterization. Read More

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Auroral Energy Flux and Joule Heating Derived From Global Maps of Field-Aligned Currents.

Geophys Res Lett 2021 Apr 1;48(7):e2020GL091527. Epub 2021 Apr 1.

National Oceanic and Atmospheric Administration Laurel MD USA.

We calculate auroral energy flux and Joule heating in the high-latitude ionosphere for 27 geomagnetically active days using two-dimensional maps of field-aligned currents determined by the Active Magnetosphere and Planetary Response Experiment. The energy input to the ionosphere due to Joule heating increases more rapidly with geomagnetic activity than that due to precipitating particles. The energy flux varies more smoothly with time than Joule heating, which is impulsive in nature on time scales from minutes to tens of minutes. Read More

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The Development of iManage-PC, an Online Symptom Monitoring and Self-management Tool for Men With Clinically Localized Prostate Cancer.

Cancer Nurs 2021 Apr 8. Epub 2021 Apr 8.

Author Affiliations: Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine (Drs Murphy, Schalet, and Victorson and Ms Sauer), Chicago; Bright Outcome (Dr Yang and Ms Hass), Buffalo Grove; Division of Urology, NorthShore University Health System (Drs Novakovic and Helfand), Evanston; and Department of Urology, Northwestern University Feinberg School of Medicine (Dr Nadler), Chicago, Illinois; and Department of Social Sciences and Health Policy, Wake Forest School of Medicine (Dr Murphy), Winston Salem, North Carolina.

Background: Prostate cancer (PC) often impacts 4 major aspects of health-related quality of life (HRQL): urinary, sexual, and bowel dysfunction, and anxiety. Online tools may be helpful in supporting the development of self-management skills that can improve HRQL.

Objective: The aim of this study was to develop and pilot-test an online symptom monitoring and self-management program, iManage-PC. Read More

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Hyperbolic relational graph convolution networks plus: a simple but highly efficient QSAR-modeling method.

Brief Bioinform 2021 Apr 19. Epub 2021 Apr 19.

College of Pharmaceutical Sciences, Zhejiang University.

Accurate predictions of druggability and bioactivities of compounds are desirable to reduce the high cost and time of drug discovery. After more than five decades of continuing developments, quantitative structure-activity relationship (QSAR) methods have been established as indispensable tools that facilitate fast, reliable and affordable assessments of physicochemical and biological properties of compounds in drug-discovery programs. Currently, there are mainly two types of QSAR methods, descriptor-based methods and graph-based methods. Read More

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Co-cultivation of Streptomyces and microalgal cells as an efficient system for biodiesel production and bioflocculation formation.

Bioresour Technol 2021 Apr 5;332:125118. Epub 2021 Apr 5.

Sri Paramakalyani Centre of Excellence in Environmental Sciences, Manonmaniam Sundaranar University, Alwarkurichi 627412, Tamil Nadu, India.

The phytohormone producing Streptomyces rosealbus MTTC 12,951 (S.R) and green microalga Chlorella vulgaris MSU-AGM 14 (C.V) were cultivated in co-culture system to evaluate exogenous hormonal activity. Read More

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Linear and nonlinear analysis of intrinsic mode function after facial stimuli presentation in children with autism spectrum disorder.

Comput Biol Med 2021 Apr 9;133:104376. Epub 2021 Apr 9.

School of Electronics and Computer Science, University of Southampton, Southampton, SO17 1BJ, UK.

In this work, a method for classifying Autism Spectrum Disorders (ASD) from typically developing (TD) children is presented using the linear and nonlinear Event-Related Potential (ERP) analysis of the Electro-encephalogram (EEG) signals. The signals were acquired during the presentation of three types of face expression stimuli -happy, fearful and neutral faces. EEGs are first decomposed using the Multivariate Empirical Mode Decomposition (MEMD) method to extract its Intrinsic Mode Functions (IMFs), which provide information about the underlying activities of ERP components. Read More

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Precision nutrition: A systematic literature review.

Comput Biol Med 2021 Apr 7;133:104365. Epub 2021 Apr 7.

Information Technology Group, Wageningen University and Research, Wageningen, the Netherlands. Electronic address:

Precision Nutrition research aims to use personal information about individuals or groups of individuals to deliver nutritional advice that, theoretically, would be more suitable than generic advice. Machine learning, a subbranch of Artificial Intelligence, has promise to aid in the development of predictive models that are suitable for Precision Nutrition. As such, recent research has applied machine learning algorithms, tools, and techniques in precision nutrition for different purposes. Read More

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Contrasting effect of coniferous and broadleaf trees on soil carbon storage during reforestation of forest soils and afforestation of agricultural and post-mining soils.

J Environ Manage 2021 Apr 15;290:112567. Epub 2021 Apr 15.

Charles University, Faculty of Science, Institute for Environmental Studies, Benátská 2, 12800, Praha 2, Czech Republic; Biology Centre CAS, ISB & SoWa RI, Na Sádkách 7, 37005, České Budějovice, Czech Republic. Electronic address:

Soils and forest soil in particular represent important pools of carbon (C). The amount of C stored in soil depends on the input of organic matter into the soil, but also on quality of the organic matter, which determines the proportion of organic matter that remains in the soil or that is released from the soil as CO. Here, we present a quantitative review of common garden experiments in which various tree species were planted alongside each other. Read More

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Ecological risk of chlorinated organic pollutants in a semi-enclosed bay impacted by aquaculture.

Sci Total Environ 2021 Apr 8;783:147000. Epub 2021 Apr 8.

Provincial Key Laboratory of Marine Biotechnology, Institute of Marine Science, Shantou University, Shantou, Guangdong 515063, China; Southern Marine Science and Engineering Guangdong Laboratory, Guangzhou 511458, China. Electronic address:

Semi-enclosed bays are used for critical economic activities such as ports, aquaculture, and human settlement due to their topography and ocean connectivity. However, the role of these geomorphological characteristics on the accumulation of chlorinated organic pollutants in semi-enclosed bays is poorly understood. We investigated the spatiotemporal distribution and potential ecological risk of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) in sediments from Shantou Bay, a semi-enclosed bay. Read More

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