134,481 results match your criteria high grade

Changes in the Health of Adolescent Athletes: A Comparison of Health Measures Collected Before and During the CoVID-19 Pandemic.

J Athl Train 2021 Apr 22. Epub 2021 Apr 22.

University of Wisconsin-Madison.

Context: In the spring of 2020, schools closed to in-person teaching and sports were cancelled to control the transmission of CoVID-19. The changes that took place to the physical and mental health among young athletes during this time remain unknown, however.

Objective: Identify changes in the health (mental health, physical activity and quality of life) of athletes that occurred during the CoVID-19 pandemic. Read More

View Article and Full-Text PDF

Wrapping double-mattress anastomosis for pancreaticojejunostomy in minimally invasive pancreaticoduodenectomy can significantly reduce postoperative pancreatic fistula rate compared with conventional pancreaticojejunostomy in open surgery: An analysis of a propensity score-matched sample.

Surg Oncol 2021 Apr 9;38:101577. Epub 2021 Apr 9.

Department of Surgery, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan.

Background: Minimally invasive pancreaticoduodenectomy (MIPD), including laparoscopic pancreaticoduodenectomy (LPD) and robotic pancreaticoduodenectomy (RPD), is technically demanding because of pancreaticojejunostomy (PJ). Postoperative pancreatic fistula (POPF) is the most serious complication of MIPD and open pancreaticoduodenectomy (OPD). Contrary to expectations, conventional PJ in MIPD did not improve POPF rate and length of hospital stay. Read More

View Article and Full-Text PDF

Downregulation of PDGFRß Signaling Overcomes Crizotinib Resistance in a TYRO3 and ALK Mutated Neuroendocrine-Like Tumor.

Transl Oncol 2021 Apr 19;14(7):101099. Epub 2021 Apr 19.

Division of Pediatric Surgery, Department of Surgery, University of Alabama at Birmingham, 1600 7th Ave. South, Lowder, Room 300, Birmingham, AL 35233, United States. Electronic address:

Patient-derived xenografts provide significant advantages over long-term passage cell lines when investigating efficacy of treatments for solid tumors. Our laboratory encountered a high-grade, metastatic, neuroendocrine-like tumor from a pediatric patient that presented with a unique genetic profile. In particular, mutations in TYRO3 and ALK were identified. Read More

View Article and Full-Text PDF

Clinical Impact of Immunotherapy in Merkel Cell Carcinoma patients: A Systematic Review and Meta-Analysis.

J Am Acad Dermatol 2021 Apr 19. Epub 2021 Apr 19.

Department of Dermatology, University Hospital "Dr. José Eleuterio González" Universidad Autónoma de Nuevo León. Electronic address:

Background: Immunotherapy is emerging as an alternative for Merkel cell carcinoma (MCC), but its long-term effects on response, survival, and safety are not well established. High-quality evidence is needed to estimate efficacy of this treatment and to review the characteristics of patients and tumor that might improve these outcomes.

Objective: To summarize immunotherapy's efficacy and safety in MCC patients. Read More

View Article and Full-Text PDF

Intra Articular Injection Of Autologous Microfat And Platelet-Rich Plasma In The Treatment Of Knee Osteoarthritis: A Double Blind Randomized Comparative Study.

Arthroscopy 2021 Apr 19. Epub 2021 Apr 19.

Cell Therapy Laboratory, Hôpital de la Conception, AP-HM, INSERM CIC BT 1409, Marseille, France; Aix Marseille Univ, INSERM, INRA, C2VN, Marseille, France. Electronic address:

Purpose: Compare a single abdominal microfat (MF) injection mixed or not with PRP Low Dose (LD) or High Dose (HD) in order to improve MRI parameters and alleviate pain and enhance functional capacity in knee osteoarthritis (OA).

Methods: Patients with symptomatic grade 2 to 4 knee OA according to the International Cartilage Repair Society MRI classification were selected. They were prospectively assessed at baseline, at 3 and 6 months of follow-up. Read More

View Article and Full-Text PDF

Noninvasive Low-Grade Papillary Urothelial Carcinoma with Degenerative Nuclear Atypia: A Grading Pitfall.

Hum Pathol 2021 Apr 19. Epub 2021 Apr 19.

Departments of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, 21231; Departments of Urology, The Johns Hopkins Medical Institutions, Baltimore, MD, 21231; Departments of Oncology, The Johns Hopkins Medical Institutions, Baltimore, MD, 21231; Johns Hopkins Greenberg Bladder Cancer Institute, Baltimore, MD, 21231. Electronic address:

Noninvasive low-grade papillary urothelial carcinoma is a papillary neoplasm with orderly appearance and mild nuclear pleomorphism. Some cases show significant nuclear pleomorphism with degenerative atypia leading to grading difficulties. Retrospective review of the pathology files identified 16 cases diagnosed as noninvasive low-grade papillary urothelial carcinoma with degenerative atypia. Read More

View Article and Full-Text PDF

Expression of B7-H4 and IDO1 is associated with drug resistance and poor prognosis in high-grade serous ovarian carcinomas.

Hum Pathol 2021 Apr 19. Epub 2021 Apr 19.

Departments of Pathology. Electronic address:

High-grade serous ovarian carcinoma (HGSC) is the most lethal gynecologic malignancy. While immune checkpoint inhibitors against PD-L1 and CTLA-4 have shown significant effects in multiple tumor types, the response rate to single-agent immune checkpoint inhibitors is low in HGSC. Alternative biomarkers and targets must be identified to guide patient selection and new therapeutic strategies in HGSC. Read More

View Article and Full-Text PDF

Safety and immunogenicity of SARS-CoV-2 recombinant protein vaccine formulations in healthy adults: interim results of a randomised, placebo-controlled, phase 1-2, dose-ranging study.

Lancet Infect Dis 2021 Apr 19. Epub 2021 Apr 19.

Sanofi Pasteur, Swiftwater, PA, USA. Electronic address:

Background: CoV2 preS dTM is a stabilised pre-fusion spike protein vaccine produced in a baculovirus expression system being developed against SARS-CoV-2. We present interim safety and immunogenicity results of the first-in-human study of the CoV2 preS dTM vaccine with two different adjuvant formulations.

Methods: This phase 1-2, randomised, double-blind study is being done in healthy, SARS-CoV-2-seronegative adults in ten clinical research centres in the USA. Read More

View Article and Full-Text PDF

Thorium-227-Labeled Anti-CD22 Antibody (BAY 1862864) in Relapsed/Refractory CD22-Positive Non-Hodgkin Lymphoma: A First-in-Human, Phase I Study.

Cancer Biother Radiopharm 2021 Apr 21. Epub 2021 Apr 21.

Department of Haematology, University College London Hospital, London, United Kingdom.

BAY 1862864 is an α-particle emitting thorium-227-labeled CD22-targeting antibody. This first-in-human dose-escalation phase I study evaluated BAY 1862864 in patients with CD22-positive relapsed/refractory B cell non-Hodgkin lymphoma (R/R-NHL). BAY 1862864 intravenous injections were administered at the starting thorium-227 radioactivity dose of 1. Read More

View Article and Full-Text PDF

Acute radiodermatitis in cancer patients: incidence and severity estimates.

Rev Esc Enferm USP 2021 16;55:e03676. Epub 2021 Apr 16.

Universidade de Brasília, Faculdade de Ciências da Saúde, Programa de Pós-Graduação em Enfermagem, Brasília, DF, Brazil.

Objective: To estimate the incidence and distribution of the degree of radiodermatitis in cancer patients submitted to radiotherapy in the regions of head and neck, breast, and pelvis.

Method: Prospective, longitudinal, quantitative study conducted from March 15, 2016 to May 4, 2017 with patients observed for five weeks of treatment. The primary outcome was the proportion of grade 1 or higher radiodermatitis each week. Read More

View Article and Full-Text PDF

Nursing assistance in patient care with external ventricular drain: a scoping review.

Rev Bras Enferm 2021 16;74(2):e20190796. Epub 2021 Apr 16.

Universidade Federal de Ciências da Saúde de Porto Alegre. Porto Alegre, Rio Grande do Sul, Brazil.

Objectives: to map the available evidence about nursing care aimed at adult patients using external ventricular drain.

Methods: this is a review using the scoping review method.

Results: Initially, 965 studies were identified and, after the eligibility criteria, a sample of 54 publications was obtained. Read More

View Article and Full-Text PDF

Over half of clinical practice guidelines use non-systematic methods to inform recommendations: A methods study.

PLoS One 2021 22;16(4):e0250356. Epub 2021 Apr 22.

Department of Anesthesiology, Pharmacology & Therapeutics, Faculty of Medicine, Cochrane Hypertension Review Group, Therapeutics Initiative, University of British Columbia, Vancouver, BC, Canada.

Introduction: Assessing the process used to synthesize the evidence in clinical practice guidelines enables users to determine the trustworthiness of the recommendations. Clinicians are increasingly dependent on guidelines to keep up with vast quantities of medical literature, and guidelines are followed to avoid malpractice suits. We aimed to assess whether systematic methods were used when synthesizing the evidence for guidelines; and to determine the type of review cited in support of recommendations. Read More

View Article and Full-Text PDF

Effects of distancing and pattern of breathing on the filtering capability of commercial and custom-made facial masks: An in-vitro study.

PLoS One 2021 22;16(4):e0250432. Epub 2021 Apr 22.

Department of Chemistry and Industrial Chemistry, University of Genoa, Genova, Italy.

Background: Since the beginning of the COVID-19 pandemics, masking policies have been advocated. While masks are known to prevent transmission towards other individuals, it is unclear if different types of facial masks can protect the user from inhalation. The present study compares in-vitro different commercial and custom-made facial masks at different distances and breathing patterns. Read More

View Article and Full-Text PDF

Retinal vessel shift and its association with axial length elongation in a prospective observation in Japanese junior high school students.

PLoS One 2021 22;16(4):e0250233. Epub 2021 Apr 22.

Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Purpose: To investigate retinal vessel shift (RVS) and its association with axial length (AL) elongation in junior high school students.

Methods: Total 161 eyes of 161 healthy junior high school students were prospectively studied. Optical AL and anterior chamber depth (ACD) measurements, and fundus photography were performed in the first and third grades. Read More

View Article and Full-Text PDF

complex and co-infection in a patient with acquired immunodeficiency syndrome: a case report.

Acta Clin Belg 2021 Apr 22:1-6. Epub 2021 Apr 22.

Department of Internal Medicine and Infectious Diseases, Centre Hospitalier Universitaire (CHU), Liege, Belgium.

Opportunistic infections (OI) are common in patients with acquired immunodeficiency syndrome (AIDS). Cryptococcus neoformans and Mycobacterium avium complex (MAC) are frequently responsible of such infections. However, concurrent infection with these two pathogens is uncommon and underreported in the literature. Read More

View Article and Full-Text PDF

Treatment Strategies and Outcomes for Osteochondritis Dissecans of the Capitellum.

Am J Sports Med 2021 Apr 22:3635465211000763. Epub 2021 Apr 22.

Brighton and Sussex University Hospital, Brighton, UK.

Background: The optimum management of osteochondritis dissecans (OCD) of the capitellum is a widely debated subject.

Purpose: To better understand the efficacy of different surgical modalities and nonoperative treatment of OCD as assessed by radiological and clinical outcomes and return to sports.

Study Design: Systematic review; Level of evidence, 4. Read More

View Article and Full-Text PDF

PARP (Poly ADP-Ribose Polymerase) inhibitors for locally advanced or metastatic breast cancer.

Cochrane Database Syst Rev 2021 Apr 22;4:CD011395. Epub 2021 Apr 22.

NHMRC Clinical Trials Centre, The University of Sydney, Camperdown, Australia.

Background: Locally advanced and metastatic breast cancer remains a challenge to treat. With emerging study results, it is important to interpret the available clinical data and apply the evidence offering the most effective treatment to the right patient. Poly(ADP Ribose) Polymerase (PARP) inhibitors are a new class of drug and their role in the treatment of locally advanced and metastatic breast cancer is being established. Read More

View Article and Full-Text PDF

Single-level fusion without decompression for high-grade spondylolithesis in adolescents: a novel surgical strategy.

Spine Deform 2021 Apr 22. Epub 2021 Apr 22.

Department of Orthopaedic Surgery, Children's Hospital, Louisiana State University Health Sciences Center, 1542 Tulane Avenue, Box T6-7, New Orleans, LA, 70112, USA.

Purpose: There is no consensus on the optimal surgical treatment for high-grade spondylolisthesis (HGS) in adolescents. The purpose of this study was to assess the radiographic and clinical outcomes of a novel surgical approach to HGS consisting of a single-level anterior reduction, placement of a lordotic cage, and circumferential fixation without decompression.

Methods: This was a retrospective consecutive case series of 11 adolescents who underwent anterior reduction through placement of a lordotic cage followed by posterior fusion using pedicle screws and rods confined to L5-S1. Read More

View Article and Full-Text PDF

Radiation-induced brain injury in patients with meningioma treated with proton or photon therapy.

J Neurooncol 2021 Apr 22. Epub 2021 Apr 22.

Department of Radiation Oncology, University of Washington, 1959 NE Pacific Street, Seattle, WA, 98195, USA.

Introduction: Radiation therapy is often used to treat meningioma with adverse features or when unresectable. Proton therapy has advantages over photon therapy in reducing integral dose to the brain. This study compared the incidence of radiological and clinical adverse events after photon versus proton therapy in the treatment of meningioma. Read More

View Article and Full-Text PDF

The growth rate and clinical outcomes of radiation induced meningioma undergoing treatment or active monitoring.

J Neurooncol 2021 Apr 22. Epub 2021 Apr 22.

Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.

Introduction: Radiation induced meningioma (RIM) incidence is increasing in line with improved childhood cancer survival. No optimal management strategy consensus exists. This study aimed to delineate meningioma growth rates from tumor discovery and correlate with clinical outcomes. Read More

View Article and Full-Text PDF

Efficacy, predictors of success and failure of an updated lateral pharyngoplasty approach as an independent procedure in treating obstructive sleep apnea with CPAP failures.

Eur Arch Otorhinolaryngol 2021 Apr 22. Epub 2021 Apr 22.

Otorhinolaryngology Department, Faculty of Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt.

Purpose: To assess predictors of success and failure of an updated lateral pharyngoplasty as an independent procedure in treating obstructive sleep apnea with CPAP failures.

Methods: Forty-six patients with known OSAS who were resistant to CPAP or failures were included. BMI, Stop-Bang score, and sleep study data were recorded before and after the updated Cahali pharyngoplasty procedure. Read More

View Article and Full-Text PDF

Intraoperative Seizure Detection During Active Resection of Glioblastoma Through a Novel Hollow Circular Electrocorticography Array.

Oper Neurosurg (Hagerstown) 2021 Apr 22. Epub 2021 Apr 22.

Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA.

Background And Importance: Data supporting the use of electrocorticography (ECoG) monitoring during electrical stimulation in awake craniotomies for resection of supratentorial neoplasms is robust, but its applicability during active resection is often limited by the inability to keep the array in place. Given the known survival benefit of gross total resection in glioma surgery, novel approaches to surgical monitoring are warranted to maximize safe resection and optimize surgical outcomes in patients with glioblastoma.

Clinical Presentation: A 68-yr-old right-handed woman presented to the emergency department with confusion. Read More

View Article and Full-Text PDF

Radiological evaluation of ex novo high grade glioma: velocity of diametric expansion and acceleration time study.

Radiol Oncol 2020 Dec 3;55(1):26-34. Epub 2020 Dec 3.

Division of Neurosurgery, Department of Neurosciences, Policlinico "G. Rodolico", University Hospital, Catania, Italy.

Background: One of the greatest neuro-oncological concern remains the lack of knowledge about the etiopathogenesis and physiopathology of gliomas. Several studies reported a strict correlation between radiological features and biological behaviour of gliomas; in this way the velocity of diametric expansion (VDE) correlate with lower grade glioma aggressiveness. However, there are no the same strong evidences for high grade gliomas (HGG) because of the lack of several preoperative MRI. Read More

View Article and Full-Text PDF
December 2020

Development of zein/soluble soybean polysaccharide nanoparticle-stabilized Pickering emulsions.

J Food Sci 2021 Apr 22. Epub 2021 Apr 22.

Key Laboratory of Fermentation Engineering, Ministry of Education, National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Hubei Key Laboratory of Industrial Microbiology, School of Biological Engineering and Food, Hubei University of Technology, Wuhan, China.

Pickering emulsions have received wide attention due to their "surfactant-free" character and the ability of delivery bioactive compounds. In the current work, zein and soluble soybean polysaccharide (SSPS) food-grade composite nanoparticles (NPs) were fabricated as Pickering stabilizers. The particle size of the composite NPs varied with the concentration of zein and SSPS, consequently leading to larger hydrodynamic diameters compared with zein nanoparticles (ZPs) in all formulations, also seen from the scanning electron microscopy (SEM) images. Read More

View Article and Full-Text PDF

Median arcuate ligament (Dunbar) syndrome: Laparoscopic management and clinical outcomes of a single centre.

J Minim Access Surg 2021 Mar 16. Epub 2021 Mar 16.

Department of General Surgery, Dicle University School of Medicine, Diyarbakır, Turkey.

Background: Median arcuate ligament syndrome (MALS) is a condition characterised by chronic abdominal symptoms associated with median arcuate ligament (MAL) compression of the coeliac artery.

Aim: In this observational study, we aimed to evaluate the outcomes of laparoscopic treatment in patients with MALS.

Materials And Methods: The data of ten patients with MALS who were subjected to laparoscopic sectioning of the MAL were retrospectively reviewed. Read More

View Article and Full-Text PDF

Carbon ion radiotherapy for recurrent calf myxoid liposarcoma: a case report.

J Int Med Res 2021 Apr;49(4):3000605211009701

Heavy Ion Radiotherapy Department of Cancer Hospital, Wuwei, Gansu, China.

Liposarcoma (LPS) is the most common soft tissue sarcoma. Myxoid LPS (MLPS) is the second most common subtype of LPS and accounts for 25% to 50% of all LPSs. Like most other soft tissue sarcomas, the mainstay of treatment for LPS is inevitably surgery. Read More

View Article and Full-Text PDF

A gastro-colic fistula secondary to high-grade B-cell gastric lymphoma in a patient with AIDS: a case report.

J Int Med Res 2021 Apr;49(4):3000605211006602

Division of Gastroenterology & Hepatology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.

To the best of our knowledge, there are no previous reports of a gastro-colic fistula (GCF) secondary to primary high-grade B-cell gastric lymphoma associated with acquired immunodeficiency syndrome (AIDS). Here, we report a 37-year-old man who presented with paroxysmal abdominal pain for 4 months, diarrhea for 15 days and weight loss of 4 kg. He had a history of human immunodeficiency virus (HIV) infection and was diagnosed with AIDS in 2013. Read More

View Article and Full-Text PDF

Caffeine content and antioxidant activity of various brews of specialty grade coffee.

Acta Sci Pol Technol Aliment 2021 Apr-Jun;20(2):179-188

Department of Chemistry and Food Toxicology, Institute of Food Technology and Nutrition, University of Rzeszów, Poland.

Background: The aim of the study was to evaluate the caffeine level and antioxidant activity of brews of specialty grade coffee compared to popular coffee brands.

Methods: Ten types of coffee were used, including 7 specialty Arabica, 1 Robusta and 2 popular cheap coffee brands. For caffeine determination, HPLC analysis and the spectrophotometric method were used as reference. Read More

View Article and Full-Text PDF

Day care as a strategy for drowning prevention in children under 6 years of age in low- and middle-income countries.

Cochrane Database Syst Rev 2021 Apr 22;4:CD014955. Epub 2021 Apr 22.

Department of Public Health and Primary Care, Faculty of Medicine, KU Leuven, Leuven, Belgium.

Background: Drowning is responsible for an estimated 320,000 deaths a year, and over 90% of drowning mortality occurs in low- to middle-income countries (LMICs), with peak drowning rates among children aged 1 to 4 years. In this age group, mortality due to drowning is particularly common in rural settings and about 75% of drowning accidents happen in natural bodies of water close to the home. Providing adequate child supervision can protect children from drowning, and organized formal day care programs could offer a way to achieve this. Read More

View Article and Full-Text PDF