Free Radic Biol Med 2021 Apr 7. Epub 2021 Apr 7.
Department of Biochemistry and Biotechnology, University of Life Sciences, 60-632 Poznań, Poland;; Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers University-New Jersey Medical School, International Center for Public Health, Newark, NJ, USA. Electronic address:
High-density lipoprotein (HDL), in addition to promoting reverse cholesterol transport, possesses anti-oxidative, anti-inflammatory, and antithrombotic activities, which are thought to be promoted by paraoxonase 1 (PON1), an HDL-associated enzyme. Reduced levels of PON1 are associated with increased oxidative stress and cardiovascular disease both in humans and Pon1 mice. However, molecular basis of these associations are not fully understood. Read More