744,553 results match your criteria high frequency

Older drivers are at increased risk of fatal crash involvement: Results of a systematic review and meta-analysis.

Arch Gerontol Geriatr 2021 Apr 6;95:104414. Epub 2021 Apr 6.

University of Brasilia, Multidisciplinary Center for the Aged, Brasília, DF, Brazil. Electronic address:

Older adults have become a larger part of the driving population, but whether they are at increased risk of being involved in fatal crashes remains unclear.

Methods: We performed a systematic review of studies investigating fatal crash involvement of older vs non-older drivers by searching the following databases: PubMed, Cochrane Library, Embase, LILACS, SciELO, Web of Science, and ProQuest. Studies that used fatal crash involvement rates per distance driven as a measure of frequency were selected for meta-analysis. Read More

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Lipid responses to environmental perfluoroalkyl substance exposure in a Taiwanese Child cohort.

Environ Pollut 2021 Mar 24;283:117007. Epub 2021 Mar 24.

Institute of Environmental and Occupational Health Sciences, College of Public Health, National Taiwan University, Taipei, Taiwan; Department of Public Health, College of Public Health, National Taiwan University, Taipei, Taiwan. Electronic address:

Although recent epidemiologic studies have focused on some of the health effects of perfluoroalkyl substance (PFASs) exposure in humans, the associations between PFASs exposure and the lipidome in children are still unclear. The purpose of this study was to assess lipid changes in children to understand possible molecular events of environmental PFASs exposure and suggest potential health effects. A total of 290 Taiwanese children (8-10 years old) were included in this study. Read More

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Improved direct synthesis of TiO catalyst using sonication and its application for the desulfurization of thiophene.

Ultrason Sonochem 2021 Apr 1;73:105547. Epub 2021 Apr 1.

Department of Chemical Engineering, Institute of Chemical Technology, Matunga, Mumbai 400019, India. Electronic address:

TiO catalyst was synthesized in the presence of ultrasound (ultrasonic horn at 20 kHz frequency and 70% duty cycle) at different power (80 W to 120 W) and durations as well as surfactant concentration with an objective of establishing best conditions for achieving lowest particle size of the photocatalyst. Detailed characterization in terms of crystal phase, crystallinity, functional groups and morphology of the photocatalyst has been performed using SEM, XRD and FTIR analysis. It was demonstrated that sonication significantly reduced the particle size with high degree of sphericity and homogeneity as compared to conventionally synthesized TiO with similar crystallinity in both cases. Read More

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An Exploratory Study of Factors Associated with Difficulties in Accessing HIV Services During COVID-19 among Chinese Gay and Bisexual Men in Hong Kong.

Int J Infect Dis 2021 Apr 9. Epub 2021 Apr 9.

Department of Social Policy, London School of Economics and Political Science, London, United Kingdom. Electronic address:

Background: The COVID-19 pandemic has resulted in the provision of HIV services being disrupted. This paper examines the factors that are associated with the difficulty in accessing HIV services during COVID-19.

Methods: An online survey of 236 Chinese-speaking gay and bisexual men in Hong Kong conducted in 2020. Read More

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Estimated dietary exposure to pesticide residues based on organic and conventional data in omnivores, pesco-vegetarians, vegetarians and vegans.

Food Chem Toxicol 2021 Apr 9:112179. Epub 2021 Apr 9.

Sorbonne Paris North University, Inserm, Inrae, Cnam, Nutritional Epidemiology Research Team (EREN), Epidemiology and Statistics Research Centre, University of Paris (CRESS), Bobigny, France.

Purpose: To examine dietary exposure to 25 pesticide residues in several diet groups including omnivores, pesco-vegetarians, vegetarians and vegans while accounting for the farming system (organic or conventional) of plant-based foods consumed.

Methods: Organic and conventional consumption data in combination with data on pesticide residues in plant-based foods were used to derive estimated dietary exposure to pesticide residues. Pesticide residue exposure was estimated based on observed data, and using two scenarios simulated for 100%-conventional and 100%-organic diets in 33,018 omnivores, 555 pesco-vegetarians, 501 vegetarians and 368 vegans from the NutriNet-Santé study. Read More

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Morphologic design of sugar-based polymer nanoparticles for delivery of antidiabetic peptides.

J Control Release 2021 Apr 9. Epub 2021 Apr 9.

Departments of Chemistry, Chemical Engineering, and Materials Science & Engineering, Texas A&M University, College Station, TX 77842, USA. Electronic address:

Zwitterionic polymer nanoparticles of diverse morphologies (spherical, cylindrical, and platelet-like) constructed from biocompatible sugar-based polymers are designed to extend the pharmacological activities of short- and long-acting insulin peptides, thereby providing potential for therapeutic systems capable of reducing the frequency of administration and improving patient compliance. Amphiphilic block copolymers composed of zwitterionic poly(d-glucose carbonate) and semicrystalline polylactide segments were synthesized, and the respective block length ratios were tuned to allow formation of nanoscopic assemblies having different morphologies. Insulin-loaded nanoparticles had similar sizes and morphologies to the unloaded nanoparticle counterparts. Read More

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Surveillance for subsequent neoplasms of the CNS for childhood, adolescent, and young adult cancer survivors: a systematic review and recommendations from the International Late Effects of Childhood Cancer Guideline Harmonization Group.

Lancet Oncol 2021 Apr 9. Epub 2021 Apr 9.

Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands.

Exposure to cranial radiotherapy is associated with an increased risk of subsequent CNS neoplasms among childhood, adolescent, and young adult (CAYA) cancer survivors. Surveillance for subsequent neoplasms can translate into early diagnoses and interventions that could improve cancer survivors' health and quality of life. The practice guideline presented here by the International Late Effects of Childhood Cancer Guideline Harmonization Group was developed with an evidence-based method that entailed the gathering and appraisal of published evidence associated with subsequent CNS neoplasms among CAYA cancer survivors. Read More

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Factors Influencing Incidence of Wheelchair Repairs and Consequences Among Individuals with Spinal Cord Injury.

Arch Phys Med Rehabil 2021 Apr 9. Epub 2021 Apr 9.

Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA; Human Engineering Research Laboratories, Veterans Affairs Pittsburgh Healthcare system, Pittsburgh, PA.

Objective: Investigate frequency and consequences of wheelchair repairs, looking at the relationship to usage, components, out-of-pocket costs, number of days impacting the user, and factors associated with the need for repairs or consequences.

Design: Survey, cross-sectional.

Setting: Nine spinal cord injury (SCI) Model Systems Centers. Read More

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Human microbiota flagellins drive adaptive immune responses in Crohn's disease.

Gastroenterology 2021 Apr 9. Epub 2021 Apr 9.

Department of Medicine, University of Alabama at Birmingham, Birmingham, AL; Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL. Electronic address:

Background And Aims: Crohn's Disease (CD) and ulcerative colitis (UC) are characterized by dysregulated adaptive immune responses to the microbiota in genetically susceptible individuals, but the specificity of these responses remains largely undefined. Therefore, we developed a microbiota antigen microarray to characterize microbial antibody reactivity, particularly to human-derived microbiota flagellins, in inflammatory bowel disease.

Methods: Sera from healthy volunteers at the University of Alabama at Birmingham (UAB), n=87; patients recruited from the Kirklin Clinic of UAB Hospital, including patients with Crohn's disease, n=152; and Ulcerative colitis, n=170; was individually probed against microbiota bacterial flagellins of both mouse and human origin and analyzed for IgG and IgA antibody responses. Read More

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Adiposity and interstitial lung abnormalities in community dwelling adults: the MESA cohort study.

Chest 2021 Apr 9. Epub 2021 Apr 9.

Department of Medicine, Weill Cornell Medical College, New York, NY.

Background: Obesity is associated with restrictive ventilatory defects and faster rate of decline in forced vital capacity (FVC). This association is not exclusively mediated by mechanical factors and may reflect direct pulmonary injury by adipose-derived mediators.

Research Question: Is adipose tissue involved in the pathogenesis of interstitial lung disease (ILD)?

Study Design And Methods: We evaluated the association of CT measures of pericardial, abdominal visceral, and abdominal subcutaneous adipose tissue, with high attenuation areas (HAA) and interstitial lung abnormalities (ILA) in a large multi-center cohort study of community-dwelling adults, using multivariable-adjusted models. Read More

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Mutation spectrum and genotype-phenotype correlations in Chinese congenital ectopia lentis patients.

Exp Eye Res 2021 Apr 9:108570. Epub 2021 Apr 9.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China. Electronic address:

Purpose: To identify the spectrum and frequency of mutations in congenital ectopia lentis (CEL) and to investigate the correlations between genotype and clinical phenotype in Chinese CEL patients.

Methods: Ninety-three participants with CEL were enrolled from March 2017 to April 2020. Ocular and systemic examinations were performed for each included patient. Read More

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Depression, Anxiety, Resilience, and Coping: The Experience of Pregnant and New Mothers During the First Few Months of the COVID-19 Pandemic.

J Womens Health (Larchmt) 2021 Apr 12. Epub 2021 Apr 12.

School of Nursing, Virginia Commonwealth University, Richmond, Virginia, USA.

It is well-documented that the mental health of pregnant and postpartum women is essential for maternal, child, and family well-being. Of major public health concern is the perinatal mental health impacts that may occur during the ongoing COVID-19 pandemic. It is essential to explore the symptom experience and predictors of mental health status, including the relationship between media use and mental health. Read More

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Heterogeneity of the Predictive Polygenic Risk Scores for Coronary Heart Disease Age-at-onset in Three Different CHD Family-based Ascertainments.

Circ Genom Precis Med 2021 Apr 12. Epub 2021 Apr 12.

Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO.

- Polygenic risk scores (PRS) for coronary heart disease (CHD) may contribute to assess the overall risk of CHD. We evaluated how PRS may influence CHD risk when the distribution of age-at-onset, sex, and family health history differ significantly. - Our study included three family-based ascertainments: Long Life Family Study (LLFS, N=4,572), which represents a low CHD risk, and Family Heart Study, which consists of randomly selected families (FamHS-Random, N=1,806), and high CHD risk families (FamHS-High Risk, N=2,301). Read More

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Omega-3 Use for the Treatment of Hypertriglyceridemia, Low High-Density Lipoprotein Cholesterol Levels, and Nonalcoholic Fatty Liver Disease in Children with Obesity.

Child Obes 2021 Apr 12. Epub 2021 Apr 12.

Center for Better Health and Nutrition, The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Omega-3 fatty acid supplementation has been investigated in treating elevated triglycerides (TGs), nonalcoholic fatty liver disease (NAFLD), and low high-density lipoprotein cholesterol (HDL) in adults, but has not been well studied in youth with obesity. This retrospective study examined the effectiveness of omega-3 as an adjunct therapy for these conditions in patients participating in a pediatric weight management program (PWMP). Patients with a BMI ≥85th percentile and abnormal alanine transaminase (ALT), TGs, or HDL, participating in our PWMP, were identified ( = 617). Read More

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Treatment for pure red cell aplasia after major ABO-incompatible allogeneic stem cell transplantation: a multicentre study.

Br J Haematol 2021 Apr 12. Epub 2021 Apr 12.

Haematology Transplant Unit, Saint-Louis Hospital, Assistance Publique-Hôpitaux de Paris (APHP), Paris, France.

Pure red cell aplasia (PRCA) following allogeneic haematopoietic stem cell transplantation (aHSCT) with major ABO incompatibility is responsible for transfusion dependent anaemia, impaired quality of life and iron overload. We conducted a retrospective study, over a 10-year period, which included all consecutive patients who received a major ABO mismatched aHSCT, to assess the impact of specific treatment on PRCA. We did not observe any PRCA in the 57 aHSCT issued from cord blood. Read More

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[Multicenter retrospective study about the epidemiological, clinical and therapeutic aspects of Kawasaki disease in children from Panama].

Rev Chilena Infectol 2020 Dec;37(6):675-682

Centro de Ciencias Médicas, Hospital Nacional de Niños, Caja Costarricense de Seguro Social, San José, Costa Rica.

Background: Kawasaki disease (KD) is the leading cause of pediatric acquired heart disease in many countries, however, there are few published studies from Latin America (LA).

Aim: To describe the epidemiology, clinical aspects, and treatment of KD in children from Panama as part of the REKAMLATINA-2 in LA.

Methods: Retrospective descriptive review of hospitalized patients diagnosed with KD, attended at three main pediatric hospitals of Panama from January-1-2009 to December-31-2013. Read More

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December 2020

[Evaluation of spoligotyping-smear sputum as an alternative and culture-independent methodology for Mycobacterium tuberculosis genotyping].

Rev Chilena Infectol 2021 Feb;38(1):61-68

Universidad Nacional Autónoma de Honduras, Honduras.

Background: Tuberculosis (TB) remains as the second cause of death by an infectious disease preceded by the acquired immune deficiency syndrome (AIDS). Currently, laboratory techniques and methodologies of diagnosis and drug susceptibility testing are constantly changing. Therefore, it has been recommended the introduction of rapid assays based on the amplification of nucleic acids test (NAAT's) through a polymerase chain reaction (PCR). Read More

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February 2021

Establishment of reference intervals for Platelet Function Analyzer -100 closure time in Algerian adults.

PLoS One 2021 12;16(4):e0249402. Epub 2021 Apr 12.

Faculty of Medicine, Djellali Liabes University, Sidi-Bel Abbès, Algeria.

Introduction: The Platelet Function Analyzer-100 (PFA-100) is a point of care instrument that simulates plug formation under high shear flow. The PFA-100 measures the time required to occlude the aperture in a biochemically active cartridge and is expressed in a term of closure time (CT). In Algeria, the reference values used in clinical laboratories are of Western origin. Read More

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Body Mass Index Differentially Moderates Heritability of Total Joint Replacement Due to Hip and Knee Osteoarthritis: A Cohort Study of 29,893 Swedish Twin Pairs.

J Bone Joint Surg Am 2021 Apr 12. Epub 2021 Apr 12.

Section of Orthopedics, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.

Background: Osteoarthritis and obesity are diseases with high prevalence, and they share common etiologies. We investigated the sex-specific genetic susceptibility to hip and knee osteoarthritis necessitating total joint replacement (TJR), and how body mass index (BMI) moderated the heritability of these osteoarthritis phenotypes.

Methods: We linked 29,893 twin pairs with information on BMI in the Swedish Twin Registry with the Swedish National Patient Register to identify twins who underwent primary TJR of the hip or knee combined with a concomitant diagnosis of primary osteoarthritis of these joints. Read More

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House Structure Is Associated with Malaria among Febrile Patients in a High-Transmission Region of Zambia.

Am J Trop Med Hyg 2021 Apr 12. Epub 2021 Apr 12.

3Johns Hopkins Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

Since the late nineteenth century, the importance of house structure as a determinant of malaria risk has been recognized. Few studies to date have examined the association of housing and malaria in clinical populations. We conducted a cross-sectional study of febrile patients (n = 282) at two rural health clinics in a high malaria-transmission area of northern Zambia. Read More

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Vibrotactile Display of Patterned Surface Textures with Kinesthetic Haptic Devices using Balanced Impulses.

IEEE Trans Haptics 2021 Apr 12;PP. Epub 2021 Apr 12.

Kinesthetic haptic devices are designed primarily to display quasistatic and low-bandwidth forces and moments. Existing methods for vibrotactile display sometimes introduce haptic and/or audio artifacts. In this paper, we propose a method to display vibrotactile stimulus signals of moderate to high frequency (20--500Hz) using kinesthetic haptic devices with a standard 1kHz haptic update rate. Read More

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Fourier-domain ultrasonic imaging of cortical bone based on velocity distribution inversion.

IEEE Trans Ultrason Ferroelectr Freq Control 2021 Apr 12;PP. Epub 2021 Apr 12.

There is significant acoustic impedance contrast between the cortical bone and surrounding soft tissue, resulting in difficulty for ultrasound penetration into bone tissue with high frequency. It is challenging for the conventional pulse-echo modalities to give accurate cortical bone images using uniform sound velocity model. To overcome these limitations, an ultrasound imaging method called full-matrix Fourier-domain synthetic aperture based on velocity inversion (FM-FDSA-VI) was developed to provide accurate cortical bone images. Read More

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Multipass low fluence, high-frequency 755-nm alexandrite laser versus high fluence, low-frequency 1064-nm long-pulsed Nd: YAG laser in axillary hair reduction of dark skin phototypes: an intra-individual randomized comparative study.

J Dermatolog Treat 2021 Apr 12:1-13. Epub 2021 Apr 12.

Assistant Professor of Dermatology & Venereology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

Background: Laser hair removal has become popular means of achieving hair reduction with improved quality of life.

Objective: This study aimed to assess the safety and efficacy of Multipass low fluence, high-frequency 755-nm Alexandrite laser versus the high fluence, low-frequency 1064-nm long-pulsed Nd: YAG laser on axillary hair reduction in women with dark skin phototypes.

Patients And Methods: This study was carried out on 30 adult women [skin type, IV-VI)] who seek axillary hair reduction. Read More

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Satiety does not affect neuroaffective electrophysiological responses to food-related or emotional visual cues.

Behav Neurosci 2021 Apr 12. Epub 2021 Apr 12.

Behavioral Science Department, The University of Texas MD Anderson Cancer Center.

Continuing to eat even when full leads to excessive calorie consumption and obesity. Thus, understanding brain responses to food cues when satiated has important implications for weight control interventions. We used the late positive potential (LPP, a component of the event-related potentials (ERP) indexing motivational relevance) to determine the extent to which satiety affects brain responses to images of highly palatable foods (high-fat, high-sugar), high and low motivationally relevant (pleasant, unpleasant) and neutral stimuli in a sample of obese (body mass index [BMI] ≥ 30 kg/m2) and lean (BMI < 25 kg/m2) individuals. Read More

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Ultrafine RhNi Nanocatalysts Confined in Hollow Mesoporous Carbons for a Highly Efficient Hydrogen Production from Ammonia Borane.

Inorg Chem 2021 Apr 12. Epub 2021 Apr 12.

Jiangsu Key Laboratory of New Power Batteries, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China.

Ammonia borane (AB) has received growing research interest as one of the most promising hydrogen-storage carrier materials. However, fast dehydrogenation of AB is still limited by sluggish catalytic kinetics over current catalysts. Herein, highly uniform and ultrafine bimetallic RhNi alloy nanoclusters encapsulated within nitrogen-functionalized hollow mesoporous carbons (defined as RhNi@NHMCs) are developed as highly active, durable, and selective nanocatalysts for fast hydrolysis of AB under mild conditions. Read More

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Incidence of Infections and Malignancy Among Elderly Male Patients with IBD Exposed to Vedolizumab, Prednisone, and 5-ASA Medications: A Nationwide Retrospective Cohort Study.

Adv Ther 2021 Apr 12. Epub 2021 Apr 12.

Department of Gastroenterology, Corporal Michael J Crescenz VA Medical Center, 3900 Woodland Avenue, Philadelphia, PA, 19104, USA.

Introduction: Vedolizumab (VDZ) is postulated to have a potentially safer side effect profile than other biologic medications owing to its gut-selective mechanism. However, extrapolating these safety data to older patients is challenging because of their underrepresentation in or exclusion from most clinical trials, higher rates of withdrawal, and higher rates of comorbidities. Our aim was to evaluate the absolute risk of infections and malignancies in an elderly group of patients with inflammatory bowel disease (IBD) exposed to VDZ vs. Read More

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Impact of Race/Ethnicity and County-Level Vulnerability on Receipt of Surgery Among Older Medicare Beneficiaries With the Diagnosis of Early Pancreatic Cancer.

Ann Surg Oncol 2021 Apr 12. Epub 2021 Apr 12.

Department of Surgery, Division of Surgical Oncology, The Urban Meyer III and Shelley Meyer Chair for Cancer Research, The Ohio State University, Wexner Medical Center, Columbus, OH, USA.

Background: Patients can experience barriers and disparities to access high-quality cancer care. This study sought to characterize receipt of surgery and chemotherapy among Medicare beneficiaries with a diagnosis of early-stage pancreatic adenocarcinoma cancer (PDAC) relative to race/ethnicity and social vulnerability.

Methods: The Surveillance, Epidemiology, and End Results (SEER)-Medicare database was used to identify patients with a diagnosis of early-stage (stage 1 or 2) PDAC between 2004 and 2016. Read More

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Technical note: multi-alleles at the DYS385ab locus with high frequency in a Han Chinese population from southwestern China.

Int J Legal Med 2021 Apr 12. Epub 2021 Apr 12.

Laboratory of Forensic DNA, the Judicial Authentication Center, Southwest Medical University, Luzhou, 646000, Sichuan, China.

Y-chromosome short tandem repeat (Y-STR) markers have been widely used in forensic applications and usually show monoallelic or diallelic genotypic patterns at certain double-copied loci. In this study, we have found 13 samples among 703 males with multi-alleles at the DYS385ab locus, including one with five mutant alleles, nine with four, and three with three. The frequency of abnormal DYS385ab genotypes was 1. Read More

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Identification of Fusobacterium nucleatum in primary and secondary endodontic infections and its association with clinical features by using two different methods.

Clin Oral Investig 2021 Apr 12. Epub 2021 Apr 12.

Department of Restorative Dentistry, Division of Endodontics, Piracicaba Dental School, State University of Campinas - UNICAMP, Av. Limeira 901. Bairro Areao, Piracicaba, SP, Brazil.

Objective: Fusobacterium nucleatum is an important oral pathogen involved in endodontic infections. This study aimed to assess the frequency of Fusobacterium nucleatum in primary and secondary endodontic infections and its associations with the clinical features in a Brazilian population by using both culture and nested PCR methods.

Methods: A total of 100 microbial samples from patients with primary (n=50) and secondary endodontic infections (n=50) were analyzed by using culture and nested PCR methods. Read More

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Telemedicine in Pediatric Headache: A Review and Practical Implementation.

Curr Neurol Neurosci Rep 2021 Apr 12;21(6):27. Epub 2021 Apr 12.

Pediatric Headache Program Children's Hospital Colorado, University of Colorado School of Medicine, 13123 E 16th Ave., Aurora, CO, 80045, USA.

Purpose Of Review: The purpose of this review was to summarize the current literature about telemedicine in pediatric headache and to provide practical guidance for its implementation.

Recent Findings: There are few studies dedicated to telemedicine in pediatric headache, and existing studies are small. Patients and families report high levels of satisfaction with telemedicine, and most are willing to continue telemedicine visits in the future. Read More

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