354,993 results match your criteria high dose


High-Dose Rate Interstitial Spine Brachytherapy Using an Intraoperative Mobile Computed Tomography-Guided Surgical Navigation System.

Oper Neurosurg (Hagerstown) 2021 Oct 20. Epub 2021 Oct 20.

Department of Radiation Oncology, University of California Los Angeles, Los Angeles, CA, USA.

Background: Up to 15% of previously irradiated metastatic spine tumors will progress. Re-irradiation of these tumors poses a significant risk of exceeding the radiation tolerance to the spinal cord. High-dose rate (HDR) brachytherapy is a treatment alternative. Read More

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October 2021

Efficacy of Mitomycin C Combined with Direct Vision Internal Urethrotomy for Urethral Strictures: A Systematic Review and Meta-Analysis.

Urol Int 2021 Oct 20:1-14. Epub 2021 Oct 20.

Department of Urology, Peking University First Hospital, Beijing, China.

Background: The high recurrence of a urethral stricture after direct vision internal urethrotomy (DVIU) has been a problem for years. Mitomycin C (MMC) is an excellent antifibrosis antigen that has been used in many fields, but its effect on a urethral stricture remains controversial. The purpose of this review was to investigate the effectiveness of MMC in reducing the recurrence rate of a urethral stricture after the first urethrotomy. Read More

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October 2021

Immune reconstitution following high-dose chemotherapy and autologous stem cell transplantation with and without pembrolizumab maintenance therapy in patients with lymphoma.

Transplant Cell Ther 2021 Oct 17. Epub 2021 Oct 17.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.

Background: Autologous stem cell transplantation (ASCT) is a standard of care for patients with chemosensitive, relapsed/refractory (R/R) classical Hodgkin lymphoma (cHL) and diffuse large B-cell lymphoma (DLBCL). While the clinical benefit of ASCT has traditionally been attributed solely to cytoreduction from intensive chemotherapy, ASCT has important immunogenic effects which may contribute to its anti-tumor efficacy and could provide a favorable immune environment for post-ASCT immune-based maintenance treatments. We previously reported clinical results of a phase II trial (NCT02362997) testing 8 doses of pembrolizumab maintenance therapy after ASCT for patients with R/R cHL or DLBCL. Read More

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October 2021

Low dose mitotane-induced neurological and endocrinological complication in a 5-year-old girl with adrenocortical carcinoma.

Ann Pediatr Endocrinol Metab 2021 Oct 18. Epub 2021 Oct 18.

Department of Pediatrics, Dong-A University Hospital, Dong-A University College of Medicine, Busan, Korea.

Mitotane is an adrenolytic drug that exhibits a therapeutic effect within a narrow target range (14-20 μg/dL). Various complications develop if the upper limit is exceeded. We present the case of a 5-year-old girl with breast development, acne, and pubic hair; she was diagnosed with an adrenal mass that was then excised. Read More

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October 2021

Current Pharmacotherapy Management of Children and Adults with Pericarditis: Prospectus for Improved Outcomes.

Pharmacotherapy 2021 Oct 20. Epub 2021 Oct 20.

OU Health, Oklahoma City.

Pericarditis is the most common inflammatory pericardial disease in both children and adults. Since the publication of the 2015 European Society of Cardiology Guidelines for the diagnosis and management of pericardial disease were published there have been significant updates to management. Pharmacotherapy has been historically reserved for idiopathic pericarditis (IP). Read More

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October 2021

Effects of aerobic physical exercise on neuroplasticity after stroke: systematic review.

Arq Neuropsiquiatr 2021 Sep;79(9):832-843

Universidade de Coimbra, Faculdade de Medicina, Departamento de Medicina do Desporto, Coimbra, Província de Coimbra, Portugal.

Background: Stroke is among the leading causes of death and disability worldwide. Interventions for stroke rehabilitation aim to minimize sequelae, promote individuals' independence and potentially recover functional damage. The role of aerobic exercise as a facilitator of post-stroke neuroplasticity in humans is still questionable. Read More

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September 2021

Obese, non-eosinophilic asthma: frequent exacerbators in a real-world setting.

J Asthma 2021 Oct 20:1-13. Epub 2021 Oct 20.

West Hertfordshire Hospitals NHS Trust.

In the UK, asthma deaths are at their highest level this century. Increased recognition of at-risk patients is needed. This study phenotyped frequent asthma exacerbators, and used machine learning to predict frequent exacerbators. Read More

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October 2021

High throughput screening identifies inhibitors for parvovirus B19 infection of human erythroid progenitor cells.

J Virol 2021 Oct 20:JVI0132621. Epub 2021 Oct 20.

Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA.

Parvovirus B19 (B19V) infection can cause hematological disorders and fetal hydrops during pregnancy. Currently, no antivirals or vaccines are available for the treatment or the prevention of B19V infection. To identify novel small-molecule antivirals against B19V replication, we developed a high throughput screening assay, which is based on an nicking assay using recombinant N-terminal 1-176 amino acids of the viral large nonstructural protein (NS1N) and a fluorescently labeled DNA probe () that spans the nicking site of the viral DNA replication origin. Read More

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October 2021

[Steroidi tra necessità e tossicità].

G Ital Nefrol 2021 Sep 7;38(Suppl 77). Epub 2021 Sep 7.

Unità Operativa Complessa e Cattedra di Nefrologia. ASST Spedali Civili e Università di Brescia, Brescia, Italy.

Steroid minimization has always been one of the most desired goals regarding immunosuppressive therapy after renal transplantation. Following the introduction of cyclosporine different steroid-free protocols became available, but their implementation was limited due to the high risk of acute rejection. In the last few years, the use of a very low dose of prednisone (5 mg/day) has been deemed to guarantee a good balance between steroid toxicity and efficacy. Read More

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September 2021

Poly (4,4'-methylenedianiline)-graphene oxide nanocomposite: synthesize and application in removal of benzothiophene from model liquid fuel.

Environ Monit Assess 2021 Oct 20;193(11):737. Epub 2021 Oct 20.

Department of Environmental Health Engineering, School of Health, Larestan University of Medical Sciences, Larestan, Iran.

The adsorption of sulfur-containing compounds from fuels on polymer nanocomposite adsorbents modified with carbon-based materials was investigated. This work reports the removal of benzothiophene from the model liquid fuel using a novel adsorbent prepared by nanopoly (4,4'-methylenedianiline)-graphene oxide (NPMDA/GO) composite. The adsorbent was successfully synthesized with the in situ electrochemical method and characterized using thermal gravimetric analysis (TGA), field-scattering scanning electron microscopy (FE-SEM), transient electron microscopy (TEM), X-ray diffraction analysis (XRD), and Fourier transform infrared (FTIR). Read More

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October 2021

Half-dose glucarpidase as efficient rescue for toxic methotrexate levels in patients with acute kidney injury.

Cancer Chemother Pharmacol 2021 Oct 20. Epub 2021 Oct 20.

Medizinische Klinik und Poliklinik 1, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden (TUD), Fetscherstrasse 74, 01307, Dresden, Germany.

Purpose: High-dose methotrexate (HDMTX)-associated acute kidney injury with delayed MTX clearance has been linked to an excess in MTX-induced toxicities. Glucarpidase is a recombinant enzyme that rapidly hydrolyzes MTX into non-toxic metabolites. The recommended dose of glucarpidase is 50 U/kg, which has never been formally established in a dose finding study in humans. Read More

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October 2021

Ultrashort echo time MRI of the lung in children and adolescents: comparison with non-enhanced computed tomography and standard post-contrast T1w MRI sequences.

Eur Radiol 2021 Oct 20. Epub 2021 Oct 20.

Department of Paediatric Radiology, Institute of Diagnostic and Interventional Radiology, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany.

Objectives: To compare the diagnostic value of ultrashort echo time (UTE) magnetic resonance imaging (MRI) for the lung versus the gold standard computed tomography (CT) and two T1-weighted MRI sequences in children.

Methods: Twenty-three patients with proven oncologic disease (14 male, 9 female; mean age 9.0 + / - 5. Read More

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October 2021

Olanzapine-Related Somnambulism: A Systematic Review of Literature and a Case Report of Anorexia Nervosa.

J Clin Psychopharmacol 2021 Oct 18. Epub 2021 Oct 18.

From the Psychiatry Unit, Department of Health Sciences, University Magna Graecia of Catanzaro, Catanzaro Center for Clinical Research and Treatment of Eating Disorders, Azienda Ospedaliera Universitaria Mater Domini, Catanzaro, Italy Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Institut de Neuropsiquiatria i Addiccions (INAD), Hospital del Mar, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Departament de Psiquiatria, Universitat Autònoma de Barcelona, Barcelona, Spain Division of Psychiatry Research, Zucker Hillside Hospital, Northwell Health, NY Department of Psychiatry, Zucker School of Medicine at Northwell/Hofstra, Hempstead, NY Psychiatry Unit, Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy.

Background: Somnambulism, or sleepwalking (SW), is one of the most common forms of arousal parasomnias. It is characterized by different complex motor behaviors leading to unwanted movements in bed or walking during sleep. It can be the consequence of psychological stress, abnormal breathing during sleep, high fever, or drug adverse effects. Read More

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October 2021

Significant reduced loss of bone mineral density after four vs. six cycles of R-CHOP: an analysis of the FLYER-trial.

Leuk Lymphoma 2021 Oct 20:1-9. Epub 2021 Oct 20.

Department of Radiology, Medical School, University of Saarland, Homburg, Germany.

Patients with diffuse large B-cell lymphoma (DLBCL) treated with the R-CHOP regime receive a high cumulative dose of prednisone. We used computer tomography-ascertained Hounsfield units (HU) as a surrogate parameter for bone mineral density (BMD) in three different locations of the L3 vertebral body at baseline and post-treatment. HU were measured in 50 patients with DLBCL of the previously published FLYER-trial which compared four cycles of R-CHOP + 2 × rituximab infusion to six cycles of R-CHOP in young, favorable DLBCL patients. Read More

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October 2021

The K18-hACE2 Transgenic Mouse Model Recapitulates Non-Severe and Severe COVID-19 in Response to Infectious Dose of SARS-CoV-2 Virus.

J Virol 2021 Oct 20:JVI0096421. Epub 2021 Oct 20.

Department of Hematology & Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California, USA.

A comprehensive analysis and characterization of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection model that mimics non-severe and severe coronavirus disease 2019 (COVID-19) in humans is warranted for understating the virus and developing preventive and therapeutic agents. Here, we characterized the K18-hACE2 mouse model expressing human (h)ACE2 in mice, controlled by the human keratin 18 (K18) promoter, in the epithelia, including airway epithelial cells where SARS-CoV-2 infections typically start. We found that intranasal inoculation with higher viral doses (2×10 and 2×10 PFU) of SARS-CoV-2 caused lethality of all mice and severe damage of various organs, including lung, liver, and kidney, while lower doses (2×10 and 2×10 PFU) led to less severe tissue damage and some mice recovered from the infection. Read More

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October 2021

Budesonide/formoterol versus salmeterol/fluticasone for asthma in children: an effectiveness and safety analysis.

J Comp Eff Res 2021 Oct 20. Epub 2021 Oct 20.

Department of Pediatrics, Minhang Hospital, Fudan University, Shanghai 201100, China.

The efficacy of budesonide + formoterol therapy compared with high-dose salmeterol + fluticasone therapy plus short-acting β-agonist (SABA) has not been evaluated specifically in children. To evaluate the efficacy and safety of budesonide + formoterol combination therapy two times a day plus as needed compared with salmeterol + fluticasone two times a day plus SABA (as needed) in children in China. This prospective cohort study included 164 children with persistent asthma (aged 12-17 years) who had experienced a minimum of one asthma exacerbation in 12 months prior to the study. Read More

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October 2021

Smoking cessation medicines and e-cigarettes: a systematic review, network meta-analysis and cost-effectiveness analysis.

Health Technol Assess 2021 Oct;25(59):1-224

Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

Background: Cigarette smoking is one of the leading causes of early death. Varenicline [Champix (UK), Pfizer Europe MA EEIG, Brussels, Belgium; or Chantix (USA), Pfizer Inc., Mission, KS, USA], bupropion (Zyban; GlaxoSmithKline, Brentford, UK) and nicotine replacement therapy are licensed aids for quitting smoking in the UK. Read More

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October 2021

Hepatitis B virus elimination status and strategies in circumpolar countries, 2020.

Int J Circumpolar Health 2021 Dec;80(1):1986975

Arctic Investigations Program, Division of Preparedness and Emerging Infections, National Center for Emerging and Zoonotic Infectious Diseases, US Centers for Disease Control and Prevention (CDC), Anchorage, Alaska, USA.

Hepatitis B virus (HBV) infection remains a global health threat. The World Health Organization (WHO) established a goal to eliminate HBV infection as a public health threat by 2030, and defined targets for key interventions to achieve that goal. We evaluated HBV burden and relevant national recommendations for progress towards WHO targets in circumpolar countries. Read More

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December 2021

Effective elimination of high-dose methotrexate by repeated hemodiafiltration and high-flux hemodialysis in patients with acute kidney injury.

J Oncol Pharm Pract 2021 Oct 20:10781552211052564. Epub 2021 Oct 20.

Section of Clinical Pharmacology and Toxicology, 58878Rambam Health Care Campus, Haifa, Israel.

Introduction: Acute kidney injury (AKI) after high dose methotrexate (HD-MTX) is associated with delayed MTX-excretion and life-threatening toxicity. Glucapridase, the recommended therapy, is expensive and not always available.

Case Series: We describe 3 cases (69, 67, 73 years) with diffuse large B-cell lymphoma who developed AKI and early-onset severely delayed MTX elimination after HD-MTX. Read More

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October 2021

Nut consumption in association with overall mortality and recurrence/disease-specific mortality among long-term breast cancer survivors.

Int J Cancer 2021 Oct 19. Epub 2021 Oct 19.

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

High nut consumption is associated with reduced total and certain cause-specific mortality in general populations. However, its association with cancer outcomes among long-term breast cancer survivors remains unknown. We examined the associations of nut consumption (including peanuts and tree nuts), assessed at 5-year postdiagnosis, with overall survival (OS) and disease-free survival (DFS) among 3449 long-term breast cancer survivors from the Shanghai Breast Cancer Survival Study, applying Cox regression analysis. Read More

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October 2021

ATS Core Curriculum 2021. Adult Pulmonary Medicine: Thoracic Oncology.

ATS Sch 2021 Sep 1;2(3):468-483. Epub 2021 Sep 1.

Division of Pulmonary, Critical Care Medicine, Clinical Immunology, and Allergy, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.

The American Thoracic Society Core Curriculum updates clinicians annually in adult and pediatric pulmonary disease, medical critical care, and sleep medicine at the annual international conference. The 2021 Pulmonary Core Curriculum focuses on lung cancer and include risks and prevention, screening, nodules, therapeutics and associated pulmonary toxicities, and malignant pleural effusions. Although tobacco smoking remains the primary risk factor for developing lung cancer, exposure to other environmental and occupational substances, including asbestos, radon, and burned biomass, contribute to the global burden of disease. Read More

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September 2021

Uveitis and autoimmune hepatitis, a real entity? A case report with review of the literature.

Saudi J Ophthalmol 2021 Jan-Mar;35(1):73-77. Epub 2021 Sep 9.

Department of Ophthalmology, King Abdulaziz Medical City, National Guard Health Affairs, Riyadh, Saudi Arabia.

A 63-year-old man presented with a 10-day history of severe pain, redness of the right eye, and reduced vision in both eyes. In addition, he had been diagnosed incidentally with liver cirrhosis and splenomegaly 1 week before he was admitted to our center. The patient was found to have severe intraocular inflammation that initially involved the right eye and then progressed to bilateral panuveitis. Read More

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September 2021

Neutrophil to apolipoprotein A-I ratio as an independent indicator of locally advanced nasopharyngeal carcinoma.

Laryngoscope Investig Otolaryngol 2021 Oct 20;6(5):1049-1061. Epub 2021 Sep 20.

Department of Radiation Oncology Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine Guangzhou China.

Purpose: To explore the peripheral blood cells (neutrophil/monocyte/lymphocyte/platelet) to apolipoprotein AI or high-density lipoprotein-cholesterol ratio (NAR, MAR, LAR, PAR, NHR, MHR, LHR, and PHR) as independent prognostic indicators for stage III nasopharyngeal carcinoma (NPC).

Patients And Methods: Between 2009 and 2014, 562 patients diagnosed with stage III NPC who were treated with a concomitant chemotherapy and intensity-modulated radiotherapy with cumulative cisplatin dose ≥200 mg/m were included in this retrospective study. Routine blood and biochemical variables and baseline clinical characteristics (T and N stage, age, sex, and induction chemotherapy) were collected. Read More

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October 2021

Comparison of severity of immunized versus non-immunized COVID-19 patients admitted to ICU: A prospective observational study.

Ann Med Surg (Lond) 2021 Oct 15:102951. Epub 2021 Oct 15.

Research & Innovation Centre King Saud Medical City, Riyadh, Saudi Arabia.

Background: Vaccines against COVID-19 show high efficacy, yet, infection is still being detected among immunized patients, although with blunted severity. The purpose of this study was to assess the severity of COVID-19 infection among immunized versus non-immunized COVID-19 patients admitted to ICU.

Method: A prospective observational cohort study, including all COVID-19 patients admitted to intensive care unit between January 1st, 2021 and June 30th, 2021 were eligible for inclusion. Read More

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October 2021

Effects of Caffeine Consumption on Autologous Full-Thickness Skin Graft Healing in an Animal Model.

Indian J Plast Surg 2021 Sep 16;54(3):314-320. Epub 2021 Sep 16.

Department of Biomedical Science, Faculty of Medicine Diponegoro University, Semarang, Jawa Tengah, Indonesia.

There exists contradictory evidence that states both the beneficial and deleterious effects of caffeine on wound healing. The general population might unknowingly consume caffeine that negatively affects wound healing. The main objective of this study is to investigate the effect of daily caffeine consumption on wound healing, specifically full-thickness skin graft (FTSG). Read More

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September 2021

Comparison of Oral versus Intramuscular Clonidine for Prolongation of Bupivacaine Spinal Anesthesia in Patients Undergoing Total Abdominal Hysterectomy.

Anesth Essays Res 2021 Jan-Mar;15(1):81-86. Epub 2021 Aug 30.

Department of Anesthesia and Critical Care, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Background: Clonidine is a commonly used agent for premedication through oral, intravenous, and intramuscular route. Very few studies mentioned intramuscular clonidine as premedication.

Aims And Objectives: The aim of the present study is to compare oral and intramuscular clonidine as predication agent in bupivacaine spinal anesthesia patients. Read More

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Mismatch negativity as an index of target engagement for excitation/inhibition-based treatment development: a double-blind, placebo-controlled, randomized, single-dose cross-over study of the serotonin type-3 receptor antagonist CVN058.

Neuropsychopharmacology 2021 Oct 20. Epub 2021 Oct 20.

Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, NY, USA.

Serotonin type-3 receptor (5-HTR) antagonists show potential as a treatment for cognitive deficits in schizophrenia. CVN058, a brain-penetrant, potent and selective 5-HTR antagonist, shows efficacy in rodent models of cognition and was well-tolerated in Phase-1 studies. We evaluated the target engagement of CVN058 using mismatch negativity (MMN) in a randomized, double-blind, placebo-controlled, cross-over study. Read More

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October 2021

Starting dose and dose adjustment of non-vitamin K antagonist oral anticoagulation agents in a nationwide cohort of patients with atrial fibrillation.

Sci Rep 2021 Oct 19;11(1):20689. Epub 2021 Oct 19.

Agenzia Italiana del Farmaco, Rome, Italy.

This study aims to provide real-world data about starting-dose of NOACs and dose-adjustment in patients with atrial fibrillation (AF). In fact, even if new oral anticoagulation agents (NOACs) have a predictable effect without need for regular monitoring, dose-adjustments should be performed according to the summary of product information and international guidelines. We employed the Italian Medicines Agency monitoring registries comprising data on a nationwide cohort of patients with AF treated with NOACs from 2013 to 2018. Read More

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October 2021

Ameliorative effect of curcumin and zinc oxide nanoparticles on multiple mechanisms in obese rats with induced type 2 diabetes.

Sci Rep 2021 Oct 19;11(1):20677. Epub 2021 Oct 19.

Department of Biochemistry, Faculty of Science, Alexandria University, Alexandria, 21511, Egypt.

The present study was carried out to investigate the therapeutic effect of synthesized naturally compounds, curcumin nanoparticles (CurNPs) and metal oxide, zinc oxide nanoparticles (ZnONPs) on a high-fat diet (HFD)/streptozotocin (STZ)-induced hepatic and pancreatic pathophysiology in type 2 diabetes mellitus (T2DM) via measuring AKT pathway and MAPK pathway. T2DM rats were intraperitoneally injected with a low dose of 35 mg/kg STZ after being fed by HFD for 8 weeks. Then the rats have orally received treatments for 6 weeks. Read More

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October 2021

Intraperitoneal pretargeted radioimmunotherapy for colorectal peritoneal carcinomatosis.

Mol Cancer Ther 2021 Oct 19. Epub 2021 Oct 19.

Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center

Peritoneal carcinomatosis (PC) is considered incurable, and more effective therapies are needed. Herein we test the hypothesis that GPA33-directed intracompartmental pretargeted radioimmunotherapy (PRIT) can cure colorectal PC. Nude mice were implanted intraperitoneally (i. Read More

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October 2021