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Association of the apoptotic marker APO1/Fas with children's predisposing factors for metabolic syndrome and with mean platelet volume.

J Pediatr Endocrinol Metab 2021 Aug 2. Epub 2021 Aug 2.

Laboratory of Biology and Biochemistry, Faculty of Health Sciences, Department of Nursing, University of Peloponnese, Tripoli, Greece.

Background: Apoptosis antigen 1/FAS receptor (APO1/Fas) signaling in endothelial cells plays a significant role in angiogenesis while increased mean platelet volume (MPV) is an important marker for platelet activation. We investigated the possible correlation between APO1/Fas and both metabolic parameters and platelet activity (indicated by the MPV) in a healthy pediatric population.

Methods: One hundred and eighty-five children, aged 5-17 years old, were enrolled in the study. Read More

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Suppression of the hazardous substances in catalytically upgraded bio-heavy oil as a precautious measure for clean air pollution controls.

J Hazard Mater 2021 Jul 24;421:126732. Epub 2021 Jul 24.

School of Environmental Engineering, University of Seoul, 163 Seoulsiripdaero, Seoul 02504, Republic of Korea. Electronic address:

Bio-heavy oil (BHO) is a renewable fuel, but its efficient use is problematic because its combustion may emit hazardous air pollutants (e.g., polycyclic aromatic hydrocarbon (PAH) compounds, NO, and SO). Read More

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Nitrate removal from groundwater using a batch and continuous flow hybrid Fe-electrocoagulation and electrooxidation system.

J Environ Manage 2021 Jul 28;297:113387. Epub 2021 Jul 28.

Department of Chemical Engineering, University of Patras, Rio, GR-26504, Patras, Greece; Institute of Chemical Engineering Sciences (ICE-HT), Stadiou Str., Platani, GR-26504, Patras, Greece.

During the last two decades nitrate contaminated groundwater has become an extensive worldwide problem with wide-reaching negative effects on human health and the environment. In this study, a combination of electrocoagulation (EC) and electrooxidation (EO) was studied as a denitrification process to efficiently remove nitrates and ammonium (a by-product produced during EC) from real polluted groundwater. Initially, EC experiments under batch operating mode were performed using iron electrodes at different applied current density values (20-40 mA cm). Read More

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A temperature-dependent Raman scattering and X-ray diffraction study of KMoO·HO and ab initio calculations of KMoO.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jul 16;263:120184. Epub 2021 Jul 16.

Instituto de Ciências Exatas e Naturais, Universidade Federal do Pará, CEP 66075-110, Belém, PA, Brazil.

This study reports a temperature-dependent Raman scattering and X-ray diffraction study of KMoO·HO. The high-temperature Raman scattering analysis shows that the material remains structurally stable, with triclinic symmetry, in a temperature range from 300 to 413 K and undergoes a structural phase transition between 413 and 418 K. This phase transition is most likely connected with the dehydration process of KMoO·HO. Read More

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Adaptive current-flow models of ECT: Explaining individual static impedance, dynamic impedance, and brain current density.

Brain Stimul 2021 Jul 28. Epub 2021 Jul 28.

Department of Biomedical Engineering, The City College of New York, CUNY, New York, NY, USA. Electronic address:

Background: Improvements in electroconvulsive therapy (ECT) outcomes have followed refinement in device electrical output and electrode montage. The physical properties of the ECT stimulus, together with those of the patient's head, determine the impedances measured by the device and govern current delivery to the brain and ECT outcomes.

Objective: However, the precise relations among physical properties of the stimulus, patient head anatomy, and patient-specific impedance to the passage of current are long-standing questions in ECT research and practice. Read More

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Affinity proteomics and deglycoproteomics uncover novel EDEM2 endogenous substrates and an integrative ERAD network.

Mol Cell Proteomics 2021 Jul 28:100125. Epub 2021 Jul 28.

Department of Molecular Cell Biology, Institute of Biochemistry, Splaiul Independenței 296, 060031, Bucharest, Romania. Electronic address:

Various pathologies result from disruptions to or stress of endoplasmic reticulum (ER) homeostasis, such as Parkinson's disease and most neurodegenerative illnesses, diabetes, pulmonary fibrosis, viral infections and cancers. A critical process in maintaining ER homeostasis is the selection of misfolded proteins by the ER quality-control system (ERQC) for destruction via ER-associated degradation (ERAD). One key protein proposed to act during the first steps of misfolded glycoprotein degradation is the ER degradation-enhancing α-mannosidase-like protein 2 (EDEM2). Read More

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Impact of scandium on mechanical properties, corrosion behavior, friction and wear performance, and cytotoxicity of a β-type Ti-24Nb-38Zr-2Mo alloy for orthopedic applications.

Acta Biomater 2021 Jul 28. Epub 2021 Jul 28.

Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325027, China. Electronic address:

β-type titanium (Ti) alloys have been extensively investigated as orthopedic implant materials due to their unique combination of low elastic modulus, high specific strength, corrosion resistance, and biocompatibility. In this study the mechanical properties, corrosion behavior, friction and wear performance, and cytotoxicity of β-type Ti-24Nb-38Zr-2Mo (TNZM) and Ti-24Nb-38Zr-2Mo-0.1Sc (TNZMS) have been comparatively investigated for orthopedic applications. Read More

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Myeloperoxidase-induced modification of HDL by isolevuglandins inhibits paraoxonase-1 activity.

J Biol Chem 2021 Jul 28:101019. Epub 2021 Jul 28.

Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, USA; Department of Medicine, Division of Clinical Pharmacology. Electronic address:

Reduced activity of paraoxonase 1 (PON1), a high-density lipoprotein (HDL)-associated enzyme, has been implicated in the development of atherosclerosis. Post-translational modifications of PON1 may represent important mechanisms leading to reduced PON1 activity. Under atherosclerotic conditions, myeloperoxidase (MPO) is known to associate with HDL. Read More

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Advanced Electrolyte Design for High-Energy-Density Li Metal Batteries under Practical Conditions.

Angew Chem Int Ed Engl 2021 Jul 31. Epub 2021 Jul 31.

Fudan University, Department of Chemistry, Room 223, Laboratory of Advanced Materials Building, Songhu Road 2005, Shanghai, Shanghai, CHINA.

Given the limitation inherent in current intercalation-based Li-ion batteries, much research attentions have focused on the potential successor of Li-ion batteries such as Lithium Sulfur (Li-S) batteries and Lithium oxygen (Li-O2) batteries. In order to realize the potential of these batteries, the use of metallic Lithium as anode is essential. Nevertheless, the growth of Li dendrites accompanied with severe safety hazards hinder the practical application of Li metal anode. Read More

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The Effect of Curcumin in Improving Lipid Profile in Patients with Cardiovascular Risk Factors: A Systematic Review of Clinical Trials.

Adv Exp Med Biol 2021 ;1291:165-177

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Cardiovascular disease (CVD) is a major cause of death worldwide. Lipid abnormalities are one of the major risk factors for CVD. Curcumin is a natural polyphenol with lipid-lowering properties. Read More

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January 2021

High uric acid levels in overweight and obese children and their relationship with cardiometabolic risk factors: what is missing in this puzzle?

J Pediatr Endocrinol Metab 2021 Jul 30. Epub 2021 Jul 30.

Division of Translational Medicine, School of Medicine, Federal University of São Paulo, São Paulo, Brazil.

Objectives: The prevalence of hyperuricemia, a common disorder, has been increasing. Moreover, the association between obesity, serum uric acid levels, and cardiometabolic markers in children is unclear. Therefore, this study aimed to analyze the inter-relationships between these factors in a sample of children aged 6-12 years. Read More

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Ultrahigh Rate Capability and Lifespan MnCo2O4/Ni-MOF Electrode for High Performance Battery-Type Supercapacitor.

Chemistry 2021 Jul 31. Epub 2021 Jul 31.

Northwest Normal University, College of Chemistry and Chemical Engineering, Anning East Road 967, 730070, Lanzhou, CHINA.

MnCo2O4 is derived from a Co/Mn bimetallic MOF. Then Ni-MOF is directly grown on the surface of the obtained MnCo2O4 to form a nano-flower structure with small balls. Big surface area, abundant active sites of MnCo2O4 and porosity of Ni-MOF allow the prepared MnCo2O4/Ni-MOF composition material to deliver an excellent electrochemical performance. Read More

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A Novel Stimuli-Responsive Injectable Antibacterial Hydrogel to Achieve Synergetic Photothermal/Gene-Targeted Therapy towards Uveal Melanoma.

Adv Sci (Weinh) 2021 Jul 31:e2004721. Epub 2021 Jul 31.

Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200025, P. R. China.

Uveal melanoma (UM) is the most prevalent primary intraocular malignant tumor with a high lethal rate. Patients who undergo conventional enucleation treatments consistently suffer permanent blindness, facial defects, and mental disorders, therefore, novel therapeutic modalities are urgently required. Herein, an injectable and stimuli-responsive drug delivery antibacterial hydrogel ([email protected]@DC_AC50) is constructed via a facile grinding method that is inspired by the preparation process of traditional Chinese medicine. Read More

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Integrated Design of Interlayer/Current-Collector: Heteronanowires Decorated Carbon Microtube Fabric for High-Loading and Lean-Electrolyte Lithium-Sulfur Batteries.

Small 2021 Jul 31:e2103001. Epub 2021 Jul 31.

Institute of Materials Research, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China.

Low sulfur loading, high electrolyte/sulfur (E/S) ratio, and sluggish sulfur redox reaction are the main challenges that severely impede the practical application of lithium-sulfur batteries (LSBs). To address these problems, a self-standing hollow carbonized cotton cloth (CCC) decorated with TiO -TiN heteronanowires ([email protected] -TiN) is proposed to replace the traditional cathode. Concretely, one side of [email protected] -TiN serves as a current-collector to load sulfur ([email protected] -TiN/S), while the other side facing the separator acts as interlayer to inhibit shuttle effect. Read More

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Fe-Ni Alloy Nanoclusters Anchored on Carbon Aerogels as High-Efficiency Oxygen Electrocatalysts in Rechargeable Zn-Air Batteries.

Small 2021 Jul 30:e2102002. Epub 2021 Jul 30.

State Key Lab of Crystal Materials, Shandong University, Jinan, 250100, P. R. China.

In this work, Fe-Ni alloy nanoclusters (Fe-Ni ANCs) anchored on N, S co-doped carbon aerogel (Fe-Ni [email protected] catalysts) are successfully prepared by the optimal pyrolysis of polyaniline (PANI) aerogels derived from the freeze-drying of PANI hydrogel obtained by the polymerization of aniline monomers in the co-presence of tannic acid (TA), Fe , and Ni ions. In addition, the optimal molar ratio of the TA, Fe , and Ni ions for synthesis of Fe-Ni [email protected] catalysts are 1:2:5, which can guarantee the formation of carbon aerogel composed of quasi-2D porous carbon sheets and the formation of high-density Fe-Ni ANCs with an ultrasmall size between 2 to 2.8 nm. Read More

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Investigating the spectral features of the brain meso-scale structure at rest.

Hum Brain Mapp 2021 Jul 31. Epub 2021 Jul 31.

Rehab Technologies Lab, Istituto Italiano di Tecnologia, Genova, Italy.

Recent studies provide novel insights into the meso-scale organization of the brain, highlighting the co-occurrence of different structures: classic assortative (modular), disassortative, and core-periphery. However, the spectral properties of the brain meso-scale remain mostly unexplored. To fill this knowledge gap, we investigated how the meso-scale structure is organized across the frequency domain. Read More

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Inhibitory synapse loss and accumulation of amyloid beta in inhibitory presynaptic terminals in Alzheimer's disease.

Eur J Neurol 2021 Jul 31. Epub 2021 Jul 31.

The University of Edinburgh, Centre for Discovery Brain Sciences, UK Dementia Research Institute, Edinburgh.

Background: Synapse degeneration in Alzheimer's disease (AD) correlates strongly with cognitive decline. There is well-established excitatory synapse loss in Alzheimer's disease with known contributions of pathological amyloid beta (Aβ) to excitatory synapse dysfunction and loss. Despite clear changes in circuit excitability in AD and model systems, relatively little is known about pathology in inhibitory synapses. Read More

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Greater reproductive assurance of asexual plant compared to sexual relative in a low density sympatric population - experimental evidence for pollen limitation.

J Evol Biol 2021 Jul 31. Epub 2021 Jul 31.

Herbarium Collections, Department of Botany, Charles University, Praha, Czechia.

High reproductive assurance is regarded as a key advantage of uniparentally reproducing organisms for establishing a new population. This demographic benefit should especially be relevant for plants with autonomous apomixis, i.e. Read More

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In Situ Chemical Lithiation Transforms Diamond-Like Carbon into an Ultrastrong Ion Conductor for Dendrite-Free Lithium-Metal Anodes.

Adv Mater 2021 Jul 31:e2100793. Epub 2021 Jul 31.

Functional Thin Films Research Center, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.

Lithium (Li)-metal anodes are of great promise for next-generation batteries due to their high theoretical capacity and low redox potential. However, Li-dendrite growth during cycling imposes a tremendous safety concern on the practical application of Li-metal anodes. Herein, an effective approach to suppress Li-dendrite growth by coating a polypropylene (PP) separator with a thin layer of ultrastrong diamond-like carbon (DLC) is reported. Read More

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Optimizing the Differentiation of Cardiomyocytes from Human Induced Pluripotent-Derived Stem Cells.

Methods Mol Biol 2021 ;2319:51-60

Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA.

Cardiovascular disease is a worldwide health issue that affects millions of lives every year, and thus, researchers are in need of high-throughput model systems with which to investigate mechanisms of disease and to develop and test potential therapies. The use of human-derived induced pluripotent stem cells (iPSCs) differentiated into cardiomyocytes aims to address this need. While cardiac differentiation protocols have been established previously in iPSCs, optimization of cardiac differentiation remains crucial to obtaining high quality cardiomyocytes for future experimental analyses. Read More

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January 2021

Modelling of possible tanker accident oil spills in the Istanbul Strait in order to demonstrate the dispersion and toxic effects of oil pollution.

Environ Monit Assess 2021 Jul 30;193(8):538. Epub 2021 Jul 30.

Liverpool Logistics, Offshore and Marine (LOOM) Research Institute, Faculty of Engineering and Technology, Liverpool John Moores University, Liverpool, UK.

Countries located on the Black Sea coast perform most of their sea trade through the Istanbul Strait (IS). Approximately 50,000 ships pass through the IS each year, with crude oil tankers making up the majority. Thus, the aim of the study is to determine the acute toxic effect of oil pollution that may occur as a result of crude oil tanker accidents in the IS. Read More

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High-resolution model of Arabidopsis Photosystem II reveals the structural consequences of digitonin-extraction.

Sci Rep 2021 Jul 30;11(1):15534. Epub 2021 Jul 30.

Department of Chemistry, Umeå University, 901 87, Umeå, Sweden.

In higher plants, the photosynthetic process is performed and regulated by Photosystem II (PSII). Arabidopsis thaliana was the first higher plant with a fully sequenced genome, conferring it the status of a model organism; nonetheless, a high-resolution structure of its Photosystem II is missing. We present the first Cryo-EM high-resolution structure of Arabidopsis PSII supercomplex with average resolution of 2. Read More

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Engineering polar vortex from topologically trivial domain architecture.

Nat Commun 2021 Jul 30;12(1):4620. Epub 2021 Jul 30.

Department of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, China.

Topologically nontrivial polar structures are not only attractive for high-density data storage, but also for ultralow power microelectronics thanks to their exotic negative capacitance. The vast majority of polar structures emerging naturally in ferroelectrics, however, are topologically trivial, and there are enormous interests in artificially engineered polar structures possessing nontrivial topology. Here we demonstrate reconstruction of topologically trivial strip-like domain architecture into arrays of polar vortex in (PbTiO)/(SrTiO) superlattice, accomplished by fabricating a cross-sectional lamella from the superlattice film. Read More

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Quasi-equilibrium phase coexistence in single component supercritical fluids.

Nat Commun 2021 Jul 30;12(1):4630. Epub 2021 Jul 30.

Department of Physics, Pohang University of Science and Technology, Pohang, Republic of Korea.

In their supercritical state simple fluids are generally thought to assume a homogeneous phase throughout all combinations of pressures and temperatures, although various response functions or transport properties may exhibit anomalous behavior, characterizing a state point as either more gas-like or liquid-like, respectively. While a large body of results has been compiled in the last two decades regarding the details of the supercritical phase in thermodynamic equilibrium, far less studies have been dedicated to out-of-equilibrium situations that nevertheless occur along with the handling of substances such as carbon dioxide or Argon. Here we consider successive compression-expansion cycles of equal amounts of Argon injected into a high-pressure chamber, traversing the critical pressure at two times the critical temperature. Read More

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Glasses denser than the supercooled liquid.

Proc Natl Acad Sci U S A 2021 Aug;118(31)

Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104;

When aged below the glass transition temperature, [Formula: see text], the density of a glass cannot exceed that of the metastable supercooled liquid (SCL) state, unless crystals are nucleated. The only exception is when another polyamorphic SCL state exists, with a density higher than that of the ordinary SCL. Experimentally, such polyamorphic states and their corresponding liquid-liquid phase transitions have only been observed in network-forming systems or those with polymorphic crystalline states. Read More

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Alternating the population and control neural networks to solve high-dimensional stochastic mean-field games.

Proc Natl Acad Sci U S A 2021 Aug;118(31)

Department of Mathematics, University of California, Los Angeles, CA 90095;

We present APAC-Net, an alternating population and agent control neural network for solving stochastic mean-field games (MFGs). Our algorithm is geared toward high-dimensional instances of MFGs that are not approachable with existing solution methods. We achieve this in two steps. Read More

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Spontaneous pneumomediastinum in accidental chlorine gas inhalational injury: case report and review of literature.

BMJ Case Rep 2021 Jul 30;14(7). Epub 2021 Jul 30.

Medicine, Aga Khan University, Karachi, Pakistan.

A young man presented in emergency department with shortness of breath and cough after accidental inhalation of chlorine gas. Initial presentation was unremarkable; therefore, he was kept under observation for 8 hours and was later discharged. After 5 hours, the patient presented again in emergency department with sudden-onset shortness of breath and chest discomfort. Read More

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High triglyceride to HDL-cholesterol ratio as a biochemical marker of severe outcomes in COVID-19 patients.

Clin Nutr ESPEN 2021 Aug 7;44:437-444. Epub 2021 May 7.

Hospital General "Dr. Rubén Leñero," Ciudad de México, Mexico. Electronic address:

Background & Aims: Coronavirus disease 2019 (COVID-19) patients with severe complications have shown comorbidities with cardiovascular-disease, hypertension and type 2 diabetes mellitus; clinical disorders that share the common metabolic alterations of insulin resistance and dyslipidaemia. A high triglyceride to high density lipoprotein cholesterol (Tg/HDL c) ratio has been associated with reduced insulin sensitivity, metabolic syndrome and adverse cardiovascular events. Our aim in this study was to determine the association between different components of the lipid profile and particularly the Tg/HDL c ratio with severe complications like the requirement of invasive mechanical ventilation in COVID-19 patients. Read More

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Precision of Lunar Dual-energy X-ray Absorptiometry (iDXA) in measuring body composition among colorectal cancer patients and healthy subjects.

Clin Nutr ESPEN 2021 Aug 6;44:316-323. Epub 2021 Jun 6.

Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway; Department of Clinical Service, Division of Cancer Medicine, Oslo University Hospital, Oslo, Norway.

Background & Aims: High quality and precise methods are needed when monitoring changes in body composition among colorectal cancer (CRC) patients and healthy subjects. The aim of this study was to estimate precision of the Dual-energy X-ray absorptiometry (Lunar iDXA, GE Healthcare software enCORE version 16) in measuring body composition in CRC patients and healthy subjects.

Methods: Precision error of iDXA in measuring body composition was investigated in the current study. Read More

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Randomized double blind clinical trial evaluating the Ellagic acid effects on insulin resistance, oxidative stress and sex hormones levels in women with polycystic ovarian syndrome.

J Ovarian Res 2021 Jul 31;14(1):100. Epub 2021 Jul 31.

Metabolic Diseases Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran.

Objective: The design of this study was due to the report of the antioxidant properties of Ellagic acid (EA) for its evaluation on the Insulin resistance (IR), oxidative stress and sex hormones levels in women with polycystic ovarian syndrome (PCOS).

Methods: In this randomized, double-blind, placebo-controlled clinical trial, 60 patients were recruited. Patients were randomly allocated consumed a capsule containing 200 mg of EA per day (n = 30) or placebo (n = 30) for 8 weeks. Read More

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