246,753 results match your criteria hif2α drive

A novel underwater bipedal walking soft robot bio-inspired by the coconut octopus.

Bioinspir Biomim 2021 Apr 9. Epub 2021 Apr 9.

Saint Petersburg State Marine Technical University, Saint-Petersburg State Marine Technical University, Russia, Sankt-Petersburg, 190008, RUSSIAN FEDERATION.

In order to increase the compatibility between underwater robots and the underwater environment and inspired by the coconut octopus's underwater bipedal walking, a method was proposed for bipedal walking for an underwater soft robot based on a spring-loaded inverted pendulum model. Using the characteristics of octopus tentacles rolling on the ground, a wrist arm was designed using the cable-driven method, and an underwater spring-loaded inverted pendulum bipedal walking model was established, which makes an underwater soft robot more suitable for moving on uneven ground. An underwater bipedal walking soft robot based on coconut octopus was then designed, and a machine vision algorithm was used to extract the motion information for analysis. Read More

View Article and Full-Text PDF

Degradation of N-nitrosamines and 1,4-dioxane using vacuum ultraviolet irradiation (UV or UV).

Chemosphere 2021 Mar 24;278:130326. Epub 2021 Mar 24.

Ingram School of Engineering, Texas State University, 601 University Drive, San Marcos, TX, 78666, USA.

Advanced oxidation processes (AOPs) play a vital role in attenuating contaminants of emerging concern (CECs) during potable water reuse. AOPs are conventionally performed by irradiating with a 254-nm low-pressure (LP) mercury-vapor (Hg) ultraviolet (UV) lamp along with chemical treatment. Compared with UV-C light treatment (200-280 nm), vacuum-UV (V-UV) light treatment (100-200 nm) is advantageous in terms of hydroxyl radical generation without the requirement for chemical treatment. Read More

View Article and Full-Text PDF

Novel Predictors of Coronavirus Protective Behaviors among US adults: The role of trait reactance, conspiracy beliefs, and belief in the apocalypse.

J Med Internet Res 2021 Apr 6. Epub 2021 Apr 6.

Center for Health Communications Research, Rogel Cancer Center, University of Michigan, North Campus Research Complex, Building 162800 Plymouth Road, Ann Arbor, US.

Background: A central component of the public health strategy to control the 2019 Sars-CoV-2 (COVID-19) virus involves encouraging mask wearing and social distancing to protect individuals from acquiring and transmitting the virus.

Objective: Understanding the psychologic factors that drive adoption or rejection of these protective behaviors can inform public health interventions to control the pandemic.

Methods: We conducted an online survey of a representative sample of 1,074 U. Read More

View Article and Full-Text PDF

Phase Equilibrium of Water with Hexagonal and Cubic Ice Using the SCAN Functional.

J Chem Theory Comput 2021 Apr 9. Epub 2021 Apr 9.

Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.

Machine learning models are rapidly becoming widely used to simulate complex physicochemical phenomena with accuracy. Here, we use one such model as well as direct density functional theory (DFT) calculations to investigate the phase equilibrium of water, hexagonal ice (Ih), and cubic ice (Ic), with an eye toward studying ice nucleation. The machine learning model is based on deep neural networks and has been trained on DFT data obtained using the SCAN exchange and correlation functional. Read More

View Article and Full-Text PDF

Prodrugs of a 1'-CN-4-Aza-7,9-dideazaadenosine -Nucleoside Leading to the Discovery of Remdesivir (GS-5734) as a Potent Inhibitor of Respiratory Syncytial Virus with Efficacy in the African Green Monkey Model of RSV.

J Med Chem 2021 Apr 9. Epub 2021 Apr 9.

Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.

A discovery program targeting respiratory syncytial virus (RSV) identified -nucleoside (RSV A2 EC = 530 nM) as a phenotypic screening lead targeting the RSV RNA-dependent RNA polymerase (RdRp). Prodrug exploration resulted in the discovery of remdesivir (, GS-5734) that is >30-fold more potent than against RSV in HEp-2 and NHBE cells. Metabolism studies in vitro confirmed the rapid formation of the active triphosphate metabolite, -, and in vivo studies in cynomolgus and African Green monkeys demonstrated a >10-fold higher lung tissue concentration of following molar normalized IV dosing of compared to that of . Read More

View Article and Full-Text PDF

High-Resolution Ion-Mobility-Enabled Peptide Mapping for High-Throughput Critical Quality Attribute Monitoring.

J Am Soc Mass Spectrom 2021 Apr 9. Epub 2021 Apr 9.

MOBILion Systems, Inc., 4 Hillman Drive, Suite 130, Chadds Ford, Pennsylvania 19317, United States.

Characterization and monitoring of post-translational modifications (PTMs) by peptide mapping is a ubiquitous assay in biopharmaceutical characterization. Often, this assay is coupled to reversed-phase liquid chromatographic (LC) separations that require long gradients to identify all components of the protein digest and resolve critical modifications for relative quantitation. Incorporating ion mobility (IM) as an orthogonal separation that relies on peptide structure can supplement the LC separation by providing an additional differentiation filter to resolve isobaric peptides, potentially reducing ambiguity in identification through mobility-aligned fragmentation and helping to reduce the run time of peptide mapping assays. Read More

View Article and Full-Text PDF

Analytical Chemistry in Astrobiology.

Anal Chem 2021 Apr 9. Epub 2021 Apr 9.

School of Chemistry & Biochemistry, Georgia Institute of Technology, North Avenue NW, Atlanta, Georgia 30332, United States.

This Feature introduces and discusses the findings of key analytical techniques used to study planetary bodies in our solar system in the search for life beyond Earth, future missions planned for high-priority astrobiology targets in our solar system, and the challenges we face in performing these investigations. Read More

View Article and Full-Text PDF

Polarity-Sensitive Ratiometric Fluorescence Probe for Monitoring Lipid Droplets/Nucleus Change During Ferroptosis.

Angew Chem Int Ed Engl 2021 Apr 9. Epub 2021 Apr 9.

National University of Singapore, Department of Chemical and Biomolecular Engineering, 4 Engineering Drive 4, National University of Singapore, 117585, Singapore, SINGAPORE.

Ferroptosis regulates cell death through reactive oxygen species associated lipid peroxide accumulation, which is expected to affect the structure and polarity of lipid droplets (LDs), but with no clear evidence. Herein, we report the first example of LD and nucleus dual-targeted ratiometric fluorescent probe of CQPP for monitoring polarity change in cellular microenvironment. Due to the appropriate donor-acceptor structure of CQPP, it offers ratiometric fluorescence emission and fluorescence lifetime signals to polarity variations. Read More

View Article and Full-Text PDF

Evaluating definitions for maternal fever as diagnostic criteria for intraamniotic infection in low-risk pregnancies.

Birth 2021 Apr 9. Epub 2021 Apr 9.

Department of Pediatrics, Medical College of Georgia at Augusta University, Augusta, GA, USA.

Background: Conflicting statements by stakeholders in obstetric care have suggested different criteria for defining peripartum fever and suspected intraamniotic infection, which have not been evaluated.

Methods: A case-control study of pregnancies between 35 and 41 weeks at a single tertiary care center between January 2016 and December 2017. Cases with pathology-confirmed chorioamnionitis were identified, and demographic data, risk factors, and neonatal outcomes were extracted from the medical record. Read More

View Article and Full-Text PDF

Agency, communion, and pubertal status: Separating between- and within-person associations to examine social goals development.

J Pers 2021 Apr 9. Epub 2021 Apr 9.

University at Buffalo, The State University of New York.

Objectives: Agentic (status/independence) and communal (acceptance/connectedness) social goals are thought to shape how adolescents transact with their social environments. Despite their theoretical importance, little work has focused on the development of these higher-order personality dimensions. Informed by developmental neuroscience and evolutionary psychology theoretical frameworks, the current study examined associations between pubertal status, a person's level of pubertal development at a single point in time, and agentic and communal social goals across early to middle adolescence. Read More

View Article and Full-Text PDF

Complete genome sequence and analysis of a Saccharomyces cerevisiae strain used for sugarcane spirit production.

Braz J Microbiol 2021 Apr 9. Epub 2021 Apr 9.

Programa de Pós-Graduação em Biotecnologia, Universidade Federal do Espírito Santo, Vitoria, ES, 29040-090, Brazil.

Distillation of fermented sugarcane juice produces both rum and cachaça, significant sources of revenue in Brazil and elsewhere. In this study, we provide a genomic analysis of a Saccharomyces cerevisiae strain isolated from a cachaça distillery in Brazil. We determined the complete genome sequence of a strain with high flocculation capacity, high tolerance to ethanol, osmotic and heat shock stress and high fermentation rates and compared the sequence with that of the reference S288c genome as well as those of two other cachaça strains. Read More

View Article and Full-Text PDF

Financial difficulties and patient-reported outcomes among patients with advanced heart failure.

Qual Life Res 2021 Apr 9. Epub 2021 Apr 9.

Lien Centre for Palliative Care, Duke-NUS Medical School, 8 College Road, Singapore, 169857, Singapore.

Purpose: Management of congestive heart failure (CHF) is associated with high health care costs and financial difficulties for patients. We aimed to comprehensively assess the association between financial difficulties and patients' quality of life (QOL) (physical, emotional, social and spiritual), perceived health care quality, and perception of being a burden to the family among patients with CHF; and to assess whether perceived control over stress moderated these associations.

Methods: This was a cross-sectional study of 250 patients using the baseline data of the Singapore Cohort of Patients with Advanced Heart Failure (SCOPAH). Read More

View Article and Full-Text PDF

Streamlining Disease Risk Analysis for Wildlife Using the Shark Bay Bandicoot as a Model.

Ecohealth 2021 Apr 9. Epub 2021 Apr 9.

Wildlife Health Australia, Suite E, 34 Suakin Drive, Mosman, NSW, 2088, Australia.

Disease risk analysis (DRA) is a process for identifying significant disease risks and proposing measures to mitigate those risks. Although numerous methodologies for DRA exist, the IUCN Disease Risk Analysis Manual Jakob-Hoff et al. (World Organisation for Animal Health, Paris, pp 160, 2014) remains the gold standard for wild animal translocations. Read More

View Article and Full-Text PDF

Parameter Estimation for Mixed-Mechanism Tear Film Thinning.

Bull Math Biol 2021 Apr 9;83(5):56. Epub 2021 Apr 9.

Department of Mathematical Sciences, University of Delaware, Newark, DE, 19716, USA.

Etiologies of tear breakup include evaporation-driven, divergent flow-driven, and a combination of these two. A mathematical model incorporating evaporation and lipid-driven tangential flow is fit to fluorescence imaging data. The lipid-driven motion is hypothesized to be caused by localized excess lipid, or "globs. Read More

View Article and Full-Text PDF

[A new hypothesis on vascular calcifi cation: the exhausting buff er syndrome (EBS)].

Neuropsychopharmacol Hung 2021 Mar;23(1):215-220

Municipal Clinic of Szentendre, Internal Medicine Szentendre,

Here we propose that the Western world lifestyle disrupts phosphate metabolism and homeostasis due to caloric or acidic hyperphagia. Psychic factors such as social defeat due to stressed social coexistence characterized by reduced activity and chronic hypoventilation (hypercapnia) also play a role. At least two mechanisms mediate the harmful vascular eff ects of phosphates with intracellular acidosis being a feature in both of them. Read More

View Article and Full-Text PDF

Simultaneous trimodal single-cell measurement of transcripts, epitopes, and chromatin accessibility using TEA-seq.

Elife 2021 Apr 9;10. Epub 2021 Apr 9.

Allen Institute for Immunology, Seattle, United States.

Single-cell measurements of cellular characteristics have been instrumental in understanding the heterogeneous pathways that drive differentiation, cellular responses to signals, and human disease. Recent advances have allowed paired capture of protein abundance and transcriptomic state, but a lack of epigenetic information in these assays has left a missing link to gene regulation. Using the heterogeneous mixture of cells in human peripheral blood as a test case, we developed a novel scATAC-seq workflow that increases signal-to-noise and allows paired measurement of cell surface markers and chromatin accessibility: integrated cellular indexing of chromatin landscape and epitopes, called ICICLE-seq. Read More

View Article and Full-Text PDF

"We Are Doing These Things So That People Will Not Laugh at Us": Caregivers' Attitudes About Dementia and Caregiving in Nigeria.

Qual Health Res 2021 Apr 9:10497323211004105. Epub 2021 Apr 9.

Manchester Metropolitan University, Manchester, United Kingdom.

Some Nigerians, in their effort to make sense of dementia symptoms, use descriptions that may stigmatize people with dementia and their families. This qualitative descriptive study focused on the everyday understanding of dementia and the impact of stigma on the caregiving experiences of informal female Nigerian dementia caregivers. Semi-structured interviews were conducted with a purposive sample of 12 adult informal female caregivers in Nigeria and analyzed for themes. Read More

View Article and Full-Text PDF

Assembly of a Rovibrational Ground State Molecule in an Optical Tweezer.

Phys Rev Lett 2021 Mar;126(12):123402

Department of Physics, Harvard University, Cambridge, Massachusetts 02138, USA.

We demonstrate the coherent creation of a single NaCs molecule in its rotational, vibrational, and electronic (rovibronic) ground state in an optical tweezer. Starting with a weakly bound Feshbach molecule, we locate a two-photon transition via the |c^{3}Σ_{1},v^{'}=26⟩ excited state and drive coherent Rabi oscillations between the Feshbach state and a single hyperfine level of the NaCs rovibronic ground state |X^{1}Σ,v^{''}=0,N^{''}=0⟩ with a binding energy of D_{0}=h×147044.63(11)  GHz. Read More

View Article and Full-Text PDF

Bath-Induced Zeno Localization in Driven Many-Body Quantum Systems.

Phys Rev Lett 2021 Mar;126(12):120603

LPTMS, CNRS, Université Paris-Saclay, 91405 Orsay, France.

We study a quantum interacting spin system subject to an external drive and coupled to a thermal bath of vibrational modes, uncorrelated for different spins, serving as a model for dynamic nuclear polarization protocols. We show that even when the many-body eigenstates of the system are ergodic, a sufficiently strong coupling to the bath may effectively localize the spins due to many-body quantum Zeno effect. Our results provide an explanation of the breakdown of the thermal mixing regime experimentally observed above 4-5 K in these protocols. Read More

View Article and Full-Text PDF

Lipid-Oriented Live-Cell Distinction of B and T Lymphocytes.

J Am Chem Soc 2021 Apr 9. Epub 2021 Apr 9.

Center for Self-Assembly and Complexity, Institute for Basic Science (IBS), Pohang 37673, Republic of Korea.

The identification of each cell type is essential for understanding multicellular communities. Antibodies set as biomarkers have been the main toolbox for cell-type recognition, and chemical probes are emerging surrogates. Herein we report the first small-molecule probe, CDgB, to discriminate B lymphocytes from T lymphocytes, which was previously impossible without the help of antibodies. Read More

View Article and Full-Text PDF

Estrogen receptor 2 mediates intraspecific aggressive behaviors of the female in the estrous cycle.

J Integr Neurosci 2021 Mar;20(1):77-85

College of Life Sciences, Qufu Normal University, Qufu, 273165 Shandong, P. R. China.

The social behavior mechanisms have not been thoroughly reported in the solitary female striped dwarf hamster (). In this study, the handling bag test and neutral arena measurements were used to detect the changes of aggression in the face of rivals of different genders of wild striped dwarf hamsters. We found that female hamsters had the highest aggressive performance in proestrus, followed by estrus, and the lowest in metestrus and the dioestrus, and the increased aggression during the proestrus or estrus period was low-intensity aggression such as intimidation, shock, boxing and counterattack, or even ritualized non-harmful behaviors to drive away opponents. Read More

View Article and Full-Text PDF

Expert opinions on the regulation of plant genome editing.

Plant Biotechnol J 2021 Apr 9. Epub 2021 Apr 9.

Department of Agricultural and Resource Economics, University of Saskatchewan, 51 Campus Drive, Saskatoon, SK, S7N 5A8, Canada.

Global food security is largely affected by factors such as: environmental (e.g. drought, flooding), social (e. Read More

View Article and Full-Text PDF

Trends in the use of antihistamines with reference to drivers between 2015 and 2019: a population-based registry analysis.

Fundam Clin Pharmacol 2021 Apr 9. Epub 2021 Apr 9.

Pharmacological Big Data Laboratory, Pharmacology and Therapeutics, Faculty of Medicine, University of Valladolid, Avda. Ramón y Cajal, 7. 47005, Valladolid, Spain.

Background: First-generation antihistamines are considered driving-impairing medicines (DIM), while second- and third-generation antihistamines are relatively safe for driving.

Objectives: The aim of this study is to know the trend of consumption of antihistamines and other DIMs in Spain between 2015 and 2019.

Methods: This is a population-based registry study. Read More

View Article and Full-Text PDF

TSC-insensitive Rheb mutations induce oncogenic transformation through a combination of constitutively active mTORC1 signalling and proteome remodelling.

Cell Mol Life Sci 2021 Apr 8. Epub 2021 Apr 8.

Lifelong Health, South Australian Health and Medical Research Institute, Adelaide, SA, 5001, Australia.

The mechanistic target of rapamycin complex 1 (mTORC1) is an important regulator of cellular metabolism that is commonly hyperactivated in cancer. Recent cancer genome screens have identified multiple mutations in Ras-homolog enriched in brain (Rheb), the primary activator of mTORC1 that might act as driver oncogenes by causing hyperactivation of mTORC1. Here, we show that a number of recurrently occurring Rheb mutants drive hyperactive mTORC1 signalling through differing levels of insensitivity to the primary inactivator of Rheb, tuberous sclerosis complex. Read More

View Article and Full-Text PDF

Crucial role of Salmonella genomic island 1 master activator in the parasitism of IncC plasmids.

Nucleic Acids Res 2021 Apr 9. Epub 2021 Apr 9.

Département de biologie, Faculté des sciences, Université de Sherbrooke, Sherbrooke, QC J1K 2R1, Canada.

IncC conjugative plasmids and the multiple variants of Salmonella Genomic Island 1 (SGI1) are two functionally interacting families of mobile genetic elements commonly associated with multidrug resistance in the Gammaproteobacteria. SGI1 and its siblings are specifically mobilised in trans by IncC conjugative plasmids. Conjugative transfer of IncC plasmids is activated by the plasmid-encoded master activator AcaCD. Read More

View Article and Full-Text PDF

Contribution of structural accessibility to the cooperative relationship of TF-lncRNA in myopia.

Brief Bioinform 2021 Apr 8. Epub 2021 Apr 8.

School of Ophthalmology and Optometry and Eye Hospital, School of Biomedical Engineering at Wenzhou Medical University, Wenzhou 325027, P. R. China.

Transcriptional regulation is associated with complicated mechanisms including multiple molecular interactions and collaborative drive. Long noncoding RNAs (lncRNAs) have highly structured characteristics and play vital roles in the regulation of transcription in organisms. However, the specific contributions of conformation feature and underlying molecular mechanisms are still unclear. Read More

View Article and Full-Text PDF