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Int J Surg Case Rep 2021 Apr 6;81:105702. Epub 2021 Mar 6.

Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, Republic of Korea. Electronic address:

Introduction And Importance: Heterotopic mesenteric ossification (HMO) is a rare condition that can be hereditary or nonhereditary. It can lead to small bowel obstruction, which may require corrective surgery. Most affected patients have a history of abdominal surgery or trauma. Read More

Case Rep Gastroenterol 2021 Jan-Apr;15(1):338-343. Epub 2021 Mar 11.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Gundersen Health System, La Crosse, Wisconsin, USA.

Pancreatic heterotopia (PH) is a common, but typically small (<1 cm), incidental and asymptomatic finding; however, PH should be considered even for large and symptomatic upper gastrointestinal masses. A 27-year-old white woman presented with a 3-week history of burning epigastric pain, nausea, early satiety, and constipation. Physical examination revealed epigastric and right upper quadrant tenderness with normal laboratory workup, but imaging revealed a 5-cm, partly cystic mass arising from the gastric antrum with resulting pyloric stenosis and partial gastric outlet obstruction. Read More

Case Rep Gastroenterol 2021 Jan-Apr;15(1):244-252. Epub 2021 Feb 26.

Department of Surgery, Dr. Hedgewar Arogya Sansthan, Delhi, India.

Giant biliary calculus in the common bile duct (CBD) is rare. Giant calculus of choledochal cyst (CC) is even rarer, and no case of giant calculus of CC with more than 100 calculi has been reported in the indexed literature. We present the case of a 8. Read More

Gastroenterology Res 2021 Feb 19;14(1):45-47. Epub 2021 Feb 19.

General Surgery Department, Rambam Health Care Campus, Haifa, Israel.

Case Rep Gastrointest Med 2021 26;2021:6617370. Epub 2021 Feb 26.

Department of Pathology, Okayama University, Graduate School of Medicine, Dentistry, and Pharmaceutical Science, Okayama, Japan.

In this report, we describe a patient with myoepithelial hamartoma, which is regarded as synonymous with adenomyosis and heterotopic pancreas. Endoscopy revealed a submucosal tumor in the antrum of the stomach. Subsequently, distal gastrectomy with Roux-en-Y reconstruction was performed. Read More

Ann Transl Med 2021 Feb;9(3):272

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Heterotopic pancreas (HP) is a developmental anomaly defined as aberrantly located pancreatic tissue with no anatomical, vascular, or neural connection to the pancreas. Bowel intussusception and gastrointestinal bleeding caused by isolated HP is extremely rare. This study explores the clinical, radiographical, pathologic, and treatment features of four patients with intussusception caused by incidental HP, with the aim of providing important insight into the diagnosis and management of these patients. Read More

J Gastroenterol Hepatol 2021 Feb 23. Epub 2021 Feb 23.

St. Mary Pathology Laboratory, Busan, South Korea.

Case Rep Med 2021 30;2021:6611291. Epub 2021 Jan 30.

Department of Medicine, Al-Basheer Hospital, Amman, Jordan.

Introduction: Heterotopic pancreas (HP) is the congenital presence of pancreatic tissue outside its normal location in the absence of vascular and anatomical connection with the main pancreas. HP can affect any part of the gastrointestinal tract, and it is mostly encountered in the stomach. The gallbladder is a rare site of HP, and our literature review revealed that only 38 cases were reported. Read More

Obes Surg 2021 May 19;31(5):2344-2345. Epub 2021 Jan 19.

Department of Surgical Disciplines, All India Institute of Medical Sciences, Ansari Nagar (East), New Delhi, 110029, India.

Incidental gastric and small bowel lesions are commonly encountered during bariatric surgery. Resection of these lesions with negative margins in the same sitting is curative; however, this may necessitate intraoperative change of plan. We present a 44-year-old super obese lady in whom an exophytic jejunal mass was found at 80 cm from the ligament of Treitz, which necessitated a change of procedure from one anastomosis gastric bypass (OAGB) to Roux-en-Y gastric bypass (RYGB). Read More

Open Med (Wars) 2021 23;16(1):87-94. Epub 2020 Dec 23.

Department of Diagnostic and Interventional Radiology, University Hospital Marburg, Philipps University, Baldingerstrasse, 35043 Marburg, Germany.

Foci of splenic tissue separated from the spleen can occur as a congenital anomaly. Isolated nodules of splenic tissue are called accessory spleens or spleniculli. However, nodules of splenic tissue can merge with other organs during embryonic development, in which case we speak of spleno-visceral fusions: most often, they merge with the tail of the pancreas (thus forming spleno-pancreatic fusion or an intrapancreatic accessory spleen), with the reproductive gland (i. Read More

Anticancer Res 2020 Dec;40(12):6781-6789

Department of Gastroenterological Surgery, Graduate School of Medicine, Nagoya University, Aichi, Japan.

Background/aim: To examine the dynamics of circulating tumour cells (CTCs) in pancreatic cancer (PC), new mouse CTC models from human PC xenografts were developed.

Materials And Methods: Orthotopic (pancreas) and heterotopic (subcutaneous) transplantation models using GFP-tagged SUIT-2 PC cells were prepared. Using a cytology-based CTC detection platform, CTCs and metastasis were compared. Read More

Med Ultrason 2021 Feb 10;23(1):22-28. Epub 2020 Nov 10.

Department of Internal Medicine, Chung-Ang University Hospital, Seoul, South Korea.

Aims: To investigate the added value of endoscopic ultrasound (EUS) with computed tomography (CT) in distinguishing heterotopic pancreas (HP) from other pathologies, when gastroduodenal subepithelial tumors (SETs) are suspected on an upper endoscopic examination.

Material And Methods: We retrospectively included 54 consecutive patients with gastroduodenal SETs who had undergone both abdominal CT and EUS within a 3-month interval. All EUS, endoscopy, and CT images were reviewed and evaluated in a blinded manner by an endoscopist and a radiologist, respectively. Read More

Int J Surg Case Rep 2020 2;77:353-356. Epub 2020 Nov 2.

Endoscopy Department, Division of Upper Gastrointestinal Endoscopy, Hospital José Martiniano de Alencar, 1526, Princesa Isabel Street, Centro District, Fortaleza, Ceará, Brazil. Electronic address:

Background: The diagnosis of gastric lesions, such as the Ectopic Gastric Pancreas (GEP), has become more frequent after the increase in bariatric surgeries. The most frequently used surgical options are: Sleeve Gastrectomy (SG) and Roux-en-Y Gastric Bypass (RYGB). The scientific papers about GEP in Bariatric Surgery consisted of intraoperative findings, approach the lesion with gastrectomy and the need to change the initial surgical strategy of the Sleeve for others techniques which allow extended gastric resections. Read More

World J Clin Cases 2020 Oct;8(20):4708-4718

Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, South Korea.

Background: Gastric heterotopic pancreas (GHP) is generally asymptomatic and rarely features complications such as pancreatitis, pseudocysts, gastric outlet obstruction, bleeding, obstructive jaundice, or intussusception. However, the treatment of complicated GHP is challenging and often requires surgical resection.

Aim: To investigate the clinical outcomes of endoscopic submucosal dissection (ESD) as alternative to surgical resection for complicated GHP. Read More

Ann Med Surg (Lond) 2020 Nov 9;59:41-43. Epub 2020 Sep 9.

University of Sousse, Department of Gastrointestinal Surgery, Sahloul Hospital, Sousse, Tunisia.

Ectopic pancreas (EP) is a rare entity characterized by the development of pancreatic tissue in areas other than the pancreas. We present the case of a 16-year-old female with a heterotopic pancreas in the jejunum revealed by occult gastrointestinal bleeding. Contrast-enhanced computed tomography (CT) of the abdomen revealed a 2 × 3 cm enhancing nodular jejunal mass suspicious of a neuroendocrine or gastrointestinal stromal tumor. Read More

Endosc Ultrasound 2020 Nov-Dec;9(6):410-412

Department of Digestive Diseases, The PLA General Hospital, Beijing, China.

Pancreas with heterotopic gastric mucosa is a rare congenital malformation and hardly be detected.In the embryonic stages, primitive gut, including foregut, midgut and hindgut, originated in the gastrula endoderm. Stomach and pancreas were stemed from the ending of foregut. Read More

Clin J Gastroenterol 2020 Dec 10;13(6):1373-1382. Epub 2020 Sep 10.

Clinical Department of Pathology, Gunma University Hospital, 3-39-15 Showa-machi, Maebashi, Gunma, 371-8511, Japan.

A woman in her 70 s was diagnosed with a tumor in her duodenal wall during a routine visit for diabetes. She subsequently underwent subtotal stomach-preserving pancreatoduodenectomy. Histologically, the tumor was present mainly in the duodenal wall, and atypical cystic ducts were seen in the muscularis propria and subserosa. Read More

Gastroenterology 2021 Jan 20;160(1):31-32. Epub 2020 Aug 20.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan, Republic of China. Electronic address:

Gastroenterology 2021 Apr 8;160(5):e4-e5. Epub 2020 Aug 8.

Department of Radiology, University of Colorado Hospital, Aurora, Colorado.

Int J Surg Case Rep 2020 15;74:284-288. Epub 2020 Jul 15.

Department of Surgery, Hiroshima City Hiroshima Citizens Hospital, 7-33, Motomachi, Naka-ku, Hiroshima, 730-5818, Japan; Department of Gastroenterological and Transplant Surgery, Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.

Introduction: Gastric heterotopic pancreas (HP) is usually asymptomatic and benign; however, it may become evident when it is complicated by pathological changes such as inflammation, bleeding, and malignant transformation.

Presentation Of Case: A 43-year old man was diagnosed with gastric HP 18 years prior suffered a haemorrhage from the enlarged gastric HP with multiple cystic lesions. Although endoscopic ultrasonography-guided fine needle aspiration showed no malignancy, he underwent a partial gastrectomy for diagnosis and treatment. Read More

ACG Case Rep J 2020 Jul 9;7(7):e00419. Epub 2020 Jul 9.

Division of Gastroenterology and Hepatology, Johns Hopkins Medical Institutions, Baltimore, MD.

Heterotopic pancreas is pancreatic tissue present outside of the normal location of the pancreas. In the presence of cystic degeneration, heterotopic pancreas is clinically significant because of the symptoms it causes and its physical resemblance to cancerous growth. A diagnosis of heterotopic pancreas is achieved with the aid of various endoscopic techniques for tissue removal. Read More

Rom J Morphol Embryol 2020 ;61(1):273-276

Institute of Histology and Embryology, Faculty of Medicine, Comenius University, Bratislava, Slovak Republic;

Lamellar (Pacinian) corpuscle is a cutaneous encapsulated sensory corpuscle, mainly functioning as a rapidly adapting low-threshold mechanoreceptor with characteristic "onion skin"-like appearance. Even though the Pacinian corpuscle is typically located in the skin, histomorphologically and confirmed by using immunohistochemical methods, we have identified it within the interstitium of the thymus of a newborn with congenital heart defect. To the best of our knowledge, this is the first such account ever to be published. Read More

Korean J Gastroenterol 2020 07;76(1):37-41

Department of Internal Medicine, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.

Gastric heterotopic pancreas is a relatively uncommon incidental finding. On the other hand, the presentation of gastric adenocarcinoma arising from a heterotopic pancreas is rare. This paper reports a case of gastric adenocarcinoma arising from a heterotopic pancreas that presented as a gastric outlet obstruction 10 years after the initial diagnosis of a suspicious submucosal tumor. Read More

Int J Surg Case Rep 2020 23;73:48-51. Epub 2020 Jun 23.

Department of General Surgery, Hospital Riviera - Chablais (HRC), Site of Montreux, Avenue de Belmont 25, 1820 Montreux, Switzerland. Electronic address:

Introduction: Ectopic pancreatic tissue is often incidentally encountered during abdominal surgery. We report a case of an incidental finding during a laparoscopic appendectomy, the approach to diagnosis and management of this. The work has been reported in line with the SCARE criteria. Read More

Abdom Radiol (NY) 2021 01 1;46(1):168-178. Epub 2020 Jul 1.

Department of Radiology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China.

Purpose: To determine whether morphologic features and semiquantitative parameters of computed tomography (CT) could be used to distinguish heterotopic pancreas from gastrointestinal stromal tumor (GIST) and leiomyoma.

Methods: This retrospective study evaluated CT images of heterotopic pancreases (n = 28), GISTs (n = 57), and leiomyomas (n = 26) located in the upper gastrointestinal tract. Morphologic imaging features of lesions were analyzed, including location, contour, margin, attenuation, growth pattern, enhancement type, enhancement degree, enlarged vessels feeding or draining the mass, hyperenhancement of the overlying mucosa, low intralesional attenuation, calcification, and a duct-like structure. Read More

Dig Dis Sci 2020 10;65(10):2800-2804

Emergency Surgical Department, St. Orsola University Hospital, Bologna, Italy.

Introduction: Isolated heterotopic pancreas (HP) as the primary cause of bowel intussusception is extremely rare. We report a case of a 33-year-old female patient with spina bifida admitted to the Emergency Surgical Department for ileal intussusception due to the presence of heterotopic pancreas associated with endometriosis.

Areas Covered: Symptomatic ileal intussusception for ectopic pancreas is usually associated with overt gastrointestinal blood loss (predominantly melena), abdominal pain, vomiting, and weight loss. Read More

Surg Case Rep 2020 Jun 18;6(1):141. Epub 2020 Jun 18.

Department of Pathology, Fukui-ken Saiseikai Hospital, Fukui, Japan.

Background: Heterotopic pancreas (HP) is defined as pancreatic tissue in organs with no anatomical continuity with the orthotopic pancreas. Based on the number of cases reported in the literature between the year 2000 and 2020, HP is rarely found causing malignant transformation of the duodenum. We herein report a case of adenocarcinoma arising from the HP in the first portion of the duodenum. Read More

World J Clin Cases 2020 May;8(10):1979-1987

Department of Gastroenterology, Zhujiang Hospital of Southern Medical University, Guangzhou 510280, Guangdong Province, China.

Background: Heterotopic pancreas is a common lesion found in the gastrointestinal tract and is usually considered a benign disease. Reports of malignant change of heterotopic pancreas are scarce.

Case Summary: A 44-year-old Chinese female underwent a gastroscopy to assess abdominal distension that had persisted for 2 months. Read More

Int J Surg Pathol 2021 Apr 2;29(2):190-193. Epub 2020 Jun 2.

Washington University in St. Louis, MO, USA.

Pancreatic heterotopia is a well-described entity occurring at multiple abdominal sites, most commonly the stomach and small intestine. They can develop similar disease processes as the pancreas ranging from acute pancreatitis, cyst formation, or neoplasms, most commonly ductal adenocarcinoma. Neuroendocrine tumors (NETs) arising in pancreatic heterotopias are exceedingly rare with only 3 prior published cases. Read More

Endoscopy 2021 Jan 29;53(1):E19-E20. Epub 2020 May 29.

St. Mary Pathology Laboratory, Busan, Korea.