231,559 results match your criteria heterogeneous oligomers


Multicenter, Observational Study of Lanreotide Autogel for the Treatment of Patients with Neuroendocrine Tumors in Routine Clinical Practice in Germany and Austria.

Exp Clin Endocrinol Diabetes 2021 Jul 22;129(7):500-509. Epub 2021 Jul 22.

ENDOC Center for Endocrine Tumors, Hamburg, Germany.

Background: The long-acting somatostatin analog lanreotide autogel is effective in the treatment of patients with neuroendocrine tumors.

Objective: To evaluate the long-term treatment response in patients with neuroendocrine tumors receiving lanreotide autogel in routine clinical practice.

Methods: Non-interventional, 24-month study in patients with neuroendocrine tumors treated with lanreotide autogel (NCT01840449). Read More

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Hydrothermal liquefaction of municipal solid wastes for high quality bio-crude production using glycerol as co-solvent.

Bioresour Technol 2021 Jul 12;339:125537. Epub 2021 Jul 12.

Department of Chemical Engineering, Indian Institute of Technology Madras, Chennai 600036, India; National Center for Combustion Research and Development, Indian Institute of Technology Madras, Chennai 600036, India. Electronic address:

This study is focused on the valorization of heterogeneous municipal solid waste collected from the landfill using hydrothermal liquefaction process using glycerol as a co-solvent. The effects of temperature (300-350 °C) and residence time (15-45 min) on the yields and quality of the product fractions were investigated at 8 wt% solid loading. The yield of bio-crude significantly increased from 15. Read More

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Heterogeneity and threshold effects of environmental regulation on health expenditure: Considering the mediating role of environmental pollution.

J Environ Manage 2021 Jul 19;297:113276. Epub 2021 Jul 19.

College of Information and Management Science, Henan Agricultural University, Zhengzhou, 450046, China. Electronic address:

A comprehensive understanding of the heterogeneity and threshold effects of environmental regulation on health expenditure is essential for policy design and decision-making. This case study seeks to analyze the heterogeneity and threshold effects using panel data, which covers 30 Chinese provinces from 2007 to 2017. We examine the linear and nonlinear impacts of environmental regulation on health expenditure by using the Bayesian quantile regression and panel threshold regression, respectively. Read More

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Hierarchical BiMoO microsphere photocatalysts modified with polypyrrole conjugated polymer for efficient decontamination of organic pollutants.

Chemosphere 2021 Jul 15;286(Pt 1):131541. Epub 2021 Jul 15.

College of Textiles & Clothing, Qingdao University, Qingdao, 266071, PR China; Collaborative Innovation Center for Eco-Textiles of Shandong Province, Qingdao, 266071, PR China.

To effectively degrade organic pollutants in wastewater, visible-light-driven BiMoO/PPy hierarchical heterogeneous photocatalysts were prepared through a solvothermal method and the following in-situ chemical oxidation polymerization. Compared with pristine BiMoO photocatalyst, the composite photocatalysts exhibited dramatically improved photocatalytic activity and photostability towards the degradation of methylene blue dye and tetracycline antibiotic. BiMoO/PPy-80 sample achieved the highest photocatalytic degradation rates for methylene blue dye (93. Read More

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Evaluation of commercial zerovalent iron sources in combination with solar energy to remove microcontaminants from natural water at circumneutral pH.

Chemosphere 2021 Jul 15;286(Pt 1):131557. Epub 2021 Jul 15.

Plataforma Solar de Almería-CIEMAT, Ctra Senés km 4, 04200, Tabernas, Almería, Spain; CIESOL, Joint Centre of the University of Almería-CIEMAT, 04120, Almería, Spain.

Solar zerovalent iron (ZVI) was studied at circumneutral pH in combination with hydrogen peroxide and persulfate for removal of imidacloprid as a model contaminant in natural water. Three commercial ZVI sources, steel wool (ZVI-SW) and two iron micro-powders (ZVI-MS and ZVI-S) were independently evaluated. First, different ZVI corrosion conditions were tested in contact with air, exposed to natural solar radiation and with addition of oxidants, such as HO and SO, demonstrating the importance of released iron. Read More

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Multicomponent exercise to improve motor functions, cognition and well-being for nursing home residents who are unable to walk - A randomized controlled trial.

Exp Gerontol 2021 Jul 19:111484. Epub 2021 Jul 19.

Institute of Human Movement Science, University of Hamburg, Mollerstr, 10, 20148 Hamburg, Germany; Biological Psychology and Neuroergonomics, TU Berlin, Fasanenstr. 1, 10623 Berlin, Germany. Electronic address:

Background: Older nursing home residents are often characterized by multimorbidity and dependency in activities of daily living. Most exercise studies in this setting aim at residents who are still able to walk despite the huge group of residents that is unable to walk. Thus, little is known about the effectiveness to improve cognitive and motor functions as well as well-being within this target group, e. Read More

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Loss of APP in mice increases thigmotaxis and is associated with elevated brain expression of IL-13 and IP-10/CXCL10.

Physiol Behav 2021 Jul 19:113533. Epub 2021 Jul 19.

Department of Pathology and Human Anatomy, School of Medicine, Loma Linda University, Loma Linda, CA, U.S.A. Electronic address:

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to memory loss and is often accompanied by increased anxiety. Although AD is a heterogeneous disease, dysregulation of inflammatory pathways is a consistent event. Interestingly, the amyloid precursor protein (APP), which is the source of the amyloid peptide Aβ, is also necessary for the efficient regulation of the innate immune response. Read More

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Surface-Promoted Evolution of Ru-bda Coordination Oligomers Boosts the Efficiency of Water Oxidation Molecular Anodes.

J Am Chem Soc 2021 Jul 22. Epub 2021 Jul 22.

Institute of Chemical Research of Catalonia (ICIQ). Barcelona Institute of Science and Technology (BIST), Avenida Països Catalans 16, 43007 Tarragona, Spain.

A new Ru oligomer of formula {[Ru(bda-κ-NO)(4,4'-bpy)](4,4'-bpy)}, (bda is [2,2'-bipyridine]-6,6'-dicarboxylate and 4,4'-bpy is 4,4'-bipyridine), was synthesized and thoroughly characterized with spectroscopic, X-ray, and electrochemical techniques. This oligomer exhibits strong affinity for graphitic materials through CH-π interactions and thus easily anchors on multiwalled carbon nanotubes (CNT), generating the molecular hybrid material . The latter acts as a water oxidation catalyst and converts to a new species, , during the electrochemical oxygen evolution process involving solvation and ligand reorganization facilitated by the interactions of molecular Ru catalyst and the surface. Read More

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Atomically Precise Dinuclear Site Active toward Electrocatalytic CO Reduction.

J Am Chem Soc 2021 Jul 22. Epub 2021 Jul 22.

National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei 230029, PR China.

The development of atomically precise dinuclear heterogeneous catalysts is promising to achieve efficient catalytic performance and is also helpful to the atomic-level understanding on the synergy mechanism under reaction conditions. Here, we report a Ni(dppm)Cl dinuclear-cluster-derived strategy to a uniform atomically precise Ni site, consisting of two Ni-N moieties shared with two nitrogen atoms, anchored on a N-doped carbon. By using synchrotron X-ray absorption spectroscopy, we identify the dynamically catalytic dinuclear Ni structure under electrochemical CO reduction reaction, revealing an oxygen-bridge adsorption on the Ni-N site to form an O-Ni-N structure with enhanced Ni-Ni interaction. Read More

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Randomized crossover trial to compare driving pressures in a closed-loop and a conventional mechanical ventilation mode in pediatric patients.

Pediatr Pulmonol 2021 Jul 22. Epub 2021 Jul 22.

Department of Pediatric Intensive Care Unit, Dr Behcet Uz Children's Disease and Surgery Training and Research Hospital, Health Sciences University, Izmir, Turkey.

Introduction: In mechanically ventilated patients, driving pressure (ΔP) represents the dynamic stress applied to the respiratory system and is related to ICU mortality. An evolution of the Adaptive Support Ventilation algorithm (ASV® 1.1) minimizes inspiratory pressure in addition to minimizing the work of breathing. Read More

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USO1 isoforms differentially promote liver cancer progression by dysregulating the ER-Golgi network.

Carcinogenesis 2021 Jul 22. Epub 2021 Jul 22.

Department of Physiology, Ajou University School of Medicine, Suwon, Republic of Korea.

Alternative splicing of RNA transcripts plays an important role in cancer development and progression. Recent advances in RNA-seq technology have made it possible to identify alternately spliced events in various types of cancer; however, research on hepatocellular carcinoma (HCC) is still limited. Here, by performing RNA-Seq profiling of HCC transcripts at isoform level, we identified tumor-specific and molecular subtype-dependent expression of the USO1 isoforms, which we designated as a normal form USO1-N (XM_001290049) and a tumor form USO1-T (NM_003715). Read More

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Effectiveness of mobile phone text message reminder interventions to improve adherence to antiretroviral therapy among adolescents living with HIV: A systematic review and meta-analysis.

PLoS One 2021 22;16(7):e0254890. Epub 2021 Jul 22.

KNCV Tuberculosis Foundation, The Hague, Netherlands.

Background: Poor adherence to antiretroviral therapy in adolescents living with HIV is a global challenge. One of the key strategies to improve adherence is believed to be the use of digital adherence tools. However, evidence is limited in this area. Read More

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Lung ultrasound features and relationships with respiratory mechanics of evolving BPD in preterm rabbits and human neonates.

J Appl Physiol (1985) 2021 Jul 22. Epub 2021 Jul 22.

Division of Pediatrics and Neonatal Critical Care, "A.Béclère" Medical Centre, Paris Saclay University Hospitals, APHP, Paris, France.

Evolving broncho-pulmonary dysplasia (BPD) is a regionally heterogeneous disorder characterized by impaired alveolarization leading to lung aeration inhomogeneities. Hyperoxia-exposed preterm rabbits have been proposed to mimic evolving BPD and we aim to verify if this model has the same lung ultrasound and mechanical features of evolving BPD in human neonates. Twenty-five preterm rabbits and twenty-five neonates with evolving BPD were enrolled and subjected to semi-quantitative lung ultrasound and lung mechanics measurement. Read More

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Polythiophene-Doped Resorcinol-Formaldehyde Resin Photocatalysts for Solar-to-Hydrogen Peroxide Energy Conversion.

J Am Chem Soc 2021 Jul 22. Epub 2021 Jul 22.

Research Center for Solar Energy Chemistry and Division of Chemical Engineering, Graduate School of Engineering Science, Osaka University, Toyonaka 560-8531, Japan.

The generation of hydrogen peroxide (HO) from water and dioxygen by sunlight-driven heterogeneous photocatalysis is a promising method for the artificial photosynthesis of a liquid solar fuel. We previously found that resorcinol-formaldehyde (RF) resin powders prepared by high-temperature hydrothermal synthesis act as highly active semiconductor photocatalysts for HO generation. Herein, we report that RF resin powders doped with poly(3-hexylthiophene-2,5-diyl) (RF/P3HT) exhibit enhanced photocatalytic activities. Read More

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Adrenal "nonadenoma" - clinical characteristic and risk of malignancy.

Endokrynol Pol 2021 Jul 22. Epub 2021 Jul 22.

Department of Surgery, Clinic of Surgical Oncology and Neuroendocrine Tumors, Maria Sklodowska-Curie National Research Institute of Oncology, Wawelska15, 02-034 Warsaw, Poland.

Introduction: There is an increasing number of adrenal tumours discovered incidentally during imaging examinations performed for many different indications. Based on imaging results, it is possible to differentiate benign from malignant adrenal masses, although there is still a number of equivocal imaging findings. Our study presents 77 cases of adrenal tumours in which imaging was inconclusive and the final diagnosis was stated only after surgery and histopathological examination. Read More

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Investigational Treatments for Epidermolysis Bullosa.

Am J Clin Dermatol 2021 Jul 22. Epub 2021 Jul 22.

Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138 Sheng-Li Road, Tainan, Taiwan.

Epidermolysis bullosa (EB) is a heterogeneous group of rare inherited blistering skin disorders characterized by skin fragility following minor trauma, usually present since birth. EB can be categorized into four classical subtypes, EB simplex, junctional EB, dystrophic EB and Kindler EB, distinguished on clinical features, plane of blister formation in the skin, and molecular pathology. Treatment for EB is mostly supportive, focusing on wound care and patient symptoms such as itch or pain. Read More

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The clinical and prognostic value of late Gadolinium enhancement imaging in heart failure with mid-range and preserved ejection fraction.

Heart Vessels 2021 Jul 22. Epub 2021 Jul 22.

Department of Cardiology, University of Groningen, University Medical Centre Groningen, Hanzeplein 1, PO Box 30.001, 9700 RB, Groningen, The Netherlands.

Heart failure (HF) with mid-range or preserved ejection fraction (HFmrEF; HFpEF) is a heterogeneous disorder that could benefit from strategies to identify subpopulations at increased risk. We tested the hypothesis that HFmrEF and HFpEF patients with myocardial scars detected with late gadolinium enhancement (LGE) are at increased risk for all-cause mortality. Symptomatic HF patients with left ventricular ejection fraction (LVEF) > 40%, who underwent cardiac magnetic resonance (CMR) imaging were included. Read More

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Ultrasound of myxofibrosarcoma.

Skeletal Radiol 2021 Jul 22. Epub 2021 Jul 22.

Department of Pathology, University of Michigan, Michigan Medicine Health System, Ann Arbor, MI, 48109-5326, USA.

The ultrasound appearance of myxofibrosarcoma is highly variable corresponding to its variable and at times heterogeneous histopathologic appearance. Myxofibrosarcomas may mimic a benign process and the infiltrative tumor margins may be difficult to precisely delineate on ultrasound imaging. These tumor characteristics pose a diagnostic challenge on ultrasound evaluation. Read More

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Incidental axillary dose delivery to axillary lymph node levels I-III by different techniques of whole-breast irradiation: a systematic literature review.

Strahlenther Onkol 2021 Jul 22. Epub 2021 Jul 22.

Radiotherapy Department, Strasbourg Europe Cancer Institute, 17 Rue Albert Calmette, 67200, Strasbourg Cedex, France.

Background And Objective: In breast cancer treatment, radiotherapy is an essential component for locoregional management. Axillary recurrence in patients with invasive breast carcinoma remains an issue. The question of whether breast irradiation may unintentionally include levels I, II, and III, and may decrease the risk of axillary recurrence, remains a topic of discussion. Read More

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Single cell analysis of M. tuberculosis phenotype and macrophage lineages in the infected lung.

J Exp Med 2021 Sep 22;218(9). Epub 2021 Jul 22.

Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY.

In this study, we detail a novel approach that combines bacterial fitness fluorescent reporter strains with scRNA-seq to simultaneously acquire the host transcriptome, surface marker expression, and bacterial phenotype for each infected cell. This approach facilitates the dissection of the functional heterogeneity of M. tuberculosis-infected alveolar (AMs) and interstitial macrophages (IMs) in vivo. Read More

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September 2021

Primary vitreoretinal lymphoma: short review of the literature, results of a European survey and French guidelines of the LOC network for diagnosis, treatment and follow-up.

Curr Opin Oncol 2021 Jul 20. Epub 2021 Jul 20.

Institut Curie, Ophthalmology Department, Paris Institut Curie, PSL University, Inserm U1288, Laboratoire d'Imagerie Translationnelle en Oncologie, Orsay Member of European Reference Network on Rare Hematological Diseases (ERN-EuroBloodNet) Sorbonne Université, IHU, ICM, Department of Neuro-Oncology, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Paris French Network for Oculo-cerebral Lymphomas (LOC network) Sorbonne Université, Department of Ophthalmology Sorbonne Université, Department of Clinical Hematology Sorbonne Université, Department of Biological Hematology, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris Institut Curie, PSL Research University, Department of Pathology, Department of Theranostic and Diagnostic Medicine Sorbonne Université, Department of Radiotherapy, Hôpital Pitié- Salpêtrière, Assistance Publique-Hôpitaux de Paris Université de Paris, UMR 144 CNRS Institut Curie, Site de Saint-Cloud, Hematology Department, Saint-Cloud INSERM U932 Institut Curie, PSL Research University, Paris, France.

Purpose Of Review: The aim of this study was to highlight the diagnostic and management challenges of primary vitreoretinal lymphoma (PVRL) through a review of the literature and a European survey on real-life practices for PVRL.

Recent Findings: The care of PVRL patients is heterogeneous between specialists and countries. Upfront systemic treatment based on high-dose methotrexate chemotherapy, with or without local treatment, might reduce or delay the risk of brain relapse. Read More

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Engineered Polystyrene-Based Microplastics of High Environmental Relevance.

Environ Sci Technol 2021 Jul 22. Epub 2021 Jul 22.

School of Mechanical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel.

Microplastic (MP) pollution-an emerging environmental challenge of the 21st century-refers to accumulation of environmentally weathered polymer-based particles with potential environmental and health risks. Because of technical and practical challenges when using environmental MPs for risk assessment, most available data are generated using plastic models of limited environmental relevancy (i.e. Read More

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Determination of trace compounds and artifacts in nitrogen background measurements by proton transfer reaction time-of-flight mass spectrometry under dry and humid conditions.

J Mass Spectrom 2021 Aug;56(8):e4777

Department of Heterogeneous Reactions, Max Planck Institute for Chemical Energy Conversion, Mülheim a.d. Ruhr, Germany.

A qualitative analysis was applied for the determination of trace compounds at the parts per trillion in volume (ppt ) level in the mass spectra of nitrogen of different qualities (5.0 and 6.0) under dry and humid conditions. Read More

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Towards an improved classification of type 2 diabetes: lessons from research into the heterogeneity of a complex disease.

J Clin Endocrinol Metab 2021 Jul 22. Epub 2021 Jul 22.

Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, Texas.

Context: Accumulating evidence indicates "type 2 diabetes (T2D)" is phenotypically heterogeneous. Defining and classifying variant forms of T2D are priorities to better understand its pathophysiology and usher clinical practice into an era of "precision diabetes".

Evidence Acquisition And Methods: We reviewed literature related to heterogeneity of T2D over the past five decades and identified a range of phenotypic variants of T2D. Read More

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Characterization of HNRNPA1 mutations defines diversity in pathogenic mechanisms and clinical presentation.

JCI Insight 2021 Jul 22;6(14). Epub 2021 Jul 22.

Translational Neurosciences, Faculty of Medicine and Health Sciences, and.

Mutations in HNRNPA1 encoding heterogeneous nuclear ribonucleoprotein (hnRNP) A1 are a rare cause of amyotrophic lateral sclerosis (ALS) and multisystem proteinopathy (MSP). hnRNPA1 is part of the group of RNA-binding proteins (RBPs) that assemble with RNA to form RNPs. hnRNPs are concentrated in the nucleus and function in pre-mRNA splicing, mRNA stability, and the regulation of transcription and translation. Read More

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SRSF5 regulates alternative splicing of pre-mRNA through modulating SF1 binding.

RNA Biol 2021 Jul 22:1-19. Epub 2021 Jul 22.

Key Laboratory of Saline-alkali Vegetation Ecology Restoration, Ministry of Education, College of Life Science, Northeast Forestry University, Harbin, China.

Abbreviations: ARF: alternative reading frame, that is, p14ARF, or CDKN2A (cyclin-dependent kinase inhibitor 2A); β-gal: β-galactosidase; CLIP-seq: crosslinking and immunoprecipitation-sequencing; : the cyclin D binding myb-like transcription factor 1; ESS/ESE: exonic splicing silencer/enhancer; Ex: exon; FBS: fetal bovine serum; Gluc: Gaussia luciferase; hnRNPs: heterogeneous nuclear ribonucleoproteins; In: intron; ISS/ISE: intronic splicing silencer/enhancer; PBS: phosphate-buffered saline; PCR: polymerase chain reaction; PSI: percent-splice-in; qPCR: quantitative real-time PCR; RIP: RNA immunoprecipitation; RNAseq: RNA sequencing; RT: reverse transcription; SF1: splicing factor 1; SR: serine/arginine-rich proteins; SRSF5: serine and arginine-rich splicing factor 5; TCGA: the cancer genome atlas; UCSC: University of California, Santa Cruz. WT: Wild type. Read More

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Sorafenib for hepatocellular carcinoma: potential molecular targets and resistance mechanisms.

J Chemother 2021 Jul 22:1-16. Epub 2021 Jul 22.

Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, India.

Hepatocellular carcinoma (HCC) is the most widespread typical therapy-resistant, unresectable type of malignant solid tumour with a high death rate constituting huge medical concern. Sorafenib is a small molecule oral multi-target kinase potent inhibitor that acts by suppressing/blocking the multiplication of the tumour cells, angiogenesis, and encouraging apoptosis of the tumour cells. Though, the precise mechanism of tumour cell death induction by sorafenib is yet under exploration. Read More

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A review of respiratory manifestations and their management in Ehlers-Danlos syndromes and hypermobility spectrum disorders.

Chron Respir Dis 2021 Jan-Dec;18:14799731211025313

Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

Background: Ehlers-Danlos Syndromes (EDS) and Hypermobility Spectrum Disorders (HSD) are a heterogeneous group of heritable genetic connective tissue disorders with multiple characteristics including joint hypermobility, tissue fragility, and multiple organ dysfunction. Respiratory manifestations have been described in EDS patients, but have not been systematically characterized. A narrative review was undertaken to describe the respiratory presentations and management strategies of individuals with EDS and HSD. Read More

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Vitamin K supplementation and vascular health after kidney transplantation: Authors' response.

Am J Transplant 2021 Jul 22. Epub 2021 Jul 22.

Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.

We thank Drs te Velde-Keyzer and de Borst for their interest in our trial. We agree that in the small, heterogeneous cohort of kidney transplant recipients (KTR) in ViKTORIES, the lack of evidence of benefit of vitamin K supplementation does not rule out a possible role for vitamin K to improve vascular health in specific circumstances or populations. However, we note that Drs te Velde-Keyzer and de Borst do not provide evidence of any clinical trials where this effect has been demonstrated in patients with kidney failure. Read More

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Volumetric coronary endothelial function assessment: a feasibility study exploiting stack-of-stars 3D cine MRI and image-based respiratory self-gating.

NMR Biomed 2021 Jul 21:e4589. Epub 2021 Jul 21.

Russel H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland, USA.

Abnormal coronary endothelial function (CEF), manifesting as depressed vasoreactive responses to endothelial-specific stressors, occurs early in atherosclerosis, independently predicts cardiovascular events, and responds to cardioprotective interventions. CEF is spatially heterogeneous along a coronary artery in patients with atherosclerosis, and thus recently developed and tested non-invasive 2D MRI techniques to measure CEF may not capture the extent of changes in CEF in a given coronary artery. The purpose of this study was to develop and test the first volumetric coronary 3D MRI cine method for assessing CEF along the proximal and mid-coronary arteries with isotropic spatial resolution and in free-breathing. Read More

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