Cells 2021 Jan 7;10(1). Epub 2021 Jan 7.
Department of Biochemistry and Molecular Biology, Medical University in Lublin, ul. Chodzki 1, 20-093 Lublin, Poland.
The Notch signaling pathway is a critical player in embryogenesis but also plays various roles in tumorigenesis, with both tumor suppressor and oncogenic activities. Mutations, deletions, amplifications, or over-expression of Notch receptors, ligands, and a growing list of downstream Notch-activated genes have by now been described for most human cancer types. Yet, it often remains unclear what may be the functional impact of these changes for tumor biology, initiation, and progression, for cancer therapy, and for personalized medicine. Read More