Stem Cell Res 2016 09 13;17(2):391-400. Epub 2016 Sep 13.
Center for Reproductive Medicine and Infertility, Weill Cornell Medical College, New York, NY 10065, United States; Tri-Institutional Stem Cell Derivation Laboratory, Weill Cornell Medical College, New York, NY 10065, United States. Electronic address:
During development, endothelial cells (EC) display tissue-specific attributes that are unique to each vascular bed, as well as generic signaling mechanisms that are broadly applied to create a patent circulatory system. We have previously utilized human embryonic stem cells (hESC) to generate tissue-specific EC sub-types (Rafii et al., 2013) and identify pathways that govern growth and trans-differentiation potential of hESC-derived ECs (James et al. Read More