52,673 results match your criteria herbal medicine


Herbal Nephropathy.

Contrib Nephrol 2021 Aug 3;199:1-12. Epub 2021 Aug 3.

Departamento de Nefrología y Metabolismo Mineral, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

An estimated one-third of adults in developed countries and more than 80% of the population in many low- and middle-income countries use herbal and traditional medicines to promote health or for the treatment of common diseases. Herbal medicines can cause kidney damage as a result of intrinsic toxicity, adulteration, contamination, replacement, misidentification, mistaken labeling, and unfavorable herb-drug interactions. The kidneys, due to their high blood flow rate, large endothelial surface area, high metabolic activity, active uptake by tubular cells, medullary interstitial concentration, and low urine pH are particularly vulnerable to development of toxic injury in the form of different syndromes like acute kidney injury, nephrolithiasis, chronic interstitial fibrosis, or uroepithelial cancer. Read More

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Rhubarb granule promotes diethylnitrosamine-induced liver tumorigenesis by activating the oxidative branch of pentose phosphate pathway via G6PD in rats.

J Ethnopharmacol 2021 Jul 31:114479. Epub 2021 Jul 31.

Department of Biochemistry and Molecular Biology, School of Integrated Chinese and Western Medicine, Anhui University of Traditional Chinese Medicine, Hefei, Anhui Province, PR China. Electronic address:

Ethnopharmacological Relevance: Rhubarb is a natural herbal medicine widely used clinically with numerous pharmacological activities including anti-cancer. Specifically, several studies reported that free anthraquinones from Rhubarb suppressed the proliferation of hepatoma cells. Nonetheless, recent studies revealed that Rhubarb caused hepatotoxicity in vivo, confirming its "two-way" effect on the liver. Read More

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Glucose-Targeted Hydroxyapatite/Indocyanine Green Hybrid Nanoparticles for Collaborative Tumor Therapy.

ACS Appl Mater Interfaces 2021 Aug 3. Epub 2021 Aug 3.

School of Life Sciences, Anqing Normal University, Anqing 246133, P. R. China.

Nanoscale hydroxyapatite (nHA) is considered as a promising drug carrier or therapeutic agent against malignant tumors. But the strong agglomeration tendency and lack of active groups seriously hamper their usage . To address these issues, we fabricated an organic-inorganic hybrid nanosystem composed of poly(acrylic acid) (PAA), nHA, and indocyanine green (ICG), and further modified with glucose to give a targeting nanosystem ([email protected]/ICG-NPs). Read More

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A systematic review on the effects of supplementation on cytokine levels: Is there a role in COVID-19?

Metabol Open 2021 Jul 29:100115. Epub 2021 Jul 29.

Canadian College of Naturopathic Medicine, Canada.

COVID-19 is the respiratory illness caused by the novel coronavirus, SARS-CoV-2. Cytokine storm appears to be a factor in COVID-19 mortality. species have been used historically for immune modulation. Read More

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Herbal tea-induced hepatic veno-occlusive disease in China: a case description.

Quant Imaging Med Surg 2021 Aug;11(8):3882-3889

Department of Radiology, Zhumadian Central Hospital, Zhumadian, China.

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Improving oral bioavailability of medicinal herbal compounds through lipid-based formulations - A Scoping Review.

Phytomedicine 2021 Jul 17:153651. Epub 2021 Jul 17.

School of Pharmacy, Monash University Malaysia, Bandar Sunway, Subang Jaya, Malaysia. Electronic address:

Background: Although numerous medicinal herbal compounds demonstrate promising therapeutic potential, their clinical application is often limited by their poor oral bioavailability. To circumvent this barrier, various lipid-based herbal formulations have been developed and trialled with promising experimental results.

Purpose: This scoping review aims to describe the effect of lipid-based formulations on the oral bioavailability of herbal compounds. Read More

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Effectiveness and tolerability of the thyme/ivy herbal fluid extract BNO 1200 for the treatment of acute cough: an observational pharmacy-based study.

Curr Med Res Opin 2021 Aug 3. Epub 2021 Aug 3.

Centre for Human & Applied Physiological Sciences, School of Basic & Medical Biosciences Faculty of Life Sciences & Medicine, King's College London, United Kingdom.

Objective: Efficacy and safety of an oral thyme/ivy syrup for the treatment of acute cough was previously demonstrated in a randomized clinical trial. Here, we present real-life data from a pharmacy-based, observational study on the effectiveness and tolerability of another thyme/ivy combination (BNO 1200, Bronchipret® drops).

Methods: This observational, prospective, uncontrolled study was conducted in 305 German pharmacies. Read More

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Acupuncture Treatment for Nocturnal Crying in Pediatric Patients: A Systematic Review of Clinical Studies.

Front Pediatr 2021 14;9:647098. Epub 2021 Jul 14.

Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon, South Korea.

Nocturnal crying is a common condition in which children intermittently or continuously cry and fuss during the night, at certain times or throughout the night. It is a common pediatric sleep disturbance for which medical assistance is highly sought by parents, and one of the non-pharmacologic treatments for nocturnal crying is pediatric acupuncture. This review aimed to review the literature about the effectiveness and safety of pediatric acupuncture for nocturnal crying. Read More

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extract protects human neuroblastoma SH-SY5Y cells against oxidative glutamate toxicity by activating redoxosome-p66Shc.

Exp Ther Med 2021 Sep 5;22(3):951. Epub 2021 Jul 5.

Sydney Pharmacy School, The University of Sydney, Sydney, New South Wales 2006, Australia.

extract (GBE), a traditional Chinese herbal medicine component, is widely used to alleviate symptoms of neurodegenerative diseases. It has been confirmed that GBE exerts its pharmacological effect mainly due to its antioxidant activity; however, the molecular mechanism responsible for this effect remains unclear. The aim of the present study was to investigate the detailed mechanism of GBE, the main component of dropping medicine, against oxidative glutamate toxicity in human neuroblastoma SH-SY5Y cells. Read More

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September 2021

HIF-1 RNAi Combined with Asparagus Polysaccharide Exerts an Antiangiogenesis Effect on Hepatocellular Carcinoma In Vitro and In Vivo.

Evid Based Complement Alternat Med 2021 23;2021:9987383. Epub 2021 Jul 23.

Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, China.

Background: Hepatocellular carcinoma (HCC) is the main form of primary liver cancer and is one of the most prevalent and life-threatening malignancies globally. Hypoxia activates hypoxia-inducible factor-1 (HIF-1), which is the key factor in promoting angiogenesis in HCC. Currently, there are few studies on the effects of HIF-1-targeted gene therapy combined with traditional Chinese herbal extracts. Read More

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New Therapeutic Insight into the Effect of Ma Huang Tang on Blood Pressure and Renal Dysfunction in the L-NAME-Induced Hypertension.

Evid Based Complement Alternat Med 2021 13;2021:9980429. Epub 2021 Jul 13.

Hanbang Cardio-Renal Syndrome Research Center, Wonkwang University, 460 Iksan-daero, Iksan, Jeonbuk 54538, Republic of Korea.

In this study, we evaluated the effect of a traditional herbal formula, Ma Huang Tang (MHT), on blood pressure and vasodilation in a rat model of N-nitro-L-arginine methylester- (L-NAME-) induced hypertension. We found that MHT-induced vascular relaxation in a dose-dependent manner in rat aortas pretreated with phenylephrine. However, pretreatment of endothelium-intact aortic rings with L-NAME, an inhibitor of nitric oxide synthesis (NOS), or 1H-[1, 2, 4]-oxadiazole-[4, 3-]-quinoxalin-1-one (ODQ), an inhibitor of soluble guanylyl cyclase, significantly abolished vascular relaxation induced by MHT. Read More

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Review of Traditional Chinese Medicines for Common Complications Related to Hemodialysis: An Evidence-Based Perspective.

Evid Based Complement Alternat Med 2021 13;2021:9953986. Epub 2021 Jul 13.

Department of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.

Renal replacement therapy is an important therapy for prolonging life in end-stage renal disease (ESRD) populations, and, in Taiwan, hemodialysis (HD) is the choice for most patients with ESRD. Although HD is effective for prolonging life, it is sometimes associated with complications that patients and doctors have to cope with every day, such as intradialytic hypotension, dialysis disequilibrium syndrome, and muscle cramps. Traditional Chinese medicine (TCM) is a complementary and alternative therapy that has been recognized for its efficacy in treating a variety of diseases by the World Health Organization. Read More

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Effectiveness and Safety of Chinese Medicine Decoctions for Behcet's Disease: A Systematic Review and Meta-Analysis.

Evid Based Complement Alternat Med 2021 17;2021:8202512. Epub 2021 Jul 17.

Department of Oral Medicine, Peking University School and Hospital of Stomatology, Beijing 100081, China.

Background: Behcet's disease (BD) is an autoimmune disease of systemic vasculitis with an unclear pathogenesis. Although western medicines remain the mainstay interventions, effectiveness and safety are significant challenges. Complementary and alternative medicine, including herbal medicine, are gaining more attention. Read More

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Water-Soluble Total Flavonoids Isolated from var (Benth.) H. Hara Promote Hepatocellular Carcinoma Sensitivity to 5-Fluorouracil.

Evid Based Complement Alternat Med 2021 17;2021:6623212. Epub 2021 Jul 17.

Hunan Traditional Chinese Medical College, Zhuzhou 412012, Hunan, China.

var (Benth.) H. Hara, a native medicinal plant produced chiefly across Southern China, is one of the mainstream varieties of Xihuangcao, which has long been applied in preventing and treating some common liver or gall diseases. Read More

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Analysis of Colorectal Carcinogenesis Paradigm between Cold Constitution and Heat Constitution: Earlier ECM Collagen Deposition.

Evid Based Complement Alternat Med 2021 17;2021:5547578. Epub 2021 Jul 17.

Pi-Wei Institute, Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.

Colorectal cancer (CRC) is a common malignant tumor around the world. Studying the unique constitution of CRC patients is conducive to the application of personalized medical treatment for CRC. The most common types of constitution in CRC are cold and heat constitution. Read More

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Herbal Medicines Targeting the Improved -Cell Functions and -Cell Regeneration for the Management of Diabetes Mellitus.

Evid Based Complement Alternat Med 2021 14;2021:2920530. Epub 2021 Jul 14.

Department of Biochemistry, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka.

There is an increasing trend of investigating natural bioactive compounds targeting pancreatic -cells for the prevention/treatment of diabetes mellitus (DM). With the exploration of multiple mechanisms by which -cells involve in the pathogenesis of DM, herbal medicines are gaining attention due to their multitasking ability as evidenced by traditional medicine practices. This review attempts to summarize herbal medicines with the potential for improvement of -cell functions and regeneration as scientifically proven by investigations. Read More

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Identification of Multi-Target Anti-AD Chemical Constituents From Traditional Chinese Medicine Formulae by Integrating Virtual Screening and Validation.

Front Pharmacol 2021 16;12:709607. Epub 2021 Jul 16.

Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Alzheimer's disease (AD) is a neurodegenerative disease that seriously threatens the health of the elderly. At present, no drugs have been proven to cure or delay the progression of the disease. Due to the multifactorial aetiology of this disease, the multi-target-directed ligand (MTDL) approach provides an innovative and promising idea in search for new drugs against AD. Read More

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Investigating the Pharmacological Mechanisms of SheXiang XinTongNing Against Coronary Heart Disease Based on Network Pharmacology and Experimental Evaluation.

Front Pharmacol 2021 14;12:698981. Epub 2021 Jul 14.

Tang Center of Herbal Medicine Research and Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL, United States.

SheXiang XinTongNing (XTN), which is composed of six traditional Chinese herbs, is a commercially available Chinese patent medicine that has been widely used as the treatment of coronary heart disease (CHD). Its mechanisms against coronary heart disease, however, remain largely unknown. This study aimed to investigate the pharmacological mechanisms of XTN against CHD via network pharmacology and experimental evaluation. Read More

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The Efficacy and Safety of Chinese Herbal Medicine Xianling Gubao Capsule Combined With Alendronate in the Treatment of Primary Osteoporosis: A Systematic Review and Meta-Analysis of 20 Randomized Controlled Trials.

Front Pharmacol 2021 16;12:695832. Epub 2021 Jul 16.

Department of Orthopaedic Surgery, Wenzhou Central Hospital, Wenzhou, China.

Herein, we purposed to evaluate the efficacy along with the safety of Xianling Gubao capsule (XLGB) combined with alendronate (ALE) for primary osteoporosis (POP) from the current literature. We carried out a search for electronic literature in the PubMed, Chinese National Knowledge Infrastructure, EMBASE, Wanfang Web of Science, Chinese Biomedical Literature Database, Cochrane Library, as well as Chinese VIP databases targeting articles published from inception to December 2020. Only randomized controlled trials (RCTs) were enrolled into the study. Read More

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Paeoniflorin: A neuroprotective monoterpenoid glycoside with promising anti-depressive properties.

Phytomedicine 2021 Jul 22:153669. Epub 2021 Jul 22.

Department of Anatomy, School of Chinese Medicine, Beijing University of Chinese Medicine, Sunshine Southern Avenue, Fang-Shan District, Beijing 102488, China. Electronic address:

Background: Depression, as a prevalent and debilitating psychiatric disease, severely decreases the life quality of individuals and brings heavy burdens to the whole society. Currently, some antidepressants are applied in the treatment of severe depressive symptoms, while there are still some undesirable drawbacks. Paeoniflorin is a monoterpenoid glycoside that was firstly extracted from Paeonia lactiflora Pall, a traditional Chinese herb that is widely used in the Chinese herbal formulas for treating depression. Read More

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Symmetrical drug-related intertriginous and flexural exanthema/baboon syndrome induced by traditional Chinese medicine.

J Cosmet Dermatol 2021 Aug 1. Epub 2021 Aug 1.

Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Background: Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) refers to an uncommon cutaneous adverse reaction that symmetrically involves the buttock and intertriginous areas after systemic exposure to the offending drug and is previously known as baboon syndrome. SDRIFE related with traditional Chinese medicine (TCM) has not been reported.

Objective: We presented a case of SDRIFE /baboon syndrome induced by TCM, Xi-Huang capsule. Read More

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Hydrogels: A potential platform for induced pluripotent stem cell culture and differentiation.

Colloids Surf B Biointerfaces 2021 Jul 20;207:111991. Epub 2021 Jul 20.

Centre for Nanosciences and Molecular Medicine, Amrita Vishwa Vidyapeetham, Kochi 682041, India; Department of Biochemistry, Centre of Molecular Medicine and Diagnostics (COMManD), Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, 600077, India. Electronic address:

Induced pluripotent stem cells (iPSCs) can be used to generate desired types of cells that belong to the three germ layers (i.e., ectoderm, endoderm and mesoderm). Read More

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Qingyangshen mitigates amyloid-β and Tau aggregate defects involving PPARα-TFEB activation in transgenic mice of Alzheimer's disease.

Phytomedicine 2021 Jul 12;91:153648. Epub 2021 Jul 12.

Mr. & Mrs. Ko Chi-Ming Centre for Parkinson's Disease Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China. Electronic address:

Background: Alzheimer's disease (AD) is the most common neurodegenerative disease. Deposition of amyloid β plaques (Aβ) and neurofibrillary tangles (NFTs) is the key pathological hallmark of AD. Accumulating evidence suggest that impairment of autophagy-lysosomal pathway (ALP) plays key roles in AD pathology. Read More

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Xin-Ji-Er-Kang protects myocardial and renal injury in hypertensive heart failure in mice.

Phytomedicine 2021 Jul 18;91:153675. Epub 2021 Jul 18.

Department of Pharmacology, Basic Medical College, Anhui Medical University, Hefei 230032, China. Electronic address:

Background: Xin-Ji-Er-Kang (XJEK) as a herbal formula of traditional Chinese medicine (TCM) has shown the protective effects on myocardial function as well as renal function in mouse models of myocardial infarction.

Hypothesis/purpose: We investigated the effects of XJEK on cardiovascular- and renal-function in a heart failure mouse model induced by high salt (HS) and the associated mechanisms.

Study Design: For the purpose of assessing the effects of XJEK on a hypertensive heart failure model, mice were fed with 8% high salt diet. Read More

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PCR-based rapid diagnostic tools for the authentication of medicinal mistletoe species.

Phytomedicine 2021 Jul 16;91:153667. Epub 2021 Jul 16.

Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, 111, Geonjae-ro, Naju, Jeollanam-do 58245, Republic of Korea. Electronic address:

Background: Taxilli Herba (TH) and Visci Herba (VH), defined as the leaves and branches of the mistletoe species Taxillus chinensis and Viscum coloratum, respectively, are popular herbal medicines in East Asia. However, commercial TH and VH products are frequently adulterated with related inauthentic mistletoe species, posing efficacy and safety concerns. Accurate species identification of herbal medicinal products is a prerequisite for quality control, but traditional morphological identification methods are hampered by difficulties in discriminating among closely related species and in identifying the source materials in processed products. Read More

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A comparative study on chemical compositions and biological activities of four essential oils: Cymbopogon citratus (DC.) Stapf, Cinnamomum cassia (L.) Presl, Salvia japonica Thunb. and Rosa rugosa Thumb.

J Ethnopharmacol 2021 Jul 28:114472. Epub 2021 Jul 28.

School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, China. Electronic address:

Ethnopharmacological Relevance: Essential oils (EOs) are important active ingredients in Chinese herbal medicine. Cymbopogon citratus (DC.) Stapf, Cinnamomum cassia (L. Read More

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Korean red ginseng alleviate depressive disorder by improving astrocyte gap junction function.

J Ethnopharmacol 2021 Jul 28:114466. Epub 2021 Jul 28.

Institute for Brain Research and Rehabilitation (IBRR), South China Normal University (SCNU), Guangzhou, 510631, China; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China; Hunan University of Chinese Medicine & Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces, Changsha 410208 Hunan, China; DME Center, Clinical Pharmacology Institute, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. Electronic address:

Ethnopharmacological Relevance: Korean red ginseng (KRG), a processed product of Panax ginseng C. A. Mey, show significant anti-depressive effect in clinic. Read More

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Curcumin: A Review of Its Effects on Epilepsy.

Adv Exp Med Biol 2021 ;1291:363-373

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Central nervous system (CNS) diseases pose an enormous healthcare burden, at both an individual and a societal level. Epilepsy has now become one of the most prevalent CNS disorders. Pharmaceutical drugs prescribed for epilepsy often have serious side effects and, for this reason, attention has turned to the use of medicinal plants. Read More

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Carbon-based Nanomaterials and Curcumin: A Review of Biosensing Applications.

Adv Exp Med Biol 2021 ;1291:55-74

Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Curcumin, the main active constituent of turmeric (Curcuma longa L.), is a naturally occurring phenolic compound with a wide variety of pharmacological activities. Although it has multiple pharmaceutical properties, its bioavailability and industrial usage are hindered due to rapid hydrolysis and low water solubility. Read More

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Turmeric and Curcumin: From Traditional to Modern Medicine.

Adv Exp Med Biol 2021 ;1291:15-39

Department of Traditional Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

The rhizome of turmeric (Curcuma longa L.) has been used as an herbal medicine, coloring agent, spice, and food additive for thousands of years in different parts of the world particularly in Asian countries. It has been used for a range of diseases in many traditional medical schools, including Islamic traditional medicine, Chinese traditional medicine, and Ayurveda. Read More

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