3,669 results match your criteria herbal ingredients

Target-Based In Silico Screening for Phytoactive Compounds Targeting SARS-CoV-2.

Interdiscip Sci 2021 Jul 25. Epub 2021 Jul 25.

The Department of Biology, York University, Life Sciences Building 327B, 4700 Keele Street, Toronto, ON, M3J 1P3, Canada.

Coronavirus disease 2019 (COVID-19), resulting from infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can cause severe and fatal pneumonia along with other life-threatening complications. The COVID-19 pandemic has taken a heavy toll on the healthcare system globally and has hit the economy hard in all affected countries. As a result, there is an unmet medical need for both the prevention and treatment of COVID-19 infection. Read More

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[Research progress on chemical constituents and quality control methods of Succus Bambusae].

Zhongguo Zhong Yao Za Zhi 2021 Jun;46(11):2753-2759

College of Traditional Chinese Medicine and Pharmaceutical Engineering,Tianjin University of Traditional Chinese Medicine Tianjin 301617,China State key Laboratory of Component-based Chinese Medicine,Tianjin University of Traditional Chinese Medicine Tianjin 301617,China.

Through the investigation of a large number of both domestic and overseas literatures and related quality standards, chemical compositions, quality evaluation system and quality control methods of Succus Bambusae were systematic summarized in this study. There were abundant chemical constituents in Succus Bambusae, mainly including volatile ingredients, amino acids, flavonoids, trace elements and vitamins, with high medicinal and edible value. The quality control methods involved traditional morphological identification, spectroscopy, chromatography and other techniques. Read More

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[Identification of quality markers of Qixuehe Capsules based on analytic hierarchy process and entropy weight methods].

Zhongguo Zhong Yao Za Zhi 2021 Jun;46(11):2710-2717

Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for Traditional Chinese Medicine Compatibility,Shaanxi University of Chinese Medicine Xi'an 712046,China.

Qixuehe Capsules is a compound Chinese patent medicine developed for treating the disorder of Qi and blood(a common etiology of gynecological disease), which has remarkable effects on smoothing liver and regulating Qi, activating blood circulation, and relieving pain. However, due to its complex prescriptions(15 herbs) and multiple effects, the quality control of Qixuehe Capsules has always been a bottleneck problem limiting its sustainable development. Therefore, this study adopted the traditional Chinese medicine Q-markers quantitative identification system established previously by our research group based on the combination of analytic hierarchy process and entropy weight methods. Read More

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[Prediction of Q-markers of Astragali Radix based on network pharmacology and fingerprint].

Zhongguo Zhong Yao Za Zhi 2021 Jun;46(11):2691-2698

Gansu University of Chinese Medicine Lanzhou 730000,China Key Laboratory of Standard and Quality Research of Chinese Medicine of Gansu Province Lanzhou 730000,China.

Astragali Radix is one of the most commonly used medicinal materials. In recent years, its cultivated varieties and a variety of adulterants have flooded the market, which makes its quality uneven, and the development of quality control methods has become a research hotspot. Therefore, figuring out the quality markers of Astragali Radix is of great significance for its comprehensive evaluation. Read More

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[Study on mechanism of Bushen Culuan Formula in treatment of polycystic ovary syndrome based on network pharmacology and molecular docking].

Zhongguo Zhong Yao Za Zhi 2021 Jun;46(11):2650-2659

Xiyuan Hospital, China Academy of Chinese Medical Sciences Beijing 100091, China.

This study used network pharmacology and molecular docking to study the mechanism of Bushen Culuan Formula in the treatment of infertility caused by polycystic ovary syndrome(PCOS). The active ingredients and potential drug targets of Bushen Cu-luan Decoction were obtained by searching the Traditional Chinese Medicine System Pharmacology(TCMSP) database, and the targets of PCOS by searching GeneCards. After the drug targets and disease targets were corrected by Uniprot, the intersection genes were obtained. Read More

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Rh2-enriched Korean ginseng (Ginseng Rh2+) inhibits tumor growth and development of metastasis of non-small cell lung cancer.

Food Funct 2021 Jul 20. Epub 2021 Jul 20.

Department of Pulmonary Diseases, Tel-Aviv Sourasky Medical Center, Israel.

Background And Objective: While there are multiple studies on the anti-tumoral effects of Panax ginseng as active ingredients (one or more ginsenosides derived from the extract) or as a whole plant extract, there is a lack of studies to assess the effects Panax ginseng's of active ingredients combined with the whole plant extract. Our aim was to study the effect of whole ginseng, enriched in the anti-tumoral Rh2 component and other ginsenosides (Ginseng Rh2+), on the metastatic capacity of non-small cell lung cancer (NSCLC).

Methods: We evaluated the effects of Ginseng Rh2+ on survival, migration and motility, induction of apoptosis, and expression of its apoptosis-related proteins in non-small cell lung cancer (NSCLC) cells in vitro and on primary tumor growth and metastatic capacity in a syngeneic mouse lung cancer model in vivo. Read More

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To Explore the Mechanism and Equivalent Molecular Group of Radix Astragali and Semen Lepidii in Treating Heart Failure Based on Network Pharmacology.

Evid Based Complement Alternat Med 2021 3;2021:5518192. Epub 2021 Jul 3.

Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250014, China.

Radix Astragali and Semen Lepidii (HQ-TLZ) is a commonly used herbal medicine combination for treatment of heart failure, which has a good clinical effect. However, its active components and mechanism of action are not clear, which limits its clinical application and development. In this study, we explored the mechanism of action of HQ-TLZ in the treatment of heart failure based on network pharmacology. Read More

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Algae-derived hydrocolloids in foods: applications and health-related issues.

Bioengineered 2021 Dec;12(1):3787-3801

Department of Chemical Engineering, National Cheng Kung University, Tainan, Taiwan.

Hydrocolloids are a class of food additives with broad applications in the food industry to develop structure in food ingredients. Hydrocolloids can be synthetic, plant-based, or animal-based. Increasing consumer awareness has led to the use of natural food ingredients derived from natural sources, making algae-derived hydrocolloids more appealing nowadays. Read More

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December 2021

The Fruits of Inhibit Colorectal Cancer Cell Migration Induced by -Derived Extracellular Vesicles.

Molecules 2021 Jul 4;26(13). Epub 2021 Jul 4.

Department of Chinese Medicine, Taipei University Hospital, Taipei 110301, Taiwan.

Colorectal cancer (CRC) is one of the most common cancers worldwide. Gut microbiota are highly associated with CRC, and was found to be enriched in CRC lesions and correlated with CRC carcinogenesis and metastases. is a well-known herbal medicine that showed anticancer activity. Read More

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The Tannins from L. (Rosaceae): A Systematic Study on the Metabolites of Rats Based on HPLC-LTQ-Orbitrap MS Analysis.

Molecules 2021 Jul 2;26(13). Epub 2021 Jul 2.

Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan 430060, China.

tannins are the major active ingredients in L. (Rosaceae), one of the most popular herbal medicines in China, is widely prescribed for hemostasis. In this study, three kinds of tannins extract from L. Read More

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Corydalis Rhizoma as a model for herb-derived trace metabolites exploration: A cross-mapping strategy involving multiple doses and samples.

J Pharm Anal 2021 Jun 10;11(3):308-319. Epub 2020 Mar 10.

School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102488, PR China.

Deciphering the metabolites of multiple components in herbal medicine has far-reaching significance for revealing pharmacodynamic ingredients. However, most chemical components of herbal medicine are secondary metabolites with low content whose in vivo metabolites are close to trace amounts, making it difficult to achieve comprehensive detection and identification. In this paper, an efficient strategy was proposed: herb-derived metabolites were predicted according to the structural characteristics and metabolic reactions of chemical constituents in Corydalis Rhizoma and chemical structure screening tables for metabolites were conducted. Read More

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Therapeutic plasma exchange in non-immune hemolytic anemia associated with henna ingestion: A case report.

Transfus Apher Sci 2021 Jul 1:103204. Epub 2021 Jul 1.

Kayseri City Hospital, Hematology Department, Kayseri, Turkey. Electronic address:

Henna is a herb that is used in traditional medicine for medical purposes as well as in the field of cosmetic. It is one of the agents that can trigger hemolytic crisis in G6PD deficient patients but it is considered safe in patients with normal G6PD enzyme. Here we present a case of non-immune hemolytic anemia occurred after ingestion of a homemade solution containing henna powder. Read More

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TCM-Blast for traditional Chinese medicine genome alignment with integrated resources.

BMC Plant Biol 2021 Jul 17;21(1):339. Epub 2021 Jul 17.

School of Chinese Materia Medica, Beijing University of Chinese Medicine, Yangguang South Avenue, Fangshan District, Beijing, 102488, China.

The traditional Chinese medicine (TCM) genome project aims to reveal the genetic information and regulatory network of herbal medicines, and to clarify their molecular mechanisms in the prevention and treatment of human diseases. Moreover, the TCM genome could provide the basis for the discovery of the functional genes of active ingredients in TCM, and for the breeding and improvement of TCM. The traditional Chinese Medicine Basic Local Alignment Search Tool (TCM-Blast) is a web interface for TCM protein and DNA sequence similarity searches. Read More

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The combination of nanotechnology and traditional Chinese medicine (TCM) inspires the modernization of TCM: review on nanotechnology in TCM-based drug delivery systems.

Drug Deliv Transl Res 2021 Jul 14. Epub 2021 Jul 14.

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.

Fast development of combination of nanotechnology with traditional Chinese medicine (TCM) broadens the field of application of TCM. Besides, it increases the research ideas and contributes to TCM modernization. As expected, TCM will be developed into the nanodrug delivery system by nanotechnology with careful design, which will enhance the medicinal value of TCM to cure and prevent disease based on benefits brought by nanometer scale. Read More

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Herbal Active Ingredients: Potential for the Prevention and Treatment of Acute Lung Injury.

Biomed Res Int 2021 22;2021:5543185. Epub 2021 Jun 22.

Key Laboratory of Experimental Animal and Safety Evaluation of Zhejiang Province, Hangzhou Medical College, Hangzhou, China.

Acute lung injury (ALI) is a life-threatening clinical syndrome with high morbidity and mortality. The main pathological features of ALI are increased alveolar-capillary membrane permeability, edema, uncontrolled migration of neutrophils to the lungs, and diffuse alveolar damage, resulting in acute hypoxemic respiratory failure. Glucocorticoids, aspirin, and other anti-inflammatory drugs are commonly used to treat ALI. Read More

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Ethnopharmacological Survey on Medicinal Plants Used for Cosmetic Treatments in Traditional and Ayurveda Systems of Medicine in Sri Lanka.

Evid Based Complement Alternat Med 2021 26;2021:5599654. Epub 2021 Jun 26.

ALBION Co.,Ltd, Ginza 1-7-10, Chuo-ku, Tokyo 104-0061, Japan.

Medicinal plants have been used for therapeutic and beauty applications in Sri Lanka with documented history of over 2,500 years. This inherited knowledge, which has been handed down from generation to generation, provides a largely unexplored source for the potential development of active ingredients for cosmetic formulations. Therefore, the present comprehensive survey was conducted to identify cosmetic potential medicinal plants species in Sri Lanka. Read More

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Recent advances in herbal combination nanomedicine for cancer: Delivery technology and therapeutic outcomes.

Expert Opin Drug Deliv 2021 Jul 13. Epub 2021 Jul 13.

Cancer Nanotechnology Research Laboratory (CNRL), Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt.

: The use of herbal compounds in cancer therapy has great potential to promote the efficacy of current cancer therapeutic strategies. Herbal compounds were successfully reported to enhance tumor cells sensitization to the action of chemo-, hormonal- and gene-therapeutic agents different mechanisms. Herbal ingredients can affect different signaling pathways, reduce the toxic side effects or inhibit the efflux of anticancer drugs. Read More

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Curcumin in decellularized goat small intestine submucosa for wound healing and skin tissue engineering.

J Biomed Mater Res B Appl Biomater 2021 Jul 13. Epub 2021 Jul 13.

Department of Polymer and Process Engineering, Indian Institute of Technology Roorkee, Roorkee, India.

Biomaterials derived from extracellular matrices (ECMs) were extensively used for skin tissue engineering and wound healing. ECM is a complex network of biomolecules (e.g. Read More

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The Use of Chinese Yang/Qi-Invigorating Tonic Botanical Drugs/Herbal Formulations in Ameliorating Chronic Kidney Disease by Enhancing Mitochondrial Function.

Front Pharmacol 2021 24;12:622498. Epub 2021 Jun 24.

Shenzhen Key Laboratory of Steroid Drug Discovery and Development, School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen, China.

Chronic kidney disease (CKD) is a leading cause of morbidity and mortality. Mitochondrial dysfunction has been implicated as a key factor in the development of CKD. According to traditional Chinese medicine (TCM) theory, many Chinese Yang/Qi-invigorating botanical drugs/herbal formulations have been shown to produce promising outcomes in the clinical management of CKD. Read More

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(Chamomile) Ameliorates Muscle Atrophy in Mice by Targeting Protein Catalytic Pathways, Myogenesis, and Mitochondrial Dysfunction.

Am J Chin Med 2021 10;49(6):1493-1514. Epub 2021 Jul 10.

Department of Biocosmetics, Institute for Convergence at SKKU (BICS), Sungkyunkwan University, Suwon 16419, Republic of Korea.

Muscle atrophy, or loss of skeletal muscle, is caused by aging, malnutrition, immobility through injury, or diseases such as cancer. Chamomile ( L.) contains various active components, including flavonoids, sesquiterpenes, polyacetylenes, and coumarins, and is used in various herbal medicines in the European Pharmacopoeia. Read More

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Calcium-activated chloride channel is involved in the onset of diarrhea triggered by EGFR tyrosine kinase inhibitor treatment in rats.

Biomed Pharmacother 2021 Jul 8;141:111860. Epub 2021 Jul 8.

Tsumura Kampo Research Laboratories, Tsumura & Co., 3586 Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki 300-1192, Japan. Electronic address:

EGFR tyrosine kinase inhibitors (TKIs) are mainly used to treat non-small cell lung cancer; however, adverse effects such as severe diarrhea represent a major obstacle towards the continuation of EGFR-TKIs therapy. Chloride channels, which control the fluid flow in the intestinal lumen, are proposed as an important target to remediate EGFR-TKIs-induced diarrhea, but the mechanism remains unclear. The aim of this study was to clarify the mechanism underlying EGFR-TKIs-induced diarrhea with a particular focus on the role of intestinal chloride channels. Read More

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Caffeine-induced hypokalemia: a case report.

BMC Nephrol 2021 Jul 9;22(1):260. Epub 2021 Jul 9.

Division of Nephrology, Department of Internal Medicine, Chung-Ang University Hospital, 102, Heukseok-ro, Dongjak-gu, 06973, Seoul, Korea.

Background: With an increase in the global popularity of coffee, caffeine is one of the most consumed ingredients of modern times. However, the consumption of massive amounts of caffeine can lead to severe hypokalemia.

Case Presentation: A 29-year-old man without a specific past medical history was admitted to our hospital with recurrent episodes of sudden and severe lower-extremity weakness. Read More

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Pharmacokinetics/pharmacometabolomics-pharmacodynamics reveals the synergistic mechanism of a multicomponent herbal formula, Baoyuan decoction against cardiac hypertrophy.

Biomed Pharmacother 2021 Jul 7;139:111665. Epub 2021 May 7.

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, People's Republic of China. Electronic address:

Multicomponent herbal formulas (MCHFs) have earned a wide reputation for their definite efficacy in preventing or treating chronic complex diseases. However, holistic elucidation of the causal relationship between the bioavailable ingredients of MCHFs and their multitarget interactions is very challenging. To solve this problem, pharmacokinetics/pharmacometabolomics-pharmacodynamics (PK/PM-PD) combined with a multivariate biological correlation-network strategy was developed and applied to a classic MCHF, Baoyuan decoction (BYD), to clarify its active components and synergistic mechanism against cardiac hypertrophy (CH). Read More

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Fingerprinting and Determination of Hepatotoxic Constituents in Polygoni Multiflori Radix Praeparata of Different Producing Places by HPLC.

J Chromatogr Sci 2021 Jul 7. Epub 2021 Jul 7.

Longhua Hospital, Shanghai University of Traditional Chinese Medicine, South Wanping Road, Xuhui District, Shanghai 200032, China.

Polygoni Multiflori Radix Praeparata (PMRP) is used as Chinese herbal medicine with long history. However, reports about PMRP hepatotoxicity have increased recently, and producing area might be one reason. This article aims to figure out the relationship between producing area and hepatotoxic ingredients in PMRP. Read More

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Effects of dietary supplementation of herbal active ingredients promoting insulin-like growth factor-1 secretion on production performance, egg quality, blood hematology, and excreta gas emission in laying hens.

Anim Biosci 2021 Jun 23. Epub 2021 Jun 23.

Department of Animal Resource & Science, Dankook University, Cheonan 31116, Korea.

Objective: The purpose of this study was to evaluate the effects of supplementing herbal active ingredients (YGF251) which can promote the secretion of insulin-like growth factor-1 (IGF-1) in the diet on production performance, egg quality, blood hematology, and excreta gas emission in laying hens.

Methods: A total of 288 ISA Brown (41-week-old) laying hens with an initial body weight of 1.83 ± 0. Read More

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[Liquid chromatography-mass spectrometry-based metabolomics study of the efficacy of Chinese medicine asthma-relieving decoction on respiratory syncytial virus infection].

Se Pu 2021 Mar;39(3):281-290

Dalian Children' s Hospital of Dalian Medical University, Dalian 116012, China.

Respiratory syncytial virus (RSV) can cause lower respiratory tract infections, such as bronchiolitis in infants. In China, traditional asthma-relieving medicine has numerous clinical applications in the treatment of RSV infections. However, due to the complexity of the traditional Chinese medicine system, its therapeutic mechanism and main pharmacological components remain unclear. Read More

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Acaricidal Activity of Colchicum autumnale (autumn crocus) Extract against Hyalomma spp. In vitro.

Arch Razi Inst 2021 07 1;76(2):293-301. Epub 2021 Jul 1.

Department of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.

Hyalomma spp. is responsible for the transmission of protozoan, bacterial, rickettsial, and viral diseases and causes huge economic loss to the livestock industry.Recently, there is a wide number of promising attempts to evaluate and use herbal preparations for ticks control. Read More

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Identifying the active compounds and mechanism of action of Banxia Xiexin decoction for treating ethanol-induced chronic gastritis using network pharmacology combined with UPLC-LTQ-Orbitrap MS.

Comput Biol Chem 2021 Jun 25;93:107535. Epub 2021 Jun 25.

School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Electronic address:

Background: Banxia Xiexin decoction (BXD), a traditionally prescribed Chinese medicine, has been used to treat chronic gastritis for many years. However, the underlying mechanism and targets for its effects remain unknown. In the present study, we predicted the targets and active compounds of BXD in the treatment of chronic gastritis through network pharmacology and ultra-performance liquid chromatography coupled with linear trap quadrupole-Orbitrap mass spectrometry (UPLC-LTQ-Orbitrap MS). Read More

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Bcl-2-dependent autophagy disruption during aging impairs amino acid utilization that is restored by hochuekkito.

NPJ Aging Mech Dis 2021 Jul 1;7(1):13. Epub 2021 Jul 1.

Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido, Japan.

Chronic undernutrition contributes to the increase in frailty observed among elderly adults, which is a pressing issue in the sector of health care for older people worldwide. Autophagy, an intracellular recycling system, is closely associated with age-related pathologies. Therefore, decreased autophagy in aging could be involved in the disruption of energy homeostasis that occurs during undernutrition; however, the physiological mechanisms underlying this process remain unknown. Read More

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Subcritical Water Extraction of Natural Products.

Molecules 2021 Jun 30;26(13). Epub 2021 Jun 30.

Department of Chemistry, East Carolina University, Greenville, NC 27858, USA.

Subcritical water refers to high-temperature and high-pressure water. A unique and useful characteristic of subcritical water is that its polarity can be dramatically decreased with increasing temperature. Therefore, subcritical water can behave similar to methanol or ethanol. Read More

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