267,880 results match your criteria hepatitis

Feasibility and early experience of a novel multidisciplinary alcohol-associated liver disease clinic.

J Subst Abuse Treat 2021 Apr 9;130:108396. Epub 2021 Apr 9.

Department of Internal Medicine, Michigan Medicine, Ann Arbor, MI, United States of America.

Background: Alcohol cessation improves mortality in alcohol-associated liver disease (ALD), but access to treatment is limited. To address this gap, implementation and early feasibility and outcomes of a multidisciplinary ALD clinic are described.

Methods: The clinic comprised a hepatologist, psychiatrist, psychologist, nurse, and social worker. Read More

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An evaluation of StaySafe, a tablet app to improve health risk decision-making among people under community supervision.

J Subst Abuse Treat 2021 May 14;130:108480. Epub 2021 May 14.

Texas Christian University, Institute of Behavioral Research, TCU Box 298740, Fort Worth, TX 76129, USA. Electronic address:

Background: A self-administered tablet app, StaySafe, helps people under community supervision to make better decisions regarding health risk behaviors, especially those linked to HIV, viral hepatitis, and other sexually transmitted infections. The multi-session StaySafe design uses an interactive, analytical schema called WORKIT that guides users through a series of steps, questions, and exercises aimed at promoting critical thinking about health risks associated with substance use and unprotected sex. Repetition of the WORKIT schema is designed to enhance procedural memory that can be rapidly accessed when individuals are faced with making decisions about risky behaviors. Read More

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Extended-release naltrexone for youth with opioid use disorder.

J Subst Abuse Treat 2021 Apr 15;130:108407. Epub 2021 Apr 15.

Friends Research Institute, 1040 Park Avenue, Suite, 103 Baltimore, MD, USA. Electronic address:

Background: Few published research studies have examined the effectiveness of extended-release naltrexone (XR-NTX) for the treatment of opioid use disorder (OUD) among adolescents and young adults.

Methods: This two-group randomized controlled trial recruited 288 youth, ages 15-21, with moderate/severe OUD from a residential addiction treatment program in Baltimore, Maryland. The study randomized the youth within the first week of treatment entry to receive either XR-NTX or treatment-as-usual (TAU; either buprenorphine maintenance treatment or treatment without OUD medication following medically managed withdrawal) prior to discharge, with continued treatment in the community for 6 months. Read More

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Correlation between the prognosis of chronic hepatitis B treated with interferon and the gene polymorphism of CGRP and its receptor.

Infect Genet Evol 2021 Jun 9:104968. Epub 2021 Jun 9.

Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, Hebei Key Laboratory of Environment and Human health, Shi Jiazhuang, PR China. Electronic address:

Objective: To investigate the relationship of the polymorphism of two gene loci (CGRP rs155209 and RAMP1 rs3754701) with the prognosis of interferon therapy for chronic hepatitis B (CHB) by case-control study.

Materials And Methods: 317 CHB patients using interferon for the first time alone were collected in northern China and peripheral blood samples were obtained, the single-nucleotide polymorphisms (SNPs) in CGRP rs155209 and RAMP1 rs3754701 were genotyped by MALDI-TOF-MS. Univariate and multivariate logistic regression methods were used to assess the correlation between the prognosis of CHB treated with interferon and the gene polymorphism of CGRP rs155209 and RAMP1 rs3754701. Read More

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Pregnancy and Viral infections: Mechanisms of fetal damage, diagnosis and prevention of neonatal adverse outcomes from cytomegalovirus to SARS-CoV-2 and Zika virus.

Biochim Biophys Acta Mol Basis Dis 2021 Jun 9:166198. Epub 2021 Jun 9.

Fetal and Perinatal Medicine and Surgery Unit, Medical and Surgical Department of Fetus, Newborn and Infant - "Bambino Gesù" Children's Hospital IRCCS, Rome, Italy.

Some maternal infections, contracted before or during pregnancy, can be transmitted to the fetus, during gestation (congenital infection), during labor and childbirth (perinatal infection) and through breastfeeding (postnatal infection). The agents responsible for these infections can be viruses, bacteria, protozoa, fungi. Among the viruses most frequently responsible for congenital infections are Cytomegalovirus (CMV), Herpes simplex 1-2, Herpes virus 6, Varicella zoster. Read More

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Mycophenolate mofetil as a treatment of severe steroid-resistant immune-related hepatitis.

Gastroenterol Hepatol 2021 Jun 9. Epub 2021 Jun 9.

Internal Medicine Department, POVISA Hospital- Ribera Salud Group, Rúa Salamanca 5, 36211 Vigo, Spain. Electronic address:

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Medicaid Expansion Association with End-Stage Liver Disease Mortality Depends on Leniency of Medicaid Hepatitis C Virus Coverage.

Liver Transpl 2021 Jun 12. Epub 2021 Jun 12.

Department of Medicine, Weill Cornell Medicine/NewYork-Presbyterian Hospital, New York.

Background And Aims: The Affordable Care Act (ACA) expanded Medicaid around the same time that direct-acting antivirals (DAAs) became widely available for the treatment of hepatitis C virus (HCV). However, there is significant variation in Medicaid HCV treatment eligibility criteria between states. We explored the combined effects of Medicaid expansion and leniency of HCV coverage under Medicaid on liver outcomes. Read More

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Advances on molecular mechanism of hepatitis B virus-induced hepatocellular carcinoma.

Zhejiang Da Xue Xue Bao Yi Xue Ban 2021 Feb;50(1):113-122

College of Pharmaceutical Sciences,Inner Mongolia Medical University,Hohhot 010000,China; 2. School of Medicine,Zhejiang University,Hangzhou 310058,China.

The pathogenesis of hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) is complicated with the crosstalk of multiple factors and the multi-step processes. The main mechanisms underlying the HBV-induced HCC include:①integration of HBV DNA into the host hepatocyte genome to alter gene function at the insertion site,resulting in host genome instability and expression of carcinogenic truncated proteins;②HBV gene mutations at S,C,and X coding regions in the genome;③HBV X gene-encoded HBx protein activates proto-oncogenes and inhibits tumor suppressor genes,leading to the HCC occurrence. In this article,the recent research progress on the molecular mechanism of HBV-induced HCC is comprehensively reviewed,so as to provide insights into the prevention,early prediction and postoperative adjuvant therapy of HCC. Read More

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February 2021

Medicinal chemistry of anthranilic acid derivatives: A mini review.

Drug Dev Res 2021 Jun 12. Epub 2021 Jun 12.

Department of Chemistry, UGC Sponsored Centre for Advanced Studies, Guru Nanak Dev University, Amritsar, Punjab, India.

Anthranilic acid and its analogues present a privileged profile as pharmacophores for the rational development of pharmaceuticals deliberated for managing the pathophysiology and pathogenesis of various diseases. The substitution on anthranilic acid scaffold provides large compound libraries, which enable a comprehensive assessment of the structure activity relationship (SAR) analysis for the identification of hits and leads in a typical drug development paradigm. Besides, their widespread applications as anti-inflammatory fenamates, the amide and anilide derivatives of anthranilic acid analogues play a central role in the management of several metabolic disorders. Read More

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Health- and treatment outcomes of patients with hemophilia in the Netherlands, 1972-2019.

J Thromb Haemost 2021 Jun 12. Epub 2021 Jun 12.

Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.

Introduction: We conducted six cross-sectional nationwide questionnaire studies among all patients with hemophilia in the Netherlands from 1972 until 2019 to assess how health outcomes have changed, with a special focus on patients >50 years of age.

Methods: Data were collected on patient characteristics, treatment, (joint) bleeding, joint impairment, hospitalizations, human immunodeficiency virus and hepatitis C infections, and general health status (RAND-36).

Results: In 2019, 1009 patients participated of whom 48% had mild, 15% moderate and 37% severe hemophilia. Read More

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Natural killer cells in antiviral immunity.

Nat Rev Immunol 2021 Jun 11. Epub 2021 Jun 11.

Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Natural killer (NK) cells play an important role in innate immune responses to viral infections. Here, we review recent insights into the role of NK cells in viral infections, with particular emphasis on human studies. We first discuss NK cells in the context of acute viral infections, with flavivirus and influenza virus infections as examples. Read More

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Multiple Roles of IL-6 in Hepatic Injury, Steatosis, and Senescence Aggregate to Suppress Tumorigenesis.

Cancer Res 2021 Jun 11. Epub 2021 Jun 11.

Goldyne-Savad Institute of Gene Therapy, Hadassah Hebrew University Hosptial

Hepatocellular carcinoma (HCC) typically develops on a background of chronic hepatitis for which the pro-inflammatory cytokine interleukin-6 (IL-6) is conventionally considered a crucial driving factor. Paradoxically, IL-6 also acts as a hepatoprotective factor in chronic liver injury. Here we used the multidrug-resistant gene 2 knockout (Mdr2-/-) mouse model to elucidate potential roles of IL-6 in chronic hepatitis-associated liver cancer. Read More

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Association of sex hormones with hepatic steatosis in men with chronic hepatitis B.

Dig Liver Dis 2021 Jun 8. Epub 2021 Jun 8.

Department of Gastroenterology and Hepatology, Tianjin Second People's Hospital, No.7, Sudi South Road, Nankai District, Tianjin 300192, China. Electronic address:

Background: No study on the relationship between hepatic steatosis and sex hormone levels in male patients with chronic hepatitis B (CHB) infection has been conducted.

Aims: We aimed to investigate the association between serum sex hormones and hepatic steatosis among a cohort of males with CHB.

Methods: In this cross-sectional study, 268 male patients with CHB were enrolled. Read More

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Use of thiopurines is not a risk factor for post-ERC pancreatitis in patients with primary sclerosing cholangitis.

Dig Liver Dis 2021 Jun 8. Epub 2021 Jun 8.

Department of Gastroenterology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Introduction: Risk of post-ERC pancreatitis (PEP) in patients with primary sclerosing cholangitis (PSC) is 1-7.8%. PSC is often associated with inflammatory bowel disease and autoimmune hepatitis, which are usually treated with thiopurines. Read More

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Management of Human and Animal Bites.

Oral Maxillofac Surg Clin North Am 2021 Jun 8. Epub 2021 Jun 8.

Oral and Maxillofacial Surgery, Cook County Health, Chicago, IL, USA; Midwestern University, Chicago, IL, USA. Electronic address:

Dogs are the animal most frequently implicated in causing bite injuries to the human face. Dog bite injuries are most prevalent in younger patients. Pasteurella species are commensals of the oral microbiome of dogs and cats and are frequently implicated in infections resulting from dog and cat bite injuries. Read More

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Assessment of immunogenicity and safety across two manufacturing lots of a 3-antigen hepatitis B vaccine, Sci-B-Vac®, compared with Engerix-B® in healthy Asian adults: A phase 3 randomized clinical trial.

Vaccine 2021 Jun 8. Epub 2021 Jun 8.

VBI Vaccines Inc., Cambridge, MA, United States.

Background: Sci-B-Vac®, a 3-antigen hepatitis B vaccine (3A-HBV), contains all three recombinant hepatitis B virus (HBV) envelope proteins (S, pre-S1, and pre-S2). In 2005, 3A-HBV manufacturing transferred facilities (A to B), where it continues to be manufactured.

Methods: This phase 3, single-blind, randomized study, conducted at one site in Vietnam, compared efficacy and safety among two 3A-HBV lots, lot A and lot B, and a single-antigen hepatitis B vaccine (1A-HBV), Engerix-B®. Read More

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Utilizing patient perception of group treatment in exploring medication adherence, social support, and quality of life outcomes in people who inject drugs with hepatitis C.

J Subst Abuse Treat 2021 Jul 7;126:108459. Epub 2021 May 7.

Clemson University School of Health Research, Clemson, SC, USA; Department of Medicine, Prisma Health-Upstate, Greenville, SC, USA; University of South Carolina School of Medicine Greenville, Greenville, SC, USA. Electronic address:

People who inject drugs (PWID) have a high prevalence of hepatitis C virus (HCV). Group treatment is a practical option for addressing barriers to treatment in this population. Prior research on group treatment has resulted in mixed conclusions about its effectiveness in addressing barriers to treatment. Read More

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Enhanced expression of miR-889 forecasts an unfavorable prognosis and facilitates cell progression in hepatocellular carcinoma.

Diagn Pathol 2021 Jun 11;16(1):51. Epub 2021 Jun 11.

School of Pharmacy, Harbin University of Commerce, 138 Tongda Street, Harbin, 150076, Heilongjiang, China.

Background: As a new type of molecular marker, microRNAs (miRNAs) can be used for early diagnosis and prognosis prediction of malignant tumors, and has broad clinical application prospects. This paper mainly studies the important role of miR-889 in the occurrence and development of hepatocellular carcinoma and the prognostic significance of miR-889 in hepatocellular carcinoma.

Methods: Quantitative real-time PCR analysis detected the expression levels of miR-889 in hepatocellular carcinoma tissues and cell lines. Read More

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Polysaccharide of Atractylodes macrocephala Koidz regulates LPS-mediated mouse hepatitis through the TLR4-MyD88-NFκB signaling pathway.

Int Immunopharmacol 2021 Jun 8;98:107692. Epub 2021 Jun 8.

Zhongkai University of Agriculture and Engineering, Guangzhou, Guangdong 510225, China; Guangdong Province Key Laboratory of Waterfowl Healthy Breeding, Guangzhou, Guangdong 510225, China. Electronic address:

Feed corruption and poor breeding environment could cause widespread bacterial infection which could cause severe liver inflammation and lead to liver damage, even death. It has been proved that Polysaccharide of Atractylodes macrocephala Koidz (PAMK) could improve the immunity of animal, but the mechanism of its protective effect on hepatitis has been rarely reported. This study investigated the protective effect of PAMK on mouse liver through LPS-induced liver inflammatory. Read More

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Characterization and prediction of viral loads of Hepatitis B serum samples by using surface-enhance Raman spectroscopy (SERS).

Photodiagnosis Photodyn Ther 2021 Jun 8:102386. Epub 2021 Jun 8.

PCR Laboratory, PINUM Hospital, Faisalabad, Pakistan.

Background: Raman spectroscopy is a promising technique to analyze the body fluids for the purpose of non-invasive disease diagnosis.

Objectives: To develop a surface-enhanced Raman spectroscopy (SERS) based method for qualitative and quantitative analysis of hepatitis B viral (HBV) infection from blood serum samples.

Methods: Clinically diagnosed hepatitis B virus (HBV) infected serum samples of patients of different levels of viral loads have been subjected for SERS analysis in comparison with the healthy ones by using silver nanoparticles (Ag NPs) based SERS substrates. Read More

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Coexistence of immune-mediated diseases in sarcoidosis Frequency and clinical significance in 1737 patients.

Joint Bone Spine 2021 Jun 8:105236. Epub 2021 Jun 8.

Department of Medicine, Universitat de Barcelona, Barcelona, Spain; Department of Autoimmune Diseases, ICMiD, Hospital Clinic, Barcelona, Spain. Electronic address:

Objective: To analyze whether immune-mediated diseases (IMDs) occurs in sarcoidosis more commonly than expected in the general population, and how concomitant IMDs influence the clinical presentation of the disease.

Methods: We searched for coexisting IMDs in patients included in the SARCOGEAS-cohort, a multicenter nationwide database of consecutive patients diagnosed according to the ATS/ESC/WASOG criteria. Comparisons were made considering the presence or absence of IMD clustering, and odds ratios (OR) and their 95% confidence intervals (CI) were calculated as the ratio of observed cases of every IMD in the sarcoidosis cohort to the observed cases in the general population. Read More

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Autoimmune hepatitis following sars-cov-2 VACCINE: MAY not be a casualty.

J Hepatol 2021 Jun 8. Epub 2021 Jun 8.

Department of Clinical Medicine and Surgery, Gastroenterology and Hepatology, University Federico II of Naples.

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Society for Maternal-Fetal Medicine (SMFM) Consult Series #56: Hepatitis C in Pregnancy: Updated Guidelines.

Am J Obstet Gynecol 2021 Jun 8. Epub 2021 Jun 8.

In the United States, it is estimated that 1% to 4% of pregnant women are infected with hepatitis C virus, which carries approximately a 5% risk of transmission from mother to infant. Hepatitis C virus can be transmitted to the infant in utero or during the peripartum period, and infection during pregnancy is associated with an increased risk of adverse fetal outcomes, including fetal growth restriction and low birthweight. The purpose of this document is to discuss the current evidence, provide updated recommendations regarding screening, review treatment, and address management of hepatitis C virus during pregnancy. Read More

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Repurposing of Clinically Approved Poly-(Adp-Ribose) Polymerase Inhibitors For The Therapy of Sepsis.

Shock 2021 Jun 10. Epub 2021 Jun 10.

Division of Infectious Diseases, Escola Paulista de Medicina, Universidade Federal de Sao Paulo - Sao Paulo - Brazil Laboratory of Medical Research - Faculty of Medicine of the University of São Paulo-USP, São Paulo, Brazil Chair of Pharmacology, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.

Abstract: Sepsis' pathogenesis involves multiple mechanisms that lead to a dysregulation of the host's response. Significant efforts have been made in search of interventions that can reverse this situation and increase patient survival. Poly (ADP-polymerase) (PARP) is a constitutive nuclear and mitochondrial enzyme, which functions as a co-activator and co-repressor of gene transcription, thus regulating the production of inflammatory mediators. Read More

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Comparison of hepatitis C treatment outcomes between primary care and specialty care.

J Am Assoc Nurse Pract 2021 Jun 9. Epub 2021 Jun 9.

Integrated Health Services, Colorado Coalition for the Homeless, Denver, Colorado, Seattle University College of Nursing, Seattle, Washington.

Background: Hepatitis C virus (HCV) infections have increased significantly in the United States recently, having tripled by 2014. Seventy-five percent of those with HCV are aging baby boomers, which places increased pressure on the medical system to provide treatment. There are not enough specialists available to treat everyone infected with HCV. Read More

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Dolutegravir/lamivudine as a first-line regimen in a test-and-treat setting for newly diagnosed people living with HIV.

AIDS 2021 Jun 9. Epub 2021 Jun 9.

Orlando Immunology Center, Orlando, FL, USA Baylor University Medical Center, Dallas, TX, USA Desert AIDS Project, Palm Springs, CA, USA Bliss Healthcare Services, Orlando, FL, USA Infectious Disease Specialists of Atlanta, Decatur, GA, USA Midway Immunology and Research Center, Fort Pierce, FL, USA ViiV Healthcare, Research Triangle Park, NC, USA GlaxoSmithKline, Brentford, UK ViiV Healthcare, Brentford, UK Stanford University, Palo Alto, CA.

Objectives: Dolutegravir/lamivudine (DTG/3TC) is indicated for treatment-naive and experienced people with HIV; however, questions remain about its utility in a test-and-treat setting because of potential transmitted resistance and baseline hepatitis B virus (HBV) co-infection. We present feasibility and efficacy of DTG/3TC in newly diagnosed individuals in a test-and-treat setting.

Design: The single-arm STAT study evaluated DTG/3TC in a US test-and-treat setting. Read More

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"I want to feel young again": experiences and perspectives of young people who inject drugs living with hepatitis C in Vancouver, Canada.

Can J Public Health 2021 Jun 11. Epub 2021 Jun 11.

British Columbia Centre on Substance Use, 400-1045 Howe St, Vancouver, V6Z 2A9, BC, Canada.

Objectives: People who inject drugs (PWID) are disproportionately impacted by hepatitis C virus (HCV). Despite the availability and efficacy of direct-acting antiviral (DAA) HCV therapies, treatment rates remain low among PWID. Among PWID, those who are young (under age 30) experience high rates of HCV and also face distinct barriers to care. Read More

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Using vibration controlled transient elastography and FIB-4 to assess liver cirrhosis in a hepatitis C virus infected population.

Medicine (Baltimore) 2021 Jun;100(23):e26200

Emory University School of Medicine, Atlanta.

Abstract: We assessed the performance characteristics of the Fibrosis-4 (FIB-4) score in a veteran population with chronic hepatitis C virus (HCV) infection and used vibration controlled transient elastography (VCTE) as the gold standard.All VCTE studies were performed by a single operator on United States veterans with HCV infection presenting for care at the Atlanta VA Medical Center (AVAMC) over a 2 year period. VCTE liver stiffness measurements (LSM) were categorized as cirrhotic if LSM was >12. Read More

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A case report on severe nivolumab-induced adverse events similar to primary sclerosing cholangitis refractory to immunosuppressive therapy.

Medicine (Baltimore) 2021 Jun;100(23):e25774

Division of Medical Oncology, Department of Medicine, Showa University School of Medicine.

Introduction: Immune checkpoint inhibitors (ICIs), particularly anti-PD-1 antibody, have dramatically changed cancer treatment; however, fatal immune-related adverse events (irAEs) can develop. Here, we describe a severe case of sclerosing cholangitis-like irAE. We report the use of 3 immunosuppressive agents that resulted in the death of the patient due to treatment inefficacy. Read More

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Unexpected Hepatitis B Virus Transmission after Liver Transplant from NAT and Serology Negative Liver Donors who are Hepatitis C Viremic.

Hepatol Res 2021 Jun 11. Epub 2021 Jun 11.

MUH James D. Eason Transplant Institute, University of Tennessee Health Sciences Center 1265 Union Avenue, 4 Shorb Tower, Memphis, TN, 38104, USA.

The opioid epidemic has led to increased availability of organs for liver transplantation (LT). The success of direct-acting antiviral (DAA) therapy for Hepatitis C (HCV) has led to the acceptance of HCV viremic donor organs. Nucleic acid testing (NAT) has led to increased detection of HCV and Hepatitis B (HBV) in potential donors. Read More

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